Ferritin Assay

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Ferritin Assay

Ferritin

The Most Sensitive & Specific Diagnostic Test For Iron Deficiency

Benefits of the Randox Ferritin Assay

Correlation

Exceptional correlation

A correlation coefficient of r=0.99 was displayed when the Randox ferritin assay was compared to commercially available methods.

Limited Interference

Limited interference

The Randox ferritin assay has shown to have limited interference from bilirubin, haemoglobin and triglycerides.

Measuring range

Wide measuring range

The Randox ferritin assay has a measuring range of 5.08 – 443ng/ml for the comfortable detection of clinically important results.

Excellent stability

The Randox ferritin assay is stable to expiry when stored at +2oC to +8oC.

Calibrator & Controls

Calibrator and controls available

Calibrator and controls available offering a complete testing package.

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox ferritin assay on a variety of clinical chemistry analysers.

  • Ordering Information
  • Physiological Significance
  • ID
  • Still's Disease
  • Sepsis
  • cHL
  • COVID-19
Cat NoSize    
FN3452R1 1 x 40ml
R2 1 x 20ml
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FN3453R1 4 x 40ml
R2 4 x 20ml
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FN3888R1 3 x 20ml
R2 3 x 11ml
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FN8037R1 4 x 16.2ml
R2 4 x 10.2ml
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Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Ferritin is an iron storage protein. It is the primary iron storage mechanism and is critical to iron homeostasis. As an iron store, ferritin has two roles 1.

  1. Provides a reserve of iron, which can be transported for the synthesis of molecules such as cytochromes, haemoglobin and iron-sulphur compounds.
  2. Safe-guards cells, DNA, lipids and proteins from the potential toxic effects of iron.

Ferritin is a vital component of iron homeostasis. It acts as as a ferroxidase, converting Fe(II) to Fe(III) as iron is internalised and sequestered in the ferritin mineral core. Iron is toxic in cellular systems due to its capacity to generate reactive oxygen species (ROS) which directly damages cells, DNA, lipids and proteins 1.

Iron deficiency without anaemia is a diagnostic challenge, as it commonly goes unrecognised for a long period of time as the patient is asymptomatic. Ferritin is the most sensitive and specific test used in the diagnosis of iron deficiency, especially when a patient presents with symptoms of iron deficiency anaemia, but their full blood count is normal 2.

Adult onset Still’s Disease (AOSD) is a rare systemic inflammatory disorder characterised by arthritis, fever and a typical skin rash. Elevated ferritin levels have been observed in 89% of patients with AOSD, with five times the normal level observed in over half of patients 3.

Elevated ferritin levels is associated with a poor outcome in patients with sepsis and can be used as a predictive marker of mortality along with current prognostic scores 4. Elevations of both ferritin and CRP during hospitalisation was associated with the highest mortality, followed by elevations of either biomarker alone (fig. 1) 5.

Fig. 1. Risk contingency table for mortality and organ dysfunction based on cut-points for C-reactive protein and ferritin and patients’ maximum value for each biomarker 5
Fig. 1. Risk contingency table for mortality and organ dysfunction based on cut-points for C-reactive protein and ferritin and patients’ maximum value for each biomarker

Data is displayed as n / N (%) for mortality outcomes

*Significant difference in high/intermediate versus low risk quadrants; {<0.001 by Mann-Whitney test PELOD2, Pediatric Logistic Organ Dysfunction Score 2

Ferritin is the most important acute phase reactant in the prediction of classical Hodgkin lymphoma (cHL). Ferritin correlates with the inflammatory activity of the cHL microenvironment, which could explain its prognostic impact. Elevated ferritin levels are associated with clinical features of aggressive disease and poor prognosis in cHL patients 6.

As an acute phase reactant, ferritin levels increase during inflammation and infection. Several studies have indicated that elevated ferritins levels were confirmed in the majority of hospitalised patients with COVID-19, approximately 60%. In the critically ill COVID-19 patients, extremely elevated ferritin concentrations were recorded, which could be attributed to a cytokine storm and secondary haemophagocytic lymphohistiocytosis (a hyperinflammatory syndrome associated with multiorgan failure) 7.

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Specific Protein Quality Control

Therapeutic Drug Quality Control

The Randox Acusera Specific Protein quality control covers 26 serum proteins including immunoglobulins, complement proteins and inflammatory proteins. Designed for use in the routine monitoring of both accuracy and precision, assayed target values and ranges are provided for both immunoturbidimetric and nephelometric based methods. The liquid ready-to-use format is not only convenient and easy to use but eliminates the possibility of reconstitution errors.

Features & Benefits

  • Liquid ready-to-use
  • 100% human serum
  • Assayed target values provided for 26 parameters
  • Contains Total & Free Lambda Light Chains and Total Kappa Light chains
  • Stable to expiry date at 2°C – 8°C
  • Open vial stability of 30 days at 2°C – 8°C
DescriptionSizeAnalytesCat No 
Specific Protein Control Level 13 x 1 ml26PS2682
Specific Protein Control Level 23 x 1 ml26PS2683
Specific Protein Control Level 33 x 1 ml26PS2684
Specific Protein Control Level 16 x 3 ml26PS10221
Specific Protein Control Level 26 x 3 ml26PS10222
Specific Protein Control Level 36 x 3 ml26PS10223

Analytes

  • AFP
  • Albumin
  • a-1-Antitrypsin
  • a-1-Acid Glycoprotein
  • a-2-Macroglobulin
  • ASO
  • Anti-thrombin III
  • b-2-Microglobulin
  • Ceruloplasmin
  • Complement C3
  • Complement C4
  • CRP
  • Haptoglobin
  • IgA
  • IgE
  • IgG
  • IgM
  • Kappa Light Chain
  • Lambda Light Chain
  • Lambda Light Chain (Free)*
  • Prealbumin (Transthyretin)
  • Serum Ferritin
  • RF
  • RBP
  • Total Protein
  • Transferrin

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