Randox Food Diagnostics: Infiniplex Array for Milk

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Randox Food Diagnostics: Infiniplex Array for Milk

Drug residues in milk present major concern for farmers, dairy processors, cheese manufacturers, authorities and consumers due to the potential public health and industrial implications. Through the potential inappropriate antimicrobial use in animals producing product for human consumption, antibiotic-resistant organisms can enter the food supply or can spread to various components of the ecosystem. For consumer protection, regulatory limits have been set for the majority of compounds.

Randox Food Diagnostics provides screening technology to monitor the levels of these potentially harmful compounds including the Infiniplex for Milk Array available on the Evidence Investigator and Evidence Multistat analysers.

Using the Randox Food technology the user can identify 130 analytes from a 200µl sample of raw milk and follows this simple process to results:

  • Pipette the sample directly onto the MultiSTAT biochip
  • Insert into the Evidence MultiSTAT
  • Press Play and follow the on-screen prompts
  • Results appear on screen in under 20 minutes

Developed to provide an easy to use option for the user, the Infiniplex Array for Multistat can be used by anyone to ensure rapid on-site testing within the dairy industry.

The InfiniPlex test menu is 98% compliant with EU regulations and screens for additional contaminants including; antiparasitic, anti-inflammatories, non-steroidal and unauthorised substances from one sample of raw milk, creating a better end product for the processor and end user.

To find out more about InfiniPlex contact info@randoxfooddiagnostics.com

 

 

 

 

 


Randox Food Diagnostics offers innovative multiplex technology for mycotoxin screening within varieties of farmed crops

Mycotoxins are poisonous chemical compounds produced by certain fungi. There are many such compounds, but only a few of them are regularly found in food, farmed crops and end product animal feeds. Since they are produced by fungi, mycotoxins are associated with diseased or mouldy crops. Those that do occur in food may have an impact on livestock and the health of humans and have been associated with conditions such as asthma, respiratory infections and chronic fatigue. The main causes of mycotoxins within stored grains are when the grain is damp, damaged or cracked and kept in insufficient storage conditions.

The formation of mycotoxins is climate-dependent, with temperature and moisture levels directly impacting fungal growth. Evidence shows that climate change is causing increasing temperatures and altered rainfall patterns. Additionally, extreme weather incidents have increased. As a consequence of these changes, increased levels of mycotoxins have been observed in some European crops.

Mycotoxins occur, and exert their toxic effects, in extremely small quantities in foodstuffs. Their identification and quantitative assessment therefore generally require sophisticated sampling, sample preparation, extraction, and analytical techniques. Under practical storage conditions, the aim should be to monitor for the occurrence of fungi. If fungi cannot be detected then there is unlikely to be any mycotoxin contamination. The presence of fungi indicates the potential for mycotoxin production, and the need to consider the fate of the batch of commodity affected.

In order to help the industry Randox Food Diagnostics developed the Evidence Investigator analyser. The Investigator uses Biochip Array Technology (BAT), a technology that was developed by Randox, to detect multiple residues (up to 45) from a single sample. Within farmed crops Randox Food Diagnostics provide testing for different matrices such as: Maize silage, maize, Barley, grass seed, rice, wheat, oats, soya, DDGS, rapeseed as well as livestock and pet foods including premixed feed.

Randox Food Diagnostics offer a mycotoxin screening array on Biochip called Myco 10 which can detect 10 mycotoxins per sample including aflatoxins G1/G2 & B1/B2, ergot alkaloids, fumonisins, paxilline, ochratoxin A, diacetoxyscirpenol, deoxynivalenol (DON), T2 toxin & zeralenone. Also offered is a range of ELISA test kits including ergot alkaloids.

Randox Food Diagnostics is a regular participant in the FAPAS proficiency testing scheme which provides an independent check of a laboratory’s procedures to ensure the delivery of quality results. To read our study on: Biochip Array Technology for the reliable performance of multi-mycotoxin determination in animal feed materials” click here: http://www.randoxfooddiagnostics.com/docs/default-source/randox-fd/posters/bat-mycotoxins-in-animal-feed-materials.pdf?sfvrsn=4

For more information on our arrays for mycotoxins please visit the website: http://www.randoxfood.com/matrices/mycotoxins or contact us via email at: info@randoxfooddiagnostics.com

 

 

 

RX series 123

We are attending Bee Happy Bulgaria 2018 on 1st – 4th March!

Bees and other pollinators are vital to three-quarters of the world’s food crops but have been in serious decline in recent decades. The destruction of wild habitats, disease and widespread pesticide use are all important factors.

Global honey production is projected to reach 2.4 million tons by 2022 this is driven by a growth in consumers demand for a natural and healthy alternative to artificial sweeteners, a rising awareness over the benefits of using honey as a sweetener over cane sugar and the realisation of the antibacterial and inflammatory properties of manuka honey.

The decline in the numbers of bees and rising demand from consumers for natural honey products has created a market for “illegal honey” being produced to supply the demand. Producers ‘cut’ their honey with additives like high-fructose corn syrup and brand it as natural honey, affecting purity and reducing cost.

‘Honey laundering’ has also become an issue, with countries such as China using non FDA approved chemicals within beekeeping and being non-compliant to regulations causing their honey to be banned from entering the USA. To get around this, Chinese honey is being shipped into countries such as Vietnam where it is then re labelled and moved into the USA with a new country of origin on the label. This has created the need for a reliable and accurate way to test honey globally.

In order to help the industry Randox Food Diagnostics developed the Evidence Investigator analyser. The Investigator uses Biochip Array Technology (BAT), a technology that was developed by Randox, to detect multiple residues (up to 45) from a single sample. Tests for honey include a vast range of antimicrobials such as Quinolones, Streptomycin, Chloramphenicol, Nitrofurans and more. Randox Food Diagnostics are also releasing a pesticides array in early 2018. Also offered are a range of ELISA test kits.

Alongside the evidence Investigator Randox Food Diagnostics developed the RX misano for enzymatic analysis of honey. The RX misano is now available for the analysis of diastase, total sugars (glucose/fructose), HMF (hydroxymethylfurfural) & colouration, with sucrose coming in 2018.

Randox Food Diagnostics will be attending Bee Happy Expo in Bulgaria from 1st – 4th March 2018 Stop by booth 25 or catch our presentation on Saturday 3rd March at 14:30 to learn more about our product offering for honey.

 

For more information visit the Randox Food Diagnostics website at: http://www.randoxfood.com/matrices/honey

Or email: info@randoxfooddiagnostics.com


Protecting Pets from the Threat of Mycotoxins

Pet Food companies worldwide are working towards constantly improving and maximising the quality of their product. The problematic topic of mycotoxin contamination in pet feed is quickly becoming a major cause for concern. This is due to the risk they pose for animal health and with the  increasing prevalence of mycotoxins globally the focus is on pet food companies to meet EU and FDA regulations and maximise the quality of their product.

What are Mycotoxins?

Mycotoxins are naturally occurring metabolites that are produced by certain moulds and with the ability to develop and grow on a variety of crops they can affect large amounts of feed and increasingly, pet food. If a sample tests positive even for low levels of contamination the toxins are still strong enough to cause illness in animals, and if low levels are consumed over a long period of time this can result in chronic illnesses including; cancer, organ damage and neurological disorders.

The main mycotoxins of concern in pet food are;

  • Deoxynivalenol (DON)
  • Fumonisins (FUM)
  • Zearalenone (ZEN)
  • Aflatoxins
  • Ochratoxin
  • T-2 Toxin

Contamination can occur in any country around the world and at any stage of production. Herein lies the issue of how to prevent mycotoxin pollution, to tackle the issue head on and work towards a mycotoxin free product is the joint responsibility of feed producers, supply chain partners and quality control laboratories ensuring the complete safety of the product.

How can you tell if an animal has ingested pet food contaminated with mycotoxins?

In terms of animal health, mycotoxins can cause a variety of problems. Severity and symptoms can vary from animal to animal but general symptoms include; hyperactivity, vomiting, high temperature and loss of coordination. If you suspect your pet has been affected by mycotoxins you must bring them to the vet for immediate treatment.

The European Union currently regulate all the mycotoxins listed above and are subject to maximum or recommended residue limits. In the US, FDA regulations are limited to aflatoxins, DON and fumonisins, see table below for FDA regulations. If mycotoxin levels in feed fail to meet FDA standards, mass amounts of feed may need to be destroyed as grain producers are prohibited from mixing contaminated feed with clean feed to reduce the mycotoxin levels.

Pets Mycotoxin Commodity Level
Immature Animals Aflatoxins Corn/ peanut/ other ingredients 20 ppb
Adult Pets Aflatoxins Corn/ peanut/ cottonseed meal/ other ingredients 20 ppb
DON Grain/ grain byproducts, not to exceed 40% of diet 5 ppm
Fumonisins Corn/ corn byproducts, not to exceed 50% of the diet 10 ppm

How do we tackle the problem?

Safe, reliable screening solutions for different variations of mycotoxins are available that can ensure only mycotoxin free feed is produced. Randox Food Diagnostics have created mycotoxin screening platforms as a response to increased levels of mycotoxins being found in feed globally.

The platforms use patented Biochip Array Technology (BAT) so pet food producers can test for multiple toxins from a single sample. Randox Food Diagnostics have a range of mycotoxin Biochip Arrays available with customised arrays available to suit the specific screening needs of certain producers. Each Biochip format uses a straightforward extraction process with a 50µl sample of feed, available tests include; Fumonisins, Ochratoxin A, Aflatoxin G1/G2, Aflatoxin B1, Paxiline, Ergot Alkaloids, Diacetoxyscirpenol, Deoxynivalenol, T2 Toxin and Zearalenone.

For more information on mycotoxin screening with Randox Food Diagnostics contact info@randoxfooddiagnostics.com

 

 

 


Randox celebrates British Science Week 2017

Randox celebrates British Science Week 2017

 

Last week was British Science Week 2017, an annual campaign that aims to inspire innovation and celebrate science. To mark the occasion, Randox Laboratories got involved by celebrating the innovation of each Randox product group. The product groups within Randox shared a series of posts, videos and blogs showcasing the #ScienceBehindRandox throughout British Science Week.

Randox

To initiate the Randox British Science Week campaign, Randox shared this video, which highlights the company’s dedication to improving health worldwide. The video provides an introduction about each product group, however throughout British Science Week, each product group has gone into further detail about the #ScienceBehindRandox.

Randox Careers, the RX series, Randox Reagents, Randox Quality Control, Randox Toxicology, Randox Biosciences, Randox Testing Services, & Randox Food Diagnostics all got involved in the British Science Week Campaign. You can read a snippet of each product groups post below, with videos and links to the full content also provided. We hope you enjoy learning about the #ScienceBehindRandox.

Randox – Dedicated to improving health wordwide.

Randox Careers

Joanne Darragh spent some time with Randox Careers to discuss her role as R&D Toxicology Manager.

“Working in this area has been both challenging and exciting as we are at the cutting edge of assay development.  We work in a great team and we work along very closely alongside other departments such as Marketing & Sales so that we are in close contact with what the customer needs, which means we are producing relevant tests very quickly and effectively.  Every day brings a new challenge.”

– Joanne Darragh, R&D Toxicology Manager

Listen to what Joanne had to say on the video above

Randox RX series

As part of British Science Week, the RX series caught up with Daniel Melly, one of our very talented Mechanical Design Engineers based in Randox Teoranta in Dungloe, Ireland.

Daniel was an integral part of the team involved in the design of our new semi-automated analyser, the RX misano. The RX series asked Daniel a few questions about why Randox created this analyser, the design process involved in creating such a unique system, and what his favourite features are.

Randox set out in creating the RX misano with the philosophy of supplying the customer with a more modern, reliable, and aesthetically pleasing analyser than those that are currently available on the market. Robust part selection was always at the fore of any design decisions, and we feel that we have delivered on all of these requirements.” 

– Daniel Melly, Randox Mechanical Design Engineer

Read the full interview the RX series had with Daniel here

The RX misano is currently unavailable to purchase in Germany

Randox Reagents

One unique test by Randox, adiponectin, is becoming an increasingly significant biomarker for health professionals. Low levels have been linked with several illnesses including metabolic syndrome, cancer and cardiovascular disease.

What is adiponectin?

Adiponectin is a protein hormone produced and secreted by fat cells called adipose tissue. Adiponectin is normally found in relatively high concentrations in healthy individuals. Its role in the body is to regulate the metabolism of lipids and glucose, which influences the body’s response to insulin and inflammation.

At Randox, our R&D Scientists are helping to change healthcare. By investing heavily into research and development to develop unique diagnostics tests, such as the adiponectin test, Randox provide doctors with the ability to identify disease risk sooner- offering the opportunity to prevent illness, rather than the need to find a cure.

adiponectin

Read the full Randox Reagents blog entry here

Randox Quality Control

One Simple Change to Randox Quality Control can save your laboratory time and money.

Randox Quality Control are a world leading manufacturer of true third party controls with over 390 analytes covering Antioxidants,  Blood Gas, Cardiac Markers, Routine Chemistry, Coagulation, Haematology, Diabetes, Immunoassay, Immunology, Lipids, POCT, Therapeutic Drugs, Toxicology and Urine Chemistry, providing complete test menu consolidation. Randox Quality Control produces the most consistent material available with the most accurate target values.

Randox Quality Control guarantee to simplify QC practice in any laboratory, just ask one of their 60,000 users worldwide.

Find out more information about Randox Quality Control in the video above

Randox Toxicology

Randox Toxicology provides trusted solutions for the screening for drugs of abuse. With significant reinvestment in Research and Development, we persistently stay ahead of this ever challenging market.  Being the first to develop New Psychoactive Substances tests such as fentanyl, bath salts and flakka allows us to maintain our position as a global leader.

Our pioneering technology has created a number of advancements in the field of toxicology. In particular, our patented Biochip Array Technology which can simultaneously screen from a multi-analyte testing platform, achieving a complete immunoassay profile from the initial screening phase.

Read the full Randox Toxicology blog post here

Randox Biosciences

During British Science Week, we are delighted to introduce you to our latest development utilising this technology; our Gastropanel Array,* a multiplex test engineered to diagnose those at risk of developing peptic ulcers and gastric cancer using non-invasive methods.

Our Gastropanel Array encompasses two quantitative assays, a H. pylori assay  for the detection of antibodies produced in response to a H. pylori infection, a common cause of gastric cancer1 as well as a 3plex Gastropanel assay, for the detection of pepsinogen I (PGI), pepsinogen II (PGII) and gastrin 17 (G17).

Currently recorded as the world’s 5th most common cancer, the majority of gastric cancer cases are diagnosed after presenting as an emergency, when treatment may be less effective due to the cancer being at an advanced stage, highlighting the need for the availability of diagnostics tests like our Gastropanel Array to enable practitioners to administer prompt treatment and ultimately increase survival rates on a global scale.

Read the full Randox Biosciences blog here

Randox Testing Services

Randox Testing Services have shown how they are at the forefront of continually reacting and developing tests for NPS. NPS (formerley known as Legal Highs) have had devastating effects on users since emerging in the UK in 2008. These substances are highly dangerous and have caused unnecessary deaths. This is due to the effects from different elements used in production. Legislation concerning the substances changed in 2016 with the implementation of the Psychoactive Substance Act.

How have Randox Testing Services implemented change? Find out in the video above

Randox Food Diagnostics

Of the 41 antibiotics that are approved for use in food-producing animals by the FDA, 31 are medically important for human health. Randox Food Diagnostics provides advanced screening solutions for 94% of these antibiotics including beta-lactams, quinolones and tetracyclines, allowing you to ensure the integrity of your end product without compromising quality. Randox Food provides multiplex screening solutions validated across a range of matrices including urine, serum, tissue, milk, honey and feed.

The Evidence Investigator matched with Biochip Array Technology (BAT) provide the end user with fast, reliable results to aid in ensuring your produce is antibiotic free. BAT provides a platform for the simultaneous determination of multiple drug residues from a single sample using miniaturised immunoassays with implications in the reduction of sample/reagent consumption and an increase in the output of test results. 

To read Randox Food Diagnostics full blog click here

We hope you enjoyed our informative British Science Week content from each of our Product Groups.

Look out for our Quiz later this week to test your knowledge on the #ScienceBehindRandox

Follow Randox on Social Media: 


World Antibiotic Awareness Week at Randox

The global crisis of antimicrobial resistance is never far from the headlines. As part of World Amicrobial Awareness Week, we’ve been discussing the dangers and importantly the work being done to combat this growing threat.

There’s a very simple reason why we must all do what we can to tackle AMR. This year it’s thought 700,000 people died from drug resistant illnesses such as bacterial infections, malaria, HIV/Aids or tuberculosis. Experts warn that by 2050, this figure will rise to 10million.

Randox’s aim is to revolutionise global healthcare and we are committed to combating the threat of antibiotic resistance. We have a number of tests on the market that can help the fight against AMR, strengthen consumer confidence and ensure quality and safety for a number of different industries. So to round off this week, we spoke to two of our experts at Randox: Business Development Manager, Dr Mary Jo Kurth, and Molecular Diagnostics Manager, Dr Martin Crockard.

70% GP’s have been reported to prescribe antibiotics when they don’t know whether the infection is caused by the virus or bacteria.

At the frontline of the battle to curb AMR are the GPs but they’re not able to access the latest technology which can help them. Dr Mary Jo Kurth said, “In the current GP setting, diagnostic testing to determine whether a respiratory infection is bacterial or viral is unavailable, and therefore doctors often have to guess – or feel pressurised into prescribing antibiotics because patients demand it. However antibiotics only work to treat bacterial infections and are useless in treating infections that are caused by viruses.

 “The consequences are severe. Medical procedures like organ transplantation and cancer chemotherapy need antibiotics to prevent and treat the bacterial infections that can be caused by the treatment. Without effective antibiotics, even routine operations could become high risk procedures if serious infections can’t be treated. The hard won victories against infectious diseases of the last fifty years will be jeopardized.”

Our Biosciences division have developed a test that can rapidly detect and identify the cause of 22 respiratory infections, in both the upper and lower respiratory tract, and therefore subsequently determine if an antibiotic is required as well as then identify the most effective antibiotic to take. Additionally our Confidante kit – the world’s first over-the-counter home sexual health test – can detect ten of the most common STIs with one patient sample and deliver accurate and reliable results securely and discreetly within one week. This takes the guesswork out of antibiotic prescription and could go a long way in fighting the antibiotic resistance crisis.

Dr Martin Crockard said, “Identifying the specific cause of illnesses provides opportunities to tailor treatment, reducing antibiotic misuse. Not all infections respond to antibiotics, however a multiplex approach which identifies bacterial, viral or fungal pathogens encourages improved clinical decision-making, refining treatment, leading to enhanced patient care.

The molecular group here at Randox are developing a range of multiplex infection detection arrays to identify specific infection agents, allowing more appropriate use of antibiotics to improve patient care and reduce the onset of antibiotic resistance.”

In addition to tackling AMR via medical settings, there is work that can be done to deal with it in our food. Randox Food Diagnostics offer a comprehensive range of diagnostic solutions to allow for the detection and quantification of antibiotic residues within animal and food products. With validation across a range of matrices Randox Food allows producers to ensure their products are free from antibiotic residues.

As consumer awareness develops so does the need for antibiotic screening within agriculture and food production. Guaranteeing an antibiotic-free product strengthens consumer confidence and ensures food integrity on a global scale. Randox Food offers the Evidence Investigator matched with biochip array technology to provide the end user with fast, reliable results to ensure antibiotic free produce.

The UK Government recently commissioned a two year review into the crisis. Led by Lord Jim O’Neill, the final report outlined a new system of ‘market entry rewards’ worth $1.6 billion to the successful developer of a new antibiotic, which meets a prospectively-defined criteria of ‘unmet need’. Developers of alternative therapies aimed at tackling areas where there is unmet need due to rising AMR would also be eligible for these rewards. Such rewards would be paid after a successful product comes to market.

Chief Medical Officer, Dame Sally Davies said, “Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. That’s why governments and organisations across the world, including the World Health Organization and G8, need to take this seriously.

“This is not just about government action. We need to encourage more innovation in the development of antibiotics – over the past two decades there has been a discovery void around antibiotics, meaning diseases have evolved faster than the drugs to treat them.”

AMR will not go away on its own. It requires complex and comprehensive action across many sectors.

If you are interested in finding out more information, please visit randox.com


The UK Government is being urged to ban excessive use of antibiotics in farming

To coincide with the start of World Antibiotic Awareness Week the UK Government is being urged to ban excessive use of antibiotics in farming by a group of leading doctors, according to The Daily Telegraph.

Made up of 12 royal medical colleges, the British Medical Association and the Faculty of Public Health, the group say that the UK should “use the opportunity afforded by Brexit to lead the world in banning” preventative prescription of medicines on animals.

A decision made by the European Parliament earlier this year to ban mass agricultural medication has not yet been ratified by member states or the European Commission.

A Department of Environment, Food and Rural Affairs’ spokesman told the newspaper that dealing with AMR is a “top priority” though the paper notes it ‘stopped short of promising a ban.’

In 2015 McDonalds set itself a two year deadline to stop its US restaurants buying chicken raised with human antibiotics. It led to one of the US’s leading meat producers – Tyson Foods – promising to end the practice by September 2017 – which is, as The Guardian stated, “one of the most aggressive timelines yet set by an American poultry company.” The company’s CEO Donnie Smith told the newspaper: “We have found as we have reduced the level of antibiotics we use, whether it’s human use or vet-only, our cost has actually gone down. A lot of the ways we’ve been able to accomplish this is by working with our farmers on better husbandry practices. If this millennial mum wants a no-antibiotic ever..nugget we better supply that.”

Farmers Weekly reported this month on a Danish Crown initiative launched in 2015 whereby pig farmers attach an antibiotics-free tag to piglets at the neonatal stage. It’s removed at any point if antibiotic treatment is deemed necessary. It claims that although early farm trials suggest a production fall of up to 2.5 piglet per sow per year, the “premium covers additional costs if 35% or more piglets carry the tag to the slaughterhouse.”

Pig farmer Stine Mikkelsen carried out a major review of hygiene and health on her farm to reduce antimicrobial use to boost revenue by £11.25 per pig. She says that although production is down and labour costs did increase, it “feels good” to farm in this way. She told the newspaper, “I am very motivated to do something about it – it’s a hard route to take but I have a good feeling about this system.”

Randox Food Diagnostics is working with global leaders in the food industry to tackle antibiotic resistance and safeguard their use for both human and veterinary treatment.

Using a dedicated research and development team, Randox have the ability to respond rapidly to emerging new drugs of abuse and regulations in relation to food and animal safety, with sixty-five new residue drug targets are currently in development to keep up with the ever changing market of food safety. Randox Food Diagnostics are ensuring that all residue screening laboratories requirements are met by providing reliable food safety screening on a global scale.

On top of the food safety product range Randox Food also offer a range of analysers, reagents and test kits for use throughout the winemaking process to ensure quality is maintained in every bottle.

This product range includes the RX misano semi-automated wine analyser and the RX Monaco fully automated wine analyser.

For more information on what we do, please visit: www.randoxfood.com

 

 

The RX misano is currently unavailable to purchase in Germany


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Clinical Laboratory Survey