Beta-2 Microglobulin

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Key Benefits

Wide measuring range

With a measuring range of 0.56-20.9 mg/l in serum and 0.04-3 mg/l in urine, it will comfortably detect levels outside of the healthy range of 0.9-3.0 mg/l (in serum)

Excellent stability

Stable to expiry when stored at 2-8⁰C

Excellent linearity

The method is linear up to 0.56 mg/l

Other features:

  • Immunoturbidimetric
  • Liquid ready-to-use reagents
  • Stable to expiry when stored at 2-8⁰C
  • Measuring range 0.56-20.9 mg/l
Cat NoSizeAnalyserEasy Read
Easy Fit
 
BM3887R1 2 x 11ml
R2 2 x 4.3ml
RX Daytona/Imola
Hitachi 717/911/912/704/902


BM8016R1 2 x 11.6ml
R2 2 x 4.9ml
RX Suzuka
Abbott Architect
Hitachi 917/Mod P
Konelab 20i/30i/60i
Beckman Coulter AU Series








Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Beta-2 Microglobulin assay used for?

Beta-2-Microglobulin is a low molecular weight protein found on the surface of most cells, including white blood cells. When kidney disease is suspected, comparing blood and urine levels helps identify where the kidney is damaged.

In healthy individuals, is synthesized at a rate of 9 mg/hours and is eliminated mostly by the kidneys. Therefore the assay is useful to find out the following:

  • Beta-2 Microglobulin is normally filtered out of the blood by the kidney’s tubules. In glomerular kidney disease, the glomeruli can’t filter it out of the blood, so levels increase in blood and decrease in urine
  • In tubular kidney disease, the tubules can’t reabsorb it back into the blood, so urine levels rise and blood levels fall
  • High levels of Beta-2 Microglobulin in urine may help detect the early stages of kidney damage
  • In AIDS serum, Beta-2 Microglobulin is an accurate predictor of the progression of the disease in HIV infected groups including haemophiliacs. Levels above 5 mg/l indicate rapid progression and poor prognosis
  • In various mylomas, Beta-2 Microglobulin levels have been related to tumour mass, prognosis, disease activity and effectiveness of treatment. Levels below 4 mg/l indicate better prognosis than levels above 20 mg/l
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