Randox Quality Control Celebrate British Science Week 2018!
This British Science Week 2018, Randox Quality Control are celebrating the hard work our team puts in every day, to help bring the best Quality Control products to the market.
We caught up with Edward Hill, QC Product Specialist, to explain a bit about what his role involves and how Randox QC are impacting on global healthcare!
What is your position and what does it involve?
I am a QC Product Specialist at Randox Laboratories. This is a hugely varied role, and some of my general duties involve; creating educational material for laboratory professionals, conducting competitor comparisons to ensure we are always one step ahead of the competition, staying up-to-date with the latest industry trends and thinking of new and innovative ways to interact with our customer-base.
For those of us who aren’t in the industry, can you give us a brief snapshot of what Quality Control is and why we use it?
When a patient has their blood/urine/serum etc. taken, it must be sent to the laboratory for analysis. Laboratory professionals run the patient sample on a clinical instrument, which gives a quantitative result for each analyte. However, the laboratory professional does not know whether the value given by the instrument is correct or not. For this reason, the laboratory professional must use a Quality Control – which is a material designed to mimic the patient sample, and has a known concentration of each analyte.
When the laboratory professional runs the QC material on their instrument, they can compare the obtained result with the expected result. If these values are comparable, then the laboratory professional can be confident that their instrument is reporting accurately. Essentially, QC is a ‘practice run’ to ensure the testing system is working correctly.
How does your teams’ work impact on global healthcare?
Quality Control is a hugely important part of laboratory quality. Around 70% of clinical decisions are made based on laboratory results, so it is plain to see how significant Quality Control practices can be in relation to global health care. My work, as well as the work of the wider Quality Control team, is focused on making end-users aware of the importance of Quality Control. We aim to provide advice and recommendations to optimise accuracy and efficiency.
As a company, Randox prioritizes quality above all else, and this ethos is perfectly reflected by the Quality Control team. We work tirelessly to provide quality products and simplify the entire testing process – giving the laboratory professionals more time to do what they do best; provide accurate results time and time again.
What is your favourite Randox QC product and why?
My favourite QC product is the Acusera Liquid Cardiac Control. It’s my favourite control because it perfectly displays all the advantages of Acusera in a single product:
- Highly consolidated analyte list without any unnecessary extras, keeping costs low
- True third party
- Manufactured with 100% human serum, giving full commutability
- Liquid ready-to-use and suitable for POC testing
- Clinically relevant ranges, with ultra-low levels of Troponin I
- Long open vial stability of 30 days
Competitors often offer additional low level Troponin I controls. The thing I like most about the Acusera Liquid Cardiac Control is that the Troponin I levels are still lower than the ‘ultra-low level’ competitor controls – showing that Acusera gets it right the first time, rather than supplementing weak QC products with additional products at an extra cost.
The theme this year for British Science Week is exploration & discovery. Randox Laboratories was established in 1982 with the aim to revolutionise healthcare through continuously improving diagnostic solutions as diagnostics are vital to improving healthcare and disease diagnosis. To achieve this, 28% of the total annual revenue is reinvested in R&D.
Did you know?
The RX series have analyser placements in over 120 countries worldwide
5th largest manufacturer of clinical chemistry reagents in the world.
3rd largest manufacturer of QC and calibrators globally, supplying to 60,000 labs worldwide.
Largest international EQA scheme, with more than 45,000 lab participants in 133 countries.
Patient care is the primary focus of clinical chemistry testing and Randox has developed the RX series of clinical chemistry analysers for high quality semi-automated and fully automated testing. The RX series combines robust hardware and intuitive software with the world leading RX series test menu, including routine chemistries, specific proteins, lipids, therapeutic drugs, drugs of abuse, antioxidants and diabetes testing.
Renowned for quality and reliability, the RX series has one of the most extensive dedicated clinical chemistry test menus on the market guaranteeing real cost savings through consolidation of routine and specialised tests onto a single platform. This extensive dedicated test menu of high quality reagents guarantees excellence in patient care ensuring unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.
The RX series offers both semi-automated and fully automated clinical chemistry analysers to suit your laboratory needs. Choose from the RX misano, RX monaco, RX daytona+, RX imola and RX modena to start your journey with the RX series today.
The market-leading reagents portfolio from Randox is internationally recognised as being of the highest quality, offering rapid and reliable results. With 118 assays, covering over 100 disease markers, Randox offers the most comprehensive product portfolio in the diagnostic market incorporating antioxidants, cardiology, diabetes, drugs of abuse, hepatic function, lipids, renal function, specific proteins, therapeutic drug monitoring and veterinary testing. Randox assays are available in a wide range of formats and methods providing greater flexibility and choice for your laboratory. In addition to flexible pack sizes, a comprehensive list of 13,000 applications for 195 clinical chemistry analysers can be provided as dedicated reagent packs (Easy Read & Easy Fit Reagents).
Through continued exploration to expand the clinical test panels, Randox discovered numerous high performing and unique tests. These tests are either unique to Randox or offer a superior methodology for more accurate results. Such tests include:
– Adiponectin is a protein hormone secreted by adipocytes which has an important role in a number of metabolic processes. Adiponectin is a diabetes biomarker as adiponectin levels are inversely correlated with abdominal visceral fat (AVF) levels, which has proven to be a strong predictor of several pathologies including metabolic syndrome, type 2 diabetes mellitus (T2DM), some cancers and cardiovascular disease (CVD).
– Cystatin C is a small cysteine proteinase inhibitor that is produced at a constant rate by all nucleated cells. Cystatin C is a more sensitive marker of renal function than creatinine as up to 50% of renal function can be lost before significant creatinine levels become detectable. Cystatin C is also useful in patients where creatinine measurements are inconclusive or unreliable, such as patients who are obese, malnourished, have liver cirrhosis or reduced muscle mass.
– 5th Generation Bile Acids is a highly sensitive marker of hepatic function, enabling the early detection of liver disease. The Randox 5th Generation Bile Acids assay utilises an advanced enzyme cycling method which displays outstanding sensitivity and precision when compared to traditional enzymatic based tests.
The Randox High Performance and Unique Tests brochure can be downloaded here for further information.
As the aim of British Science Week 2018 is to inspire innovation and celebrate science, Randox Quality Control are celebrating the fact that we have evolved into one of the principal manufacturers of quality controls and calibrators in the world. With approximately 70% of clinical decisions based on laboratory test results, it is clear to see the significant role laboratory testing plays. Our extensive range of Acusera Controls help labs to find and correct flaws in their analytical processes before potentially incorrect patient results are released, ultimately helping to improve health worldwide.
With more than 390 analytes available across the range, labs can significantly reduce costs without compromising on quality. We specialise in consolidation, our range of multi-analyte controls is designed to cover your test menu, ultimately reducing costs, preparation and storage space for any lab.
Manufactured independently, our third-party range of controls delivers unbiased performance assessment with any instrument or method, furthermore our commutable materials are designed to mimic the patient sample and ensures accurate and reliable test results. Designed to complement our range of third party controls the Acusera 24•7 software is the only peer group program to offer automatic calculation of measurement uncertainty helping laboratories to meet ISO 15189 requirements. Peer group statistics are also uniquely updated live, in real-time giving you access to the most up-to-date information possible enabling rapid and effective troubleshooting.
As the largest EQA scheme in the world, RIQAS (Randox International Quality Assessment Scheme) is used by more than 45,000 laboratory participants in 133 countries worldwide. Comprising 33 programmes a wide range of clinical testing is covered. Each RIQAS programme delivers high quality samples spanning clinically relevant levels to allow identification of concentration related biases; our frequent, user-friendly reporting enables early identification of system errors and our report turnaround time of less than 72 hours from the submission deadline, ensures corrective action can be implemented earlier, reducing costly errors with patient results.
Diagnostics is the key enabler to improve healthcare, patient outcomes and reduce the burden on healthcare; 80% of all medical decisions are based on diagnostic tests. In 1982, we had meagre resources, but we felt we could develop and manufacture world class diagnostic tests. Through continuously improving diagnostic solutions through exploration and discovery, Randox are a world leading manufacturer of diagnostic solutions.
Randox celebrates British Science Week 2017
Last week was British Science Week 2017, an annual campaign that aims to inspire innovation and celebrate science. To mark the occasion, Randox Laboratories got involved by celebrating the innovation of each Randox product group. The product groups within Randox shared a series of posts, videos and blogs showcasing the #ScienceBehindRandox throughout British Science Week.
To initiate the Randox British Science Week campaign, Randox shared this video, which highlights the company’s dedication to improving health worldwide. The video provides an introduction about each product group, however throughout British Science Week, each product group has gone into further detail about the #ScienceBehindRandox.
Randox Careers, the RX series, Randox Reagents, Randox Quality Control, Randox Toxicology, Randox Biosciences, Randox Testing Services, & Randox Food Diagnostics all got involved in the British Science Week Campaign. You can read a snippet of each product groups post below, with videos and links to the full content also provided. We hope you enjoy learning about the #ScienceBehindRandox.
Randox – Dedicated to improving health wordwide.
Joanne Darragh spent some time with Randox Careers to discuss her role as R&D Toxicology Manager.
“Working in this area has been both challenging and exciting as we are at the cutting edge of assay development. We work in a great team and we work along very closely alongside other departments such as Marketing & Sales so that we are in close contact with what the customer needs, which means we are producing relevant tests very quickly and effectively. Every day brings a new challenge.”
– Joanne Darragh, R&D Toxicology Manager
Listen to what Joanne had to say on the video above
Randox RX series
As part of British Science Week, the RX series caught up with Daniel Melly, one of our very talented Mechanical Design Engineers based in Randox Teoranta in Dungloe, Ireland.
Daniel was an integral part of the team involved in the design of our new semi-automated analyser, the RX misano. The RX series asked Daniel a few questions about why Randox created this analyser, the design process involved in creating such a unique system, and what his favourite features are.
“Randox set out in creating the RX misano with the philosophy of supplying the customer with a more modern, reliable, and aesthetically pleasing analyser than those that are currently available on the market. Robust part selection was always at the fore of any design decisions, and we feel that we have delivered on all of these requirements.”
– Daniel Melly, Randox Mechanical Design Engineer
One unique test by Randox, adiponectin, is becoming an increasingly significant biomarker for health professionals. Low levels have been linked with several illnesses including metabolic syndrome, cancer and cardiovascular disease.
What is adiponectin?
Adiponectin is a protein hormone produced and secreted by fat cells called adipose tissue. Adiponectin is normally found in relatively high concentrations in healthy individuals. Its role in the body is to regulate the metabolism of lipids and glucose, which influences the body’s response to insulin and inflammation.
At Randox, our R&D Scientists are helping to change healthcare. By investing heavily into research and development to develop unique diagnostics tests, such as the adiponectin test, Randox provide doctors with the ability to identify disease risk sooner- offering the opportunity to prevent illness, rather than the need to find a cure.
Randox Quality Control
One Simple Change to Randox Quality Control can save your laboratory time and money.
Randox Quality Control are a world leading manufacturer of true third party controls with over 390 analytes covering Antioxidants, Blood Gas, Cardiac Markers, Routine Chemistry, Coagulation, Haematology, Diabetes, Immunoassay, Immunology, Lipids, POCT, Therapeutic Drugs, Toxicology and Urine Chemistry, providing complete test menu consolidation. Randox Quality Control produces the most consistent material available with the most accurate target values.
Randox Quality Control guarantee to simplify QC practice in any laboratory, just ask one of their 60,000 users worldwide.
Find out more information about Randox Quality Control in the video above
Randox Toxicology provides trusted solutions for the screening for drugs of abuse. With significant reinvestment in Research and Development, we persistently stay ahead of this ever challenging market. Being the first to develop New Psychoactive Substances tests such as fentanyl, bath salts and flakka allows us to maintain our position as a global leader.
Our pioneering technology has created a number of advancements in the field of toxicology. In particular, our patented Biochip Array Technology which can simultaneously screen from a multi-analyte testing platform, achieving a complete immunoassay profile from the initial screening phase.
During British Science Week, we are delighted to introduce you to our latest development utilising this technology; our Gastropanel Array,* a multiplex test engineered to diagnose those at risk of developing peptic ulcers and gastric cancer using non-invasive methods.
Our Gastropanel Array encompasses two quantitative assays, a H. pylori assay for the detection of antibodies produced in response to a H. pylori infection, a common cause of gastric cancer1 as well as a 3plex Gastropanel assay, for the detection of pepsinogen I (PGI), pepsinogen II (PGII) and gastrin 17 (G17).
Currently recorded as the world’s 5th most common cancer, the majority of gastric cancer cases are diagnosed after presenting as an emergency, when treatment may be less effective due to the cancer being at an advanced stage, highlighting the need for the availability of diagnostics tests like our Gastropanel Array to enable practitioners to administer prompt treatment and ultimately increase survival rates on a global scale.
Randox Testing Services
Randox Testing Services have shown how they are at the forefront of continually reacting and developing tests for NPS. NPS (formerley known as Legal Highs) have had devastating effects on users since emerging in the UK in 2008. These substances are highly dangerous and have caused unnecessary deaths. This is due to the effects from different elements used in production. Legislation concerning the substances changed in 2016 with the implementation of the Psychoactive Substance Act.
How have Randox Testing Services implemented change? Find out in the video above
Randox Food Diagnostics
Of the 41 antibiotics that are approved for use in food-producing animals by the FDA, 31 are medically important for human health. Randox Food Diagnostics provides advanced screening solutions for 94% of these antibiotics including beta-lactams, quinolones and tetracyclines, allowing you to ensure the integrity of your end product without compromising quality. Randox Food provides multiplex screening solutions validated across a range of matrices including urine, serum, tissue, milk, honey and feed.
The Evidence Investigator matched with Biochip Array Technology (BAT) provide the end user with fast, reliable results to aid in ensuring your produce is antibiotic free. BAT provides a platform for the simultaneous determination of multiple drug residues from a single sample using miniaturised immunoassays with implications in the reduction of sample/reagent consumption and an increase in the output of test results.
In celebration of British Science Week 2017, we will be giving you an introduction to diagnostics, and exploring how Randox Scientists are helping to change healthcare.
You may or may not already know that Randox are one of the leading diagnostics companies globally. But what exactly does clinical diagnostics involve? It is one of the fundamental steps of finding out what is wrong with a person when they are ill. Read on to find out a bit more about diagnostics, and how the Randox Reagents R&D Scientists are helping to change healthcare globally!
What is a diagnostic test?
A diagnostic test is any kind of analysis performed on a patient sample (a sample is typically blood, urine or cerebrospinal fluid (CSF)), to aid in the diagnosis or detection of disease. The information found from a test can be used to:
- Diagnose disease
- Assess the extent of damage
- Monitor the effectiveness of treatment
- Confirm a person to be free from disease
Examples of substances that may be tested for the blood include proteins, nutrients, waste products, antibodies, hormones, salts, trace elements or vitamins. These are sometimes referred to as ‘analytes’, ‘markers’ or ‘biomarkers’.
This is where reagents come in…
A reagent is a substance which is mixed with the patient sample to create a chemical reaction to detect the biomarker. These reactions are analysed by machines known as analysers.
Using data gathered from both clinical symptoms and laboratory tests, the doctor will follow a sometimes painstaking process of analysis and elimination to perform a successful diagnosis!
Last week marked British Science Week 2016, an annual campaign that aims to inspire innovation and celebrate science. To mark the occasion, thousands of events took place across the UK. Randox Laboratories got involved, celebrating the innovation of Randox scientists, and the complementary work of our teams, through a series of tweets and articles. Read on to find out more about our teams, and how we contribute to science!
What are the different divisions within Randox?
The Randox team encompasses our clinical chemistry teams Randox Reagents, Randox QC and the RX series of clinical chemistry analysers; our niche divisions including Randox Food Diagnostics, Randox Toxicology and Randox Biosciences; and, our service divisions including Randox Testing Services and Randox Health. The contribution each team has made to science is simply marvellous.
How do we contribute to science?
We contribute to the innovation of diagnostic technologies
At the forefront of the Randox success is our investment in R&D. Beginning our journey in 1982 with a small selection of reagents, our test menu now comprises of over 116 biomarkers. Today our reagents and QC products are used to ensure the accuracy of patient diagnosis across the world; even American astronauts use Randox reagents to test their antioxidant levels before going into space!
On par with this is our RX series range of clinical chemistry analysers. Launched in 2003, the RX daytona was the first in the range of flexible analysers; still in circulation, the RX daytona is currently used by GB athletes to ensure their health and wellbeing in the run up to Olympics 2016.
We are paving the way for personalised, preventative healthcare
From the creation of our revolutionary Biochip Array Technology (BAT) and launch of our first Biochip analyser in 2002, our thirst for innovation and creativity has continued to grow. Dedicated to advancing scientific discovery, drug development and diagnostics; the Randox Biosciences team pave the way to the future of healthcare with tailored solutions for clinical and research use.
From personalised healthcare to preventative healthcare, our succession to improving healthcare continues to expand; with our own Randox Health clinics we utilise our own innovative materials and technologies to provide private health care across the UK, soon to be the world with our acquisition of 10 new international clinics!
We are pioneers in the industry of drug and alcohol testing
As the first company to bring to market synthetic cannabinoids, Kratom and Bath Salts, Randox Toxicologists pioneer to strengthen 21st century drug testing. Sharing in this vision, the Randox Testing Services team recently helped the UK Home Office to shape the drug driving law that was passed in 2015; they created the tests needed to enforce the law. These tests can detect even the smallest amounts of illegal drugs in the body, and since then, drug drive arrests have soared by 800%.
And our innovation does not stop there!
Randox entered the realm of food and wine screening with the Randox Food Diagnostics team, a team of specialists who aim to improve the standards of global food safety with the development of superior screening solutions. Exported all over the world, our products, including dedicated kits for wine analysis, are utilised on such a large scale that our Randox Food Diagnostic scientists analyse enough wine to fill 40 Olympic swimming pools every year!
Maintaining the Randox goal to improve health worldwide is what motivates our R&D scientists, who work hard to help this be achieved!
What do Randox do to inspire others to enter a career in science?
Inspirational in itself is the success of Randox; founded in 1982 in Northern Ireland, it is now a global success with presence in over 145 countries. The company’s success is largely due to the determination of founder Dr Peter Fitzgerald. In fact, in 2010 Dr Peter Fitzgerald was appointed as CBE for services to business in Northern Ireland.
In addition to the company’s awe inspiring success, the Randox Careers team aspire to inspire, and attend careers fairs and presentations, along with Randox scientists and engineers, to share their experiences of working in the industry; most recently our ‘Women in STEM’ initiative has focused on encouraging women to enter careers in the areas of Science, Technology, Engineering and Maths.
To celebrate British Science Week 2016, we shared the story of two Randox scientists; read Michael Mullan’s interview ‘A day in the life of a Molecular Biologist’ or listen to Clinical Analyst Emmet Donnelly in our ‘Interview with a Randox R&D scientist’.
So what does the future hold for Randox?
As the future of science continues to prosper, so does the future of Randox! With the new Randox Science Park in the works, exciting developments in the areas of manufacturing, R&D, and healthcare awaits; accelerated development of products will be facilitated with further investment in R&D, and next generation medical diagnostics manufacturing. In addition a Transformative Healthcare Centre from the Randox Health division will also be included. Randox Science Park will advance our efforts of improving health worldwide!
This British Science Week 2016, the Reagents Team at Randox are celebrating the hard work our Research and Development Team put in every day, to help bring the best quality diagnostic reagents to the market.
We caught up with Emmet Donnelly, Clinical Chemistry R&D Scientist, to explain a bit about what his work involves, and how it’s impacting on global healthcare!
What is your position and what does it involve?
I am a Clinical Analyst on the Clinical Chemistry R&D Team. This role involves the development of new reagents and the improvement of existing reagents. It also involves the transfer and testing of existing chemistries onto new analyser platforms. Troubleshooting and resolving customer queries also forms part of a clinical analyst’s role.
For those of us who aren’t in the industry, can you explain what reagents and assays are?
A reagent is a chemical used to detect the quantity of another component or analyte in a sample (blood or urine), for example a cholesterol reagent contains the necessary chemical make-up to detect the amount of cholesterol in a patient sample.
An assay is the procedure involved in determining the amount of analyte in a sample using a reagent. For example a cholesterol assay involves enzymes within the reagent breaking the cholesterol down into its chemical constituents. These constituents react with other components in the reagent to form a coloured indicator. If this assay is being used on a clinical chemistry analyser, light is passed through the coloured mixture and the amount of light absorbed is proportional to the concentration of analyte in the sample.
How does you work impact on global healthcare?
The diagnostic assays are a vital component in the diagnosis of disease. In order to find out, for example, why a patient is feeling poorly they must first have a blood test to measure all their blood analytes. This will help diagnose the underlying problem and aid in choosing and monitoring the correct treatment for that patient. For example a patient suffering from diabetes must constantly have their glucose levels monitored so that correct doses of insulin can be administered.
What is your favourite Randox product and why?
I like some of the old products like glucose, ALP and cholesterol because they are the tried and tested reagents that are essential for monitoring the health of our vital organs. These always comprise part of the panel of testing to be done when our GP takes a blood sample from us.
I also like the newer reagent products such as the DOA (Drugs of Abuse) reagents. They offer a means of detecting illegal substances in urine samples offering aid to law enforcement.