Randox Food Diagnostics: Infiniplex Array for Milk

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Randox Food Diagnostics: Infiniplex Array for Milk

Drug residues in milk present major concern for farmers, dairy processors, cheese manufacturers, authorities and consumers due to the potential public health and industrial implications. Through the potential inappropriate antimicrobial use in animals producing product for human consumption, antibiotic-resistant organisms can enter the food supply or can spread to various components of the ecosystem. For consumer protection, regulatory limits have been set for the majority of compounds.

Randox Food Diagnostics provides screening technology to monitor the levels of these potentially harmful compounds including the Infiniplex for Milk Array available on the Evidence Investigator and Evidence Multistat analysers.

Using the Randox Food technology the user can identify 130 analytes from a 200µl sample of raw milk and follows this simple process to results:

  • Pipette the sample directly onto the MultiSTAT biochip
  • Insert into the Evidence MultiSTAT
  • Press Play and follow the on-screen prompts
  • Results appear on screen in under 20 minutes

Developed to provide an easy to use option for the user, the Infiniplex Array for Multistat can be used by anyone to ensure rapid on-site testing within the dairy industry.

The InfiniPlex test menu is 98% compliant with EU regulations and screens for additional contaminants including; antiparasitic, anti-inflammatories, non-steroidal and unauthorised substances from one sample of raw milk, creating a better end product for the processor and end user.

To find out more about InfiniPlex contact info@randoxfooddiagnostics.com

 

 

 

 

 


Rheumatoid Arthritis and Women’s Health

Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterised by pain, swelling and stiffness in joints which commonly affects the hands, wrists and feet.  Whilst both men and women can suffer from rheumatoid arthritis, it is more commonly seen in women than men.

Rheumatoid arthritis is the most common autoimmune disease with a higher prevalence rate compared to lupus, multiple sclerosis, type 1 diabetes, Crohn’s disease and psoriasis.

(Simmons, 2013)

The incidence rates of rheumatoid arthritis differ between men and women.  The onset of RA occurs much earlier for women, for most, during their 30’s and 40’s.  In an American study, it was noted that the incidence rates peak for women around the ages of 55 to 64, compared to 75 to 84 years of age for men.

(Simmons, 2013)

As most women are diagnosed with rheumatoid arthritis in their 30’s and 40’s, a study found that the diagnosis negatively impacts both the body and mind of women, as indicated in their pain, disease activity, and quality of life scores.  This is due to women being diagnosed at a time when their burdens are the heaviest as this is the time when women are most likely to have children or are raising children combined with work and socialising.

Changes in hormone levels also impacts women.  It has been noted that before a menstrual period, women find the symptoms of rheumatoid arthritis to be more severe, but settles during their cycle.  Also, due to the changes in hormone levels during pregnancy, 50 – 60% of women with rheumatoid arthritis noticed that their symptoms improved.

The key to managing rheumatoid arthritis is to start the treatment as early as possible as it can halt or slow the disease, preventing joint damage and complications, including: osteoporosis and cardiovascular disease.  Rheumatoid arthritis increases the risk of heart attack by 60%.  To start treatment as early as possible, it is important that it is diagnosed as early as possible.

Randox offer a number of key assays for the diagnosis of rheumatoid arthritis.

Rheumatoid factor is the most routinely run test to diagnose rheumatoid arthritis as 80% of rheumatoid arthritis patients test positive for rheumatoid factor.  The Randox Rheumatoid Factor reagent offers the following benefits:

  • Wide measuring range of 6.72 – 104lU/ml for the accurate measurement of clinically important results
  • Accurate assessment of rheumatoid factor titre (calibrant standardised against primary WHO material; 1st British Standard 64/2)
  • No interference from complement C1q
  • Automated immunoturbidimetric assay
  • Applications available for a wide range of biochemistry analysers, detailing instrument-specific settings

It has been found that complement C4 and CRP upregulation indicates the middle to late stages of rheumatoid arthritis.

The Randox Complement C4 reagent offers the following benefits:

  • Wide measuring of 3.41 – 152mg/dl for the accurate measurement of clinically significant results
  • Limited interferences from Bilirubin, Haemoglobin, Intralipids, and Triglycerides, producing more accurate results
  • Automated immunoturbidimetric assay
  • Applications available for a wide range of biochemistry analysers, detailing instrument-specific settings

The Randox High-Sensitivity CRP reagent offers the following benefits:

  • Wide measuring of 0.477 – 10mg/l fir the accurate measurement of clinically significant results
  • Liquid ready-to-use reagents for convenience and ease of use
  • Applications available for a wide range of biochemistry analysers, detailing instrument-specific settings

RTS: The Dangers of Psychoactive Substances

Psychoactive substances, formerly known as legal highs, are substances which produce the same or similar effects as many illegal drugs such as cannabis, ecstasy and cocaine. With many psychoactive substances it is extremely difficult to know their potency and therefore how they will affect the user.

They are divided into four main groups:

Sedatives – Cause reduced concentration and slowing of reactions, leading user to feel physically unsteady and lethargic.

Hallucinogenic – These substances cause psychedelic reactions which can lead the user to act erratically, putting their own safety at risk.

Stimulants – Substance temporarily causes increase in alertness and energy, while also putting a strain on the nervous system.

Synthetic Cannabinoids – Large doses can lead to life-threatening intoxication. Also effects the central nervous system causing seizures, high blood pressure, rapid heart rate and increased body temperature.

Incidents

Last month two men were arrested and jailed for four and a half years for selling psychoactive substances. The offences were committed in Scotland and eight of the men’s customers needed hospital treatment after taking the substances.

Free samples and loyalty cards were used by the men selling the psychoactive substances and two users were left in comas after taking a substance known as Psyclone. Court was told that the shops took in as much as £2,500 in sales every day.

The sister of a man who died from taking psychoactive substances said it changed her brother “mentally and physically.” BBC Scotland was told that he started dabbling with psychoactive substances because he believed they were legal. “Some of them were a substitute of heroin, others to mimic the effects of cannabis. He became very withdrawn with the family and just wanted to stay away.”

 

Randox Testing Services

At Randox Testing Services we reacted to the issues caused by psychoactive substances by releasing the world’s first Synthetic Cannabinoids (JWH/AM) and ‘Bath Salt’s’ (MPDV) tests in 2012. This enables companies to test for popular types of psychoactive substances and showed that it was possible to detect these substances.

However as new psychoactive substances emerged new tests also had to be created and next generation Synthetic Cannabinoids tests (UR144 and JWH250) were released in 2013. These tests represented a milestone in the fight against the highly dangerous psychoactive substances and provided a way for laboratories and companies to stay on top of the developing drug trends.

Psychoactive Substances we currently screen for;

 

 

 

 

 

 

Today, in the endless pursuit of creating innovative tests for new and emerging psychoactive substances, our expertise sets us apart from the rest of the industry. We will continue to develop our test menus and grow our range of tests.

For more information contact us today at testingservices@randox.com.

 

 

 

 

 


We Are Randox | Christopher McNally climbs the career leader from Placement to PhD

The name Christopher McNally may be one that you already recognise. In 2016 he earned 1st place in the Science category of the Randox Pinnacle Placement Awards, having caught the attention of Senior Management for his pioneering work developing a new diagnostic for pancreatic cancer.

Fast-forward two years and Christopher is now back at Randox as a PhD student, conducting research in prostate cancer as part of the recently-announced Randox-Ulster University PhD Academy.

We sat down with Chris to hear all about his revolutionary prostate cancer project, what motivated him to sign up to our PhD Academy and what it’s like to be back in the place where his scientific career began.

Here’s Chris’ story.

I came into Randox when I was just 19 years old for my third year at university as part of the company’s year-long placement programme. It was a great way to truly experience a working laboratory outside of the classroom and really cemented my desire to work in biomedical science.  

I was lucky enough to be placed in the company’s Donegal branch, Randox Teoranta, which is close to where I grew up in Gartan, and offered me the opportunity to carry out ground-breaking medical research surrounded by my home of Donegal.

I would highly recommend the opportunity to perform an industrial placement to anyone. It helps you to prepare for what comes after university, develops your skills in the area in which you are interested, and refines your laboratory techniques. I was delighted to hear I won in the Science Category of the Randox Pinnacle Placement Awards during my time there as well, and this really inspired a confidence in me that I had become a talented scientist even before I graduated.

When I completed my fourth year of studies at Ulster University, I graduated with a degree in Biomedical Science and Professional Practice, and returned to work for Randox. The traits and qualities I learned during my placement had subsequently brought me to post-graduate employment, and I was thrilled. I was lucky enough to be able to walk straight back into the lab knowing exactly what to do and how to do it.

Despite becoming employed within Randox straight out of university however, I had this feeling that I was not finished with regards to academic study. I knew I wanted to do more, to perform more research. So, when I heard about the Randox-Ulster University PhD Academy I really was intrigued. It was the perfect platform to further my studies and be able to give more to the scientific community.

When choosing the area of research for my PhD I was keen to hear more about a collaborative prostate cancer project led by two of Northern Ireland’s leading cancer researchers Dr Mark Ruddock (Randox) and Dr Declan McKenna (Ulster University). From my time at university and my time spent at Randox, I thought I could bring my experience and knowledge in cancer research into this project, so I thought, let’s go for it. 

Ultimately, the project involves looking at prostate cancer patients as well as patients who have other non-serious prostate conditions, and recognising any potential differences in the two. We can then develop a clinical diagnostic test that can identify the men at the highest risk of prostate cancer and stratify the patients accordingly.

The earlier we can do this, the quicker a patient can be treated, or not treated as the case may be. Overdiagnosis is a significant problem in prostate cancer care and many men, who do not have prostate cancer, but present with prostate cancer-like symptoms, unfortunately go through invasive, uncomfortable and most importantly, unnecessary procedures.

This work therefore has real potential to improve the management of prostate cancer, which is currently the most common cancer in males within the UK. It’s a very rewarding field to be working in and I thoroughly enjoy the work I’m doing knowing that it will have a real-life impact on many men. I’m very proud to be able to say that my PhD research will really make a difference and I now know for certain that I will continue working in cancer research after my project is complete.

Knowing that I’m helping to improve the quality of patient’s lives brings a great deal of satisfaction that few jobs can replicate and I’m excited to see what the next three years will bring.

We’re very proud of Christopher and the amazing work he is doing in prostate cancer research, and are delighted that he has made the decision to join the Randox-Ulster University PhD Academy.

For more We Are Randox stories about our amazing colleagues, make sure to follow us on Facebook, Instagram and Twitter and follow the hashtag #WeAreRandox.

For current vacancies in our team, visit careers.randox.com

To find out more about the Randox-Ulster University PhD Academy, please email randoxpr@randox.com

 

 

 

 

 


RCLS – Tackling the Increase of Gonorrhoea and Syphilis

A report published by Public Health England (PHE) reveals that there was 7,137 diagnoses of syphilis reported in 2017, a 20% increase compared to 2016 and 44,676 diagnoses of gonorrhoea reported in 2017, a 22% increase compared to 2016.1

Overall, there were 422,147 diagnoses of sexually transmitted infections (STIs) in England during 2017.

To help with the increase of STI testing, Randox Clinical Laboratory Services offer a multiplex Sexually Transmitted Infection (STI) test kit allowing your clinic, laboratory or GP practice to outsource sample STI testing.

Our STI array is the broadest IVD multiplex array on the market simultaneously detecting 10 infections due to our patented and intelligent Biochip Array Technology which utilises multiplex testing methodology in a rapid and accurate format. These 10 bacterial, viral and protozoan infections consist of:

·        Chlamydia·        Trichomonas Vaginalis
·        Gonorrhoea·        Mycoplasma Hominis
·        Syphilis·        Mycoplasma Genitalium
·        Herpes Simplex 1·        Ureaplasma Urealyticum
·        Herpes Simplex 2·        Chancroid

 

The type of sample which should be sent to our Randox Clinical Laboratory Service lab is determined by the visibility of the patient’s symptoms.

Non-visible symptoms – urine sample required

Visible symptoms – swab sample required

The process of sending samples to RCLS is simple and easy to follow. Our project management teams incorporate a wealth of knowledge and are available accordingly, providing support and guidance. This enables support to be available from your initial enquiry through to the shipment of the samples. As a result we are always delivering to your project aims and timelines.

RCLS currently has four state of the art, fully functional ISO12025 accredited laboratories across the UK. They are situated in Liverpool, London and two in Northern Ireland, Hollywood and Randox Science Park in Antrim.

Overall, by utilising Randox Clinical Laboratory Services you can save your laboratory time and money. Due to our multiplex panels we offer a cost effective, labour saving and time reducing solutions for your STI testing. Providing your laboratory with the best solution to outsource your samples.

Contact us at info@rcls.com to find out more information about RCLS and our STI testing service.

Sources
1 – Public Health England

 

 

 


Every woman deserves to make her health a top priority

At a time when a quarter of people under the age of 75 die prematurely from avoidable causes, we have developed a range of health checks which aim to help people extend their lives and live healthier for longer – by promoting wellbeing and actively preventing sickness.

And this month at Randox, in celebration of Women’s Health Month, we’re focussing on our revolutionary Female Health Check – the pioneering Everywoman Programme.

We all have women in our lives who work hard, spend much of their time looking after others, and put everyone else’s needs before their own.  Or maybe you’re one yourself.

Well it’s time we, aswell as our mothers, daughters, sisters, aunties and friends started to appreciate ourselves more, by making sure our health is at the top of our priority list.  Once we make sure that’s taken care of, we can make plans, share experiences and enjoy life the way we choose.

Thanks to the Randox Health Everywoman Programme, you can take steps to avoid developing illness and protect your future health.

The world’s most advanced scientific female health, 150 tests are carried out on a sample of blood to assess the health of individual elements of your body. This includes fertility health, heart health, metabolic syndrome and liver health.

By taking a holistic approach to your body’s health you gain a complete understanding of your current health, and also gain the knowledge you need to manage your future health. Our tests are so sensitive they can identify risk of pre-disease in conditions such as diabetes – which means you can take action to stop it before it becomes a lifelong condition to manage.

Each one of our programmes lasts for twelve months and include personalised health plans, private consultations and repeat testing. This unique aspect enables you to see exactly what impact you’re making on your health as you follow our recommendations.

Programmes are available from as little as £41.66 per month and vouchers can be purchased to give as gifts. Tests are available at our clinics in London, Holywood and Crumlin, and also through our innovative mobile health clinic.

To find out more about the Randox Health Everywoman Programme this Women’s Health Month, email info@randoxhealth.com or phone 0800 2545 130.

 

 

 


June focus: Women’s Health

Randox is dedicated to improving health worldwide. Throughout the month of June we hope to highlight how the Randox clinical product range can ensure accurate and swift diagnosis and, by doing so, improve women’s health. We can do this by allowing for necessary steps to be taken post-diagnosis. A common-held misconception is that breast cancer is the biggest threat to a woman’s health, however, the biggest health risk to women statistically is heart disease which accounts for roughly 27% of female deaths. The Randox clinical product range offers a wide range of products to combat heart issues including the RX series extensive cardiac testing panel, reagents such as H-FABP, Adiponectin an TxB Cardio and an extensive cardiac QC range available in both liquid & lyophilised format.

Randox Reagents

Randox Reagents have the highest quality reagents on the market and a test menu comprising of over 118 assays covering over 100 disease markers. Several of these reagents will play a key role in diagnosis in women such as Randox’s Lipoprotein (a) – Lp(a) test,   The Randox Lp(a) offers swift and accurate diagnosis of elevated circulation Lp(a) levels which is significant for women as they have an increased risk of CVD due to elevated levels of Lp(a).  Several traditional CVD risk markers, including elevated LDL may be absent in some women, elevated Lp(a) levels may identify women at high risk of developing CVD.

RX Series

The RX series range of clinical chemistry analysers offers the most comprehensive testing profile for assessing health in males and females. Urinary tract infections are more commonly found in women and the RX series extensive renal function panel will provide clarity  in terms of a woman’s urological health by testing for 19 separate analytes, including microalbumin. The RX series microalbumin test can detect very low levels of albumin in urine and if albumin is detected it can be an indicator of kidney injury and can result in irreversible damage. To view the full RX series test menu click here.

Quality Control

The Randox Acusera Maternal Screening quality control is the only commercially available control which covers all six analytes used during first and second trimester screening of Down’s syndrome and Spina Bifida. Instrument-specific target values and ranges are provided for AFP, Inhibin A, PAPP-A, β hCG, Total hCG and Unconjugated Estriol. The inclusion of PAPP-A and Inhibin A eliminates the need to purchase additional controls at extra expense.

RIQAS

The RIQAS Maternal Screening EQA programme is designed to monitor the performance of screening tests used during the first and second trimester of pregnancy to assess the risk of Down’s syndrome, Spina Bifida and Trisomy 18. 100% human serum ensures commutability while the lyophilised material allows for enhanced stability. Monthly reporting allows laboratories to become aware of issues and remedy them early.

Get in touch with our clinical divisions here.

 

 

 


The Evidence Evolution – The newest member of the Evidence series

Launched in 2016, the Evidence Evolution has set new standards in the world of clinical, forensic and food testing.

With the most extensive test menu on offer, we can provide more tests than any other supplier and we are continually investing in R&D to keep up with industry developments and challenges, such as our extensive clinical test menu with a range of routine and novel tests including our CKD panel which detects the early stages of Chronic Kidney Disease.

The Evidence Evolution utilises Randox’s cutting-edge Biochip Array Technology, offering diagnostic testing from a single sample. The Evidence Evolution boasts 2640 tests per hour and when put to the test against our competitor machines, the Evidence Evolution gives a true walk away time of up to 2 hours, meaning staff can fully load the machine and get up to 44 results from each sample every minute, while they get on with important laboratory tasks.

The Evidence Evolution has been designed to meet the needs of a variety of laboratories. Delivering quality results, efficiently and economically in forensic and clinical immunoassay locations.

The Evidence Evolution is the latest development in our Evidence Series range, which was first launched in 2002. This trusted technology is powered by Biochip and is used throughout the world in a range of different sites for clinical, toxicology and food testing. The Evidence Series has a range of analysers that can meet the need of any laboratory.

For more information on any of the Evidence Series analysers, please visit https://www.randox.com/evidence-series/ or contact us evidenceseries@randox.com.

 

 

 

 


Biochip vs ELISA: Which testing platform is right for me?

Biochip Vs ELISA

Randox Toxicology’s latest video series, ‘Biochip Vs ELISA’, highlights our routine and novel ELISA products and how they differ from Biochip Array Technology.

Showcasing the journey and ongoing brand evolution of Randox Toxicology, these videos will help you to discover which method is right for you!

Episode 1: Meet ELISA

Episode 1 “Meet ELISA” uses speed reading to showcase Randox Toxicology’s extensive and ever-expanding ELISA test menu, including our range of New Psychoactive Substances, drugs of abuse, stimulants, analgesics and sedatives. Manufactured in the United Kingdom, our continuous reinvestment in research and development has enabled us to develop a range of exclusive ELISA kits such as, Mitragynine, MT-45, and U-47700 which was involved in the death of the famous singer Prince.

 

Our cost effective ELISA kits are the highest quality on the market and results provide excellent correlation with confirmatory methods, typically <10% CV.

Episode 2: Meet Biochip

Based on ELISA principles, Episode 2 “Meet Biochip” illustrates Biochip Array Technology as a solid-state device with discrete test sites onto which antibodies specific to different drug compounds are immobilised and stabilised. Moving away from traditional single analyte assays, Biochip Array Technology boasts cutting-edge multiplex testing capabilities for rapid and accurate drug detection from a single sample.

As the primary manufacturers of Biochip Array Technology, Randox Toxicology offer the most advanced screening technology on the market. With the world’s largest test menu capable of detecting over 500 drugs, Randox Toxicology are changing the landscape of drugs of abuse testing.

Episode 3: Biochip Vs ELISA

Episode 3 “Biochip Vs ELISA” gives you the opportunity to hear from a professional! Laura Keery our Senior Research and Development Team Leader gives you a behind the scenes look at our Biochip Array Technology and ELISA products in action at our new Science Park, answering some of those must know questions.

Episode 4: Biochip Vs ELISA 360-Degrees

If you missed it at SOFT-TIAFT 2017, our Biochip Vs ELISA 360-degree video allows you to experience Biochip and ELISA in action.

Discover which method is right for you! #biochipvselisa

For more information about our revolutionary Biochip Array Technology and ELISA kits, email info@randoxtoxicology.com or visit www.randoxtoxicology.com

 

 

 

 

 


Contaminated Cereal Products Rejected at EU Borders

In the month of May alone, over 20 cases of feed and cereal based products have been rejected at EU borders after testing positive for aflatoxins with a risk decision level marking of ‘serious’, countries of origin include; Turkey, Egypt, Gambia, U.S, Indonesia, India, Azerbaijan and Spain.

The European Union have set tolerance levels for Aflatoxin B1 at 2 parts per billion (ppb) and total aflatoxins at 4ppb for nuts, cereals and dried fruits.

Aflatoxins are a mycotoxin produced by a fungus and thrive in hot and humid climates. Aflatoxin B1 is the most prevalent among food products and commonly occur among cereals (including wheat, barley, rice and corn) oilseeds (peanuts, almonds, pistachios and other nuts) spices, fruits, vegetables, milk and dairy products.

Screening for Mycotoxins

There are various screening methods available for mycotoxins in food, but few offer the choice of screening for multiple mycotoxins from one sample. Randox Food Diagnostics has created patented Biochip Array Technology (BAT), an immunoassay ELISA based method, to save the feed and cereal industry time and money on testing.

The Myco Array kit range can screen for 3-10 mycotoxins simultaneously from a single sample and depending on the users testing requirements, customisable kits are available.

For more information on mycotoxin screening with Randox Food Diagnostics contact info@randoxfooddiagnostics.com

 

 

 

 


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