RCLS: The Future of Outsourcing
Randox Clinical Laboratory Services (RCLS) utilises the expertise and knowledge that Randox has built up over 35 years producing high quality IVD products. We strive to provide a clinical laboratory service to meet the time sensitive, bespoke requirements of research and clinical projects globally.
Moving away from traditional single analyte assays, Biochip Array Technology (BAT) boosts cutting edge multiplex capabilities. Biochip Array Technology provides a unique platform for assessment of biological samples in a rapid, accurate and easy to use format and users can have the utmost confidence in this proven technology.
Our technology facilitates the simultaneous quantitative or qualitative detection of a wide range of analytes, providing a rapid and accurate diagnosis from a single patient sample. As well as having time and cost saving benefits, which drive towards an increase in clinical performance, testing for multiple markers given a more comprehensive picture of a patient’s condition.
By RCLS utilising the innovative Biochip Array Technology that Randox have created, we are able to avail the Evidence Evolution. The Evidence Evolution is the world’s first fully automated random access biochip testing platform. It sets new standards in diagnostic quality and efficiency to deliver precise results quickly and economically. With the capability to process up to 2,640 tests per hour, the Evidence Evolution offers complete system integration, as well as the most comprehensive multiplex test menu on the market.
Overall, the Evidence Evolution provides benefits that allows us to offer you a cost effective, labour saving and time reducing solution for your sample testing. Randox Clinical Laboratory Services also utilise the wide array of Randox analysers, both clinical and Immunoassay, several third party analysers are also used by RCLS.
To find out more information on what Randox Clinical Laboratory Services has to offer email us at firstname.lastname@example.org
Randox Biosciences is a world-leading primary manufacturer of high quality monoclonal and polyclonal antibodies, antibody fragments and human recombinant proteins. Our team of scientists possess unrivalled expertise which enables us to provide you with a comprehensive suite of products and services dedicated to advancing biopharmaceutical research and diagnostics.
Randox Biosciences offers an extensive portfolio of over 900 products for a multitude of R&D applications including more than 500 monoclonal and polyclonal antibodies and over 140 human recombinant proteins as well as antibody fragments, buffers & diluents and plasma.
- Biochemical markers: Biochemical messengers, fatty acid binding proteins and products with applications in the following therapeutic areas; cardiovascular/cerebrovascular and metabolic/Nutrition
- Drugs of abuse: Alcohol, anti-depressants, barbituates, hallucinogens, opiates, stimulants
- Drug Residues: antimicrobial drugs, growth promoters, mycotoxins
- Biochemical markers: Biochemical messengers, fatty acid binding proteins and products with applications in the following therapeutic areas; Immunology, Oncology, Cardiovascular/Cerebrovascular and Metabolic/Nutrition
- Drugs of abuse: Alcohol, Analgesics, Anti‑depressants, Barbituates, Benzodiazepines, Hallucinogens, Opiates, Sedatives, Stimulants, Synthetic Drugs, Therapeutic drugs
- Drug Residues: Anti-inflammatory Drugs, Antimicrobial Drugs, Anti-Parasitic Drugs, Growth Promoters, Mycotoxins
Recombinant Antibody Fragments
- Single chain variable fragment (scFvs)
- Single domain antibodies (sdAbs)
Frozen Human Plasma
- Available in three formats (Male, Female and Mixed Gender)
- Highly screened for; HIV, Hepatitis B+C, HTLV I + II, Syphilis, CMV and Procleix WNV
Human Recombinant Proteins (E.Coli & Mammalian)
- Adhesion Molecules
- Tumour markers
Buffers & Diluents
- Complementary range available
Key Features & Benefits
- All products manufactured at our ISO 13485 accredited UK manufacturing plant
- Product range of over 900 products
- 30 years’ experience in raw material manufacture and assay development
- Many unique and novel products including designer drugs, Mycotoxins and oncology markers
- As our host animals are sheep, our antibodies have higher sensitivity and specificity
- Excellent reproducibility between lot numbers
- Products reflect the components used in-house in the production of Randox diagnostic products and research programs
- Highly experienced in developing difficult targets (i.e. small molecules and novel biomarkers)
- Full customisation service available
- A range of pack sizes available including bulk quantities for commercial development
- Products can be used in a multitude
Custom Development Services
To meet your precise requirements, Randox Biosciences offer customised antibody generation services to the pharmaceutical and biotechnology industry. Our custom development service, which encompasses antibodies and human recombinant proteins has achieved tremendous success within the biopharmaceutical and diagnostic industries. Key components of our custom service are our range of monoclonal antibodies as well as our recombinant antibody fragments (sdAbs, scFvs, fAbs).
Our customisation service has proven incredibly successful in the research and development industries allowing access our expertise to obtain the antibody and protein most relevant to your line of work. With over 300 highly trained research scientists and over 30 years’ experience in commercial assay development, Randox Biosciences can also provide a tailor-made assay development service to meet your specifications in both a timely and cost-effective manner.
For more information contact: info@Randoxbiosciences.com
Did you know that copper is an essential trace mineral present in all tissues? It works with iron to help the body form red blood cells. It also helps keep the blood vessels, nerves, immune system and bones healthy while also aiding in iron absorption. In rare situations, copper deficiency can occur and lead to anaemia and osteoporosis.
Symptoms of copper deficiency include:
- Fatigue & weakness as cells use copper to generate ATP, the body’s main source of energy. This means that copper deficiency could affect your energy levels.
- Frequent sickness as copper plays an important role in maintaining a healthy immune system.
- Weak and brittle bones as copper is involved in the processes that create cross-links inside your bones. These cross-links ensure bones are healthy and strong.
- Problems with memory and learning as copper plays an important role in brain function and development.
Sensitivity to cold as copper, along with minerals like zinc, help maintain optimal thyroid gland function. Low thyroid levels can make you feel colder more easily.
There are many foods that are high in copper. These include leafy greens, including turnip, greens, spinach, kale and mustard greens. Asparagus and summer squash are two other excellent sources of copper while legumes, whole grains, nuts and seeds are also good sources of the substance.
Randox Reagents, RX and QC are helping to diagnose copper deficiency at the earliest possible stage. The Randox copper assay is used to measure the levels of copper in the blood in order to determine copper toxicity. Combining this with the Randox zinc assay can aid in identifying the cause of liver damage in a patient, leading to correct treatment and recovery.
Find out more about how Randox is helping to diagnose nutritional status and deficiencies here: https://www.randox.com/nutritional-status/
Biomedical Science Day is taking place this year on the 19th of July. This is an annual celebration with the aim of raising public awareness of the importance of biomedical science and the vital role it plays in the world.
To celebrate biomedical science day the RX series interviewed Aidan Murphy, one of our laboratory analysts at Randox to find out more about what his job in the lab entails day-to-day. Aidan works with the RX series of clinical chemistry analysers and Randox QC on a daily basis.
We asked Aidan a few questions about his life as a scientist. See what he gets up to in Randox on a daily basis …
1. What attracted you to a career in laboratory science?
Science has always interested me in both my academic and personal life, I always aspired to get a science based degree and after achieving this I now hope to improve my laboratory skills to increase my employability.
2. What were your stronger subjects at school?
My strongest subjects in school were biology, chemistry, music and politics. Some of which are more applicable to my current role than others.
3. What does your job in Randox entail?
My job entails a variety of roles ranging from testing Randox diagnostic kits before they’re released to customers as well as maintenance and precision checks of the machines in our lab.
4. What aspects of your job do you enjoy the most?
The independence in my job is great. Knowing what I have to do at the start of each week and the deadlines to do these jobs requires me to organise and prioritise my work accordingly.
5. What are some common preconceived ideas the public have about what laboratory staff do?
From my friends’ ideas of what I do in the lab I have found that a stereotypical image of a lab is one of a dark quiet lab full of strange equipment and even stranger people. However fortunately my lab is a lively one and thankfully with normal people.
6. In your opinion, what are the most important aspects of laboratory work?
Following correct protocols and procedures are imperative in an efficient laboratory. As well as this, good lab practice and good hygiene can have a massive effect on the accuracy of our results.
7. What’s in your lab coat pocket?
My lab coat pockets are quite boring. I have a pair of safety goggles, some post-its and some pens and markers.
8. In what ways does your work make a difference to people’s lives?
Randox is dedicated to improving the quality of diagnostics globally, so knowing that the kits that I have tested are then sent to customers to be used in patient diagnosis gives me a level of job satisfaction that I haven’t got from previous jobs.
Aidan is a fundamental member of the Randox team and plays an essential role in the diagnosis and prevention of disease through his work. Without our valuable laboratory team working extremely hard behind the scenes the lifesaving work we do here at Randox would not be possible.
To find out more about Randox products contact us at theRXseries@randox.com.
Check out our social media sites for more on Biomedical Science Day.
At Randox, we’re dedicated to improving health worldwide and are consistently trying to break our own innovative records. Throughout the month of July, we’ll be introducing you to how we’re helping to diagnose nutritional deficiencies and define individual nutritional status among patients.
Randox Reagents have the highest quality reagents on the market and a test menu comprising of over 113 assays. Unique to Randox is the zinc assay which is important in the diagnosis of kidney and liver damage.
Our zinc assay can be used to measure the levels of zinc in a patient’s urine providing insight into the levels of zinc in the body. This, combined with our copper assay, can aid in identifying the cause of liver damage in a patient, leading to correct treatment and recovery.
The RX series
The RX series offers the most comprehensive testing profile for assessing nutritional status to identify any nutritional deficiencies or any other nutritional issues within an individual.
The RX series zinc test can identify a zinc deficiency in an individual which is often a result of a low dietary intake and can lead to many problems including impaired immune and cognitive functions, kidney disease and diabetes.
Randox Quality Control
World-leading diagnostics would be nothing without world-leading quality control materials to ensure consistency and accuracy across all results. The Randox Acusera Liquid Chemistry Premium Plus control is the most comprehensive chemistry control available.
Stay tuned over the course of the month as we highlight how we’re helping in the fight against nutrient deficiencies.
The Evidence Investigator is a compact, semi-automated benchtop analyser that offers efficient and comprehensive testing across a range of applications including clinical diagnostics, molecular, research, toxicology and food diagnostics.
Renowned for its versatility, robustness and effective reporting methods, the Evidence Investigator has been used in a wide range of laboratory settings for over 15 years. This highly advanced yet simple to use analyser has only one moving part, giving the user peace of mind.
The Evidence Investigator contains a host of innovative on-board data analysis features ensuring manual processes are kept to a minimum.
By utilising the same multiplex technology as the other Evidence Series analysers, the Evidence Investigator can process up to 44 results from a single sample, with a maximum throughput of up to 2376 tests per hour. Offering efficiency without compromising on accuracy, the Evidence Investigator is the perfect fit for medium throughput laboratories seeking maximum use of bench space.
Accurate and Robust
Like all the Evidence Series analysers, what sets it apart is technology. The Evidence Investigator is extremely well equipped to provide reliable results, while simultaneously robust enough to withstand frequent, heavy use.
Results are generated using a Charge Coupled Device (CCD) camera, which quantifies chemiluminescent light. This light measures the degree of binding between the patient sample and specific biochip bound ligands, generating highly accurate and reliable results.
The Evidence Investigator is the world’s first platform allowing consolidation of immunoassay and molecular diagnostics. This is achieved through utilising protein and DNA based biochips. By giving the user the ability to consolidate tests, the Evidence Investigator improves laboratory efficiency and reduces costs.
The Evidence Investigator image processing software translates light signal generated from chemiluminescent reactions into analyte concentration. This removes the need for any manual processing of data.
Previously unreported tests can also be retrieved, so they can be tested retrospectively. This saves time, labour costs and reduces any reagents wastage. All data is then analysed on-board, removing issues related to human error and result manipulation.
About the Randox Evidence Series
The Evidence Series is set to revolutionise diagnostic testing forever. Offering unrivalled capabilities across all analysers, we truly believe that the Evidence Series range of immunoassay analysers can meet your diagnostic testing capabilities.
A letter published by The New England Journal of Medicine documented that officials from the Food and Drug Administration (FDA); Douglas C. Throckmorton, Scott Gottlieb and Janet Woodcock have warned that non-opioid painkillers could be at the forefront of the next wave of drug abuse.
The Centers for Disease Control and Prevention reported that over 42,000 deaths in the US were due to opioid abuse in 2016, with 40% of all opioid related deaths having involved prescription opioids. As a result, the FDA are encouraging doctors to prescribe alternative opioid drugs when possible and are developing new therapeutics to help people dealing with pain.
However, fears have been raised that curbing prescription opioid abuse could lead to opioid substitutes being used. Substances that are being closely watched include over the counter treatments; benzodiazepines and kratom.
Benzodiazepines are minor tranquillisers used to treat anxiety and insomnia. The effects include sedation, suppressing fits and making the user feel calm and relaxed. When mixed with other depressant drugs like heroin or alcohol, benzodiazepines can cause short term memory loss and nasty withdrawal symptoms such as tremors, anxiety and vomiting. These tranquillisers come in tablet form which people may crush or melt to inject, making them extremely dangerous and sometimes fatal.
The tropical tree known as kratom, grows in marshy areas around Asia and contains the active chemicals mitragynine, mitraphylline and 7-hydroxymitragynine. The effects of taking kratom include an opiate like sedation and a stimulated state of alertness, whilst higher doses can trigger severe nausea and vomiting. Heavy use of the drug can also cause constipation, darkening of the skin, insomnia, dry mouth and anorexia.
Did you know that cardiovascular disease is the most common cause of death in women? Cardiovascular disease, or CVD, accounts for 27% of all female deaths. That’s much higher than what is commonly thought to be the biggest killer of women – breast cancer. At Randox, we’re using our innovative technology to diagnose CVD cases as early as possible so appropriate treatment can be sought.
The Randox clinical product range offers a wide range of products to combat heart issues including the RX series extensive cardiac testing panel, reagents such as H-FABP, Adiponectin an TxB Cardio and an extensive cardiac QC range available in both liquid & lyophilised format.
You can find out more about how Randox is helping to diagnose women’s health issues, such as CVD, here.
What is CVD?
Cardiovascular disease (CVD) is a general terms for conditions that affect the heart and/or blood vessels. It is usually associated with the build-up of fatty deposits in the arteries and an increased risk of blood clots.
CVD is one of the main causes of death and disability in the UK but can often largely be prevented with a healthy lifestyle.
Types of CVD
Coronary heart disease
This occurs when the flow of oxygen-rich blood to the heart muscle is blocked or reduced
A stroke is where the blood supply to part of the brain is cut off, which can cause brain damage and possibly death. A transient ischaemic attack (also called a TIA or “mini-stroke”) is similar, but the blood flow to the brain is only temporarily disrupted.
Causes of CVD
The exact cause of CVD isn’t clear, but there are lots risk factors that can increase your risk of getting it. The more risk factors you have, the greater your chances of developing CVD. Risk factors include:
- High blood pressure
- High cholesterol
- Being overweight or obese
- Family history of CVD
- Ethnic background
- Stop smoking
- Have a balanced diet
- Exercise regularly
- Maintain a healthy weight
- Cut down alcohol consumption
How is Randox helping to detect CVD?
Randox has developed the RX series of clinical chemistry analysers for superior semi-automated and fully automated testing. The RX series extensive dedicated test menu goes beyond routine testing and has many unique and high-performance tests available. Our range of tests covers many tests for the diagnosis and monitoring of cardiac diseases.
|Cholesterol||CRP Full Range(0.3-160mg/l)||Direct LDL Cholesterol||sLDL|
|CK-MB||CRP High Sensitivity||Heart-Type Fatty Acid Binding Protein (H-FABP)||Triglycerides|
|CRP||Direct HDL Cholesterol||Myoglobin||Adiponectin|
Our world leading test menu of high quality reagents guarantees excellence in patient care ensuring unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.
The RX series clinical chemistry analysers provide laboratories with a robust and smart solution ensuring you maintain a consistent workflow and can provide accurate results first time, every time. Offering excellent customer support services, our trained engineers are on hand to work with you in preserving the continuity of your operations while maximising the potential of your RX series instrument.
For more information visit: https://www.randox.com/clinical-chemistry-analysers/
Drug residues in milk present major concern for farmers, dairy processors, cheese manufacturers, authorities and consumers due to the potential public health and industrial implications. Through the potential inappropriate antimicrobial use in animals producing product for human consumption, antibiotic-resistant organisms can enter the food supply or can spread to various components of the ecosystem. For consumer protection, regulatory limits have been set for the majority of compounds.
Randox Food Diagnostics provides screening technology to monitor the levels of these potentially harmful compounds including the Infiniplex for Milk Array available on the Evidence Investigator and Evidence Multistat analysers.
Using the Randox Food technology the user can identify 130 analytes from a 200µl sample of raw milk and follows this simple process to results:
- Pipette the sample directly onto the MultiSTAT biochip
- Insert into the Evidence MultiSTAT
- Press Play and follow the on-screen prompts
- Results appear on screen in under 20 minutes
Developed to provide an easy to use option for the user, the Infiniplex Array for Multistat can be used by anyone to ensure rapid on-site testing within the dairy industry.
The InfiniPlex test menu is 98% compliant with EU regulations and screens for additional contaminants including; antiparasitic, anti-inflammatories, non-steroidal and unauthorised substances from one sample of raw milk, creating a better end product for the processor and end user.
To find out more about InfiniPlex contact email@example.com
Psychoactive substances, formerly known as legal highs, are substances which produce the same or similar effects as many illegal drugs such as cannabis, ecstasy and cocaine. With many psychoactive substances it is extremely difficult to know their potency and therefore how they will affect the user.
They are divided into four main groups:
Sedatives – Cause reduced concentration and slowing of reactions, leading user to feel physically unsteady and lethargic.
Hallucinogenic – These substances cause psychedelic reactions which can lead the user to act erratically, putting their own safety at risk.
Stimulants – Substance temporarily causes increase in alertness and energy, while also putting a strain on the nervous system.
Synthetic Cannabinoids – Large doses can lead to life-threatening intoxication. Also effects the central nervous system causing seizures, high blood pressure, rapid heart rate and increased body temperature.
Last month two men were arrested and jailed for four and a half years for selling psychoactive substances. The offences were committed in Scotland and eight of the men’s customers needed hospital treatment after taking the substances.
Free samples and loyalty cards were used by the men selling the psychoactive substances and two users were left in comas after taking a substance known as Psyclone. Court was told that the shops took in as much as £2,500 in sales every day.
The sister of a man who died from taking psychoactive substances said it changed her brother “mentally and physically.” BBC Scotland was told that he started dabbling with psychoactive substances because he believed they were legal. “Some of them were a substitute of heroin, others to mimic the effects of cannabis. He became very withdrawn with the family and just wanted to stay away.”
Randox Testing Services
At Randox Testing Services we reacted to the issues caused by psychoactive substances by releasing the world’s first Synthetic Cannabinoids (JWH/AM) and ‘Bath Salt’s’ (MPDV) tests in 2012. This enables companies to test for popular types of psychoactive substances and showed that it was possible to detect these substances.
However as new psychoactive substances emerged new tests also had to be created and next generation Synthetic Cannabinoids tests (UR144 and JWH250) were released in 2013. These tests represented a milestone in the fight against the highly dangerous psychoactive substances and provided a way for laboratories and companies to stay on top of the developing drug trends.
Psychoactive Substances we currently screen for;
Today, in the endless pursuit of creating innovative tests for new and emerging psychoactive substances, our expertise sets us apart from the rest of the industry. We will continue to develop our test menus and grow our range of tests.
For more information contact us today at firstname.lastname@example.org.
The Wild Atlantic Adventure Race (WAAR) boasted another successful competition on Saturday 12th May 2018 as over 600 competitors braved the challenging but exhilarating course.
The event, sponsored by Randox Teoranta for a fourth year and hosted by Naomh Mura GAA club, gave competitors a choice of two courses that included cycling, running and kayaking.
As promised, this year’s Wild Atlantic Adventure Race delivered an incredible display of stamina, strength and perseverance as outdoor pursuit enthusiasts once again completed the demanding 55.5km course or 39km sprint.
The full Wild Atlantic Adventure Race features a 10km run, 42.5km cycle, 2km hike and 1km kayak, starting and finishing at CLG Naomh Muire, Mullaghderg, Co. Donegal. Set along one of the most beautiful natural coastlines in the world, the west coast of Ireland was once again proud to play host to one of the most challenging yet enjoyable races in Ireland, featuring both novice and elite individuals, as well as several relay teams.
Congratulations to Marty Lynch who won the mens’ solo race with a time of 2hrs 22mins 33seconds and to Sonia Knox who won the womens’ solo race in a time of 2hrs 51mins and 11 seconds.
Dr. Ciaran Richardson, Head of Research & Development at Randox Teoranta in Dungloe, said:
“We are delighted to, once again, partner with WAAR. The event is a real test of physical wellbeing and here at Randox, we take our on-going work to promote positive physical and mental health very seriously. In the last few years, our labs in Dungloe have led the way in world-leading diagnostic research in a wide range of areas including Alzheimer’s disease, kidney disease, cancer, gastrointestinal disorders and stroke.
The Wild Atlantic Adventure Race was a great success and we congratulate all the enthusiastic competitors who took part.”
The full list of WAAR 2018 results can be viewed here.
For more information on Randox Teoranta, please contact the Randox PR team at RandoxPR@randox.com or phone (+44) 28 9442 2413.