Reagents | Syphilis
Quantative and qualitative results available
For choice and convenience
Stable to expiry when stored at 2-8°C
- Treponema Pallidum Haemagglutination Assay (TPHA) method
- Liquid ready-to-use reagents
- Stable to expiry when stored at 2-8°C
- Qualitative or quantitative results
What is the Syphilis assay used for?
Syphilis is a chronic, contagious and often congenital venereal disease caused by Treponema pallidum. Infection results from contact with moist surfaces, originating in lesions of the epithelial tissue of the skin and mucous membranes. If untreated the disease may result in irreversible changes in the cardiovascular and nervous system. Syphilis remains a disease of high incidence, despite advances in modern antibiotic therapy.
- Temmerman, M., et al. Effect of a syphilis control programme on pregnancy outcome in Nairobi, Kenya. Sex Transm. Infect2000, 76: 117-121 (TPHA).
- Altaf, A. et al. High risk behaviors of injection drug users registered with harm reduction programme in Karachi, Pakistan. Harm Reduction Journal. 2007, 4: 7 (TPHA).
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What is syphilis?
Syphilis is caused by the bacterium Treponema pallidum. Although spread through sexual contact, it is frequently passed to an unborn child by its infected mother, where it can cause congenital syphilis resulting in high rates of stillbirth and increased risk of infant mortality.
Primary syphilis is when sores appear at the point where the bacteria entered the body. These sores can appear anywhere such as: around the opening of the urethra, penis, foreskin and anus in men; the vulva, clitoris, cervix, urethra and anus in women.
Secondary syphilis occurs when untreated sores have appeared and healed. It is still infectious and maintains its ability to be passed on.Tertiary syphilis is a progression from untreated secondary forms of the infection. Left untreated, after many years, the infection can cause serious damage to the heart, brain, eyes, internal organs and nervous system, which can ultimately lead to death.
Below are some statistics that have been published: about syphilis in recent years.
- In 2017, there were approximately 422,000 diagnoses of sexually transmitted infections (STIs) made in England, around the same number that was reported in 2016.
- There were 7,137 diagnoses of syphilis reported in 2017, a 20% increase (from 5,955) relative to the year prior and a 148% increase relative to 2008.
- The impact of STIs remains greatest in young heterosexuals 15 to 24 years; black ethnic minorities; and gay, bisexual and other MSM
- The increase in syphilis follows a 10-year trend, with 78% of diagnoses in gay, bisexual and other men who have sex with men (MSM).
How is the infection passed on?
Syphilis is passed on from one person to another through sex (vaginal, anal and oral) and also by direct skin contact with syphilis sores or rashes. Symptoms do not have to be visible for it to be passed on. It can still be transmitted before sores appear or after they have disappeared. Pregnant women can also pass syphilis onto their unborn baby.
What are the complications?
If syphilis is not treated effectively, it can spread to other parts of the body. This can result in long term complications, such as damage to the heart, brain, eyes and other organs. Ultimately, this damage can even lead to death.
Confidante avoids any embarrassing examinations, allowing you to take a test in the privacy of your own home. The Confidante test is made to be quick and easy to use, with no technical jargon, making it extremely convenient.
Confidante is now only £40 with free postage and packaging (RRP £85). Your results will be delivered discreetly via post within 7 days and will not appear on your medical record.