Lipid Reagents
Randox Lipids Reagents
Lipid tests are used to assess an individual’s risk of heart attack or stroke. Lipid tests are the most important of the cardiac risk tests as they provide a clear indication of whether someone is likely to have a coronary event caused by a blockage of the blood vessels or atherosclerosis (narrowing of the arteries caused by build-up of fatty deposits).
A complete lipid profile involves routine tests such as Total Cholesterol, Triglycerides, HDL Cholesterol and LDL Cholesterol to measure the levels of triglycerides and cholesterol in the blood. An extended lipid profile measures emerging risk factors of cardiovascular disease (CVD).
Key Benefits
Lipid tests are vital for risk assessment
Lipid tests are used to assess an individual’s risk of heart attack or stroke. Lipid tests are the most important of the cardiac risk tests as they provide a clear indication of whether someone is likely to have a coronary event caused by a blockage of the blood vessels or atherosclerosis (narrowing of the arteries caused by build-up of fatty deposits).
Lipid tests aim to assess the risk of cardiovascular disease by screening for abnormalities of triglyceride and cholesterol levels in the blood. Triglycerides and cholesterol contribute to the build-up of fatty deposits, and thus lipid profiling enables preventative measures to be taken to maintain safe levels and reduce the chances of cardiovascular disease.
A complete lipid profile involves routine tests such as Total Cholesterol, Triglycerides, HDL Cholesterol and LDL Cholesterol to measure the levels of triglycerides and cholesterol in the blood. An extended lipid profile measures emerging risk factors of cardiovascular disease (CVD).
Routine Tests
Routine tests include a Total Cholesterol test assessing overall cholesterol levels, a HDL Cholesterol test to measure the level of ‘good cholesterol’ in the blood, an LDL Cholesterol test to measure the level of ‘bad cholesterol’ in the blood, and a Triglycerides test assessing triglyceride levels (of which high levels are associated with increased risk of developing cardiovascular disease).
Extended analysis of blood lipids and emerging risk factors
In addition to the conventional lipid profile Total Cholesterol, HDL Cholesterol, LDL Cholesterol and Triglycerides, we also have extended tests which can provide extra information on a patient’s lipid profile. This includes measurement of lipoproteins and their counterparts, apolipoproteins, which have the role of transferring triglycerides, cholesterol and other fats to appropriate cells for metabolism. Measurement of these allows investigation into why abnormal lipid levels may be occurring.
Apolipoprotein A-I (removes excess cholesterol from extra-hepatic tissues) test is used to find the cause of high lipid levels and discover if a disorder is causing Apo A-I deficiency
Apolipoprotein B (the main protein in LDL cholesterol aka ‘bad cholesterol’) test is used as an extended risk assessment of cardiovascular disease; elevated levels indicate increased risk even when total and LDL cholesterol levels are normal.
Apo A-I and Apo B are useful to assess patients with a personal or family history of high concentrations of lipids and/or heart diseases, for diagnosis of conditions causing elevated lipid levels, for monitoring the effectiveness of lipid lowering treatments, and, when used together they can determine Apo B/Apo A-I ratio as an alternative to total cholesterol/HDL cholesterol ratio when determining CVD risk.
Analysis of emerging risk factors also contributes to risk assessment of cardiovascular disease:
Lipoprotein (a) levels are genetically determined and remain fairly constant as they are not affected by lifestyle factors such as diet. High levels can occur in individuals with an otherwise normal lipid profile and can increase risk of cardiovascular disease. It is recommended that patients who have developed cardiovascular disease at a young age or those with a family history of premature heart disease be tested.
sdLDL Cholesterol, a subtype of LDL Cholesterol aka ‘bad cholesterol’ is a vital marker for heart attack; elevated levels are associated with a three-fold increased risk of heart attack
Apolipoprotein A-II, a major constituent of HDL Cholesterol, plays an important role in reverse cholesterol transport and lipid metabolism; the production of Apo A-II levels determine the distribution of Apo A-I in HDL (Apo A-I removes excess cholesterol), and therefore increased production of Apo A-II promotes atherosclerosis
Apolipoprotein C-II, an aid in the assessment of CVD; Apo C-II deficiency can lead to hypertriglyceridemia (elevated triglyceride levels) in patients
Apolipoprotein C-III, an aid in CVD risk assessment with elevated levels associated with both primary and secondary hypertriglyceridemia, in addition to being reported higher in patients with type 2 diabetes, hyperbilirubinemia, kidney deficiency and decreased thyroid function
Apolipoprotein E, responsible for the transport of triglycerides to the liver and distribution of cholesterol between cells; deficiency can lead to premature atherosclerosis
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Diabetes Reagents
Diabetes Reagents
Diabetes is a life-long condition causing blood sugar levels to become too high and affects millions of people worldwide. Whilst the condition cannot be cured, it can be controlled and monitored. Randox diabetes reagents cover a spectrum of laboratory testing requirements from disease diagnosis to monitoring of associated complications.
Benefits
The 3 Types of Diabetes
Type 1 diabetes manifests in childhood and is caused by deficiency (inherited or acquired) in the production of insulin by the pancreas and so the daily monitoring and administration of insulin is required.
Type 2 diabetes manifests later in life and occurs when the body produces insulin but does not use it effectively (known as insulin resistance). It is more common than type 1 diabetes, and is usually caused as a result of excess body fat and lack of physical activity. Type 2 diabetes can occur in any individual regardless of weight. Excess abdominal visceral fat has also been correlated with increased risk of type 2 diabetes. Visceral fat is the fat that surrounds the vital organs in our bodies. High levels of visceral fat is common on those who have a high BMI, however those with a healthy BMI but do not eat a healthy diet or exercise also can have high levels of visceral fat. Additionally, heart disease, hypertension, stroke and some cancers has also been linked to type 2 diabetes.
Gestational diabetes is the development of diabetes during pregnancy as a result of the body being unable to produce enough insulin to meet the extra needs during pregnancy. Gestational diabetes can cause problems for both the mother and baby during and after birth, including: polyhydramnios, pre-eclampsia, the baby developing jaundice or low blood sugar levels after birth, or stillbirth. However it is possible to reduce the chances of these risks occurring if gestational diabetes is diagnosed and consistently monitored.
Diagnosis and Monitoring
Routine tests are carried out in conjunction with diabetes testing include;
- Microalbumin to ensure normal kidney function and Albumin to ensure normal liver function.
- Glucose is a major source of energy for most cells in the body and obtained through carbohydrate enriched foods. Insulin helps control blood glucose levels to ensure they do not get too high, and as such, high levels of glucose in the blood is an indicator of diabetes.
- HbA1c is used to identify the average amount of glucose in the blood over a 2-3-month period. It is a good indicator of diabetes, as well as enabling diabetic patients to understand how well their diabetes is being controlled.
- Fructosamine is used in the monitoring of diabetes and is particularly useful in reviewing the effectiveness of medication adjustments. This is because it enables average glucose levels to be obtained over a 2-3 week period. In addition, it is used to monitor glucose levels of pregnant woman suffering from gestational diabetes which allows for the monitoring of both, mother and baby glucose levels. This is crucial in decreasing risks associated with gestational diabetes such as premature birth, immediate infant health problems, miscarriage or stillbirth.
Complications Monitoring – Speciality Tests
The Randox specialist tests include;
- Cystatin C is a more sensitive indicator of renal dysfunction than routine creatinine due to the creatinine blind range. Also, the elevated creatinine levels found in stage 2 and halfway through stage 3 renal dysfunction cannot be detected. Therefore, patients can suffer from 50% of kidney dysfunction before elevated levels are detected. Using the Cystatin C test enables more accurate patient results, and allows time for treatment to begin before it is too late.
- Beta-2 Microglobulin is used when kidney damage has occurred to distinguish between the two most commonly affected sites, glomeruli and renal tubules.
- D-3-Hydroxybutyrate is used in the identification of diabetic ketoacidosis, a serious complication of diabetes which occurs when blood sugar levels are consistently high and insulin levels are severely low. Immediate diagnosis is vital as the condition can lead to coma or death if not treated immediately. Symptoms include nausea, vomiting and abdominal pain
- Non-Esterified Fatty Acids (NEFA) is linked to an increased risk of developing diabetes. The measurement of NEFA is important in cases where insulin deficiency results in the metabolism of fat. An increase in NEFA concentration has also been associated with adiposity (high level of body fat), malignant disease (progressive disease) and other metabolic syndromes such as high blood pressure and abdominal obesity. Non-Esterified Fatty Acids (NEFA) to assess diabetic patients risk of developing adiposity (high level of body fat), malignant disease (progressive disease) and other metabolic syndromes such as high blood pressure and abdominal obesity (NEFA test is important in cases where insulin deficiency results in the metabolism of fat).
Related biomarkers include:
Many health complications associated with diabetes include; kidney disease, eye disease, cardiovascular disease and diabetic ketoacidosis (a life-threatening condition that can develop in insulin dependent diabetics). Therefore, it is important to control and monitor the condition.
- Cystatin C is a sensitive marker of kidney function used for the detection of early renal dysfunction in diabetic patients. It is important to note that creatinine is the routine test for renal dysfunction, however it has a blind range which means it is unable to detect elevated creatinine levels found in stage 2 and halfway through stage 3 renal dysfunction. As a result of this, 50% of kidney function can be lost before elevated creatinine levels are detectable. The cystatin C test is a more sensitive marker and can detect early stages of renal dysfunction, allowing treatment to begin before it is too late.
If you would like more information or require informative materials for your laboratory please contact us, or alternatively download our diabetes brochure.
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Potassium
Reagent | Potassium
Key Benefits
Exceptional correlation
The Potassium assay showed a correlation of r=0.99 against another commercially available method
Applications available
For a wide variety of clinical chemistry analysers including the RX series
Excellent precision
The Potassium assay has a precision of less than 4% CV
Randox Potassium (Colorimetric & UV)
- Colorimetric and UV method
- Lyophilised reagents
- Working reagent stable for 7 days when stored at 2-8⁰C
Cat No | Size | ||||
---|---|---|---|---|---|
PT3852 | R1 3 x 20ml R2 3 x 9ml | Enquire | Kit Insert Request | MSDS | Buy Online |
PT8329 | R1 4 x10ml R2 4 x 6ml | Enquire | Kit Insert Request | MSDS | Buy Online |
(S) Indicates standard included in kit |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Potassium assay used for?
Potassium measurements are used to monitor electrolyte balance in the diagnosis and treatment of disease conditions characterised by low or high blood potassium levels or at regular intervals when taking a medication that can affect potassium levels.
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Clinical Chemistry Panel
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Veterinary Panel
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Phosphorus (Inorganic)
Reagent | Phosphorus
Key Benefits
Exceptional correlation
The Phosphorus (Inorganic) assay showed a correlation of r=0.99 against another commercially available method
Applications available
For a wide variety of clinical chemistry analysers including the RX series
Excellent precision
The Phosphorus (Inorganic) assay has a precision of less than 4% CV
Other features
- UV method
- Liquid ready-to-use reagents
- Stable to expiry when stored at +15 to +25⁰C
Cat No | Size | ||||
---|---|---|---|---|---|
PH3872 | R1a 6 x 14ml (L) R1b 6 x 6ml | Enquire | Kit Insert Request | MSDS | Buy Online |
PH8048 | R1 6 x 68ml (L) R2 6 x 40.3ml | Enquire | Kit Insert Request | MSDS | Buy Online |
PH8328 | R1 4 x 12.7ml (L) R2 4 x 7.1ml | Enquire | Kit Insert Request | MSDS | Buy Online |
(L) Indicates liquid option |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Phosphorus (Inorganic) assay used for?
The human body contains approximately one kilogram of phosphorous. The calcium phosphate salts which comprise the inorganic substance of bone account for approximately 80% of the total phosphorous content. The remainder is distributed throughout other cells of the body primarily as organic phosphorous in phospholipids and phosphoproteins. Measurements of phosphorus (inorganic) are used in the diagnosis and treatment of various disorders including parathyroid gland and kidney diseases, and vitamin D imbalance.
Related Products
Standard included in kit PH1016
Clinical Chemistry Panel
For more information or to view more reagents within the clinical chemistry panel, please click here
Clinical Chemistry Reagents
Clinical Chemistry Reagents
The Randox range of clinical chemistry reagents is extensive with a wide range of assays to suit your needs. Investing heavily in research and development, we continuously expand our portfolio to ensure increased choice of high quality reagents.
Randox understand the importance of accurate results, and provide reagents of the highest quality and accuracy to ensure trustworthy results and accurate diagnosis. Rigorously tested, our reagents have strong correlations with standard methods, and ensure uniformity across batches for total confidence in quality across lots.
Benefits
Clinical Chemistry Reagents Panel
Useful Links
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Get in touch with your local sales representative via email at reagents@randox.com
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Pancreatic Amylase
Pancreatic Amylase
Randox Pancreatic Amylase Benefits
Excellent Stability
Stable to expiry when stored at +2 to +8ºC
Excellent correlation to standard methods
A correlation coefficient of 1.00 was obtained with another commercially available method
Liquid ready-to-use reagents
Offers convenience and ease-of-use
Other Features
- EPS
- Liquid ready-to-use reagents
- Stable to expiry when stored at 2-8⁰C
Ordering Information
Cat No | Size | ||||
---|---|---|---|---|---|
AY3855 | R1 4 x 16ml (L) R2 4 x 5ml | Enquire | Kit Insert Request | MSDS | Buy Online |
AY7934 | R1 6 x 20ml (L) R2 3 x 10ml | Enquire | Kit Insert Request | MSDS | Buy Online |
AY8149 | R1 7 x 11ml (L) R2 7 x 4.8ml | Enquire | Kit Insert Request | MSDS | Buy Online |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Pancreatic Amylase assay used for?
Amylase is an enzyme present in pancreatic fluids within the small intestine. It is responsible for digesting many types of sugars, and is released into the blood when the pancreas is inflamed or diseased.
Amylase measurements are used primarily for the diagnosis and treatment of pancreatitis (severe inflammation of the pancreas) as well as pancreatic diseases. Amylase levels rise quickly at the start of a pancreatitis attack and fall after around 2 days. Elevated levels may also be associated with cancer of the pancreas, a perforated ulcer, gallbladder disease, mumps or ectopic pregnancy.
Clinical Chemistry Panel
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Magnesium
Reagent | Magnesium
Key Benefits
Excellent precision
The Magnesium assay showed a precision of less than 3% CV
Exceptional correlation
The Magnesium assay showed a correlation of r=0.99 against another commercially available method
Completely automated protocols
Are available for a wide range of analysers
Randox Magnesium (Xylidyl Blue and Methylthy. Blue)
- Xylidyl Blue and Methylthy. Blue method
- Liquid ready-to-use reagents
- Stable to expiry when stored at +2 to +8⁰C
Ordering information
Cat No | Size | ||||
---|---|---|---|---|---|
MG3880 | 6 x 20ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
MG8137 | 4 x 20ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
MG8326 | 2 x 16.5ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
(L) Indicates liquid option |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Magnesium assay used for?
Magnesium is one of the major intracellular cations in the body. Its action is closely related to that of calcium. Magnesium deficiency, hypomagnesaemia can result in various neuromuscular disorders, weakness, tremors, tetany and convulsions. It is associated with hypocalcaemia, intravenous therapy, diabetes mellitus, alcoholism, dialysis and pregnancy.
Increased serum magnesium levels are associated with dehydration, severe diabetic acidosis and Addison’s Disease. Conditions that interfere with glomerular filtration as in renal failure result in retention of magnesium and hence elevation of serum levels.
Clinical Chemistry Panel
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Veterinary Panel
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Lactate Dehydrogenase
Reagent | Lactate Dehydrogenase
Key Benefits
Excellent precision
The LD assay showed a precision of less than 4% CV
Exceptional correlation
The assay showed a correlation of r=0.98 against another commercially available method
Flexibility
Liquid and lyophilised reagents available, offering greater consumer choice
Randox Lactate Dehydrogenase L-P (LDH) (NAD)
- LDH NAD method
- Liquid ready-to-use reagents
- Stable to expiry at 2-8°C
Cat No | Size | ||||
---|---|---|---|---|---|
LD3842 | R1 6 x 20ml (L) R2 3 x 18ml | Enquire | Kit Insert Request | MSDS | Buy Online |
LD8052 | R1 4 x 68ml (L) R2 4 x 37.2ml | Enquire | Kit Insert Request | MSDS | Buy Online |
(L) Indicates liquid option |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Randox Lactate Dehydrogenase P-L (UV)
- UV method
- Liquid and lyophilised reagents available
- Stable to expiry at 2-8°C
Cat No | Size | ||||
---|---|---|---|---|---|
LD401 | R1a 1 x 70ml R1b 20 x 3ml | Enquire | Kit Insert Request | MSDS | Buy Online |
LD3818 | R1 6 x 20ml (L) R2 3 x 11ml | Enquire | Kit Insert Request | MSDS | Buy Online |
LD8051 | R1 6 x 56ml (L) R2 6 x 20ml | Enquire | Kit Insert Request | MSDS | Buy Online |
LD8322 | R1 4 x 20ml (L) R2 4 x 7ml | Enquire | Kit Insert Request | MSDS | Buy Online |
(L) Indicates liquid option |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Lactate Dehydrogenase assay used for?
Lactate dehydrogenase (LD) catalyses the interconversion of lactic acid and pyruvic acid. The enzyme is composed of 4 peptide chains and exists in 5 isomeric forms. LD is widely distributed throughout the body, and the highest concentrations are found in the liver, heart and skeletal muscle. LD activity is significantly elevated during myocardial infarction. Maximum levels are reached 24 to 48 hours after the onset of chest pain and may remain elevated for 7 to 12 days post infarction. Increases in LD activity are also associated with other pathological conditions including liver disease, progressive muscular dystrophy, megaloblastic and pernicious anaemia.
Clinical Chemistry Panel
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Veterinary Panel
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Lactate
Reagent | Lactate
Key Benefits
Excellent stability
Stable to expiry date when stored at +2 to +8°C
Exceptional correlation
The assay showed a correlation of r=0.99 against another commercially available method
Lyophilised reagents
The Randox L-Lactate assay is supplied in a lyophilised format, enhancing stability and reducing wastage
Other features
- Colorimetric method
- Lyophilised reagents
- Working reagent stable for 2 weeks at 15-25°C
Ordering information
Cat No | Size | ||||
---|---|---|---|---|---|
LC2389 | R1a 1 x 100ml (S) R1b 16 x 6ml | Enquire | Kit Insert Request | MSDS | Buy Online |
LC3980 | R1a 4 x 20.5ml R1b 4 x 20.5ml | Enquire | Kit Insert Request | MSDS | Buy Online |
(S) Indicates standard included in kit |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Lactate assay used for?
Increased concentration of lactate in the blood is an indicator of anaerobic metabolism i.e. blood flow to the tissues decrease and oxygen delivery is insufficient. In cases of severe oxygen deprivation “Lactic Acidosis” may occur. L-Lactate may therefore be used as an indicator of severity of circulatory failure.
Clinical Chemistry Panel
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Veterinary Panel
For more information or to view more reagents within the veterinary panel, please click here
Iron
Reagent | Iron
Key Benefits
Excellent precision
The Iron (ferene) assay showed a precision of less than 3.5% CV
Exceptional correlation
The assay showed a correlation of r=0.99 against another commercially available method
Liquid and lyophilised reagents available
Offering convenience and choice
Randox Iron- Ferrozine
- Ferrozine method
- Liquid ready-to-use reagents
- Stable to expiry when stored at 15-25⁰C
Cat No | Size | ||||
---|---|---|---|---|---|
SI3821 | R1 6 x 20ml (L) R2 3 x 11ml | Enquire | Kit Insert Request | MSDS | Buy Online |
SI8049 | R1 7 x 15.5ml (L) R2 7 x 6.7ml | Enquire | Kit Insert Request | MSDS | Buy Online |
SI8330 | R1 4 x 20ml (L) R2 4 x 7ml | Enquire | Kit Insert Request | MSDS | Buy Online |
(L) Indicates liquid option |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Iron assay used for?
Iron deficiency is one of the most prevalent human disorders. In adults iron deficiency is often symptomatic of chronic blood loss. Iron deficiency results in deficient haem synthesis with the subsequent symptoms of anaemia due to tissue hypoxia. Iron (non-heme) measurements are used in the diagnosis and treatment of diseases such as iron deficiency anaemia, hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin), and chronic renal disease.
Clinical Chemistry Panel
For more information or to view more reagents within the clinical chemistry panel, please click here