Molecular Testing on the Evidence Investigator
The Evidence Investigator is a compact, semi-automated benchtop analyser which is renowned for its versatility, robustness and effective reporting methods. The Evidence Investigator has offered efficient and comprehensive testing in a wide range of laboratory settings for many years including, clinical diagnostics, molecular, research, toxicology and food diagnostics.
The Evidence Investigator is the perfect fit for medium throughput laboratories seeking maximum use of bench space and can process up to 44 results from a single sample, with a maximum throughput of up to 2376 tests per hour.
It is extremely well equipped to provide reliable and accurate results because results are generated using Charge Coupled Device (CCD) camera, which quantifies chemiluminescent light. The light then measures the degree of binding between the sample and specific biochip bound ligands. The Evidence Investigator image processing software translates light signal generated from chemiluminescent reactions into analyte concentrations which removes the need for any manual processing of data.
Our molecular product range offers diagnostic, prognostic and predictive solutions across a variety of disease areas including sexually transmitted infection (STI), respiratory tract infection, colorectal cancer, familial hypercholesterolemia (FH) and cardiovascular disease (CVD). Additionally, we can provide a wide range of assay formats including single nucleotide polymorphisms (SNP) genotyping, pathogen detection and mutation detection. The technology allows simultaneous detection of multiple analytes from a single sample for efficient and cost-effective testing.
STI and Respiratory Arrays
Sexually transmitted infections (STIs) affect more than 1 million people every day and each year 500 million new cases of STIs occur.1 Therefore, it is vital for early and accurate detection. Randox’s Sexually Transmitted Infections Multiplex Array simultaneously detects 10 bacterial, viral and protozoan including primary, secondary and asymptomatic co-infection for a complete infection profile. The assay is based on a combination of multiplex PCR and biochip array hybridisation. Innovative PCR priming technology permits high discrimination between multiple targets.
Respiratory tract infections are caused by many viral and bacterial pathogens and are the second most common cause of morbidity and mortality worldwide.2 The Respiratory Multiplex Array is the most comprehensive screening test for infections of both the upper and lower respiratory tracts, simultaneously detecting 22 bacterial and viral pathogens from a single sputum lavage or nasopharyngeal sample.
Both arrays detect the most common and frequently requested infections in sexual and respiratory health. These comprehensive, highly sensitive and specific tests enable identification of co-infections simultaneously, often in asymptomatic patients and enable antibiotic stewardship.
KRAS, BRAF, PIK3CA Array and Familial Hypercholesterolemia Arrays I & II
The colorectal cancer (CRC) is the third most common cancer worldwide. Overall, the lifetime risk of developing colorectal cancer is: about 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.3 The KRAS, BRAF, PIK3CA Array simultaneously detects 20 point mutations within the KRAS, BRAF and PIK3CA genes. The assay is validated for use with the DNA extracted from fresh/frozen and formalin fixed paraffin embedded tissue. The array is CE marked for routine clinical use.
Familial Hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism. 4It is the most common autosomal dominant, or inherited disease and affects the plasma clearance of LDL-cholesterol, resulting in premature onset of cardiovascular disease and higher mortality risk.5 Early diagnosis is crucial as by the time the FH sufferer enters early adulthood they will have accumulated >20 years of continuous exposure to build up of fatty or lipid masses in the arterial walls and are at the hundred-fold greater risk of a heart attack than other young people. The Familial Hypercholesterolemia (FH) Arrays I & II are rapid, simple and accurate detection of 40 FH-causing mutations within the LDLR ApoB and PCSK9 genes.
These unique biochip assays permit high discrimination between multiple targets in several genes with a rapid turnaround time (3 hours). The arrays enable detection of the most frequently occurring mutations known to cause disease (FH) and adversely affect patient treatment (KRAS, BRAF, PIK3CA). A unique primer set is designed for each target which will hybridise to a complimentary oligo-nucleotide probe spotted on a biochip discrete test region (DTR).
Cardiovascular Risk Prediction Array
Coronary Heart Disease is the leading cause of death in the developed world and its prevention is a core activity for public health systems worldwide.6 Randox have the Cardiac Risk Prediction Array which will allow for 19 SNPs to be genotyped simultaneously, which incorporate a test to identify patients predisposed to statin-induced myopathy.
This array identifies individuals with a genetic predisposition to coronary heart disease (CHD). The innovative multiplex primers are designed to discriminate DNA sequences which differ only at one base.
For more information on our Evidence Series or Molecular range of Assays, contact us at firstname.lastname@example.org
A stroke can happen to anyone at any time. It is a serious life-threatening medical condition which occurs when the blood supply to part of the brain is cut off. It causes the brain cells to die resulting the abilities controlled by the brain such as memory and muscle control to become damaged. 1
According to the Stroke Association, strokes are considered the fourth biggest killer in the UK. There are more than 100,000 strokes each year which equals around one stroke every five minutes.2 Some people recover from the condition; however, two thirds of the survivors will have some sort of disability. 3
There are two mains types of strokes which are defined as “Ischemic strokes” and “Hemorrhagic stroke”.
Ischemic stroke is by far the most common kind of stroke, accounting for about 88% of all cases4. Ischemic strokes occur when there is an artery blockage which cuts off the blood supply to certain areas of the brain, which then results in brain cells being unable to make energy and dying. The arteries are vital for the brain as they bring fresh blood from the heart and lungs carrying oxygen and nutrients and taking away carbon dioxide and cellular waste. 4
The hemorrhagic stroke is less common but is more severe as there is a higher risk of dying within the first three months. It is when a blood vessel ruptures causing a bleed inside the brain, resulting in the death of brain cells. They are responsible for 40% of all stroke deaths.5
The most commons symptoms of a stroke are:
- Weakness or numbness of the face, arm, or leg on one side of the body
- Loss of vision or dimming in one or both eyes
- Loss of speech, difficulty talking, or understanding what others are saying
- Sudden, severe headache with no known cause
- Loss of balance or unstable walking, usually combined with another symptom
Many risk factors can increase your chance of having a stroke. Some life style factors include being obese/overweight, not exercising enough, heavy drinking, use of illegal drug such as cocaine, cigarette smoking, high cholesterol, diabetes, disruptive sleeping pattern and family history of having stroke or heart attack.
Up to 80% of strokes are preventable. 3 There are simple healthy lifestyle recommendations that could decrease your chances of developing a stroke in the future which include:
- Controlling your blood pressures as it is one of the biggest preventions of developing a stroke.
- Maintaining a healthy weight through a well-balanced diet involving rich fruit and vegetables as well as decreasing the amount of cholesterol, saturated fat and sodium intake.
- Exercising regularly and staying within a good routine will also reduce your risk of having a stroke.
- Quitting tobacco usage and decreasing alohcal intake will help as well as regular usage increases the risk of having high blood pressure.
- Avoid taking illegal drugs such as cocaine as it reduces your blood flow which narrows the arteries.
Randox Biosciences offers a stroke array which works quickly to determine which type of stroke a person has experienced. Ischaemic stroke can be treated by thrombolysis and, with early usage, it can help limit stroke damage and disability.
However, inappropriate administration of thrombolytic therapy can cause serious adverse effects, including intracranial haemorrhage. Hence, there is an unmet clinical need for a rapid and highly sensitive testing that complements existing CT scanning approaches and facilitate the definitive identification of ischaemic stroke patients.
Randox’s innovative Biochip Array Technology enables simultaneous detection of eight stroke biomarkers from a single blood sample.
The eight biomarkers that can be detected in a single blood sample are:
- Glutathione S-Transferase-Pi (GSTP-Pi)
- Nucleoside Diphosphate Kinase A (NDKA)
- Parkinson Protein 7 (PARK7)
- Glial Fibrillary Acidic Protein (GFAP)
- Interleukin 6 (IL-6)
- Heart Fatty Acid Binding Protein (H-FABP)
Staff Newsletter January - March 2019 Edition
We are delighted to be able to share with you the Q1 2019 edition of our We Are Randox staff newsletter!
Click here for a range of company and staff news from January to March 2019 – including a visit from the UK Health Secretary Matt Hancock and the 2019 launch of our popular Randox Health Grand National Family Fun Day in Donegal!
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A new and ambitious initiative to reach out to all Donegal people and all those who have a love and an affinity for Donegal was launched on Friday 1st March at Donegal Airport.
Donegal Connect is a 10 day event which will take place this autumn from 27th Sept to 6th Oct and aims to continue to strengthen links with Donegal people both on the island of Ireland and across the world by reaching out to them and inviting them to come home and connect again with the county.
There will be something for everyone including events focussed on culture and heritage, sport, and music, genealogy, employment and business development opportunities, education and career opportunities, networking events and workshops on the practicalities of relocating or returning to Donegal.
Cathaoirleach of Donegal County Council Cllr. Seamus O’Domhnaill believes that this initiative will be a celebration of all things Donegal saying:
”We in Donegal are very fortunate to live in a county of outstanding beauty and one that offers a unique family friendly lifestyle, a fantastic quality of life, a place where investment and employment opportunities exist and where businesses and employees can successfully operate and compete on a global stage through many of our locally based worldwide employers. Through connecting with our diaspora we want to create mutually beneficial opportunities that build on the success of the work of our Diaspora office”.
Donegal Connect is about enticing people to make the journey back to Donegal to explore the county and find out why it is a great place to visit, to relocate to, to grow up in, to be educated in, to work in, to invest in or to retire in.
An important element of the initiative is the creation of new opportunities for investment, business development and employment. Donegal Connect wants to communicate the message that Donegal is open for business, has lots of employment opportunities and offers a great quality of life.
Donegal has received some impressive accolades over the last few years including being named as the ‘coolest place on the planet’ in 2017 by National Geographic and more recently Donegal Airport being voted the most scenic landing strip in the world. This along with the filming of Star Wars at Malin Head – Ireland’s most northerly point – and the hosting of the Dubai Duty Free Irish Open in Ballyliffin last summer has showcased the splendour of Donegal to the world and putting it most definitely on the map.
Speaking at the launch event, Breid Gallagher of Randox Teoranta in Dungloe, Donegal, said:
“We are tremendously excited for Donegal Connect and to showcase the very best Donegal has to offer. There are certainly fantastic opportunities available here, as evidenced at our state-of-the-art global diagnostic facility at Randox Teoranta. There are amazing career opportunities right on the doorstep here in Donegal and, being in the most beautiful part of the world with quality of life like no other, you couldn’t ask for a better place to ‘live the journey’!”
For more information on Donegal Connect, please visit https://www.donegalconnect.com/ or email RandoxPR@randox.com.
Randox Clinical Laboratories Service (RCLS) has been built on 35 years of Randox Laboratories experience. The aim of our RCLS team is to meet the time sensitive, custom-made requirements of research and clinical projects. They specialize in biomarker and multiplex testing to provide full laboratory services to aid the project aims and timelines whilst saving time and money. Currently, there are four laboratories across the UK located in Liverpool, London, Holywood and the Randox Science Park in Antrim where knowledgeable and proficient teams are situated and are available accordingly to provide support and guidance.
Continuing with National Heart Month, RCLS would like to take the opportunity to reinforce the importance of taking care of your hearts health. (WHO) highlighted Ischemic heart disease and stroke are the world’s biggest killers. An estimated 17 million people die of cardiovascular disease particularly heart attacks and strokes every year.1
Lipoprotein (a) which is also known as Lp(a) consists of two protein molecules, apolipoprotein (a) or apo(a). It is a large lipoprotein particle made by the liver. The Apo(a) particle is a very sticky protein particle, thought to be involved in the clotting system and its addition can be likened to adding a patch of Velcro on to a normal LDL particle. 2 Having some cholesterol and Lp(a) in your blood is normal however, high levels of LDL cholesterol would increase your risk of having some serious heart implications.
It has been highlighted in recent research that blood levels of Lp(a) could be an important indication as it is currently the strongest inherited risk factor for developing cardiovascular disease and stroke. Globally, one in five people have high levels of Lp(a) greater than 50mg 3. As a result, gradually narrow the arteries, limiting blood supply to the brain, heart kidney, legs and can also increase the risk of blood clots, heart attack and stroke.
High Lp(a) can also be related to other common risks factors of cardiovascular diseases for example, smoking, diet, diabetes, high blood pressure and lack of exercise. Therefore, it is possible that those who appear “healthy” can have high Lp(a) in their genes and still be at high risk of cardiovascular diseases.
The Lipoprotein(a) Foundation strongly emphasized that the Lp(a) test would be advised if you have the following:
- If there is a family who has history with cardiovascular disease including stroke, heart attack, circulation problems in the legs and/or narrowing of the aorta, at a young age. If someone in your family has high Lp(a), their children have a 50/50 chance inheriting it.
- Stroke or heart attack are classical risk factors including high LDL-cholesterol, obesity, diabetes and smoking have been eliminated
- High levels of LDL-cholesterol following treatment with statins or other LDL lowering medications
Randox Clinical Laboratory Services offer you our Lipoprotein (a) assay as well as our variety of analysers across all RCLS laboratories including our RX Series and Evidence Series as well as third party analysers ensuring the testing abilities are diverse. The Randox Lp(a) assay is one of the only methodologies on the market that detects the non-variable part of the Lp(a) molecule providing accurate and consistent results.
If you would like more information on RCLS please contact email@example.com
With fierce displays of stamina, strength and speed, WAAR or the Wild Atlantic Adventure Race is one of the most challenging adventure races in Ireland, and this year returns to the Donegal coast with headline sponsor Randox Teoranta in tow for the fifth year.
Launched in the Fitness Room at CLG Naomh Muire, last night on Wednesday 20th February 2019, this year’s WAAR promises to deliver a thrilling adrenalin rush for participant and spectator alike. Both expert and novice will take to the demanding 55.5km course or 39km sprint on Saturday 11th May 2019.
The full route features a 10km run, 42.5km cycle, 2km hike and 1km kayak, starting and finishing at C.L.G. Naomh Muire in Mullaghderg. This year, for the first time, the race will also be included in the National Adventure Race Series, allowing competitors to gain points towards becoming the all-Ireland Adventure Race champion 2019.
The WAAR event was launched by Adam Speer of Speer Performance in Letterkenny. Known as one of the top strength and conditioning coaches in Ireland, Adam was responsible for the Donegal GAA senior team’s rags-to-riches tale during their dominant 2010-2015 period.
Speaking at the event, WAAR organiser and spokesperson Brian O’Donnell commented:
“It is fantastic to launch the 2019 Wild Atlantic Adventure Race, an event which not only tests the limits of the human body but also brings the whole community together. This is a great family event and we are sure that it will pull the crowds again in Donegal. The event is designed to allow individuals of any ability to enter and be part of what is fast becoming one of the biggest annual sporting events in the North West.”
Innovative global diagnostics firm Randox Teoranta attended the launch as headline sponsor and pledged to continue their strive for faster patient diagnoses through revolutionary technology as it supports this prestigious local event once again from its Dungloe base.
Dr. Ciaran Richardson, Head of Research & Development at Randox Teoranta, said:
“We are delighted to once again partner with the Wild Atlantic Adventure Race here in Donegal. The ethos of the race – of physical and mental health, of camaraderie and of community – is one we share at Randox Teoranta.
“Our state-of-the-art facility at Randox Teoranta in Dungloe has spearheaded world-changing health research in the areas of Alzheimer’s disease, kidney disease, cancer, gastrointestinal disorders and stroke, and we hope to continue this vital work long in to the future.
“Like Randox Teoranta, WAAR has become an integral part of the landscape in Donegal with over 200 locals volunteering to help with the race last year, never mind the 600 who took part. We are delighted to bring the thrilling Wild Atlantic Adventure Race once again to Donegal in 2019.”
Also in attendance was Eilis Docherty from Donegal Airport who commented:
“We were delighted to continue our support of this very successful event and look forward to having hundreds of competitors run on the runway as they did last year. What other adventure race in the world can competitors run on the live runway of the most scenic landing in the world, in the coolest place on the planet to live? It really is a special event.”
The famous WAAR After Party will again be held at Entertainment Headquarters, Caislean Óir Hotel in Annagry and the committee are delighted to announce that Phil Cawley from Today FM will be joining once again as MC and DJ on the night.
Anyone interested in taking part in the WAAR can visit the website at www.waar.ie. The event is open to anyone who is 16 or over on the 11th May 2019. If you would like to help out on the day of the event and be part of it all then please send your name and contact number to firstname.lastname@example.org.
For more information, or to arrange interviews, please contact RandoxPR@randox.com.
National Heart Month is held every February to raise awareness and remind the public of the importance of taking care of your heart. Every day, your heart will beat approximately 100,000 times and it is responsible for pumping blood throughout the body via the circulatory system, supplying oxygen and nutrients to the tissues and removing carbon dioxide and other wastes. 1
British Health Foundation (BFH) states that over 7 million people are living with heart and circulatory disease in the UK: 3.5 million men and 3.5 million women. 2
There are many different heart conditions and problems that can arise which include angina, heart attack, heart failure and abnormal heart rhythms, congenital heart disease and inherited heart conditions which are highlighted further below:
Angina is a chest pain which is often caused when the coronary arties become partially blocked. It causes an uncomfortable feeling of heaviness or tightness which is often mistaken to indigestion. 3
Whereas a heart attack is when the arteries are completely blocked which can cause permanent damage to the heart muscle therefore, it is essential to be aware of the symptoms. The signs are similar to angina although it is more severe. This may include feeling pain in the arms, jaw, neck and back, lightheadness, sweating, nausea and breathlessness. 3
Heart failure is the most dangerous condition. It often occurs when the individuals heart is too weak to pump blood around the body making it difficult for the person to breathe. There are two types of heart failure. Acute heart failure which can occur suddenly or chronic heart failure which develops over time. 3
Being aware of the different types of heart disease and the symptoms can save a person’s life in the long-run. There are many ways to avoid developing heart disease. One of the simple changes could include having a healthier diet to reduce your risk of developing heart disease and maintaining a healthy weight. A healthy diet could include plenty of fruit and vegetables, starchy food, choosing whole grain varieties, including some dairy products and a small amount of fat and sugar in your diet. Exercising regularly can benefit your heart and its health, making small changes to your lifestyle can make a difference for example, walking to work or school instead of driving or taking public transport, taking the stairs instead of using the lift or even taking on a hobby! Quitting smoking, decreasing your alcohol intake, eating healthier and exercising more will make a huge impact to your health!
Randox offer the Cardiac Risk Prediction Array on their Evidence Investigator. We developed a rapid array which will allow all 19 SNPs to be genotyped simultaneously on one single sample. The genotype information is then put into an algorithm which weights each SNP and calculates a CHD genetic risk score. This score is combined with common risk factors and an overall CHD risk score is calculated. A SNP which can predict response to statin therapies is also included. The results are easy to interpret using our Evidence Investigator which allows for more accurate classification and prevention actions to be taken.
For further information about the Randox Cardiac Risk Prediction Array or our Evidence Investigator, please email: email@example.com or visit our newly improved website: https://goo.gl/8qkYkg
Scotland is set to introduce a new “zero tolerance” policy to those caught driving under the influence of drugs. Ministers in Scotland want to make it easier for police officers to target people driving with illegal drugs in their bloodstream. The policy will supersede the current need to prove that someone was driving in an impaired manner as a result of drug consumption. The law in Scotland currently states that it is illegal to drive if impaired by drugs, be it prescription or illegal drugs.
Justice Secretary Humza Yousaf said “The introduction of drug driving limits will strengthen the power of Scotland’s police and prosecutors to tackle the minority of drivers who irresponsibly put themselves and other road-users at risk. Drug driving is completely unacceptable, and we will continue to use all of the tools at our disposal to prevent the avoidable deaths and damage caused by those who drive under the influence of drugs. Together with our stringent drink-driving limits, these new laws will ensure that Scotland have the UK’s most robust laws against impaired and unsafe driving.”
Under the new plan, eight of the most commonly abuse illegal drugs – including heroin, ketamine and ecstasy – will have limits set very close to zero to rule out claims of accidental exposure. A further eight drugs, which can have medicinal purposes – such as diazepam and methadone – will have higher limits based on their ability to impair drivers. These proposals would mean just having drugs in your system that breach the limits, this is sufficient evidence to prosecute.
Randox Biosciences is delighted to officially announce the launch of our new website which offers a sleek, simple yet informative platform to further your knowledge of our product range and how we can assist you.
After six months of hard work and dedication the website has a fresh look. The interactive aspect of the website provides an easy way for our visitors to learn about Randox Biosciences products and services.
The improved interactive navigation ensures the user enjoys a seamless transition through Randox Biosciences extensive range of products and services with a better experience for both mobile and desktop versions. Potential customers will be able to identify with ease which client segment they fit into – whether it be Academic Research, Biopharma or Clinical Laboratory, enjoying a fully responsive experience.
During the redesign of the Randox Biosciences website we ensured that the brand identity remained consistent throughout, incorporating the brand colours across the site. We in cooperated GIFS (Graphics Interchange Format or moving images) on the top of the homepage as the main header of the website to automatically attract visitors with a moving graphic.
The GIF represents the Biochip Array Technology and the two different diagnostics testing we offer at Randox Biosciences. The GIFs images were continued throughout the website to highlight the three industries we cater for. Brochure downloads are also available on the new website for customers to enhance their knowledge with more in-depth information of Randox’s products and services.
The incorporation of an overview video on the homepage enables website users to gain a snapshot view of Randox Biosciences products and services. The idea of presenting the video first is to allow the visitor to understand our company from a visual method rather than processing a lot of written information.
73% of consumers worldwide would prefer seeing a video than text because they are more “entertaining”.1 The video itself, captures exactly what Randox Biosciences is and what we do. A short yet effective video clearly illustrates the science behind of Randox Biosciences and how this reaches the patient through drug discovery and development.
Julie-Ann O’Hare, Director of Randox Biosciences, commented:
“I am thrilled with the final product of the website, which I hope our current and potential customers will utilise it with ease. The website is another aspect of aligning our marketing strategy and branding to ensure our messaging is clear, concise and consistent across the board. We look forward to the continuation of promoting Randox Biosciences in the digital landscape throughout 2019.”
An e-commerce section of the website is under construction for the sale of our BioReagent products, which they are very excited to launch upon completion in Q3.
Check out our new and improved website for yourself. It is available at: https://www.randoxbiosciences.com/. Also, to find out more email us at firstname.lastname@example.org
Staff Newsletter 2018 Edition
We are delighted to be able to share with you the bumper 2018 edition of our We Are Randox staff newsletter!
Click here for a range of company and staff news from the past year – including the world’s greatest steeplechase The Randox Health Grand National, Randox Teoranta’s Open Day in Donegal and, of course, our annual Christmas Raffle and Santa Visit– at which we raised an impressive £3,380, taking our fundraising total to £8,846.98 from July to December 2018!
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