Copper Assay

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Copper Assay

Reagent | Copper

A Unique Test for the Determination of Copper

Benefits of the Randox Copper Assay

Exceptional correlation

A correlation coefficient of r=0.97 was displayed when the Randox copper assay was compared to commercially available methods.

Excellent precision

The Randox copper assay displayed a precision of <2.15% CV.

Wide measuring range

The Randox copper assay has a measuring range of 6.6 – 86µmol/l for the comfortable detection of clinically important results.

Standard supplied with the kit

The Randox copper kit includes the standard simplifying the ordering process. Calibrator is available for automated use.

Controls available

Controls available offering a complete testing package.

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox copper assay on a variety of clinical chemistry analysers.

Ordering information

Cat NoSize
CU2340R1a 1 x 105ml
R1b 5 x 20ml
R2 1 x 30ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

  • PHYSIOLOGICAL SIGNIFICANCE
  • ANTIOXIDANT / PRO-OXIDANT
  • DEFICIENCY
  • TOXICITY

Copper (CU) is an essential trace mineral, naturally available in some foods and as dietary supplements. CU is a cofactor for several enzymes, known as cuproenzymes, which are involved in connective tissue synthesis, energy production, iron metabolism, neuropeptide activation and neurotransmitter synthesis. CU is also involved in brain development, immune system functioning, neurohormone homeostasis, pigmentation, regulation of gene expression, and several physiological processes, such as angiogenesis 1.

CU has been recognised as both an antioxidant and pro-oxidant. Naturally occurring within the body, free radicals interact with genetic material, damage cell walls and contribute to the development of several health problems. As an antioxidant, CU scavenges to neutralise the free radicals, aiding in the prevention of oxidative damage. Conversely, as a pro-oxidant, CU can promote free radical damage, inducing the development of health problems such as Alzheimer’s disease. Consequently, CU is vital as part of a balanced diet 2.

CU deficiency in Western countries is rare, however, altered CU metabolism may influence CU deficiency which negatively impacts the connective tissue, nervous, immune and cardiovascular systems. Such conditions that can predispose CU deficiency include: prematurity, gastric bypass, burns, over-the-counter vitamins containing zinc and iron and infants fed with unmodified cow milk 3.

Menkes disease is a rare x-linked recessive disorder of CU metabolism caused by mutations to the ATP7A gene. Menkes disease affects an estimated 1 in every 100,000 – 250,000 births and is characterised by sparse, kinky hair and failure to thrive and progressive deterioration of the nervous system. Symptoms commonly present during infancy, but, in some cases, the symptoms may present in early to middle childhood. If treatment is started early, the prognosis may improve 4.

Copper toxicity is also rare but can be caused by consuming too many dietary supplements high in copper, drinking contaminated water and from fungicides containing CU sulphates 3.

Wilson’s disease is an autosomal recessive disorder caused by mutations to the ATP7B gene, which is highly expressed in the liver, kidneys and placenta. Wilson’s disease affects approximately 1 in every 40,000 and is characterised by hepatic, neuropsychiatric and ophthalmic symptoms as a result of excess copper accumulation. Unlike most genetic diseases, early detection and implementation of a treatment plan for those with Wilson’s disease can prevent longer term morbidity due to copper induced end organ dysfunction 3.

Related products

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Clinical Chemistry EQA


Triglycerides

Reagent | Triglycerides

Key Benefits

Excellent stability

Working reagents stable for 21 days at 2-8⁰C or 3 days at 15-25 °C

Applications available

For a wide variety of clinical chemistry analysers including the RX series

Strong correlation

The Triglycerides assay showed a correlation coefficient of 0.9965 against another commercially available method

Randox Triglycerides (GPO-PAP)

  • GPO-PAP method
  • Liquid and lyophilised reagents available
  • Working reagents stable for 21 days at +2 to +8⁰C or 3 days at +15 to +25 ⁰C
  • Applications available
Cat NoSize
TR2106 x 15ml (S)EnquireKit Insert RequestMSDSBuy Online
TR16974 x 100ml (S)EnquireKit Insert RequestMSDSBuy Online
TR38236 x 51mlEnquireKit Insert RequestMSDSBuy Online
TR80674 x 58mlEnquireKit Insert RequestMSDSBuy Online
TR97804 x 58mlEnquireKit Insert RequestMSDSBuy Online
TR83324 x 20ml (L)EnquireKit Insert RequestMSDSBuy Online
TR81478 x 20ml (L)EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option
(S) Indicates standard included in kit

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Triglycerides assay used for?

Triglyceride measurements are used in the diagnosis and treatment of diseases involving lipid metabolism and various endocrine disorders e.g. diabetes mellitus, nephrosis and liver obstruction.

High levels of triglycerides in the blood are associated with an increased risk of developing cardiovascular disease (CVD). Certain factors can contribute to high triglyceride levels, including lack of exercise, being overweight, smoking cigarettes, consuming excess alcohol, and medical conditions such as diabetes and kidney disease.


Total Cholesterol

Reagent | Total Cholesterol

Key Benefits

Exceptional correlation with standard methods

A correlation coefficient of r=0.99 was obtained with a competitor method

Excellent stability

Stable to expiry when stored at 2-8°C

Liquid ready-to-use

The Randox Cholesterol Total reagent is available in a liquid ready to use format for convenience and ease of use.

Other Features

  • Liquid ready-to-use reagents
  • Correlation coefficient of r=0.99 with competitor method
  • Stable to expiry when stored at 2-8°C
Cat NoSize
CH2006 x 30ml (S)EnquireKit Insert RequestMSDSBuy Online
CH38109 x 51mlEnquireKit Insert RequestMSDSBuy Online
CH80194 x 68mlEnquireKit Insert RequestMSDSBuy Online
CH83104 x 20mlEnquireKit Insert RequestMSDSBuy Online
(S) Indicates standard included in kit

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Total Cholesterol assay used for?

Cholesterol measurements are used in the diagnosis and treatments of lipid lipoprotein metabolism disorders. Lipids play an important role in the body; they serve as hormones or hormone precursors, aid in digestion, provide energy, storage and metabolic fuels, act as functional and structural components in biomembranes and form insulation to allow nerve conduction and prevent heat loss.

In clinical chemistry, over the last decade however, lipids have become associated with lipoprotein metabolism and atherosclerosis.

A patient will be offered a blood cholesterol level test if they:

    • have been diagnosed with coronary heart disease, stroke or mini-stroke
    • are over 40
    • have a family history of early cardiovascular disease
    • have a close family member who has an inherited cholesterol-related condition
    • are overweight or obese
    • have high blood pressure or diabetes
    • Have another medical condition such as a kidney condition, an underactive thyroid gland or pancreatitis

Publications

    • Sajjadi, S.E., et al. Antihyper lipidemic effect of hydroalcoholic extract, and phenolic fraction from Dracocephalum kotschyi Boiss. Pharmaceutica Acta Helvetiae 1998, 73(3): 167-170
    • Wallace, J.M.W., et al. Boron supplementation and activated factor VII in healthy men. EJCN 2002, 56(11): 1102-1107
    • Joshi, S., et al. Fish oil supplementation of rats during pregnancy reduces adult disease in their offspring. J. Nutr., 2003, 133: 3170-3174
    • Ahmed, H.H. and Manna, F. Curcumin as an effective protective agent against ethinylestradiol-induced hepatocellular cholestasis. EGYPT. J. Med. Lab. Sci. 2004, 13(2)
    • Ghorbanihaghjo, A., et al. Effect of nandrolone decanoate on serum lipoprotein (a) and its isoforms in hemodialysis patients. Lipids Health Dis. 2004, 3: 16
    • Panagia, M., et al. PPAR-α activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. Am. J. Physiol. Heart Circ. Physiol. 2005, 288: H2677-H2683
    • Chen, C-W and Cheng, H-H. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J. Nutr. 2006, 136: 1472-1476
    • Macut, G., et al. Oxidised low-density lipoprotein concentration-early marker of an altered lipid metabolism in young women with PCOS. Eur. J. Endocrinol. 2006, 155: 131-136
    • Moreira Lima, L., et al. Níveis Plasmàticos Elevados de Lipoproteína(a) Correlacionados com a Gravidade da Doenca Arterial Coronariana em Pacientes Submetidos à Angiografia (Increased Serum Levels of Lipoprotein(a) Correlated with the Severity of Coronary Artery Disease in Patients Submitted to Angiography. Arquivos Brasileiros de Cardiologia. 2006, 87(3): 260-266
    • Oyetayo, F.L. Responses of plasma lipids to edible mushroom diets in albino rats. Afr. J. Biotechnol. 2006, 5(13): 1263-1266
    • James, A.P., et al. Prior exercise does not affect chylomicron particle number following a mixed meal of moderate fat content. Lipids Health Dis. 2007, 6: 8
    • Shen, L., et al. Hypothalamic apolipoprotein A-IV is regulated by leptin. Endocrinology. 2007, 148(6): 2681-2689
    • Lawal, H.A., et al. Hypoglycaemic and hypolipidaemic effects of aqueous leaf extract of Murraya koenigii in normal and alloxan-diabetic rats. Nigerian Journal of Physiological Sciences. 2008, 23(1-2): 37-40
    • Mineo, D., et al. Effects of lung volume reduction surgery for emphysema on glycolipidic hormones. Chest. 2008, 134(1): 30-37
    • Zaragozá, M.C., et al. Toxicity and antioxidant activity in vitro and in vivo of two Fecus vesiculosus extracts. J. Agric. Food. Chem. 2008, 56: 7773-7780
    • Bajaj, S., et al. A case-control study on insulin resistance, metabolic co-variates and prediction score in non-alcoholic fatty liver disease. Indian J. Med. Res. 2009, 129: 285-292
    • Chou T-W., et al. A Rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced Type 2 diabetes. J.Clin. Biochem.Nutr. 2009, 45(1): 29-36
    • Hossein-nezhad, A., et al. Association of VDR gene polymorphism with insulin resistance in diabetic patients. Iranian Journal of Diabetes and Lipid Disorders. 2009, 143-150
    • Komolafe, O.A., et al. Streptozotocin-induced diabetes alters the serum lipid profiles of adult Wistar rats. The internet Journal of Cardiovascular Research 2009, 7(1) doi: 10.5580/2251
    • Lim, W,Y.A., et al. Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally administered glycyrrhizic acid-treated rats. Lipids in Health and Disease, 2009, 8: 31
    • Perše, M., et al. Effect of high-fat mixed-lipid diet and exercise on the antioxidant system in skeletal and cardiac muscles of rats with colon carcinoma. Pharmacol. Rep. 2009, 61(5): 909-916
    • Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393
    • Velasco-Martínez, R.M., et al. Obesity and insulin resistance among adolescents from Chiapas. Nutr. Hosp. 2009, 24(2)
    • Eu, C.H.A., et al. Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Lipids and Health Disease. 2010, 9: 81
    • Mahadik, S.R. et al. Role of adipocytokines in insulin resistance: Studies from Urban Western Indian Population. Int. J. Diabetes & Metab. 2010, 18(9): 35-42
    • Wonnacott, K.E. et al. Dietary omega-3 and-6 polyunsaturated fatty acids affect the composition and development of sheep granulose cells, oocytes and embryos. Reproduction. 2010, 139(1): 57-69
    • Kojic, Z., et al. Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits. Physiol. Res. 2011, 60(1): S177-S184
    • Srinivasa, G., et al. Comparison between serum insulin levels and its resistance with biochemical, clinical and anthropometric parameters in South Indian children and adolescents. Ind. J. Biochem. 2011, 26(1): 22-27
    • Yahaya, N. et al. Type 2 diabetes with good glycemic control have improved insulin response and lower non-esterified fatty acid level after a meal challenge. Journal of Diabetes Mellitus 2012, 2(1): 1-7

    LDL Cholesterol

    Reagent | LDL Cholesterol

    Key Benefits

    Exceptional correlation with standard methods

    A correlation coefficient of r=0.99 was found when measured against the Ultracentrifugation method

    Excellent stability

    Stable to expiry when stored at +2 to +8°C

    Other Features

    • Direct Clearance Method
    • Liquid ready-to-use reagents
    • Correlation coefficient of r=0.99 with Ultracentrifugation method
    • Stable to expiry when stored at +2 to +8°C
    Cat NoSize
    CH2656R1 6 x 78ml (L)
    R2 3 x 52ml
    EnquireKit Insert RequestMSDSBuy Online
    CH3841R1 3 x 51ml (L)
    R2 3 x 20ml
    EnquireKit Insert RequestMSDSBuy Online
    CH8032R1 4 x 19.2ml (L)
    R2 4 x 10.1ml
    EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid option

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is LDL Cholesterol assay used for?

    Low Density Lipoproteins (LDL) are synthesised in the liver by the action of various Lipolytic enzymes on triglyceride rich Very Low Density Lipoproteins (VLDLs). Specific LDL receptors exist to facilitate the elimination of LDL from plasma by liver parenchymal cells. It has been shown that most of the cholesterol stored in atherosclerotic plaques originates from LDL. For this reason the LDL-Cholesterol concentration is considered to be the most important clinical predictor, of all single parameters, with respect to coronary atherosclerosis.

    Accurate measurement of LDL-Cholesterol is of vital importance in therapies which focus on lipid reduction to prevent atherosclerosis or reduce its progress and to avoid plaque rupture.

    It is recommended a patient get tested when aged 40; as part of a routine CV health check; if they are already thought to be at risk of CVD for another reason; or to monitor their response to treatments which lower LDL Cholesterol.

    • Moloney, F., et al. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus 1,2,3. Am. J. Clin. Nutr. 2004, 80(4): 887-895
    • Nowak, M., et al. Changes in lipid metabolism in women with age-related macular degeneration. Clin. Exp. Med., 2005, 4(4): 183-187
    • Chen, C-W and Cheng, H-H. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J. Nutr. 2006, 136: 1472-1476
    • Moreira Lima, L., et al. Níveis Plasmàticos Elevados de Lipoproteína(a) Correlacionados com a Gravidade da Doenca Arterial Coronariana em Pacientes Submetidos à Angiografia (Increased Serum Levels of Lipoprotein(a) Correlated with the Severity of Coronary Artery Disease in Patients Submitted to Angiography. Arquivos Brasileiros de Cardiologia. 2006, 87(3): 260-266
    • Chou T-W., et al. A Rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced Type 2 diabetes. J.Clin. Biochem.Nutr. 2009, 45(1): 29-36
    • Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393
    • Wonnacott, K.E. et al. Dietary omega-3 and-6 polyunsaturated fatty acids affect the composition and development of sheep granulose cells, oocytes and embryos. Reproduction. 2010, 139(1): 57-69
    • Ganguli, D., et al. Association between inflammatory markers and cardiovascular risk factors in women from Kolkata, W.B, India. Arq. Bras. Cardiol. 2011, 96(1): Epub
    • Srinivasa, G., et al. Comparison between serum insulin levels and its resistance with biochemical, clinical and anthropometric parameters in South Indian children and adolescents. Ind. J. Biochem. 2011, 26(1): 22-27
    • Yahaya, N. et al. Type 2 diabetes with good glycemic control have improved insulin response and lower non-esterified fatty acid level after a meal challenge. Journal of Diabetes Mellitus 2012, 2(1): 1-7

    High Sensitivity CRP

    Reagent | High Sensitivity CRP

    Key Benefits of the Randox High Sensitivity CRP

    Limited Interference

    From Conjugate and Free Bilirubin, Haemoglobin, Intralipid and Triglycerides

    Wide measuring range

    High Sensitivity CRP assay has a wide measuring range of 0.270 – 10 mg/l which will comfortably detect levels outside of the healthy range

    Excellent stability

    Stable to expiry when stored at 2-8⁰C

    Randox High Sensitivity CRP (Latex Enhanced Immunoturbidimetric)

    • Latex Enhanced Immunoturbidimetric method
    • Liquid ready-to-use reagents
    • Stable to expiry when stored at 2-8⁰C
    • Measuring range 0.270-10 mg/l

    Ordering information

    Cat NoSize
    CP3885R1 2 x 11ml(L)
    R2 2 x 11ml
    EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid option

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is High Sensitivity CRP assay used for?

    C-reactive protein is present in serum of normal individuals at levels between 0-5mg/l. Research has indicated that CRP levels, which are within the normal range, can be used in a variety of different population subgroups for the assessment of cardiovascular risk for developing a fatal myocardial infarction. CRP levels within the normal range have been associated with coronary heart disease mortality in high-risk individuals. Elevated serum cholesterol levels, elevated diastolic blood pressure and cigarette smoking indicate high-risk.

    A complete clinical history is required for accurate interpretation of CRP levels. CRP levels within the normal range may be affected by a number of different factors and should always be compared to previous values.

    Publications

      Cardiology Panel

      For more information or to view more reagents within the cardiology panel, please click here


      HDL Cholesterol

      Reagent | HDL Cholesterol

      Key Benefits

      There are several methods available for measurement of HDL Cholesterol

      Including Direct Clearance and Phosphotungstic Acid

      Exceptional correlation with standard methods

      A correlation coefficient of r=0.99 for the Precipitation and Ultracentrifugation methods, was verified against the CDC reference method

      Excellent stability

      Stable to expiry date when stored at +2 to +8ºC

      HDL Cholesterol-Direct Clearance Method

      • Direct Clearance Method
      • Liquid ready-to-use reagents
      • Stable to expiry when stored at 2-8°C
      Cat NoSize
      CH1383R1 3 x 2.5L (L)
      R2 1 x 2.5L
      EnquireKit Insert RequestMSDSBuy Online
      CH2655R1 6 x 78ml (L)
      R2 3 x 52ml
      EnquireKit Insert RequestMSDSBuy Online
      CH3811R1 3 x 51ml (L)
      R2 3 x 20ml
      EnquireKit Insert RequestMSDSBuy Online
      CH8033R1 4 x 38.2ml (L)
      R2 4 x 18.2ml
      EnquireKit Insert RequestMSDSBuy Online
      CH8311R1 4 x 20ml (L)
      R2 4 x 9ml
      EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      Randox HDL Cholesterol Precipitant-Phosphotungstic Acid

      • AMP method
      • Liquid and lyophilised reagents available
      • Stable to expiry when stored at +15 to +25°C
      • Wide measuring range of 0.071-23.7 mmol/l
      Cat NoSize
      CH203 *4 x 80ml (L)EnquireKit Insert RequestMSDSBuy Online
      * CH203 is a precipitant product which can be used alongside the CHOD PAP assays
      (L) Indicates liquid option

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      What is the HDL Cholesterol assay used for?

      High-density lipoproteins (HDL) are one of the major classes of plasma lipoproteins. They are composed of a number of heterogeneous particles, including cholesterol and vary with respect to size and content of lipid and Apolipoprotein. HDL serves to remove cholesterol from the peripheral cells to the liver, where the cholesterol is converted to bile acids and excreted into the intestine.

      Accurate measurement of HDL-C is of vital importance when assessing patient risk from CHD. Direct measurement gives improved accuracy and reproducibility when compared to precipitation methods.

      HDL is usually requested with other tests, either with cholesterol or as part of a lipid profile, including LDL and triglycerides. The combination of total cholesterol and HDL is very useful for screening for the risk of heart disease.

      Patients at risk include:

        • Smokers
        • Men over 45 years and women over 55 years
        • Those with Hypertension (blood pressure 140/90 or higher or if taking medications for high blood pressure)

      Publications

        • Wallace, J.M.W., et al. Boron supplementation and activated factor VII in healthy men. EJCN 2002, 56(11): 1102-1107
        • Joshi, S., et al. Fish oil supplementation of rats during pregnancy reduces adult disease in their offspring. J. Nutr., 2003, 133: 3170-3174
        • Ghorbanihaghjo, A., et al. Effect of nandrolone decanoate on serum lipoprotein (a) and its isoforms in hemodialysis patients. Lipids Health Dis. 2004, 3: 16
        • Saeed, B.O., et al. Comparison of three homogeneous methods for measuring high-density lipoprotein cholesterol with a precipitation method in diabetic and non-diabetic subjects. Br. J. Biomed. Sci., 2004, 61(4): 194-199
        • Nowak, M., et al. Changes in lipid metabolism in women with age-related macular degeneration. Clin. Exp. Med., 2005, 4(4): 183-187
        • Moreira Lima, L., et al. Níveis Plasmàticos Elevados de Lipoproteína(a) Correlacionados com a Gravidade da Doenca Arterial Coronariana em Pacientes Submetidos à Angiografia (Increased Serum Levels of Lipoprotein(a) Correlated with the Severity of Coronary Artery Disease in Patients Submitted to Angiography. Arquivos Brasileiros de Cardiologia. 2006, 87(3): 260-266
        • Mineo, D., et al. Effects of lung volume reduction surgery for emphysema on glycolipidic hormones. Chest. 2008, 134(1): 30-37
        • Bajaj, S., et al. A case-control study on insulin resistance, metabolic co-variates and prediction score in non-alcoholic fatty liver disease. Indian J. Med. Res. 2009, 129: 285-292
        • Hossein-nezhad, A., et al. Association of VDR gene polymorphism with insulin resistance in diabetic patients. Iranian Journal of Diabetes and Lipid Disorders. 2009, 143-150
        • Komolafe, O.A., et al. Streptozotocin-induced diabetes alters the serum lipid profiles of adult Wistar rats. The internet Journal of Cardiovascular Research 2009, 7(1) doi: 10.5580/2251
        • Lim, W,Y.A., et al. Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally administered glycyrrhizic acid-treated rats. Lipids in Health and Disease, 2009, 8: 31
        • Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393
        • Velasco-Martínez, R.M., et al. Obesity and insulin resistance among adolescents from Chiapas. Nutr. Hosp. 2009, 24(2)
        • Eu, C.H.A., et al. Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Lipids and Health Disease. 2010, 9: 81
        • Mahadik, S.R. et al. Role of adipocytokines in insulin resistance: Studies from Urban Western Indian Population. Int. J. Diabetes & Metab. 2010, 18(9): 35-42
        • Wonnacott, K.E. et al. Dietary omega-3 and-6 polyunsaturated fatty acids affect the composition and development of sheep granulose cells, oocytes and embryos. Reproduction. 2010, 139(1): 57-69
        • Ganguli, D., et al. Association between inflammatory markers and cardiovascular risk factors in women from Kolkata, W.B, India. Arq. Bras. Cardiol. 2011, 96(1): Epub
        • Kojic, Z., et al. Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits. Physiol. Res. 2011, 60(1): S177-S184
        • Srinivasa, G., et al. Comparison between serum insulin levels and its resistance with biochemical, clinical and anthropometric parameters in South Indian children and adolescents. Ind. J. Biochem. 2011, 26(1): 22-27
        • Hossein-nezhad, A. et al. Circulating omentin-1 in obesity and metabolic syndrome status compared to control subjects. Endocrinol. Metabol. Syndrome 2012: S1:008 doi:10.4172/2161-1017.S1-008
        • Yahaya, N. et al. Type 2 diabetes with good glycemic control have improved insulin response and lower non-esterified fatty acid level after a meal challenge. Journal of Diabetes Mellitus 2012, 2(1): 1-7

        Apolipoprotein B

        Reagent | Apolipoprotein B (Immunoturbidimetric)

        Key Benefits

        Excellent stability

        The Randox Apolipoprotein B (Immunoturbidimetric) is stable to expiry when stored at 2-8°C

        Liquid ready-to-use reagents

        Apolipoprotein B reagent comes in a liquid format which is more convenient, and can also help reduce the risk of errors occurring

        Applications available

        Applications available detailing instrument-specific settings for a variety of clinical chemistry analysers.

        Ordering information

        Cat NoSize
        LP2117R1 4 x 50ml (L) (C)
        R2 4 x 9ml
        EnquireKit Insert RequestMSDSBuy Online
        LP3839R1 4 x 20ml (L)
        R2 4 x 6ml
        EnquireKit Insert RequestMSDSBuy Online
        LP8008R1 2 x 10ml (L)
        R2 2 x 4ml
        EnquireKit Insert RequestMSDSBuy Online
        (C) Indicates calibrator included in kit
        (L) Indicates liquid reagent

        Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

        What is Apolipoprotein B assay used for?

        The B Apolipoproteins are the main form of protein found in Low Density Lipoproteins (LDL). Two forms of APO B are found in humans. APO B is the main cholesterol carrying protein in the blood and is the ligand concerned with the uptake of cholesterol into cells by the LDL-receptor pathway. APO B shows atherogenic signs and is thus useful for the evaluation of coronary risk.

        The test is undertaken:

        • When the patient has a personal or family history of heart disease and/or high concentrations of lipids in the blood
        • To determine the patient’s risk of developing CVD
        • To help monitor treatment for hyperlipidaemia
        • To help diagnose APO B deficiency

        Apolipoprotein B Related Products

        RIQAS EQA Scheme

        Lipid programme

        .

        Calibrators

        Lipid Calibrators

        Standard included in LP2117


        Apolipoprotein C-III (Apo C-III) Assay

        Reagent | Apolipoprotein C-III (Apo C-III)

        An Independent Risk Factor for CVD

        Benefits of the Randox Apo C-lll Assay

        Limited Interference

        Immunoturbidimetric method

        The immunoturbidimetric method limits interference from Bilirubin, Haemoglobin, Intralipid® and Triglycerides, producing more accurate results.

        Logos-09

        Exceptional correlation

        A correlation coefficient of r=1.00 was displayed when the Randox apo C-III assay was compared to commercially available methods.

        Wide Measuring Range

        Excellent measuring range

        The Randox apo C-III assay has a measuring range of 2.06 – 21.7mg/dl for the comfortable detection of clinically important results.

        Logos-06

        Liquid ready-to-use

        The Randox apo C-III assay is available in a liquid ready-to-use format for convenience and ease-of-use.

        Calibrator & Controls

        Dedicated calibrator and controls available

        Randox offer dedicated apolipoprotein calibrator and controls for a complete testing package.

        Logos-07

        Applications available

        Applications available detailing instrument-specific settings for the convenient use of the Randox apo C-III assay on a variety of clinical chemistry analysers.

        Ordering Information

        Cat NoSize
        LP3865R1 2 x 11ml (L)
        R2 2 x 5ml
        EnquireKit Insert RequestMSDSBuy Online
        (L) Indicates liquid reagent

        Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

        Clinical Significance

        Not only is apo C-III a key regulator in the metabolism of triglycerides, but it is also an independent risk factor for CVD. Not only does apo C-III contribute to CVD through the regulation of triglycerides but also through its direct atherogenic effects, promoting atherosclerosis (fig 1) 1.

        Fig. 1. Pleiotropic effects of apo C-III 1
        Fig. 1. Pleiotropic effects of apo C-III

        Physiological Significance

        Apo C-III is composed of 79 amino acids and has a molecular weight of 8.8kDa. Apo C-III promotes hypertriglyceridemia via several mechanisms. Firstly, like apo C-II, apo C-III also inhibits the activity of LPL, distributing lipid lipolysis. Apo C-III hinders the binding of apolipoprotein B and apolipoprotein E to the hepatic receptors resulting in the delayed catabolism of triglyceride – rich lipoproteins (TRLs). Finally, apo C-III prefers the production and secretion of very low-density lipoproteins (VLDL) in the liver 1.

        Useful links

        Reagents Home

        Apolipoprotein Control

        Apolipoprotein Calibrator


        Extraction | Viral RNA Extraction Kit

        Extraction | Reagent Kit

        Viral RNA Extraction Kit

        Designed to enable Automated Purification

        • null
          Extracts viral total nucleic acid (RNA) from nasal/throat swabs following brief lysis steps
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          200µl of sample from the nasal/throat swab required for analysis
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          Universal kit which can be used for the efficient and automated purification of nucleic acid material
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          Kit includes Lysis buffer, Proteinase K and Elution buffer material suitable for the extraction
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          Yields highly concentrated nucleic acids that are ready to use in downstream applications such as qualitative or quantitative PCR
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          Automated nucleic acid extraction platform available from Randox

        The Randox Viral RNA Purification kit is designed for the optimal automated extraction of total nucleic acid (RNA) from nasal/throat samples.

        Viral nucleic acid extraction is a critical step in infectious disease testing. Nucleic acid-based detection of viral pathogens requires the extraction of RNA allowing simultaneous detection of any viral infection.

        Randox also offer a range of COVID-19 testing solutions including Molecular and Point of Care platforms along with RT-qPCR assays, Quality Controls and EQA schemes.

        Want to know more?

        Contact us or visit our COVID-19 Monitoring & Management page

        Related Products

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        Superoxide Dismutase (Ransod)

        Superoxide Dismutase (Ransod)

        Benefits of the Randox Ransod Assay

        Excellent correlation

        A correlation coefficient of r=0.965 was displayed when the Randox Ransod assay was compared against commercially available methods.

        Excellent precision

        The Randox Ransod assay displayed a within run precision of <4.65% CV.

        Excellent measuring range

        The Randox Ransod assay has a measuring range of 0.00 – 5.50 U/ml for the comfortable detection of clinically important results.

        Standard included in kit

        The standard is supplied with the Ransod kit, simplifying the ordering process.

        Dedicated Ransod control available

        A dedicated Ransod control is available offering a complete testing package.

        Applications available

        Applications available detailing instrument-specific settings for the convenient use of the Randox Ransod assay on a variety of clinical chemistry analysers.

        Ordering information

        • Ordering Information

        Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

        Cat NoSize
        SD1255 x 20ml (S)EnquireKit Insert RequestMSDSBuy Online
        (S) Indicates standard included in kit
        • PHYSIOLOGICAL SIGNIFICANCE
        • Clinical Significance

        Superoxide dismutase (SOD) are a group of metalloenzymes, the first line of defence against reactive oxygen species (ROS)-medicated injury. SOD is responsible for catalysing the dismutation of the superoxide anion free radical (O2) into molecular oxygen and hydrogen peroxide (H2O2). The aim of this process is to reduce the levels of O2 as it damages cells at excessive concentrations 1.

        SOD is the most important antioxidant defence against oxidative stress. SOD is a severe anti-inflammatory agent and can prevent precancerous cell changes. Reduced SOD levels have been observed in older generations as SOD levels drop as the body ages and so are more prone to oxidative related diseases. Reduced SOD activity has been identified as having a strong correlation with Alzheimer’s Disease. The overexpression of SOD-2 reduces hippocampal superoxide, preventing memory defects 1. Moreover, SOD has been identified as a potential diagnostic and prognostic marker in patients with gastric cancer 2. SOD has also been linked to other health conditions, including: rheumatoid arthritis, RBC-related disorders, Crohn’s Disease, cystic fibrosis, malignant breast cancer and neuronal apoptosis 1, 3.

        Fig. 1. Pathological effects associated with SOD gene mutation or SOD deficiency 4
        Pathological effects associated with SOD gene mutation or SOD deficiency - Ransod
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        Publications

          Related Products

          Ransod Control

          Antioxidants Panel

          Reagents Home

          Reagents Resource Hub


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