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Superior Performance & Unique Tests

Superior Performance & Niche Reagents

Randox offer a range of high performance, unique and niche reagents that are designed to enhance your laboratory testing capabilities.

Our impressive portfolio of high performance & unique tests together with our standard assays sets us apart in the in vitro diagnostics market. Our superior performance reagents and methodologies deliver highly accurate and specific results, that can facilitate earlier diagnosis of disease states with confidence and precision.

Benefits of High Performance Reagents

Reduce costs

Reduce Costs

We can help create cost-savings for your laboratory through excellent stability, eliminating the requirement for costly test re-runs. Our quality reagents also come in a range of different kit sizes to reduce waste and for your convenience.

patient results-08

Confidence in Patient Results

Our traceability of material and extremely tight manufacturing tolerances ensure uniformity across our reagent batches. All of our assays are validated against gold-standard methods.

Applications

Applications Available

Applications are available detailing instrument-specific settings for the convenient use of the Randox superior performance & unique assays on a wide variety of clinical chemistry analysers.

Superior Performance

Superior Performance Offering

Randox offer an extensive range of 115 assays across routine and niche tests, and cover over 100 disease makers.  Our high performance assays deliver superior methodologies, more accurate and specific results compared to traditional methods.

Reduce labour

Reduce Labour

Reduce valuable time spent running tests. Randox reagents come in liquid ready-to-use formats and various kit sizes for convenient easy-fit. Barcode scanning capabilities for seamless programming.

Unique Offering

Unique Offering

Our range of unique assays means that Randox are one of the only manufacturers to offer these tests in an automated biochemistry format.

  • Risk Assessment using Randox Reagents
Lp(a)

The Randox Lp(a) assay is calibrated in nmol/l and traceable to the WHO/IFCC reference material (IFCC SRM 2B) and provides an acceptable bias compared with the Northwest Lipid Metabolism Diabetes Research Laboratory (NLMDRKL) gold standard. A five-point calibrator with accuracy-based assigned target values (in nmol/l) is available, accurately reflecting the heterogeneity of the apo(a) isoforms.

Bile Acids

The Randox bile acids test utilises an advanced enzyme cycling method which displays outstanding sensitivity and precision when compared to traditional enzymatic based tests. The Randox 5th Generation Bile Acids test is particularly useful in paediatrics where traditional bile acids tests are affected by haemolytic and lipaemic samples.

Bilirubin

A superior assay from Randox, the vanadate oxidation method offers several advantages over the diazo method, including less interference by haemolysis and lipaemia, which is particularly evident for infant and neonatal populations.

Fructosamine

The Randox Fructosamine assay utilises the enzymatic method which offers improved specificity and reliability compared to conventional NBT-based methods. The Randox enzymatic method does not suffer from non-specific interferences unlike other commercially available fructosamine assays.

sTfR

Soluble transferrin receptor (sTfR) is a marker of iron status. In iron deficiency anaemia, sTfR levels are significantly increased, however remain normal in the anaemia of inflammation. Consequently, sTfR measurement is useful in the differential diagnosis of microcytic anaemia.

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TAS & NEFA: Benefits for dairy cattle during the transition period

The transition period between late pregnancy and the onset of lactation requires quick metabolic adaption by dairy cattle as foetal growth, calving and the onset of lactation causes increased energy demands on the body. To support the increase in energy requirements, increased nutrients are required; however, limitations to dietary intake can occur as a result of reduced appetite caused by the growing foetus restricting the size of the rumen. In addition, during this period almost all glucose intake is utilised for lactose synthesis. As a result, during the transition period dairy cattle can be prone to negative energy balance.

Negative energy balance occurs when energy demands exceed dietary intake, and in cases where energy requirements are not met by diet, dairy cattle will utilise their own fat reserves as an energy source; this being non-esterified fatty acids (NEFA), a major component of triglycerides (fats) in the body. Excessive metabolism of NEFA, however, can result in accumulation of fat which can result in fatty liver disease (resulting in decreased liver function), and ketosis which can be toxic and damaging to the liver and kidneys (it has been associated with pregnancy complications, decreased milk production and hypoglycaemia).

Additionally, during the transition period, as a result of the increase in metabolic processes, dairy cattle are more susceptible to metabolic stress. This is due to the increase in Reactive Oxygen Species (ROS).

ROS are free radical by-products of normal metabolic processes which can be harmful and destructive to the cells in the body. To defend against them the body utilises antioxidants to inhibit the formation of free radicals, destroy free radicals or repair the damage caused by free radicals; however if there is an imbalance of antioxidants to ROS then the body’s natural defence system is decreased. This can result in free radical damage to surrounding cells, tissue and DNA.

Free radicals have been implicated in many disease states in addition to suppression of the immune response system. As a result, in the first 10 days after calving dairy cows are at maximum risk of infectious and metabolic disorders; in fact, approximately 75% of disease occurs in herds within the first month of lactation (Abuelo et al. 2014). Complications for dairy cattle suffering metabolic stress include not only fatty liver disease and ketosis, but also mastitis, retained foetal membranes, reduced milk production and increased risk of cancer, CVD, lung, liver and renal disease, inflammatory conditions such as arthritis, infectious conditions, and, neurological disorders.

How can the health and well-being of dairy cattle be protected during the transition period?

To ensure animal well-being, and indeed reduce economic impact for dairy farmers, dairy cattle should be monitored for their antioxidant capacity, particularly during pregnancy.  As the antioxidant defence system includes many components, the Total Antioxidant Status (TAS) test is used to assess overall antioxidant capacity. This test is beneficial in gaining an overall view of the body’s ability to defend against free radical attack; it can therefore help to determine if nutritional supplements are required to ensure good body condition during the transition period. Further antioxidant testing may be required to ensure nutritional requirements are fully understood before antioxidant supplementation begins.

In addition, the NEFA test indicates negative energy balance, and can therefore be used to monitor whether their nutrient intake is adequate for the high energy demands experienced during the transition period. Additionally, research (Li, H.Q et al. 2016) has found that supplementing dairy cattle with rumen-protected folic acid (RPFA) may benefit negative energy balance by decreasing plasma concentrations of NEFA and increasing glucose plasma. Results show increased milk protein levels and improved nutrient ingestion, milk production and reproductive performance.

Randox provides TAS and NEFA for a wide range of biochemistry analysers. For more information please contact reagents@randox.com.

References:

Abuelo A., Hernandez J. and Beneditor J.L (2014) The importance of oxidative status of dairy carrel in the periparturient period: revisiting antioxidant supplementation. Journal of Animal Physiology and Animal Nutrition. 99(6):1003-1016

Li, H. Q., et al. (2016) Effects of dietary supplements of rumen-protected folic acid on lactation performance, energy balance, blood parameters and reproductive performance in dairy cows. Animal Feed Science and Technology


Antioxidant Calibrators

Therapeutic Drug Quality Control

Glutathione Peroxidase (Ransel) Calibrator

A dedicated Glutathione Peroxidase calibrator designed specifically for use with the Randox Glutathione Peroxidase assay on a wide range of clinical analysers.

Features & Benefits

  • Lyophilised for enhanced stability
  • Bovine based whole blood
  • Stable to expiry date at 2°C – 8°C
  • Reconstituted stability of 1 days at 2°C to 8°C or 8 hours at 15°C to 25°C
Description SizeAnalytesCat No
Glutathione Peroxidase (Ransel) Calibrator10 x 1 ml1SC10154

Analytes

  • Glutathione Peroxidase (Ransel)

Glutathione Reductase Calibrator

A dedicated Glutathione Reductase calibrator designed specifically for use with the Randox Glutathione Reductase assay. This product is compatible for use on most clinical chemistry analysers.

Features & Benefits

  • Lyophilised for enhanced stability
  • Bovine based whole blood
  • Stable to expiry date at 2°C – 8°C
  • Reconstituted stability of 3 days at 2°C – 8°C
DescriptionSizeAnalytesCat No
Glutathione Reductase Calibrator10 x 5 ml1GR2609

Analytes

  • Glutathione Reductase

Total Antioxidant Status Quality Control

Therapeutic Drug Quality Control

Dedicated control for use in the routine monitoring of the Randox Total Antioxidant Status assay on clinical chemistry analysers

Features & Benefits

  • Lyophilised for enhanced stability
  • Bovine based serum
  • Stable to expiry date at 2°C – 8°C
  • Reconstituted stability of 2 days at 2°C – 8°C or 12 hours at 15°C – 25°C
DescriptionSizeAnalytesCat No
Total Antioxidant Status Control10 x 5 ml1NX2331

Analytes

  • Total Antioxidant Status

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