New report highlights scale and causes of prescription drug dependence in UK

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New report highlights scale and causes of prescription drug dependence in UK

10 December 2019

New report highlights scale and causes of prescription drug dependence in UK

 

A new report has highlighted the scale and causes of prescription drug dependence in the UK. In 2017, the minister for public health and primary care commissioned Public Health England (PHE) to identify the scale, distribution and causes of prescription drug dependence, and what might be done to address it.

The review covered adults (aged 18 and over) and 5 classes of medicines:

  • benzodiazepines (mostly prescribed for anxiety)
  • z-drugs (sleeping tablets with effects similar to benzodiazepines)
  • gabapentin and pregabalin (together called gabapentinoids and used to treat epilepsy, neuropathic pain and, in the case of pregabalin, anxiety)
  • opioids for chronic non-cancer pain
  • antidepressants

PHE’s analysis shows that, in 2017 to 2018, 11.5 million adults in England (26% of the adult population) received, and had dispensed, one or more prescriptions for any of the medicines within the scope of the review. The totals for each medicine were:

  • z-drugs – 1.0 million (2%)
  • benzodiazepines – 4 million (3%)
  • gabapentinoids – 5 million (3%)
  • antidepressants – 3 million people (17% of the adult population)
  • opioid pain medicines – 6 million (13%)

Trends

Between 2015 to 2016 and 2017 to 2018 the rate of prescribing for antidepressants increased from 15.8% of the adult population to 16.6% and for gabapentinoids from 2.9% to 3.3%. There was a small decrease in prescribing rates for the other 3 medicine classes. Rates of prescribing were higher for women (1.5 times those of men), and the rates generally increased with age. After a long increasing trend, the annual number of prescriptions for opioid pain medicines has slightly decreased since 2016. There is a continuing longer-term fall in prescription numbers for benzodiazepines. A longer-term increase in annual prescription numbers for z-drugs started to reverse in 2014.

Officials said long-term use on such a scale could not be justified and was a sign of patients dependence.

PHE medical director Prof Paul Cosford said he was worried.

“These medicines have many vital clinical uses and can make a big difference to people’s quality of life.”

But he added there were too many cases where patients were using them for longer than “clinically” appropriate – where the drugs would have simply stopped working effectively or where the risks could outweigh the benefits.

Conclusions

One in 4 adults in England were prescribed benzodiazepines, z-drugs, gabapentinoids, opioids for chronic non-cancer pain, or antidepressants. Prescriptions for antidepressants and gabapentinoids are increasing, but prescriptions for opioid pain medicines are decreasing. Prescriptions for benzodiazepines continue to fall, and those for z-drugs have more recently started to fall.

Peter Burkinshaw at PHE, one of the authors said: “The long-term prescribing of opioid pain medicines and benzodiazepines is not supported by guidelines and is not effective.”

Fellow author Rosanna O’Connor, said: “We know that GPs in some of the more deprived areas are under great pressure but, as this review highlights, more needs to be done to educate and support patients, as well as looking closely at prescribing practice and what alternative treatments are available locally.

References

Dependence and withdrawal associated with some prescribed medicines (PHE)

https://www.theguardian.com/uk-news/2019/sep/10/addictive-medication-nhs-opioid-crisis-government-study-england

Randox Testing Services

At Randox Testing Services we are at the forefront of alcohol and drug testing. We aim to spread the message of alcohol and drug misuse and the effects substance abuse can have on individuals and businesses. Prescription & OTC medication if taken incorrectly can have a devastating impact. It’s important to communicate with employers if you are taking prescription medication for any reason. If your organisation undertakes workplace testing, our chain of custody process provides clarity on the steps needed to ensure confidentiality is maintained.

For more information on drug & alcohol testing, including the wide range of substances we can test for, please visit www.randoxtestingservices.com or email testingservices@randox.com

 

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Give your loved ones the Gift of Health this Christmas

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02 December 2019

Randox Health Christmas Gift Cards

Give your loved ones the Gift of Health this Christmas

This year, you can give the ‘gift of health’ to someone you love, with a Randox Health Gift Card.

Randox Health has the most comprehensive health check packages in the world, as well as a wide range of specialised tests. The EveryMan, EveryWoman packages carry out 150 different health tests while the Signature package does 350. That means your results deliver a complete understanding of your health; your heart, kidneys, thyroid, fertility, bones and more.

And it doesn’t just tell you how you are now, but helps you to manage your health for the future.

Each one of our packages lasts for twelve months and include personalised health plans, a private consultation with an expert and repeat testing. This unique aspect enables you to see exactly what impact you’re making on your health as you follow our recommendations.

Specialised testing is also available on areas including cardiac health, coeliac autoimmune disease, hormonal health and genetic testing.

The health check packages are available at our clinics in London, Liverpool, Holywood and Crumlin, and also through our innovative mobile health clinic. Gift cards can be purchased from as little as £20.

To find out more and purchase the most thoughtful of Christmas presents – a gift card for the ‘gift of health’ – click here.

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California announces ban of Chlorpyrifos Pesticide from February 2020

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26 November 2019

Chlorpyrifos Pesticide ban in California

California announces ban of Chlorpyrifos Pesticide from February 2020

A recent Forbes article has stated that; “California plans to ban all sales of chlorpyrifos after Feb. 6, 2020, according to an agreement between the California Department of Pesticide Regulation (DPR) and manufacturers. Growers must use their chlorpyrifos supplies by the end of Dec. 31, 2020, and will not be allowed to own the pesticide after this date.

The DPR cited concerns about chlorpyrifos affecting the health of children, such as causing “impaired brain and neurological development.”

Chlorpyrifos is an agricultural pesticide with a variety of uses, including the ability to kill insects that harm crops. Introduced by the Dow Chemical Company in 1965, chlorpyrifos can eliminate insects by interfering with an enzyme called acetylcholinesterase in their bodies, which breaks up the neurotransmitter acetylcholine.

When an insect’s body cannot produce the enzyme, the levels of acetylcholine build up and overstimulate the nervous system until the insect dies. People also have acetylcholinesterase and acetylcholine in their bodies, so there have been ongoing concerns about the pesticide’s impact on human health.

The Agency for Toxic Substances and Disease Registry (ATSDR) explained, “In people, short-term oral exposure (one day) to low (milligrams) levels of chlorpyrifos can cause dizziness, fatigue, runny nose or eyes, salivation, nausea, intestinal discomfort, sweating and changes in heart rate. Short-term oral exposure to much higher (grams) levels of chlorpyrifos may cause paralysis, seizures, loss of consciousness and death.”

In order to help the industry Randox Food Diagnostics have developed Biochip Array Technology. Biochip allows for the detection of multiple pesticides including Chlorpyrifos, from a single honey or milk sample. The platform enables the user to run up to 54  samples on the Evidence Investigator analyser with a short sample preparation, allowing the user to consolidate costs and time.

For further information please contact the Randox Food Diagnostics team by emailing info@randoxfooddiagnostics.com.

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Vivalytic Powered by Randox Biochip Technology: Upper and Lower Respiratory Tract Testing

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15 November 2019

 

Vivalytic Powered by Randox Biochip Technology: Upper and Lower Respiratory Tract Testing  

Vivalytic will revolutionise the way laboratories and healthcare professionals access molecular diagnostics.  A result of a collaboration between Bosch – providing innovative strength – and Randox Laboratories – dedicated to improving global healthcare – Vivalytic is the new innovative testing platform.  It’s the perfect fit for any laboratory, with numerous benefits to enhance testing capabilities.

The Vivalytic is a fully-automated, cartridge-based platform capable of both Hi-Plex and Lo-Plex testing.  Vivalytic cartridges are compact, utilising micro-fluidics to enable simple and accurate diagnostic testing.  Hi-Plex tests utilise Randox patented Biochip Technology, enabling end-point qualitative PCR and providing multiple test results from each sample.  Lo-Plex tests are based on a variety of detection methods including real-time qualitative PCR and melting curve analysis.  Nucleic acid extraction, PCR amplification followed by a suite of detection methods are combined in a truly revolutionary platform.  Manual preparation, cold chain reagents and the use of multiple devices are no longer required.

Vivalytic is the perfect fit for a healthcare professional in a point of care setting to a laboratory, which can implement the Vivalytic Up – modular and expandable testing system for higher throughput.

Benefits include:

  • Fully Automated Platform
  • Protected System
  • Direct and Clear Results
  • Hygienic and Space Saving

Vivalytic Test Menu

Vivalytic offers the most comprehensive multiplex screening test for infectious diseases including respiratory, genitourinary and hospital acquired infections; simultaneously detecting both viral and bacterial infections (please see figure 1.).

Respiratory Tract Infection Array Sexually Transmitted Infection Array Hospital Acquired Infections
Bacterial Viral
Bordetella Pertussis Influenza A Chlamydia trachomatis (CT) Methicillin-resistant

Staphylococcus aureus (MRSA)

Chlamydophila pneumoniae Influenza B Ureaplasma urealyticum (UU) Methicillin-sensitive

Staphylococcus aureus (MSSA)

Haemophilus influenzae Human adenovirus A/B/C/D/E Neisseria gonorrhoea (NG) Methicillin-resistant

coagulase-negative Staphylococci (MRCoNS)

Legionella pneumophila Human bocavirus 1/2/3 Mycoplasma genitalium (MG)
Moraxella catarrhalis Human coronavirus 229E/NL63 Trichomonas vaginalis (TV)
Mycoplasma pneumoniae Human coronavirus OC43/HKU1 Haemophilus ducreyi (HD)
Streptococcus pneumoniae Human enterovirus A/B/C Mycoplasma hominis (MH)
Bordetella parapertussis Human Metapneumovirus Treponema pallidum (TP)
Human parainfluenza virus 1 Herpes simplex Virus 1 (HSV-1)
Human parainfluenza virus 2 Herpes simplex Virus 2 (HSV-2)
Human parainfluenza virus 3
Human parainfluenza virus 4
Human respiratory syncytial virus A & B
Human rhinovirus A/B/C

Figure 1.

Lower and Upper Respiratory Tract Infections

The economic burden of respiratory illness in the UK costs a staggering £11 billion every year on lung disease alone1.  Lower respiratory tract infections (LRIs) are a substantial public health problem and a leading cause of illness and death in people of all ages2. It is estimated that LRI causes nearly 4 million deaths annually3.  Upper respiratory tract infections (URIs) account for an estimated 10 million outpatient appointments a year. Most of these appointments end with physicians needless writing of antibiotic prescriptions4.

Randox Biosciences offers a Respiratory Multiplex Array which rapidly detects and identifies the cause of 22 bacterial and viral pathogens helping to reduce the risk of antibiotic resistance.  Given that only bacterial infections can be treated with antibiotics, rapid diagnostic tests are urgently needed to distinguish between bacterial and viral infections.  This test will aid clinicians in their selection of the most appropriate antibiotic treatment for patients.  GPs would have additional efficiency savings for the NHS, by eliminating the need for lengthy microbiology lab tests and unnecessarily writing prescriptions.

The test is performed utilising our Biochip Technology which enables the simultaneous detection of multiple results from one patient sample. Biochip Technology powers Vivalytic which is the all-one solution for molecular diagnostics.

The main benefits of the Respiratory Multiplex Array are:

  • Turnaround time of 2 hours
  • Validated for sputum, lavage and nasopharyngeal samples
  • Panel includes viral and bacterial species to consolidate testing

Randox Biosciences are committed to the ongoing development of diagnostic tests, through our research into numerous disease areas, to improve health worldwide.

MEDICA World Forum for Medicine International Trade Fair

Randox Biosciences team will be attending Medica from the 18th – 21st of November 2019 at Messe Dusseldorf, Germany.  Stop by and say hello to some of our team members at our stand, and to learn more about our latest game-changing partnership with Bosch – the innovative Vivalytic platform!

Medica is at the forefront of new approaches in laboratory medicine, addressing the complexity of an evolving healthcare landscape.  This event attracts more than 5,100 exhibitors from 70 countries, engaging diverse professionals enabling them to discover new and innovative solutions to improving patient outcomes through effective lab testing, diagnosis and treatment.

To learn more about the Vivalytic offering, visit https://www.randoxbiosciences.com/clinical-laboratory/infectious-diseases/molecular-arrays/ or email us at info@randoxbiosciences.com

References:

  1. British Lung Foundation. (2019). Estimating the economic burden of respiratory illness in the UK. [online] Available at https://www.blf.org.uk/policy/economic-burden [Accessed 06 Nov. 2019].
  2. The Lancet Infectious Diseases. (2015). Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015. [online] Available at https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(17)30396-1/fulltext [Accessed 29 Oct. 2019].
  3. Forum of International Respiratory Societies. The Global Impact of Respiratory Disease – Second Edition. Sheffield, European Respiratory Society, 2017.
  4. Thomas, M. and Bomar, P.   The National Centre for Biotechnology. Upper Respiratory Tract Infection. United States of America.

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Practical steps for dealing with substance misuse in the workplace

11 November 2019

Practical steps for dealing with substance misuse in the workplace

 

What is substance misuse?

Substance misuse (or abuse) is defined as the sustained use of any mind-altering substance. This includes legal substances like solvents and alcohol as well as illegal drugs. Through this continued use the user’s physical and mental health are severely affected. The misuse of substances in the workplace can cause issues such as increased absenteeism, low productivity and create an unsafe working environment.

It is estimated that between 3% and 5% of all work absences are due to alcohol abuse and that 1 in 30 employees has had drugs in their system at one time in the workplace. All employers have a legal responsibility to ensure the health, safety and welfare of their employees and so statistics like this cannot be ignored.

What can employers do?

As an employer, it is important that measures are taken to protect all employees and the company from potential dangers. To do this, employers should:

Introduce a comprehensive drug and alcohol policy. This lets all stakeholders know exactly where the company stands on substance misuse and shows that you are being proactive in your approach.

Conduct drug and alcohol testing. Utilising random and/or with cause testing can help quickly identify any substance misuse issues. Consider including a contractual obligation for employees to co-operate with this.

Train staff to identify the signs of substance misuse. Make everyone aware of the issue and give them the ability to look for the key signs. This can only help increase safety.

Keep up-to-date with the latest legislation. The laws on substance misuse can change quite quickly, especially as new substances like legal highs are identified and re-classified. Ensure you are aware of the latest changes.

Support employees. Addiction or frequent misuse of substances should be treated the same way as other health issues. Offer support to your employees and help them make a quick return to work.

The above steps can help better manage the issue of substance misuse in the workplace. Effectively communicating the company’s stance on this issue to employees brings clarity and lets everyone know where they stand.

Randox Testing Services

At Randox Testing Services we offer comprehensive drug and alcohol testing solutions for workplaces. We incorporate cutting-edge screening methods to provide an outstanding testing service and are well-positioned to provide consultancy and support to help you put an effective workplace drug and alcohol testing policy in place.

For more information contact us at testingservices@randox.com.

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Free prostate health blood tests return to Randox Health for Movember

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01 November 2019

Movember Offer 2019

Free prostate health blood tests return to Randox Health for Movember

Following successful initiatives in both 2017 and 2018, we are pleased to announce that Randox Health will once again be offering free prostate health blood tests during the month of November.

The free health check tests for Prostate Specific Antigen (PSA) to provide an overall profile of your prostate health.

The PSA blood testing can be booked in Randox Health’s clinics in London, Liverpool, Holywood and Crumlin, offers a pre-cursor to a physical examination, and can stratify clients who may need further investigation.

Dr. Peter FitzGerald, Founder and Managing Director, Randox Health, commented;

“Prevention is better than cure, and it is so easy to get information about your prostate health which could ultimately save and extend your life.

“Prostate cancer is the most common cause of cancer in men across the UK, however if it is detected early enough, the outlook for patients is extremely positive. If caught at stage 1, almost everyone will survive their cancer for 5 years or more, but if caught at stage 4, this reduces to just a 30% survival rate.

“It is unsurprising therefore that we want to get the word out there as much as we can about the free prostate health tests we are offering, so that as many men as possible can take advantage of this unique opportunity in our clinics in London, Liverpool, Holywood and Crumlin.”

Prostate health Movember

How to book

Prostate Health Check Appointments are made by booking only by directly phoning your nearest Randox Health clinic: Randox Health Holywood 028 95622300 / Randox Health Crumlin 028 94477498 / Randox Health London 020 30112970 / Randox Health Liverpool: 0151 665 0700. Each booking includes complimentary body composition analysis and a phonecall with a Scientific Consultant to discuss your results.*

*Please note that there are no specific blood tests for cancer. PSA is not a diagnostic for prostate cancer, but rather, for overall prostate health.

A high PSA result may suggest prostate cancer but other causes include an enlarged prostate, prostatitis, exercise, urinary tract infection, recent sex or ejaculation, recent prostate examination, recent prostate surgery, a urinary catheter, or some medications.

Randox Health may suggest repeat testing, prostate examination or referral to a urologist for further investigation.

Randox Health: What We Do

Randox Health packages go beyond a health check. We have the world’s most comprehensive full-body health programmes available on the market today, thanks to Randox Biochips which enable hundreds of individual tests to be carried out from one sample and giving you truly unrivalled knowledge about your health and wellbeing both now and in the future. Our goal is to help you extend your life. Your health matters to us and, above all, we are committed to improving healthcare worldwide by identifying and preventing illness at the earliest possible stage.

How we can help you

Identifying the very first signs and risks of disease can help prevent health problems that may be on the horizon. Randox Health aim to do this before the appearance of unpleasant symptoms or illness. Prevention is always better than cure. Long-term mild dehydration may have caused damage to your health and our packages tests for up to 350 different biomarkers. Read about our packages here, or contact a member of our team for more information!

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Drug Abuse Screening in the Emergency Department

News       About Us        Randox Toxicology

21 October 2019

 

Drug Abuse Screening in the Emergency Department

On a global scale, emergency departments have been providing critical access to the health care system for many years, however, more recently visits to the emergency department has been an opportunity to identify patients with substance use disorders. Screening patients for illicit drugs and drug abuse has become increasingly more regular when a patient is admitted to the emergency department. Screening is vital to treat a patient with effective treatment. Nearly half of all emergency department visits in the US are categorized as relating to substance use disorders.

In a study completed at Ghent University Hospital in 2017  it was found that the most frequently reported drugs abused by emergency department patients are cannabis, cocaine, amphetamines, and opiates. It is important to screen patients in the emergency department if the patient is showing signs of confusion, deliriousness, unconsciousness, panic attacks, chest pain, difficulty breathing, vomiting, or seizures as these symptoms usually indicate drug intoxication or overdose.

Randox Toxicology’s Evidence MultiSTAT is a fully automated immunoanalyser that enables on-site simultaneous detection of up to 21 analytes from a single sample, making it ideal for an emergency department. It requires a small sample volume and generates results in 20 minutes. The process from sample entry to results can be completed in 3 simple steps, with minimum room for human error. The MultiSTAT is designed to analyse as quick, simple and reliable as possible.

 

Available Tests
AB-CHMINACA AB-PINACA Amphetamine
Barbiturates Benzodiazepines I (Oxazepam) Benzodiazepines II (Lorazepam)
Benzoylecgonine (Cocaine Metabolite) Buprenorphine Cannabinoids (THC)
Creatinine Ethyl Glucuronide (EtG) Fentanyl
LSD Methadone Methamphetamine
Opiate Oxycodone Phencyclidine (PCP)
Pregabalin Propoxyphene Tramadol
Tricyclic Antidepressants (TCA) UR-144/XLR-11 α-PVP (Flakka)

 

If you would like to find out more about the Evidence MultiSTAT, Biochip Array Technology, or our Evidence range of analysers, contact info@randoxtoxicology.com or visit www.randoxtoxicology.com

 

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RTS | Which company testing is right for me?

04 October 2019

Which company testing method is right for me?

 

Implementation of an effective substance misuse policy establishes employer rights to conduct workplace drug and alcohol testing if required. In addition, it ensures adherence to the duty of care of an employer to protect their workforce and keep employees safe. There are a range of approaches available to complement your policy to ensure a safer working environment. In this blog we take a look at two common types of testing; random testing and with-cause testing.

Random Testing

With knowledge that a test could be conducted with anyone at any time, random testing is the most effective deterrent of drug abuse or alcohol misuse among employees. Ensuring the integrity of staff across all levels, random testing can be conducted with employees at any level, from temporary employees to managers and directors.

Process

The process includes ensuring a clear workplace drug and alcohol testing policy is in place. Employees should also be made aware that random drug and alcohol testing is carried out; this can take the form of a clear statement in an employee’s contract outlining that random testing can be conducted with little to no notice. Notification of this conforms to legislation whilst respecting employee rights.

Secondly, we will work with you to determine the percentage of your workforce you would like to test, and how often you would like testing to be carried out. Whilst we recommend random drug and alcohol testing should be performed at least quarterly, the decision is yours. To avoid employee discrimination and to ensure testing is random, we use our random selection technology to eliminate bias and provide accurate random selections.

Finally, we will arrive to your workplace unannounced to carry out sample collections from the random selection of employees.

Key Benefits

By implementing a random drug testing may help employers by:

  • Deterring current employees from engaging in drug use
  • Preventing the need for substance abuse recovery programs
  • Employees are less likely to tactfully try to disguise results, or alter their habits, as they will be given little to no notice that a test is going to be conducted
  • Improving attendance and employee productivity
  • Providing a safer workplace with reduced accidents

With-Cause Testing

Under the Misuse of Drugs Act (1971), if an employer suspects an employee is under the influence of drugs or alcohol, they are legally required to take appropriate action to protect the safety of the employee concerned, other members of staff and the public.

Process

The nature of with-cause testing means that testing can be required ‘on-the-spot’. At Randox Testing Services, we offer a 24-hour call-out service which guarantees an experienced collection officer will arrive to your company within a maximum of 2 hours to perform a sample collection. This service is available 24/7, 365 days a year and complies fully with chain of custody procedures.

Benefits

  • Legal compliance with correct measurements being taken if an employee is suspected of being under the influence of drugs or alcohol
  • Can deter employee misuse of drugs or alcohol due to a workplace testing policy being in place
  • Cost savings because of increased productivity with issues being discovered and rectified early

How Randox Testing Services can help

At Randox Testing Services we possess a wealth of experience and knowledge that enables us to offer holistic packages to meet the needs of the customer, regardless of their location or industry. This knowledge comes from over 35 years of testing experience in the diagnostics industry and through our involvement with bodies that help shape testing legislation.

For more information about our range of drug & alcohol testing products, our expertise in this industry and our array of support services, visit www.randoxtestingservices.com.

If you would like to speak with one of our experts, use any of the following methods:

Email: testingservices@randox.com

Phone: +44 (0) 28 9445 1011

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The world’s most comprehensive health checks from Randox Health

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01 October 2019

Randox Health Checks

Do you know about our world-leading health checks?

Randox Health provides the world’s most comprehensive full-body health screen packages available. Our patented technology enables 100’s of individual tests to be carried out from your sample, giving you truly unrivalled knowledge about your health now and in the future.

Identifying the very first signs and risks of disease could help prevent many health problems, before the appearance of unpleasant symptoms or illness. We can provide an extensive test menu with our health care due to the high performance diagnostic tests that we run.

Randox Health do this by detecting small changes in your blood. Early identification, paired with expert advice, provides the potential to prevent health problems developing.

Randox Health complete more tests in each health check than anyone else. With up to 350 results in each health check, you’ll get the most comprehensive understanding of your health available – including your heart, hormonal, lungs, digestive system and more.

The Randox Health process couldn’t be simpler.

When booking an appointment at one of our clinics the process couldn’t be simpler.

  1. Book your appointment – Online, via our app or on the phone, you can book an appointment with our health experts at one of the clinic locations or alternatively book an “on the move” appointment and we will come to you.
  2. Clinic appointment – this will last no longer than 30mins, involving a review of your details, bio-measurements and sample collection.
  3. Scientific Analysis – all of your samples collected are analysed quickly by our Bio-Medical Scientists, using the latest Randox patent technology, which generates a vast amount of data about your current and future health.
  4. Results and Consultation – You will receive a detailed report in the post and via our app containing a clear explanation of your results. We will then invite you for a consultation with one of our Health Experts to discuss your report in full. This is all included in your package.
  5. Repeat appointment – We want you to continue to monitor your health status based on our results, so you will be invited back for a retest as part of your initial package which will ensure the corrections we have suggested are having a positive effect.
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The vision of Randox is one of ambition, innnovation and commitment to improving health worldwide.

To book an appointment, email  info@randoxhealth.com or phone  0800 2545 130.

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World Heart Day from Randox Biosciences

News       About Us        Randox Biosciences

29 September 2019

 

World Heart Day 2019

 

The World Heart Federation (WHF) is the acting global voice in leading the universal fight against cardiovascular disease (CVD).  Part of the WHF mission is to ensure heart health equity for everyone. They believe everybody is entitled to cardiovascular health and well-being through health promotion, access to prevention, control and management of CVD 1.

World Heart Day falls on the 29th September where people make a promise to promote and implement healthier lifestyles to maintain a happy and healthy heart, reducing the potential risks of heart disease and stroke.  CVD takes the lead being the number one cause of death world-wide 2 relating to all heart and circulatory diseases consisting of coronary heart disease, angina, heart attack, congenital heart disease, hypertension, stroke and vascular dementia 3.

According to the World Health Organisation2:

  • An estimated 17.9 million people died from CVD in 2016, representing 31% of all global deaths. Of these deaths, 85% were due to heart attack and stroke.
  • Out of the 17 million premature deaths (under the age of 70) due to noncommunicable diseases in 2015, 82% were in low- and middle-income countries, and 37% were caused by CVD.
  • Most cardiovascular diseases can be prevented by addressing behavioural risk factors such as tobacco use, unhealthy diet and alcohol abuse.
world-heart-day-2019

Cytokines have a central role within the immune system; they are a category of signalling molecules that mediate and regulate immunity, inflammation and hematopoiesis 4.  Cytokine and inflammatory mechanisms have major implications for the vascular system and can lead to CVD.

Cytokines exist in broad families that are structurally related but exhibit diverse function.  The major classes of cytokines include: pro- and anti-inflammatory cytokines, cytokines of neutrophil and eosinophil recruitment and activation, cytokines derived from T-helper (Th) and T-regulatory (Tregs) cells, and cytokines of T-cell recruitment and growth factors.

Randox offers a comprehensive menu of 26 cytokine, cytokine receptors and growth factors over four multi-analyte arrays.  Each cytokine assay is performed on biochip array technology with spatially discrete test regions containing antibodies specific to each of the analytes.  The combination of highly specific antibodies and advanced chemistries enables up to 12 cytokines and growth factors to be detected simultaneously in a single sample.

Cytokine Array I                                                            Cytokine Array III

  • Epidermal Growth Factor (EGF) –    Granulocyte Macrophage Colony Stimulating
  • Interferon-y –    Interleukin-5
  • Interleukin-1a –    Interleukin-15
  • Interleukin-1b –    Macrophage Inflammatory Protein-1a
  • Interleukin-2
  • Interleukin-4
  • Interleukin-6
  • Interleukin-8
  • Interleukin-10
  • Monocyte Chemotactic Protein-1
  • Tumour Necrosis Factor-a
  • Vascular Endothelial Growth Factor

Cytokine Array IV                                                                         Cytokine Array V

  • Matrix Metalloproteinase-9 –    Interleukin-3
  • Soluble IL-2 Receptor a –    Interleukin-7
  • Soluble IL-6 Receptor –    Interleukin-13
  • Soluble Tumour Necrosis Factor Receptor I –   Interleukin-12 p70
  • Soluble Tumour Necrosis Factor Receptor II –   Interleukin-23

Key Benefits of Randox Cytokine Arrays:

  • Multiplex testing from a single sample.
  • Suitable for human serum and plasma samples.
  • Small sample volume required.
  • Excellent analytical performance.
  • Fast throughput.
  • Applicable to fully automated and semi-automated Evidence analysers.

Randox manufacture the majority of assay raw materials in-house and can therefore take a more tailored approach, by adapting assays to the needs of your research project to best fit your individual requirements.

  1. https://www.world-heart-federation.org/
  2. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
  3. https://www.bhf.org.uk/informationsupport/conditions/cardiovascular-disease
  4. https://www.sinobiological.com/cytokine-rerview-receptor-source-targets-main-function-disease-association-a-1310.html
  5. https://www.sciencedirect.com/topics/neuroscience/cytokines
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