Apolipoprotein C-III (Apo C-III) Assay

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Apolipoprotein C-III (Apo C-III) Assay

Reagent | Apolipoprotein C-III (Apo C-III)

An Independent Risk Factor for CVD

Benefits of the Randox Apo C-lll Assay

Limited Interference

Immunoturbidimetric method

The immunoturbidimetric method limits interference from Bilirubin, Haemoglobin, Intralipid® and Triglycerides, producing more accurate results.

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Exceptional correlation

A correlation coefficient of r=1.00 was displayed when the Randox apo C-III assay was compared to commercially available methods.

Wide Measuring Range

Excellent measuring range

The Randox apo C-III assay has a measuring range of 2.06 – 21.7mg/dl for the comfortable detection of clinically important results.

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Liquid ready-to-use

The Randox apo C-III assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Calibrator & Controls

Dedicated calibrator and controls available

Randox offer dedicated apolipoprotein calibrator and controls for a complete testing package.

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Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox apo C-III assay on a variety of clinical chemistry analysers.

Ordering Information

Cat NoSize
LP3865R1 2 x 11ml (L)
R2 2 x 5ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid reagent

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Clinical Significance

Not only is apo C-III a key regulator in the metabolism of triglycerides, but it is also an independent risk factor for CVD. Not only does apo C-III contribute to CVD through the regulation of triglycerides but also through its direct atherogenic effects, promoting atherosclerosis (fig 1) 1.

Fig. 1. Pleiotropic effects of apo C-III 1
Fig. 1. Pleiotropic effects of apo C-III

Physiological Significance

Apo C-III is composed of 79 amino acids and has a molecular weight of 8.8kDa. Apo C-III promotes hypertriglyceridemia via several mechanisms. Firstly, like apo C-II, apo C-III also inhibits the activity of LPL, distributing lipid lipolysis. Apo C-III hinders the binding of apolipoprotein B and apolipoprotein E to the hepatic receptors resulting in the delayed catabolism of triglyceride – rich lipoproteins (TRLs). Finally, apo C-III prefers the production and secretion of very low-density lipoproteins (VLDL) in the liver 1.

Useful links

Reagents Home

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Extraction | Viral RNA Extraction Kit

Extraction | Reagent Kit

Viral RNA Extraction Kit

Designed to enable Automated Purification

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    Extracts viral total nucleic acid (RNA) from nasal/throat swabs following brief lysis steps
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    200µl of sample from the nasal/throat swab required for analysis
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    Universal kit which can be used for the efficient and automated purification of nucleic acid material
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    Kit includes Lysis buffer, Proteinase K and Elution buffer material suitable for the extraction
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    Yields highly concentrated nucleic acids that are ready to use in downstream applications such as qualitative or quantitative PCR
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    Automated nucleic acid extraction platform available from Randox

The Randox Viral RNA Purification kit is designed for the optimal automated extraction of total nucleic acid (RNA) from nasal/throat samples.

Viral nucleic acid extraction is a critical step in infectious disease testing. Nucleic acid-based detection of viral pathogens requires the extraction of RNA allowing simultaneous detection of any viral infection.

Randox also offer a range of COVID-19 testing solutions including Molecular and Point of Care platforms along with RT-qPCR assays, Quality Controls and EQA schemes.

Want to know more?

Contact us or visit our COVID-19 Monitoring & Management page

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Superoxide Dismutase (Ransod)

Superoxide Dismutase (Ransod)

Benefits of the Randox Ransod Assay

Excellent correlation

A correlation coefficient of r=0.965 was displayed when the Randox Ransod assay was compared against commercially available methods.

Excellent precision

The Randox Ransod assay displayed a within run precision of <4.65% CV.

Excellent measuring range

The Randox Ransod assay has a measuring range of 0.00 – 5.50 U/ml for the comfortable detection of clinically important results.

Standard included in kit

The standard is supplied with the Ransod kit, simplifying the ordering process.

Dedicated Ransod control available

A dedicated Ransod control is available offering a complete testing package.

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox Ransod assay on a variety of clinical chemistry analysers.

Ordering information

  • Ordering Information

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Cat NoSize
SD1255 x 20ml (S)EnquireKit Insert RequestMSDSBuy Online
(S) Indicates standard included in kit
  • PHYSIOLOGICAL SIGNIFICANCE
  • Clinical Significance

Superoxide dismutase (SOD) are a group of metalloenzymes, the first line of defence against reactive oxygen species (ROS)-medicated injury. SOD is responsible for catalysing the dismutation of the superoxide anion free radical (O2) into molecular oxygen and hydrogen peroxide (H2O2). The aim of this process is to reduce the levels of O2 as it damages cells at excessive concentrations 1.

SOD is the most important antioxidant defence against oxidative stress. SOD is a severe anti-inflammatory agent and can prevent precancerous cell changes. Reduced SOD levels have been observed in older generations as SOD levels drop as the body ages and so are more prone to oxidative related diseases. Reduced SOD activity has been identified as having a strong correlation with Alzheimer’s Disease. The overexpression of SOD-2 reduces hippocampal superoxide, preventing memory defects 1. Moreover, SOD has been identified as a potential diagnostic and prognostic marker in patients with gastric cancer 2. SOD has also been linked to other health conditions, including: rheumatoid arthritis, RBC-related disorders, Crohn’s Disease, cystic fibrosis, malignant breast cancer and neuronal apoptosis 1, 3.

Fig. 1. Pathological effects associated with SOD gene mutation or SOD deficiency 4
Pathological effects associated with SOD gene mutation or SOD deficiency - Ransod
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    RX modena and Randox Reagents used in COVID-19 hospital in India

    News       RX modena       COVID-19

     

     

    18 June 2020

    RX modena and Randox Reagents used in COVID-19 hospital in India

    Randox Laboratories has installed an RX modena into a COVID-19 hospital in India; the Netaji Subhash Chandra Bose Medical College in Madhya Pradesh state.

    The installation, which marks the first RX modena to be used in an Indian Government Medical College, replaces existing instrumentation in the Medical College laboratory, an initiative which was driven by College Dean Dr. Pradeep Kumar Kasar and Head of Department Dr. Ashok Kumar Sahu.

    The RX modena will cater for an additional 38 samples compared to the previous instrumentation, and is running a range of biochemistry tests that play a pivotal role in COVID-19 patient management, including C-Reactive Protein (CRP), Ferritin, and Lactate Dehydrogenase (LDH).

    Dr. Ashok Kumar Sahu, Head of Biochemistry at Netaji Subhash Chandra Bose Medical College, commented;

    “We are very pleased with the performance of the RX modena, and in particular with its wide menu of tests that can be utilized for COVID-19 patient management. Its high throughput and versatility have been a great support for the clinicians working in our COVID-19 hospital, in determining risk stratification, disease progression, and response to treatment.”

    The RX modena is a high volume, floor standing, fully automated clinical chemistry analyser with a world leading test menu which covers specific proteins, lipids, therapeutic drugs, antioxidants, diabetes and veterinary testing. The versatile analyser offers advanced methodologies with excellent correlation to the gold standard, and excellent reagent CV ranges.

    Shail Dholabhai, Randox India Sales Manager, commented;

     “We are delighted that the team at Netaji Subhash Chandra Bose Medical College have chosen the RX modena to fulfil the testing requirements of this COVID-19 hospital. Offering an unrivalled test menu of routine and specialized chemistries, the RX modena provides laboratories with the superior precision, reliability and accuracy that the Randox RX series is renowned for.

    “Capable of performing a total of 1200 tests per hour including ISE, the RX modena presents a new class of efficiency which will result in faster and more accurate diagnoses, and ultimately, lead to better patient outcomes.”

    Benefits of the RX modena

    • Capable of performing 800 photometric and a total of 1200 tests per hour including ISE.
    • World-leading extensive test menu covering routine chemistries, specific proteins, lipids, antioxidants, cardiac, diabetes and veterinary testing, offering cost savings through consolidation of routine and novel tests on a single platform.
    • Economic platform with low water consumption of less than 20 litres per hour saving on consumable costs. The RX modena also requires less than 5 minutes minimal maintenance.
    • Interactive touch-screen technology with integrated barcode readers for reagent and sample identification. Increased functionality with 13 wavelengths generated via diffraction grating (340-800nm) ensuring a multitude of chemistries are possible on one system.
    • Easy-to-use advanced Microsoft 10 software with a built-in Inventory Management System calculating the number of tests remaining, providing alerts of shortages and expired reagents and calibrators. The RX modena also features automatic test re-run function and sample dilution.
    • Dedicated reagent and sample pipettes to minimise the risk of errors and contamination. The RX modena also features a continuous loading hatch to allow for samples to be analysed quickly and easily during a run.
    • Advanced QC capabilities with daily, monthly and batch QC with data archiving, Levey-Jennings charts and automatic QC and calibration. There are also 7 different calibration options available.

    For further information about the RX modena click here. 

    For information about laboratory tools for COVID-19 patient management please click here.

    For other enquiries please contact marketing@randox.com

     

    Want to know more about Randox?

    Contact us or visit our homepage to view more.

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    Diabetes diagnosis with Randox Reagents

    The prevalence of diabetes is steadily increasing across the world, with approximately 422million people worldwide with diabetes and is currently one of the leading causes of death in the world. A diabetes diagnosis comes in three forms; Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus and Gestational Diabetes. Each type of diabetes can have long-term, detrimental effects to your health if it is not controlled, with some of the key complications being heart disease, kidney damage, retinopathy and even limb amputations.

    Diabetes can be controlled through maintaining a healthy diet and regular exercise, however in situations where complications occur, innovative testing can aid in the prevention and management of detrimental consequences to patients.  Randox Reagents offer a range of high performance and unique tests which can be used to manage complications of diabetes such as:

    Diabetic Nephropathy

    Kidney disease is a life threatening complication of diabetes, commonly called diabetic nephropathy in patients with diabetes. Around 40% of people with diabetes develop diabetic nephropathy, characterised through prolonged periods of high glucose levels in the blood. To effectively monitor diabetic nephropathy, it is essential to test cystatin C levels in patients, which is a useful indicator of renal function in patients where creatinine measurements are unreliable. Unlike creatinine, cystatin C does not have a ‘blind area’ – up to 50% of renal function can be lost before significant creatinine elevation occurs. This makes cystatin C capable of detecting early stage kidney dysfunction in patients with diabetic nephropathy.

    Microalbumin testing is also important to identify patients with diabetic nephropathy approximately 5-10 years earlier than proteinuria tests, helping to reduce the incidence of end stage renal disease. This is because low albumin concentrations in the urine are the earliest market of renal damage and therefore enable preventative measures to be taken.

    Metabolic Syndrome

    Metabolic syndrome is a severe complications of uncontrolled diabetes which contains a number of conditions which occur together, increasing your risk of heart disease, stroke and diabetes. Metabolic syndrome can be monitored through measuring Non-Esterified Fatty Acids (NEFA), which are molecules released from triglycerides by the action of the enzyme lipase and are transported in the blood bound to albumin. NEFA contributes a small proportion of the body’s fat, however they provide a large part of its energy, with elevated concentrations having adverse effects on both carbohydrate and lipid metabolism.

    With the global burden of diabetes rising year on year, diabetes complications monitoring has never been more important. Randox Reagents offer a wide range of innovative testing to laboratories, to help clinicians accurately diagnose and monitor diabetes complications.

     

    Download our diabetes brochures to find out about our full range of diabetes reagents

    Randox reagents are available for a wide range of clinical chemistry analysers. For more information, please contact reagents@randox.com


    Drugs of Abuse – A Global Pandemic

    4th September 2019

    Drugs of Abuse – A Global Pandemic

    The prevalence of drug addiction and abuse across the globe has become a growing concern. It is currently estimated that 71 million people use drugs of abuse with around 166,000 direct deaths occurring from drug use in 2017.

    The WHO (World Health Organisation) estimate that 11 million people inject drugs across the globe, of which 1.3 million are living with HIV, 5.5 million with hepatitis C, and 1 million with both HIV and hepatitis C. In addition to infectious disease, long term drug abuse increases the risk of several cancers, cardiovascular effects, respiratory effects, gastrointestinal effects, kidney & liver damage and mental health issues.

    The abuse of drugs is one of the most pressing issues in the USA and other countries globally. Drug abuse not only affects the individual, but can also have far-reaching consequences that affect family, employment, personal health, health care systems, local communities, and society as a whole.

    Global Drug Abuse – The buzz that keeps on going!

    > Misuse of illicit drugs affects society through secondary costs incurred such as crime, reduced productivity at work, and health care expenses.

    > Substance abuse costs the US health care system about $11 billion, with overall costs reaching $193 billion.

    > Substance abuse and addiction also affects other areas of life leading to broken families, destroyed careers, death due to negligence or accident, domestic violence, physical abuse and child abuse.

    > Drug abuse and addiction changes the chemistry of your brain. The longer an individual abuses drugs, the more damage is caused, making it more difficult to return to ‘normal’ during drug rehabilitation.

    > Treating and tackling drug addiction is a challenge. As drug treatment and health services continue to fall short, there is an increased need to continuously adapt drug detection and analysis.

    Randox laboratories are at the forefront, aiding the fight against drugs of abuse with a comprehensive range of 10 drugs of abuse assays including several stimulants, sedatives and opioids available to run on Randox’s very own clinical chemistry analysers, the RX series. To find out now how Randox is helping to tackle the ongoing prevalence of drugs of abuse click here or buy directly from the Randox Online Store.

    About Randox Laboratories

      As a world leader in the in-vitro diagnostic industry with over 35 years’ experience, Randox is leading the charge in moving from a one-size-fits-all approach towards decisions, practices and products tailored to the needs of the individual.  This innovative approach to diagnostics has facilitated the development of revolutionary products designed specifically to enhance a patients’ quality of life.

      Want to know more?

      Contact us or visit our Drugs of Abuse pages to learn more.

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