Randox launches Mental Health & Wellbeing Month

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Randox launches Mental Health & Wellbeing Month

Randox Health Holywood is this week hosting a fundraising event for mental health charities AWARE NI and Ulster University’s Mind Your Mood to launch Randox’s Mental Health & Wellbeing Month throughout October.

Held on Saturday 6th October 2018, 10am – 12noon, the health check company’s coffee morning event will offer customers, visitors and the residents of Holywood the opportunity to call in, grab a tea or coffee, and sample some scones and sweet treats, all while helping to raise money for those who need it most.

By shining a light on mental health issues, Randox hopes to educate its staff on how to look after their mental health while also raising funds for its two official charity partners. The fundraising coffee morning launches a month of staff initiatives including a Wear Yellow for World Mental Health Day on Wednesday 10th October, a company-wide Bake Sale on Friday 26th October, and a freefall abseil from the dome of Victoria Square Belfast on Sunday 21st October.

Randox Founder and Managing Director, Dr Peter FitzGerald, commented;

“Every one of us has been touched either directly or indirectly by these issues and it’s something we at Randox wish to help to address. We have for example invested significantly in research that will determine how problems with the digestive system can affect your mood, sleep and stress levels. We hope that our partnerships not only help those affected by mental ill-health across Northern Ireland, but also empower our Randox staff to take care of their own mental well-being.”

AWARE NI is the depression charity for Northern Ireland with an established network of 23 support groups in rural and urban areas across the country, all run by trained volunteers. AWARE deliver mental health and wellbeing programmes in to communities, schools, colleges, universities and workplaces while also running a 24hr email help service.

Mind Your Mood, managed by Ulster University, is designed and delivered by students who have life experience of mental health illness to help other students avoid mental illness, provide support at the earliest point, build awareness of mental illness and provide support to students who are already diagnosed with mental illness.

Donations for the Randox Team Abseil can be made here: https://www.justgiving.com/teams/RANDOXAWARE

For more information about Randox Mental Health & Wellbeing Month, please contact RandoxPR@randox.com.

 

 


RCLS: The Future of Outsourcing

Randox Clinical Laboratory Services (RCLS) utilises the expertise and knowledge that Randox has built up over 35 years producing high quality IVD products. We strive to provide a clinical laboratory service to meet the time sensitive, bespoke requirements of research and clinical projects globally.

Moving away from traditional single analyte assays, Biochip Array Technology (BAT) boosts cutting edge multiplex capabilities. Biochip Array Technology provides a unique platform for assessment of biological samples in a rapid, accurate and easy to use format and users can have the utmost confidence in this proven technology.

Our technology facilitates the simultaneous quantitative or qualitative detection of a wide range of analytes, providing a rapid and accurate diagnosis from a single patient sample. As well as having time and cost saving benefits, which drive towards an increase in clinical performance, testing for multiple markers given a more comprehensive picture of a patient’s condition.

By RCLS utilising the innovative Biochip Array Technology that Randox have created, we are able to avail the Evidence Evolution.  The Evidence Evolution is the world’s first fully automated random access biochip testing platform. It sets new standards in diagnostic quality and efficiency to deliver precise results quickly and economically. With the capability to process up to 2,640 tests per hour, the Evidence Evolution offers complete system integration, as well as the most comprehensive multiplex test menu on the market.

Overall, the Evidence Evolution provides benefits that allows us to offer you a cost effective, labour saving and time reducing solution for your sample testing. Randox Clinical Laboratory Services also utilise the wide array of Randox analysers, both clinical and Immunoassay, several third party analysers are also used by RCLS.

To find out more information on what Randox Clinical Laboratory Services has to offer email us at info@rcls.com

 

 

 


Antibodies & Human Recombinant Proteins

Randox Biosciences is a world-leading primary manufacturer of high quality monoclonal and polyclonal antibodies, antibody fragments and human recombinant proteins. Our team of scientists possess unrivalled expertise which enables us to provide you with a comprehensive suite of products and services dedicated to advancing biopharmaceutical research and diagnostics.

Product Portfolio

Randox Biosciences offers an extensive portfolio of over 900 products for a multitude of R&D applications including more than 500 monoclonal and polyclonal antibodies and over 140 human recombinant proteins as well as antibody fragments, buffers & diluents and plasma.

Monoclonal Antibodies

  • Biochemical markers: Biochemical messengers, fatty acid binding proteins and products with applications in the following therapeutic areas; cardiovascular/cerebrovascular and metabolic/Nutrition
  • Drugs of abuse: Alcohol, anti-depressants, barbituates, hallucinogens, opiates, stimulants
  • Drug Residues: antimicrobial drugs, growth promoters, mycotoxins

Polyclonal Antibodies 

  • Biochemical markers: Biochemical messengers, fatty acid binding proteins and products with applications in the following therapeutic areas; Immunology, Oncology, Cardiovascular/Cerebrovascular and Metabolic/Nutrition
  • Drugs of abuse: Alcohol, Analgesics, Anti‑depressants, Barbituates, Benzodiazepines, Hallucinogens, Opiates, Sedatives, Stimulants, Synthetic Drugs, Therapeutic drugs
  • Drug Residues: Anti-inflammatory Drugs, Antimicrobial Drugs, Anti-Parasitic Drugs, Growth Promoters, Mycotoxins

Recombinant Antibody Fragments

  • Single chain variable fragment (scFvs)
  • Single domain antibodies (sdAbs)

Frozen Human Plasma

  • Available in three formats (Male, Female and Mixed Gender)
  • Highly screened for; HIV, Hepatitis B+C, HTLV I + II, Syphilis, CMV and Procleix WNV

Human Recombinant Proteins (E.Coli & Mammalian)

  • Adhesion Molecules
  • Chemokines
  • Cytokines
  • Proteases
  • Tumour markers

Buffers & Diluents

  • Complementary range available

Key Features & Benefits

  • All products manufactured at our ISO 13485 accredited UK manufacturing plant
  • Product range of over 900 products
  • 30 years’ experience in raw material manufacture and assay development
  • Many unique and novel products including designer drugs, Mycotoxins and oncology markers
  • As our host animals are sheep, our antibodies have higher sensitivity and specificity
  • Excellent reproducibility between lot numbers
  • Products reflect the components used in-house in the production of Randox diagnostic products and research programs
  • Highly experienced in developing difficult targets (i.e. small molecules and novel biomarkers)
  • Full customisation service available
  • A range of pack sizes available including bulk quantities for commercial development
  • Products can be used in a multitude

Custom Development Services

To meet your precise requirements, Randox Biosciences offer customised antibody generation services to the pharmaceutical and biotechnology industry. Our custom development service, which encompasses antibodies and human recombinant proteins has achieved tremendous success within the biopharmaceutical and diagnostic industries. Key components of our custom service are our range of monoclonal antibodies as well as our recombinant antibody fragments (sdAbs, scFvs, fAbs).

Our customisation service has proven incredibly successful in the research and development industries allowing access our expertise to obtain the antibody and protein most relevant to your line of work. With over 300 highly trained research scientists and over 30 years’ experience in commercial assay development, Randox Biosciences can also provide a tailor-made assay development service to meet your specifications in both a timely and cost-effective manner.

For more information contact: info@Randoxbiosciences.com

 

 

 


Nutritional status: copper deficiency

Did you know that copper is an essential trace mineral present in all tissues? It works with iron to help the body form red blood cells. It also helps keep the blood vessels, nerves, immune system and bones healthy while also aiding in iron absorption. In rare situations, copper deficiency can occur and lead to anaemia and osteoporosis.

Symptoms of copper deficiency include:

  • Fatigue & weakness as cells use copper to generate ATP, the body’s main source of energy. This means that copper deficiency could affect your energy levels.
  • Frequent sickness as copper plays an important role in maintaining a healthy immune system.
  • Weak and brittle bones as copper is involved in the processes that create cross-links inside your bones. These cross-links ensure bones are healthy and strong.
  • Problems with memory and learning as copper plays an important role in brain function and development.

Sensitivity to cold as copper, along with minerals like zinc, help maintain optimal thyroid gland function. Low thyroid levels can make you feel colder more easily.

There are many foods that are high in copper. These include leafy greens, including turnip, greens, spinach, kale and mustard greens. Asparagus and summer squash are two other excellent sources of copper while legumes, whole grains, nuts and seeds are also good sources of the substance.

Randox Reagents, RX and QC are helping to diagnose copper deficiency at the earliest possible stage. The Randox copper assay is used to measure the levels of copper in the blood in order to determine copper toxicity. Combining this with the Randox zinc assay can aid in identifying the cause of liver damage in a patient, leading to correct treatment and recovery.

Find out more about how Randox is helping to diagnose nutritional status and deficiencies here: https://www.randox.com/nutritional-status/

 

 

 

 


The RX series celebrate Biomedical Science Day

Biomedical Science Day is taking place this year on the 19th of July. This is an annual celebration with the aim of raising public awareness of the importance of biomedical science and the vital role it plays in the world.

To celebrate biomedical science day the RX series interviewed Aidan Murphy, one of our laboratory analysts at Randox to find out more about what his job in the lab entails day-to-day. Aidan works with the RX series of clinical chemistry analysers and Randox QC on a daily basis.

We asked Aidan a few questions about his life as a scientist. See what he gets up to in Randox on a daily basis … 

1. What attracted you to a career in laboratory science?

Science has always interested me in both my academic and personal life, I always aspired to get a science based degree and after achieving this I now hope to improve my laboratory skills to increase my employability.

2. What were your stronger subjects at school?

My strongest subjects in school were biology, chemistry, music and politics. Some of which are more applicable to my current role than others.

3. What does your job in Randox entail?

My job entails a variety of roles ranging from testing Randox diagnostic kits before they’re released to customers as well as maintenance and precision checks of the machines in our lab.

4. What aspects of your job do you enjoy the most?

The independence in my job is great. Knowing what I have to do at the start of each week and the deadlines to do these jobs requires me to organise and prioritise my work accordingly.

5. What are some common preconceived ideas the public have about what laboratory staff do?

From my friends’ ideas of what I do in the lab I have found that a stereotypical image of a lab is one of a dark quiet lab full of strange equipment and even stranger people. However fortunately my lab is a lively one and thankfully with normal people.

6. In your opinion, what are the most important aspects of laboratory work?

Following correct protocols and procedures are imperative in an efficient laboratory. As well as this, good lab practice and good hygiene can have a massive effect on the accuracy of our results.

7. What’s in your lab coat pocket?

My lab coat pockets are quite boring. I have a pair of safety goggles, some post-its and some pens and markers.

8. In what ways does your work make a difference to people’s lives?

Randox is dedicated to improving the quality of diagnostics globally, so knowing that the kits that I have tested are then sent to customers to be used in patient diagnosis gives me a level of job satisfaction that I haven’t got from previous jobs.

Aidan is a fundamental member of the Randox team and plays an essential role in the diagnosis and prevention of disease through his work. Without our valuable laboratory team working extremely hard behind the scenes the lifesaving work we do here at Randox would not be possible. 

To find out more about Randox products contact us at theRXseries@randox.com.

Check out our social media sites for more on Biomedical Science Day.

RX series 123

How Randox is helping to diagnose nutritional status

At Randox, we’re dedicated to improving health worldwide and are consistently trying to break our own innovative records. Throughout the month of July, we’ll be introducing you to how we’re helping to diagnose nutritional deficiencies and define individual nutritional status among patients.

Zinc

Randox Reagents

Randox Reagents have the highest quality reagents on the market and a test menu comprising of over 113 assays. Unique to Randox is the zinc assay which is important in the diagnosis of kidney and liver damage.

 

Our zinc assay can be used to measure the levels of zinc in a patient’s urine providing insight into the levels of zinc in the body. This, combined with our copper assay, can aid in identifying the cause of liver damage in a patient, leading to correct treatment and recovery.

The RX series

The RX series offers the most comprehensive testing profile for assessing nutritional status to identify any nutritional deficiencies or any other nutritional issues within an individual.

 

The RX series zinc test can identify a zinc deficiency in an individual which is often a result of a low dietary intake and can lead to many problems including impaired immune and cognitive functions, kidney disease and diabetes.

Randox Quality Control

World-leading diagnostics would be nothing without world-leading quality control materials to ensure consistency and accuracy across all results. The Randox Acusera Liquid Chemistry Premium Plus control is the most comprehensive chemistry control available.

Stay tuned over the course of the month as we highlight how we’re helping in the fight against nutrient deficiencies.

 

 

 

 

 


Evidence Investigator | Adaptable, Efficient & Comprehensive

The Evidence Investigator is a compact, semi-automated benchtop analyser that offers efficient and comprehensive testing across a range of applications including clinical diagnostics, molecular, research, toxicology and food diagnostics.

Renowned for its versatility, robustness and effective reporting methods, the Evidence Investigator has been used in a wide range of laboratory settings for over 15 years. This highly advanced yet simple to use analyser has only one moving part, giving the user peace of mind.

The Evidence Investigator contains a host of innovative on-board data analysis features ensuring manual processes are kept to a minimum.

By utilising the same multiplex technology as the other Evidence Series analysers, the Evidence Investigator can process up to 44 results from a single sample, with a maximum throughput of up to 2376 tests per hour. Offering efficiency without compromising on accuracy, the Evidence Investigator is the perfect fit for medium throughput laboratories seeking maximum use of bench space.

 

Accurate and Robust

Like all the Evidence Series analysers, what sets it apart is technology. The Evidence Investigator is extremely well equipped to provide reliable results, while simultaneously robust enough to withstand frequent, heavy use.

Results are generated using a Charge Coupled Device (CCD) camera, which quantifies chemiluminescent light. This light measures the degree of binding between the patient sample and specific biochip bound ligands, generating highly accurate and reliable results.

Consolidation

The Evidence Investigator is the world’s first platform allowing consolidation of immunoassay and molecular diagnostics. This is achieved through utilising protein and DNA based biochips. By giving the user the ability to consolidate tests, the Evidence Investigator improves laboratory efficiency and reduces costs.

Advanced Reporting

The Evidence Investigator image processing software translates light signal generated from chemiluminescent reactions into analyte concentration. This removes the need for any manual processing of data.

Previously unreported tests can also be retrieved, so they can be tested retrospectively. This saves time, labour costs and reduces any reagents wastage. All data is then analysed on-board, removing issues related to human error and result manipulation.

About the Randox Evidence Series

The Evidence Series is set to revolutionise diagnostic testing forever. Offering unrivalled capabilities across all analysers, we truly believe that the Evidence Series range of immunoassay analysers can meet your diagnostic testing capabilities.

For more information on the Evidence Investigator, or any of the Evidence Series analysers, visit https://www.randox.com/evidence-series/ or contact us evidenceseries@randox.com.

 

 

 

 

 

 

 


Randox Toxicology: The Next Wave in Drug Abuse

A letter published by The New England Journal of Medicine documented that officials from the Food and Drug Administration (FDA); Douglas C. Throckmorton, Scott Gottlieb and Janet Woodcock have warned that non-opioid painkillers could be at the forefront of the next wave of drug abuse.

The Centers for Disease Control and Prevention reported that over 42,000 deaths in the US were due to opioid abuse in 2016, with 40% of all opioid related deaths having involved prescription opioids. As a result, the FDA are encouraging doctors to prescribe alternative opioid drugs when possible and are developing new therapeutics to help people dealing with pain.

However, fears have been raised that curbing prescription opioid abuse could lead to opioid substitutes being used. Substances that are being closely watched include over the counter treatments; benzodiazepines and kratom.

Benzodiazepines

Benzodiazepines are minor tranquillisers used to treat anxiety and insomnia. The effects include sedation, suppressing fits and making the user feel calm and relaxed. When mixed with other depressant drugs like heroin or alcohol, benzodiazepines can cause short term memory loss and nasty withdrawal symptoms such as tremors, anxiety and vomiting. These tranquillisers come in tablet form which people may crush or melt to inject, making them extremely dangerous and sometimes fatal.

 

 

 

 

Kratom

The tropical tree known as kratom, grows in marshy areas around Asia and contains the active chemicals mitragynine, mitraphylline and 7-hydroxymitragynine. The effects of taking kratom include an opiate like sedation and a stimulated state of alertness, whilst higher doses can trigger severe nausea and vomiting. Heavy use of the drug can also cause constipation, darkening of the skin, insomnia, dry mouth and anorexia.

As the primary manufacturer of Biochip Array Technology, our cutting-edge multiplex testing capabilities offer rapid and accurate drug detection. Providing the most comprehensive drugs of abuse test menu across multiple forensic matrices, our multi-analyte testing platform allows toxicologists to achieve a complete immunoassay profile in the initial screening phase from a single sample and CVs are typically less than 10%.

With new designer drugs appearing all too frequently, it’s essential to react and create new tests. Our level of expertise in toxicology research and development allows us to do exactly that, evident through our NPS II panel which detects the latest designer drugs including Mitragynine. As new psychoactive substances are proliferating at an unprecedented rate the rapid evolution of adequate equipment remains vital.

Alongside our NPS II panel, Randox Toxicology provide the highest quality ELISAs available on the market including our exclusive mitragynine ELISA and results provide excellent correlation with confirmatory methods.

By adapting quickly to the ever-changing market influences and developing assays with optimum target compounds and excellent specificities for current and novel drug trends, Randox Toxicology continue to advance the future of toxicology and minimise laboratory workflow constraints.

For more information about our unrivalled toxicology test menu, email info@randoxtoxicology.com or visit www.randoxtoxicology.com

Did you know that cardiovascular disease is the most common cause of death in women? Cardiovascular disease, or CVD, accounts for 27% of all female deaths. That’s much higher than what is commonly thought to be the biggest killer of women – breast cancer. At Randox, we’re using our innovative technology to diagnose CVD cases as early as possible so appropriate treatment can be sought.

The Randox clinical product range offers a wide range of products to combat heart issues including the RX series extensive cardiac testing panel, reagents such as H-FABP, Adiponectin an TxB Cardio and an extensive cardiac QC range available in both liquid & lyophilised format.

You can find out more about how Randox is helping to diagnose women’s health issues, such as CVD, here.

What is CVD?

Cardiovascular disease (CVD) is a general terms for conditions that affect the heart and/or blood vessels. It is usually associated with the build-up of fatty deposits in the arteries and an increased risk of blood clots.

CVD is one of the main causes of death and disability in the UK but can often largely be prevented with a healthy lifestyle.

Types of CVD

Coronary heart disease

This occurs when the flow of oxygen-rich blood to the heart muscle is blocked or reduced

Stroke

A stroke is where the blood supply to part of the brain is cut off, which can cause brain damage and possibly death. A transient ischaemic attack (also called a TIA or “mini-stroke”) is similar, but the blood flow to the brain is only temporarily disrupted.

Causes of CVD

The exact cause of CVD isn’t clear, but there are lots risk factors that can increase your risk of getting it. The more risk factors you have, the greater your chances of developing CVD. Risk factors include:

  • High blood pressure
  • Smoking
  • High cholesterol
  • Diabetes
  • Inactivity
  • Being overweight or obese
  • Family history of CVD
  • Ethnic background

Preventing CVD

  • Stop smoking
  • Have a balanced diet
  • Exercise regularly
  • Maintain a healthy weight
  • Cut down alcohol consumption

How is Randox helping to detect CVD?

Randox has developed the RX series of clinical chemistry analysers for superior semi-automated and fully automated testing. The RX series extensive dedicated test menu goes beyond routine testing and has many unique and high-performance tests available. Our range of tests covers many tests for the diagnosis and monitoring of cardiac diseases.

Cardiac Panel

Cholesterol CRP Full Range(0.3-160mg/l) Direct LDL Cholesterol sLDL
CK-MB CRP High Sensitivity Heart-Type Fatty Acid Binding Protein (H-FABP) Triglycerides
CK-NAC Digoxin Lipoprotein(a) TxB Cardio
CRP Direct HDL Cholesterol Myoglobin Adiponectin

 

Our world leading test menu of high quality reagents guarantees excellence in patient care ensuring unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.

The RX series clinical chemistry analysers provide laboratories with a robust and smart solution ensuring you maintain a consistent workflow and can provide accurate results first time, every time. Offering excellent customer support services, our trained engineers are on hand to work with you in preserving the continuity of your operations while maximising the potential of your RX series instrument.

For more information visit: https://www.randox.com/clinical-chemistry-analysers/

 

 

 


Randox Food Diagnostics: Infiniplex Array for Milk

Drug residues in milk present major concern for farmers, dairy processors, cheese manufacturers, authorities and consumers due to the potential public health and industrial implications. Through the potential inappropriate antimicrobial use in animals producing product for human consumption, antibiotic-resistant organisms can enter the food supply or can spread to various components of the ecosystem. For consumer protection, regulatory limits have been set for the majority of compounds.

Randox Food Diagnostics provides screening technology to monitor the levels of these potentially harmful compounds including the Infiniplex for Milk Array available on the Evidence Investigator and Evidence Multistat analysers.

Using the Randox Food technology the user can identify 130 analytes from a 200µl sample of raw milk and follows this simple process to results:

  • Pipette the sample directly onto the MultiSTAT biochip
  • Insert into the Evidence MultiSTAT
  • Press Play and follow the on-screen prompts
  • Results appear on screen in under 20 minutes

Developed to provide an easy to use option for the user, the Infiniplex Array for Multistat can be used by anyone to ensure rapid on-site testing within the dairy industry.

The InfiniPlex test menu is 98% compliant with EU regulations and screens for additional contaminants including; antiparasitic, anti-inflammatories, non-steroidal and unauthorised substances from one sample of raw milk, creating a better end product for the processor and end user.

To find out more about InfiniPlex contact info@randoxfooddiagnostics.com

 

 

 

 

 


RTS: The Dangers of Psychoactive Substances

Psychoactive substances, formerly known as legal highs, are substances which produce the same or similar effects as many illegal drugs such as cannabis, ecstasy and cocaine. With many psychoactive substances it is extremely difficult to know their potency and therefore how they will affect the user.

They are divided into four main groups:

Sedatives – Cause reduced concentration and slowing of reactions, leading user to feel physically unsteady and lethargic.

Hallucinogenic – These substances cause psychedelic reactions which can lead the user to act erratically, putting their own safety at risk.

Stimulants – Substance temporarily causes increase in alertness and energy, while also putting a strain on the nervous system.

Synthetic Cannabinoids – Large doses can lead to life-threatening intoxication. Also effects the central nervous system causing seizures, high blood pressure, rapid heart rate and increased body temperature.

Incidents

Last month two men were arrested and jailed for four and a half years for selling psychoactive substances. The offences were committed in Scotland and eight of the men’s customers needed hospital treatment after taking the substances.

Free samples and loyalty cards were used by the men selling the psychoactive substances and two users were left in comas after taking a substance known as Psyclone. Court was told that the shops took in as much as £2,500 in sales every day.

The sister of a man who died from taking psychoactive substances said it changed her brother “mentally and physically.” BBC Scotland was told that he started dabbling with psychoactive substances because he believed they were legal. “Some of them were a substitute of heroin, others to mimic the effects of cannabis. He became very withdrawn with the family and just wanted to stay away.”

 

Randox Testing Services

At Randox Testing Services we reacted to the issues caused by psychoactive substances by releasing the world’s first Synthetic Cannabinoids (JWH/AM) and ‘Bath Salt’s’ (MPDV) tests in 2012. This enables companies to test for popular types of psychoactive substances and showed that it was possible to detect these substances.

However as new psychoactive substances emerged new tests also had to be created and next generation Synthetic Cannabinoids tests (UR144 and JWH250) were released in 2013. These tests represented a milestone in the fight against the highly dangerous psychoactive substances and provided a way for laboratories and companies to stay on top of the developing drug trends.

Psychoactive Substances we currently screen for;

 

 

 

 

 

 

Today, in the endless pursuit of creating innovative tests for new and emerging psychoactive substances, our expertise sets us apart from the rest of the industry. We will continue to develop our test menus and grow our range of tests.

For more information contact us today at testingservices@randox.com.

 

 

 

 

 


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