Superior Performance & Unique Tests

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Superior Performance & Unique Tests

Superior Performance & Unique Tests

Specialty Reagents Designed to Expand Your Routine Testing Panel

Superior Performance & Unique Tests – Innovating clinical diagnostics and enhancing laboratory testing!

In vitro diagnostics is the heart and soul of the healthcare system as healthcare professionals not only rely on diagnostic tests to diagnose and treat patients, but also to rule out the different contributing causes of a disease state. The implementation of superior performance & unique tests can aid in the early and accurate diagnosis of disease states, enabling the appropriate and effective implementation of a personalised treatment plan 1.

Benefits of the Randox Superior Performance & Unique Tests

Superior Performance

Superior Performance Offering

Offering a range of assays with superior methodologies, delivering more accurate and specific results compared to traditional methods.

Unique Offering

Unqiue Offering

Offering a range of unique assays meaning that Randox are one of the only manufacturers to offer these tests in an automated biochemistry format.

Reduce labour

Reduce Labour

Reduce time spent running tests with liquid ready-to-use formats, automated methods and our easy-fit options.

Reduce costs

Reduce Costs

Creating cost-savings for your laboratory through excellent reagent stability; by eliminating costly re-runs, as a result of high quality of products and the availability of a range of kit sizes (including smaller kits for unique tests, reducing wastage).

Confidence in Patient Results

All our superior performance & unique diagnostic reagents are validated against gold-standard methods, offering low CV’s and excellent precision giving you the confidence that you are sending out accurate patient results.

Applications Available

Applications are available detailing instrument-specific settings for the convenient use of the Randox superior performance & unique assays on a wide variety of clinical chemistry analysers.

  • Superior Performance & Niche Assays
  • Risk Assessment using Randox Reagents
Lp(a)

The Randox Lp(a) assay is calibrated in nmol/l and traceable to the WHO/IFCC reference material (IFCC SRM 2B) and provides an acceptable bias compared with the Northwest Lipid Metabolism Diabetes Research Laboratory (NLMDRKL) gold standard. A five-point calibrator with accuracy-based assigned target values (in nmol/l) is available, accurately reflecting the heterogeneity of the apo(a) isoforms.

Bile Acids

The Randox bile acids test utilises an advanced enzyme cycling method which displays outstanding sensitivity and precision when compared to traditional enzymatic based tests. The Randox 5th Generation Bile Acids test is particularly useful in paediatrics where traditional bile acids tests are affected by haemolytic and lipaemic samples.

Bilirubin

A superior assay from Randox, the vanadate oxidation method offers several advantages over the diazo method, including less interference by haemolysis and lipaemia, which is particularly evident for infant and neonatal populations.

Adioponectin

Adiponectin has been identified as having pleiotropic functions widely associated with anti-atherogenic, anti-diabetic, cardioprotective and anti-inflammatory effects. Adiponectin levels inversely correlate with insulin levels, BMI, triglyceride levels, insulin resistance (IR), glucose, and most importantly, visceral fat accumulation.

sTfR

Soluble transferrin receptor (sTfR) is a marker of iron status. In iron deficiency anaemia, sTfR levels are significantly increased, however remain normal in the anaemia of inflammation. Consequently, sTfR measurement is useful in the differential diagnosis of microcytic anaemia.

Fructosamine

The Randox Fructosamine assay utilises the enzymatic method which offers improved specificity and reliability compared to conventional NBT-based methods. The Randox enzymatic method does not suffer from non-specific interferences unlike other commercially available fructosamine assays.

Current Challenges

CVD
Cardiovascular Disease (CVD)

CVD accounts for 45% of all deaths in europe and 37% of all deaths in the EU. Atherogenesis is a circulatory disease whereby atheromas are formed (plaque build-up) within the artery.  Plaque is a combination of cholesterol, fat, calcium, lipids and other substances within the blood stream.  As time progresses, the plaque hardens, narrowing the arteries.  This is known as atherosclerosis. Consequently, blood flow through the narrowed artery is reduced, limiting the supply of blood to vital organs and bodily tissues.  As atherogenesis can affect any artery within the body, different diseases may develop based on the artery that is affected.  Such diseases include: coronary heart/artery disease, carotid artery disease, peripheral artery disease and chronic kidney disease 2, 3, 4.

Type 2 Diabetes Mellitus

425 million people are living with type 2 diabetes mellitus (T2DM) and 352 million are at risk of developing T2DM. T2DM is a serious condition whereby blood glucose levels are elevated (hyperglycaemia). T2DM is characterised by insulin resistance or insulin deficiency. T2DM is the most common form of diabetes, accounting for 90% of cases. The key to T2DM is control. Implementing lifestyle changes, oral medication and in more severe cases, insulin, a diabetic can take control of their disease, keeping glucose levels stable. When glucose levels are not monitored and controlled, associated complications may arise including: diabetic nephropathy, CVD and renal impairment 5, 6.

Chronic Kidney Disease (CKD)

Worldwide 1/5 of men and 1/4 of women between 65 and 74 years of age have Chronic kidney disease (CKD). CKD is an umbrella term encompassing a wide range of renal conditions from commonly prevalent sub-clinical, asymptomatic to rare end-stage renal disease requiring dialysis or a transplant to sustain life. Kidney disease is ranked in stages from stage 1 (very mild damage) through to stage 5 (kidney failure) 7. Symptoms are commonly expressed in the later stages of renal impairment, however, at this point dangerous levels of fluid, electrolytes and waste products can build up inside the body. The aim of CKD treatment is to slow the progression of the disease, thus early intervention is vital 8.

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TAS & NEFA: Benefits for dairy cattle during the transition period

The transition period between late pregnancy and the onset of lactation requires quick metabolic adaption by dairy cattle as foetal growth, calving and the onset of lactation causes increased energy demands on the body. To support the increase in energy requirements, increased nutrients are required; however, limitations to dietary intake can occur as a result of reduced appetite caused by the growing foetus restricting the size of the rumen. In addition, during this period almost all glucose intake is utilised for lactose synthesis. As a result, during the transition period dairy cattle can be prone to negative energy balance.

Negative energy balance occurs when energy demands exceed dietary intake, and in cases where energy requirements are not met by diet, dairy cattle will utilise their own fat reserves as an energy source; this being non-esterified fatty acids (NEFA), a major component of triglycerides (fats) in the body. Excessive metabolism of NEFA, however, can result in accumulation of fat which can result in fatty liver disease (resulting in decreased liver function), and ketosis which can be toxic and damaging to the liver and kidneys (it has been associated with pregnancy complications, decreased milk production and hypoglycaemia).

Additionally, during the transition period, as a result of the increase in metabolic processes, dairy cattle are more susceptible to metabolic stress. This is due to the increase in Reactive Oxygen Species (ROS).

ROS are free radical by-products of normal metabolic processes which can be harmful and destructive to the cells in the body. To defend against them the body utilises antioxidants to inhibit the formation of free radicals, destroy free radicals or repair the damage caused by free radicals; however if there is an imbalance of antioxidants to ROS then the body’s natural defence system is decreased. This can result in free radical damage to surrounding cells, tissue and DNA.

Free radicals have been implicated in many disease states in addition to suppression of the immune response system. As a result, in the first 10 days after calving dairy cows are at maximum risk of infectious and metabolic disorders; in fact, approximately 75% of disease occurs in herds within the first month of lactation (Abuelo et al. 2014). Complications for dairy cattle suffering metabolic stress include not only fatty liver disease and ketosis, but also mastitis, retained foetal membranes, reduced milk production and increased risk of cancer, CVD, lung, liver and renal disease, inflammatory conditions such as arthritis, infectious conditions, and, neurological disorders.

How can the health and well-being of dairy cattle be protected during the transition period?

To ensure animal well-being, and indeed reduce economic impact for dairy farmers, dairy cattle should be monitored for their antioxidant capacity, particularly during pregnancy.  As the antioxidant defence system includes many components, the Total Antioxidant Status (TAS) test is used to assess overall antioxidant capacity. This test is beneficial in gaining an overall view of the body’s ability to defend against free radical attack; it can therefore help to determine if nutritional supplements are required to ensure good body condition during the transition period. Further antioxidant testing may be required to ensure nutritional requirements are fully understood before antioxidant supplementation begins.

In addition, the NEFA test indicates negative energy balance, and can therefore be used to monitor whether their nutrient intake is adequate for the high energy demands experienced during the transition period. Additionally, research (Li, H.Q et al. 2016) has found that supplementing dairy cattle with rumen-protected folic acid (RPFA) may benefit negative energy balance by decreasing plasma concentrations of NEFA and increasing glucose plasma. Results show increased milk protein levels and improved nutrient ingestion, milk production and reproductive performance.

Randox provides TAS and NEFA for a wide range of biochemistry analysers. For more information please contact reagents@randox.com.

References:

Abuelo A., Hernandez J. and Beneditor J.L (2014) The importance of oxidative status of dairy carrel in the periparturient period: revisiting antioxidant supplementation. Journal of Animal Physiology and Animal Nutrition. 99(6):1003-1016

Li, H. Q., et al. (2016) Effects of dietary supplements of rumen-protected folic acid on lactation performance, energy balance, blood parameters and reproductive performance in dairy cows. Animal Feed Science and Technology


Antioxidant Calibrators

Therapeutic Drug Quality Control

Glutathione Reductase Calibrator

A dedicated Glutathione Reductase calibrator designed specifically for use with the Randox Glutathione Reductase assay on a wide range of clinical analysers.

Features & Benefits

  • Lyophilised for enhanced stability
  • Bovine based whole blood
  • Stable to expiry date at 2°C – 8°C
  • Reconstituted stability of 1 day at 2°C – 8°C or 8 hours at 15°C – 25°C
DescriptionSizeAnalytesCat No 
Glutathione Reductase Calibrator10 x 5 ml1GR2609

Analytes

  • Glutathione Reductase

Glutathione Peroxidase (Ransel) Calibrator

A dedicated Glutathione Peroxidase calibrator designed specifically for use with the Randox Glutathione Peroxidase assay on a wide range of clinical analysers.

Features & Benefits

  • Lyophilised for enhanced stability
  • Bovine based whole blood
  • Stable to expiry date at 2°C – 8°C
  • Reconstituted stability of 3 days at 2°C – 8°C
DescriptionSizeAnalytesCat No 
Glutathione Peroxidase (Ransel) Calibrator10 x 1 ml1SC10154

Analytes

  • Glutathione Peroxidase (Ransel)

Total Antioxidant Status Quality Control

Therapeutic Drug Quality Control

Dedicated control for use in the routine monitoring of the Randox Total Antioxidant Status assay on clinical chemistry analysers

Features & Benefits

  • Lyophilised for enhanced stability
  • Bovine based serum
  • Stable to expiry date at 2°C – 8°C
  • Reconstituted stability of 2 days at 2°C – 8°C or 12 hours at 15°C – 25°C
DescriptionSizeAnalytesCat No 
Total Antioxidant Status Control10 x 5 ml1NX2331

Analytes

  • Total Antioxidant Status

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