Featured Reagent – Complement C4

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Featured Reagent – Complement C4

Featured Reagent | Complement C4

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What is Complement C4?

The complement system is one of the major mechanisms of innate immunology consisting of more than 30 plasma and membrane-associated  serum proteins which evokes cytolytic immune responses to pathogens, including viruses, bacteria and anything that is classified as foreign to the body.

Complement c4 works alongside Complement c3 to accurately diagnose and monitor autoimmune disorders. Low levels of complement c4 levels are associated with the risk of developing disorders such as rheumatoid arthritis and Systematic Lupus Erythematosus (SLE), due to the cell-bound levels of processed complement activation products. On the other hand, higher levels of complement c4 are highlighted in patients with autoimmune haemolytic anaemia.

Key Features

Liquid ready-to-use reagents – for convenience and ease of use
Exceptional correlation with standard methods – Our assay showed a correlation coefficient of r=0.98 when compared against other commercially available methods
Wide measuring range – 2.90 – 152 mg/dl comfortably detecting levels outside the healthy range of 7 – 49 mg/dl
Immunoturbidimetric method
Excellent stability – Stable to expiry when stored at +2°C – + 8°C

Applications available for a wide number of clinical chemistry analysers. Please contact us at reagents@randox.com for more information.

Did you know?

Approximately 1 in 250 people may end up developing Systemic Lupus Erythematosus (SLE) at some point with 90% of SLE patients being female.

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Featured Reagent – Complement C3

Featured Reagent | Complement C3

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What is Complement C3?

Complement C3 is a complex biological system which works in conjunction with antibodies and other factors to protect the body from invasion by pathogens. When activated by either the classical or alternative pathway Complement acts on biological membranes and may cause cell death. Complement C3 and complement C4 levels are important in determining inherited or acquired deficiencies.

Complement testing can be used to help diagnose the cause of recurrent microbial infections, unexplained swellings or inflammation. In addition, low levels of complement C3 can be found in patients diagnosed with Systemic Lupus Erythematosus (SLE), a form of lupus, which is a chronic autoimmune disease that triggers inflammation in different organs and tissues of the body and can cause widespread inflammation and tissue damage in the affected organs. Periodic tests should be carried out to help monitor known long term diseases that affect the complement system.

Did you know?

There are approximately 80 different autoimmune diseases, with around 5-10% of the world’s population affected by one.


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