Copper Assay

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Copper Assay

Reagent | Copper

A Unique Test for the Determination of Copper

Benefits of the Randox Copper Assay

Exceptional correlation

A correlation coefficient of r=0.97 was displayed when the Randox copper assay was compared to commercially available methods.

Excellent precision

The Randox copper assay displayed a precision of <2.15% CV.

Wide measuring range

The Randox copper assay has a measuring range of 6.6 – 86µmol/l for the comfortable detection of clinically important results.

Standard supplied with the kit

The Randox copper kit includes the standard simplifying the ordering process. Calibrator is available for automated use.

Controls available

Controls available offering a complete testing package.

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox copper assay on a variety of clinical chemistry analysers.

Ordering information

Cat NoSize
CU2340R1a 1 x 105ml
R1b 5 x 20ml
R2 1 x 30ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

  • PHYSIOLOGICAL SIGNIFICANCE
  • ANTIOXIDANT / PRO-OXIDANT
  • DEFICIENCY
  • TOXICITY

Copper (CU) is an essential trace mineral, naturally available in some foods and as dietary supplements. CU is a cofactor for several enzymes, known as cuproenzymes, which are involved in connective tissue synthesis, energy production, iron metabolism, neuropeptide activation and neurotransmitter synthesis. CU is also involved in brain development, immune system functioning, neurohormone homeostasis, pigmentation, regulation of gene expression, and several physiological processes, such as angiogenesis 1.

CU has been recognised as both an antioxidant and pro-oxidant. Naturally occurring within the body, free radicals interact with genetic material, damage cell walls and contribute to the development of several health problems. As an antioxidant, CU scavenges to neutralise the free radicals, aiding in the prevention of oxidative damage. Conversely, as a pro-oxidant, CU can promote free radical damage, inducing the development of health problems such as Alzheimer’s disease. Consequently, CU is vital as part of a balanced diet 2.

CU deficiency in Western countries is rare, however, altered CU metabolism may influence CU deficiency which negatively impacts the connective tissue, nervous, immune and cardiovascular systems. Such conditions that can predispose CU deficiency include: prematurity, gastric bypass, burns, over-the-counter vitamins containing zinc and iron and infants fed with unmodified cow milk 3.

Menkes disease is a rare x-linked recessive disorder of CU metabolism caused by mutations to the ATP7A gene. Menkes disease affects an estimated 1 in every 100,000 – 250,000 births and is characterised by sparse, kinky hair and failure to thrive and progressive deterioration of the nervous system. Symptoms commonly present during infancy, but, in some cases, the symptoms may present in early to middle childhood. If treatment is started early, the prognosis may improve 4.

Copper toxicity is also rare but can be caused by consuming too many dietary supplements high in copper, drinking contaminated water and from fungicides containing CU sulphates 3.

Wilson’s disease is an autosomal recessive disorder caused by mutations to the ATP7B gene, which is highly expressed in the liver, kidneys and placenta. Wilson’s disease affects approximately 1 in every 40,000 and is characterised by hepatic, neuropsychiatric and ophthalmic symptoms as a result of excess copper accumulation. Unlike most genetic diseases, early detection and implementation of a treatment plan for those with Wilson’s disease can prevent longer term morbidity due to copper induced end organ dysfunction 3.

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Celebrating World Diabetes Day 2022!

Celebrating World Diabetes Day, 14th November 2022!

Diabetes is a serious medical condition that causes blood glucose (sugar) levels to become too high.  This can cause complications such as heart disease, stroke, kidney problems or nerve damage if not treated.

Although there is no cure for Diabetes, the condition can be controlled and monitored.

There are three main types of diabetes, type one, type two and gestational diabetes. The former two are lifelong and can cause life threatening complications if not monitored effectively.

Type one diabetes is when the body can’t make insulin, which is thought to be caused by an autoimmune reaction. In the UK, around 8% of the population have type one.

Type two diabetes is generally caused from lifestyle, when the pancreas doesn’t work properly and can’t keep your blood sugar levels from rising. Type two represents around 90% of people with diabetes in the UK.

Gestational diabetes Mellitus (GDM) is a form of diabetes that appears in pregnancy, characterised by high blood sugar due to the hormones produced in pregnancy. In the UK, around 5% of pregnant women are diagnosed every year.

 

Globally, Diabetes affects more than 415 million people, with type 2 being the most common.

People with T1D have an estimated 50% risk of developing Chronic Kidney Disease over their lifetime. CKD can progress to kidney failure, requiring dialysis or a kidney transplant. Taking a personalized approach to kidney disease screening for people with type 1 diabetes (T1D) may reduce the time that chronic kidney disease (CKD) goes undetected, according to a new analysis performed by the Epidemiology of Diabetes Interventions and Complications study group.

World Diabetes Day aims to increase visibility around the condition and can help sufferers feel less alone. Charities such as Diabetes UK also use the day to help promote awareness and information around the condition to help get people diagnosed earlier through campaigns such as #RewriteTheStory.

 

Randox reagents cover a spectrum of laboratory testing which can help monitor Diabetes and the effectiveness of management. This can help prevent serious complications which can become life threatening.

 

Diagnosis and Monitoring

Fructosamine (Glycated Protein) has been identified as an early indicator of diabetic control compared to other markers such as HbA1c.  HbA1c represents the average blood glucose levels for the previous 2-3 months, conversely fructosamine reflects average blood glucose levels of the previous 2-3 weeks.  HbA1c levels may also be impacted by genetic, haematological and disease-related factors.  The enzymatic Fructosamine method also offers improved specificity and reliability compared to conventional NBT-based methods and does not suffer from non-specific interferences unlike other commercially available Fructosamine assays.

Complications Monitoring – Ketoacidosis

D-3-Hydroxybutyrate (Ranbut) is the most sensitive ketone for the diagnosis of ketosis, in particular diabetic ketoacidosis (DKA) , because it represents approximately 80% of ketones present in blood during DKA. The nitroprusside method commonly used in semi-quantitative dipstick tests only detects acetone and acetoacetate making it less accurate.

Complications Monitoring – Renal Dysfunction

Cystatin C is extremely sensitive to very small changes in GFR and has been identified as a strong predictor of clinical outcomes associated with chronic kidney disease (CKD). Cystatin C doesn’t have a ‘blind area’ like creatinine. Up to 50% of renal function may be lost before significant creatinine elevation occurs. NICE guidelines recommend cystatin C testing due to its higher specificity for significant disease outcomes.

 

To find out more visit: https://www.randox.com/diabetes-reagents/

Or email us at: reagents@randox.com


Celebrating Lp(a) Awareness Day 2022 today!

Randox are raising awareness for Lipoprotein(a), we want to drive awareness on tests that are available to you to decrease the risk of stroke, heart attack or other heart diseases.

Lp(a) is a risk factor for atherosclerosis and related diseases including CHD and stroke. It is increasingly recognised as the strongest known genetic risk factor for premature coronary artery disease. The biggest challenge that exists surrounding Lp(a) measurement is the heterogeneity of the apolipoprotein(a) isoforms, resulting in the underestimation or overestimation of Lp(a) concentrations.

Benefits of the Randox Lp(a) assay

WHO/IFCC reference material – The Randox Lp(a) assay is calibrated in nmol/l and traceable to the WHO/IFCC reference material (IFCC SRM 2B) and provides an acceptable bias compared with the Northwest Lipid Metabolism Diabetes Research Laboratory (NLMDRKL) gold standard method.

Dedicated calibrator & control available – Five point calibrator with accuracy-based assigned target values (in nmol/l) is available, accurately reflecting the heterogeneity of the apo(a) isoforms. Dedicated Lp(a) control is available offering a complete testing package.

Excellent correlation – A correlation coefficient of r=0.995 was displayed when the Randox method was compared against other commercially available methods.

Excellent precision – The Randox Lp(a) assay displayed a within run precision of <2.54%.

Liquid ready-to-use – The Randox Lp(a) assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Applications available – Instrument-specific settings can be provided for a wide range of clinical chemistry analysers.

 

The biggest challenge that exists surrounding Lp(a) measurement is the heterogeneity of the apo(a) isoforms, resulting in the underestimation or overestimation of Lp(a) concentrations. In immunoassays, the variable numbers of repeated KIV-2 units in Lp(a) act as multiple epitopes. This is where standardisation across calibrators is vital. Unless the calibrants do have the same range of isoforms as test samples, those with higher numbers of the KIV-2 repeat, will represent with an overestimation in Lp(a) concentrations and those with smaller numbers of the KIV-2 repeat, will represent with an underestimation. The smaller isoforms are strongly associated with higher Lp(a) concentrations. Lack of standardisation of the calibrant would result in an underestimation of Lp(a) associated CVD risk. It is important to note that an Lp(a) immunoassay employing isoform insensitive antibodies does not exist.

 

DID YOU KNOW?

Lp(a) has been identified to be a key risk factor for cardiovascular complications in individuals with COVID-19!

It is well documented that pre-existing comorbidities such as diabetes and CVD are associated with greater severity and higher fatality rates in those with COVID-19.  Those with either baseline elevated Lp(a) or those whose Lp(a) levels increased following infection from COVID-19, or both, maybe at a significantly increased risk of developing thromboses. Elevated Lp(a) levels may cause acute destabilisation of pre-existing but quiescent, atherosclerotic plaques, which could induce an acute myocardial infarction or stroke.

Identifying any possible health conditions that would relate to early signs of stroke, heart attack or other heart diseases will allow you to make any decisions on an appropriate diet, lifestyle changes and early treatment to reduce your risk of further problems.

For more information about Lp(a):

Visit our website: Lipoprotein(a) [Lp(a)] | Reagents | Randox Laboratories

Or email: marketing@randox.com

 

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RX daytona/imola /daytona plus/monaco

Randox Acetaminophen Reagent

We develop a range of applications for the RX daytona/ imola/ daytona plus/ monaco analysers so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer, Randox Laboratories. We have a range of assays available for the RX daytona/ imola/ daytona plus/ monaco, and we are always developing more applications. If you don’t see the application you are looking for, please contact us to request an application.

All kits are produced to international standard and have ISO 13485 accreditation.

Existing customers can access IFU’s through Powerline.

Rx daytona/imola /daytona plus/monaco - Reagents
AUTOIMMUNE
Complement Component 3 CRP Full Range (0.3-160mg/l)IgECRP
Complement Component 4 CRP High Sensitivity IgG
IgAIgMRheumatoid Factor
BASIC METABOLIC PROFILE
Calcium Creatinine EnzymaticPotassiumCO2 Total
Creatinine (Jaffe)SodiumChlorideGlucose
Urea
BONE
Alkaline PhosphataseCalciumPhosphorusTotal Protein
CARDIAC
CholesterolCRP Full Range (0.3-160mg/l)Direct LDL CholesterolMyoglobin
CK-MBCRP High Sensitivity Heart-Type Fatty Acid Binding Protein (H-FABP) sLDL
CK-NACDigoxinHomocysteineTriglycerides
CRP Direct HDL CholesterolLipoprotein (a)
COMPREHENSIVE METABOLIC PROFILE
Albumin Direct BilirubinCreatinine (Jaffe)Sodium
Alkaline PhosphataseCalcium GlucoseTotal Bilirubin
ALTChlorideLactateTotal Protein
AST (GOT) CO2 Total Potassium Urea
DIABETES
CholesterolDirect HDL CholesterolGlycerol Ranbut (Hydroxybutyrate)
Creatinine EnzymaticDirect LDL Cholesterol HbA1c/Hb Total Protein
Creatinine (Jaffe)FructosamineMicroalbumin Triglycerides
Cystatin CGlucoseNEFA (Non-Esterified Fatty Acids)Urinary Protein
ELECTROLYTES
Calcium CO2 Total Magnesium Sodium (Direct / Nondirect)
Chloride (Direct / Nondirect)LithiumPotassium (Direct / Nondirect)
HAEMOLYTIC ANAEMA
G-6-P-DHHaptoglobinLDH
HEPATIC FUNCTION
AlbuminCholinesteraseHaptoglobin Total Bilirubin
AldolaseComplement C3 IgA Total Protein
Alkaline PhosphataseComplement C4IgG Transferrin
Alpha-1 AntitrypsinDirect Bilirubin IgMTransthyretin (Prealbumin)
ALTGamma GTIron (UIBC)Ammonia
GLDHLeucine Arylamidase (LAP)AST (GOT) Glycerol
LDH
INFLAMMATION AND INFECTION
Acid PhosphataseASOLactateAlpha-1Acid Glycoprotein
CRPRheumatoid Factor
LIPIDS
Apolipoprotein A-IApolipoprotein C-IICholesterolLipoprotein (a)
Apolipoprotein A-II Apolipoprotein C-IIIDirect HDL CholesterolsLDL
Apolipoprotein BApolipoprotein EDirect LDL CholesterolTriglycerides
NEONATAL SCREENING
Alpha-1 AntitrypsinCRP Full Range (0.3-160mg/l) IgECRP
CRP High SensitivityTransthyretin (Prealbumin)
NEUROLOGICAL DISORDERS (CSF)
IgAIgGIgM
NUTRITIONAL STATUS
AlbuminIronMagnesiumTransferrin
Copper Iron (UIBC)PotassiumTransthyretin (Prealbumin)
FerritinLipaseTIBCZinc
PANCREATIC FUNCTION
AmylaseLDHPancreatic AmylaseGlucose
Lipase
RENAL FUNTION
Albumin Creatinine EnzymaticIgGSodium
AmmoniaCreatinine (Jaffe)LDHPhosphorus (Inorganic)
Beta-2 MicroglobulinCystatin CMagnesium Urinary Protein
CalciumGlucose Microalbumin Urea
Chloride HbA1c/HbPotassiumUric Acid
VETERINARY
Albumin Cholinesterase (Butyryl)HDLSuperoxide Dismutase (Ransod)
Alkaline phosphataseCK-NAC Iron (UIBC) Sodium
ALT (GPT) CO2 Total Lactate Therapeutic drugs
AldolaseCopper Lactate dehydrogenase Total Protein
Ammonia CreatinineLDLTriglycerides
AmylaseCRPLipaseUrea
AST (GOT) Canine CRP Magnesium Uric Acid
Bile acidsFructosamine NEFA (Non-esterified fatty acids)Urinary protein
BilirubinGamma-GT Phosphorus (Inorganic) Zinc
CalciumGLDH PotassiumChloride
GlucoseRanbut (Hydroxybutyrate)CholesterolGlycerol
Glutathione Peroxidase (Ransel)
TOXICOLOGY
Therapeutic Drugs
AcetaminophenGentamicinPhenytoinValproic Acid
CarbamazepineLithiumSalicylateDigoxin
PhenobarbitolTheophyline
Drugs of Abuse
BarbituratesCocaine metaboliteEthanolOpiates
BenzodiazepinesEDDPMethadoneCannabinoids
EcstasyMethamphetamine
SPECIFIC PROTEINS
Alpha-1 AntitrypsinASOCystatin CIgM
Alpha-1 Acid GlycoproteinBeta-2 MicroglobulinFerritinLipoprotein (a)
Apolipoprotein A-I CeruloplasminFructosamineMicroalbumin
Apolipoprotein A-II Complement C3 HaptoglobinMyoglobin
Apolipoprotein B Complement C4HbA1c/Hb Rheumatoid Factor
Apolipoprotein C-II CRP IgA Transthyretin (Prealbumin)
Apolipoprotein C-IIICRP Full Range (0.3-160mg/l)IgETransferrin
Apolipoprotein ECRP High Sensitivity IgG
RESEARCH
Antioxidants
AlbuminGlutathione Reductase TIBCUric Acid
BilirubinGlutathione Peroxidase (Ransel)Total Antioxidant StatusFerritin
Superoxide Dismutase (Ransod)Transferrin
Biotechnology
GlutamateGlutamine
Food and Wine Testing
Acetic AcidCopperGlycerolMalic Acid
Ammonia Glucose Iron Potassium
CalciumGlucose/FructoseL-Lactic AcidTotal Antioxidant Status

 


SARS-CoV-2 Vascular & Multi-System Dysfunction Whitepaper

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30 June 2021

SARS-CoV-2 Vascular & Multi-System Dysfunction Whitepaper Download

COVID-19, the disease caused by SARS-CoV-2, is an infectious disease caused by a newly discovered coronavirus. While many of whom become infected by the disease will experience mild to moderate cold or flu-like symptoms, those with health complications – such as autoimmune diseases, asthma, heart disease and diabetes – are at risk of developing serious illness and adverse outcomes.

As of September 2021, over 228 million COVID-19 cases have been confirmed worldwide, with an estimated one in six patients experiencing complications which could be life threatening, with over £116 billion spent by the UK government alone on measures to combat the disease. This drastic spending has been mirrored across the globe, with the significant economic burden expected to be suffered for generations to come.

The whitepaper provides a brief overview of the COVID-19 pandemic, before discussing vascular abnormalities and associated complications brought on by the virus, such as multi-system disfunction, acute respiratory disease syndrome (ARDS) and hepatic, renal & cardiovascular function.

 

Want to know more about Randox?

Contact us or visit our homepage to view more.

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Why does Randox sponsor Equine Sports events?

Why does Randox sponsor Equine Sports?

1 September 2021: Why does Randox sponsor Equine Sports?

Some may be wondering, why is a healthcare company so invested in the equine industry? Why would they sponsor the world’s most famous steeplechase – The Randox Grand National?

It’s a labour of love… Peter FitzGerald’s fond attachment to the equestrian world, together with 40 years’ experience in the in vitro diagnostics industry, was the perfect match.

Clinical diagnostics is at the heart of Randox and our experience and expertise has paved the way for the development of innovative and accurate diagnostic products for Equine Health.

You could say ‘it runs in our blood.’

With 70% of all medical decisions based on the analysis of blood, Randox are set to release the VeraSTAT-V, a stable-side Equine Serum Amyloid A test device designed to detect levels of inflammation in horse blood in a matter of minutes.

The ability to quickly detect and monitor your horse’s health, at the stable side, brings huge benefits to both horse and owner. Early detection of inflammatory states means treatment plans can start sooner, recovery periods are shorter, and the horse can return to work healthy much earlier.

When performance is key, monitoring inflammation is vital.

Whether it’s detecting inflammation related to joint injury, or screening for infection before or after transport, competition or surgery, the VeraSTAT-V is a valuable means to monitor Equine Health.

At Randox, we have enjoyed a long-standing partnership with the Jockey Club and will continue to deliver innovative diagnostics solutions to the Equine Industry for the years ahead.

Interested in finding out more? 

For all Equine SAA and/or Veterinary related inquiries, please email marketing@randox.com or visit www.randox.com/veraSTAT-V for more information.

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Syphilis

Reagents | Syphilis

Key Benefits

Quantative and qualitative results available

For choice and convenience

Excellent stability

Stable to expiry when stored at 2-8°C

Randox Syphilis

  • Treponema Pallidum Haemagglutination Assay (TPHA) method
  • Liquid ready-to-use reagents
  • Stable to expiry when stored at 2-8°C
  • Qualitative or quantitative results
Cat NoSize
SY1480100T (L)EnquireKit Insert RequestMSDSBuy Online
SY1478100T (Card test) (L)Buy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the Syphilis assay used for?

Syphilis is a chronic, contagious and often congenital venereal disease caused by Treponema pallidum. Infection results from contact with moist surfaces, originating in lesions of the epithelial tissue of the skin and mucous membranes. If untreated the disease may result in irreversible changes in the cardiovascular and nervous system. Syphilis remains a disease of high incidence, despite advances in modern antibiotic therapy.

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Roche Cobas

Randox Acetaminophen Reagent

Applications for Roche Cobas 4000 / 6000 / 8000 / PURE / PRO

We develop a range of applications for the Roche Cobas Series (4000 / 6000 / 8000 / PURE / PRO) analysers so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer, Randox Laboratories.

Applications available for Roche Cobas

We have 72 reagents available for the Roche Cobas Series (4000 / 6000 / 8000 / PURE / PRO), and are always developing more. If you don’t see the application you are looking for, please email us to request an application. All kits are produced to international standard and have ISO 13485 accreditation.

Email Us

Get in touch with Randox via email at reagents@randox.com

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Download your kit insert for free on our online portal

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Order your reagents kits online by visiting our online store 


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DEVELOPMENT OF A BIOCHIP ARRAY FOR THE SIMULTANEOUS DETECTION OF CANCER BIOMARKERS ON THE RANDOM ACCESS, FULLY AUTOMATED EVIDENCE EVOLUTION ANALYSER

DEVELOPMENT OF A DUPLEX BIOCHIP ASSAY FOR THE SIMULTANEOUS DETECTION OF ANTI-THYROGLOBULIN AND ANTI-THYROID PEROXIDASE ANTIBODIES ON THE FULLY AUTOMATED EVIDENCE EVOLUTION ANALYSER

DEVELOPMENT OF NEW BIOCHIP ARRAYS FOR THE DETERMINATION OF BIOMARKERS RELATED TO ACUTE KIDNEY INJURY APPLIED TO THE EVIDENCE INVESTIGATOR ANALYSER

DEVELOPMENT OF A NEW BIOCHIP BASED IMMUNOASSAY FOR THE DETECTION OF PARATHYROID HORMONE APPLIED TO THE EVIDENCE EVOLUTION ANALYSER

DEVELOPMENT OF A HIGHLY MULTIPLEXED MOLECULAR ASSAY FOR DETECTION OF INFECTION IN CF AIRWAYS

Repeatability and within-laboratory precision were assessed (n=80): Assay Repeatability Within-laboratory precision CV (%) CV (%) VCAM-1 4.5 6.8 ICAM-1 5.6 8.8 ESEL 12.8 16.6 PSEL 3.5 4.7 LSEL 5.7 8.2 17.096, 097.105RDRT DEVELOPMENT OF A BIOCHIP ARRAY FOR THE DETECTION OF ADHESION MOLECULES ON THE NEW RANDOM ACCESS FULLY AUTOMATED EVIDENCE EVOLUTION ANALYSER

DEVELOPMENT OF A NEW BIOCHIP BASED IMMUNOASSAY UNAFFECTED BY DHEA-S INTERFERENCE FOR THE ACCURATE MEASUREMENT OF SERUM PROGESTERONE

DEVELOPMENT OF A BIOCHIP ARRAY FOR THE RAPID, SIMULTANEOUS DETECTION OF PEPSINOGEN I, PEPSINOGEN II AND GASTRIN 17, ON THE NEW RANDOM ACCESS, FULLY AUTOMATED EVIDENCE EVOLUTION ANALYSER

CLINICAL EVALUATION OF A RAPID FULLY-AUTOMATED MULTIPLEX BIOCHIP ARRAY FOR STROKE DIAGNOSIS

DEVELOPMENT OF A NEW BIOCHIP ARRAY APPLIED TO THE NEW RANDOM ACCESS FULLY AUTOMATED EVIDENCE EVOLUTION ANALYSER FOR THE SIMULTANEOUS MEASUREMENT OF TSH, FREE T4 AND FREE T3

DEVELOPMENT OF A NEW BIOCHIP BASED IMMUNOASSAY FOR THE MEASUREMENT OF TOTAL 25-HYDROXYVITAMIN D IN SERUM AND THE ACCURATE CLASSIFICATION OF VITAMIN D STATUS

DEVELOPMENT OF A BIOCHIP ASSAY FOR THE DETECTION OF THYROXINE-BINDING GLOBULIN (TBG) ON THE NEW RANDOM ACCESS FULLY AUTOMATED EVIDENCE EVOLUTION ANALYSER

GENETIC DIAGNOSIS OF MONOGENIC OR POLYGENIC FAMILIAL HYPERCHOLESTEROLEMIA IN NORTHERN IRELAND: EVALUATION OF THE RANDOX FH ARRAYS IN COMBINATION WITH THE RANDOX 6SNP POLYGENIC HYPERCHOLESTEROLEMIA ARRAY

DEVELOPMENT OF A BIOCHIP ARRAY FOR THE SIMULTANEOUS MEASUREMENT OF DISTINCT FATTY ACID-BINDING PROTEINS (FABPs)

DEVELOPMENT OF A NEW ENZYME-LINKED IMMUNOSORBENT ASSAY KIT TO DETECT NGAL IN HUMAN SERUM AND ITS APPLICATION TO CHRONIC KIDNEY DISEASE