Cardiology Reagents

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Cardiac health and regular cardiovascular screening is important to enable risk factors to be detected in their earliest stages. Randox reagents enable the risk assessment of cardiac events with key assays including sLDL Cholesterol, Lipoprotein(a), Homocysteine and hsCRP; early detection of a cardiac episode having taken place with use of our H-FABP assay; and, measurement of response to Aspirin therapy with use of our TxBCardio assay. In addition we manufacture a range of high performing and unique cardiology reagents to ensure vital detection is possible; these include Adiponectin, sPLA2-IIA, Apo C-II, Apo C-III and Apo E.

To discover more about our range of cardiology assays select an option from the drop-down menu. Alternatively, to gain an understanding of cardiovascular disease and the relevance of Randox cardiology assays please read the sections below.

Cardiology products available from Randox

Cardiovascular disease is a leading cause of morbidity and mortality!

Cardiovascular disease refers to a variety of diseases which cause reduced blood flow to the heart, brain or body. Such diseases include those affecting the blood vessels supplying the heart (coronary heart disease), brain (cerebrovascular disease) and arms and legs (peripheral arterial disease). Restrictions to blood flow can be a result of a blood clot (thrombosis), or narrowed arteries caused by a build-up of fatty deposits (atherosclerosis). The effects of this can lead to stroke or heart attack.

How can you prevent cardiovascular disease?

Lifestyle factors can implicate your risk of cardiovascular disease; these include smoking and being overweight in addition to other risk factors including high blood pressure and high blood cholesterol. Simple lifestyle measures such as exercising and maintaining a healthy diet can be effective in preventing cardiovascular disease, however familial factors such as a family history of heart disease may enhance your risk of cardiovascular disease.

Ask your doctor to assess your risk of cardiovascular disease!

If you are worried about your cardiovascular health, or whether you are at risk of a heart attack or stroke, ask your doctor for a cardiovascular risk assessment. Routinely they will run lipid tests such as Total Cholesterol, HDL Cholesterol, LDL Cholesterol and Triglycerides to assess your overall cholesterol and triglyceride levels, and allow corrective action to be taken. Specific tests you may want to discuss with your doctor include:

  • sLDL Cholesterol and Lipoprotein(a) to assess for genetically inherited risks of cardiovascular disease – even if your cholesterol levels are safe you may still be at risk of cardiovascular disease as a result of familial traits
  • Adiponectin to assess level of abdominal visceral fat, of which high levels can increase your cardiovascular risk. Please note that abdominal visceral fat levels or body fat cannot be determined by BMI score, which assesses whether weight is within a healthy range. As such, the Adiponectin test provides a clearer indication of health and is a good predictor of cardiovascular risk
  • TxBCardio to assess response to Aspirin therapy for the prevention of cardiovascular disease. Up to 30% of patients receiving Aspirin therapy suffer unknowingly from Aspirin resistance. This test enables treatment to be modified and corrected

Asking your doctor for these tests creates an opportunity for corrective action to be taken and can have significant benefits for your health.

CVD and more specifically, Myocardial Infarction (MI) remains a leading cause of morbidity and mortality!

Narrowing arteries caused by build-up of fatty deposits (atherosclerosis) is a major cause of MI or stroke; the reduction of blood flow to the heart, body or brain can result in various forms of cardiovascular disease (coronary heart disease, cerebrovascular disease and peripheral arterial disease). Often a heart attack or stroke is the first warning sign of cardiovascular disease; however this could be prevented by carrying out cardiovascular risk assessments on your patients with a few simple tests:

  • Routine lipid tests to determine the patient’s cholesterol and triglyceride levels – HDL Cholesterol, LDL Cholesterol, Total Cholesterol and Triglycerides
  • Independent risk assessment tests such as sLDL Cholesterol and Lipoprotein(a) to determine any genetic factors which may increase their risk of CVD. Please note this is necessary even for patients who have good cholesterol levels
  • Secondary tests, such as hsCRP, in addition to risk assessment markers and lipid evaluation – secondary tests are important in predicting future cardiac events of individual’s with no previous history of CVD and those deemed healthy as a result of primary tests; approximately half of all heart attacks occur in patients classified as low risk. In addition, they can also be used to evaluate the risk of a recurrent cardiac event
  • Speciality tests such as
    • Homocysteine – elevated levels of homocysteine have been linked to various disease states including CVD. Extremely high levels are found in patients with homocystinuria, of which many suffer from early arteriosclerosis
    • Adiponectin – low levels of Adiponectin indicate high abdominal visceral fat, which can increase a patient’s cardiovascular risk. It provides a much clearer indication of health than BMI scoring which does not indicate the patient’s level of body fat

It is important to test the effectiveness of treatment methods…

Once this stage has been completed Aspirin therapy may be deemed an appropriate treatment for risk reduction, however patient response to Aspirin should be measured; up to 30% of patients receiving Aspirin therapy suffer unknowingly from Aspirin resistance. Our simple TxBCardio™ (11dhTxB₂) test enables accurate measurement of Aspirin therapy response.

In addition, our Digoxin assay allows effective monitoring of digoxin levels, useful in managing chronic heart conditions.

Quick diagnosis of Myocardial Infarction is crucial…

In addition to cardiovascular risk assessment, it is crucial that in the event of MI quick diagnosis is made. This is possible with the H-FABP (Heart-type fatty acid binding protein) test which is a rapid, accurate and a highly sensitive early rise marker of acute coronary syndrome. It is a novel marker which offers quick detection; it is detectable as early as 30 minutes following the onset of an Ischemic episode providing rapid diagnosis when it is critically needed.

Another biomarker for the detection of MI includes CK-MB for use in patients with chest pain; Creatine Kinase is an enzyme produced in many different types of cells, of which high levels indicate muscle trauma or damage. CK-MB levels indicate damage which is heart specific. In addition Myoglobin, a small protein which leaks out of muscle cells after injury, is also considered a biomarker for the detection of MI.

For informative materials for your laboratory or further information please contact us, or alternatively download our cardiology brochure.

Randox is a leading provider of diagnostic reagents for the assessment of cardiovascular disease risk. Our extensive menu of cardiac biomarkers offers routine lipid tests in addition to independent risk factors such as Homocysteine, hsCRP, Apo A-I, Apo A-II, Apo B and Lp(a). Our assays offer superior performance and are available for use on a wide range of clinical chemistry analysers.

Randox range of cardiology assays also includes a range of unique products for cardiac risk assessment such as sLDL Cholesterol, Apo C-II, Apo C-III, Apo E and Adiponectin. In addition, our range of unique assays includes H-FABP for the diagnosis of heart attack, and TxBCardio for therapy monitoring.

Benefits of Randox cardiology assays include:

  • Liquid ready-to-use reagents for convenience; we also offer lyophilised reagents for CK-MB, HDL Cholesterol and Triglycerides
  • Wide measuring ranges for accurate detection of abnormal levels
  • Strong correlation to reference methods for trusted results
  • Applications available for a wide range of clinical chemistry analysers
  • Unique reagents enable impeccable patient care with an expanded profile for cardiac risk assessment

To order your cardiology kits visit our online store or contact reagents@randox.com to get in touch with your local sales representative. Alternatively, contact us to request a kit insert, or refer to our individual product pages for more information.

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