Iron

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Iron

Reagent | Iron


Key Benefits

Excellent precision

The Iron (ferene) assay showed a precision of less than 3.5% CV

Exceptional correlation

The assay showed a correlation of r=0.99 against another commercially available method

Liquid and lyophilised reagents available

Offering convenience and choice

Randox Iron- Ferrozine

  • Ferrozine method
  • Liquid ready-to-use reagents
  • Stable to expiry when stored at 15-25⁰C
Cat NoSize
SI3821R1 6 x 20ml (L)
R2 3 x 11ml
EnquireKit Insert RequestMSDSBuy Online
SI8049R1 7 x 15.5ml (L)
R2 7 x 6.7ml
EnquireKit Insert RequestMSDSBuy Online
SI8330R1 4 x 20ml (L)
R2 4 x 7ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Iron assay used for?

Iron deficiency is one of the most prevalent human disorders. In adults iron deficiency is often symptomatic of chronic blood loss. Iron deficiency results in deficient haem synthesis with the subsequent symptoms of anaemia due to tissue hypoxia. Iron (non-heme) measurements are used in the diagnosis and treatment of diseases such as iron deficiency anaemia, hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin), and chronic renal disease.

Publications


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    Haemoglobin

    Reagent | Haemoglobin

    Key Benefits

    Applications available

    For a wide variety of clinical chemistry analysers

    Excellent stability

    The diluted reagent is stable for at least 6 months at +15°C to +25°C when stored in a tightly closed dark bottle

    Excellent linearity

    This method is linear up to 21 g/dl

    Other Features

    • Colorimetric method
    • Liquid reagents
    • Stable to expiry when stored at 2-8⁰C
    • Excellent linearity up to 21 g/dl
    • No extraction needed with whole blood application
    • For manual use only

    Ordering Information

    Cat NoSize
    HG15395 x 100ml (L)EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid option

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is Haemoglobin assay used for?

    Haemoglobin measurement is part of the full blood count which is requested when a doctor suspects an illness related to above or below normal levels. Haemoglobin levels are also measured:

    • before operations to make sure the patient is fit for surgery
    • to detect and measure the severity of anaemia or polycythaemia
    • to monitor response to treatment
    • to help make decisions about blood transfusions

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    Glycerol

    Reagent | Glycerol

    Key Benefits

    Applications available

    For a wide variety of clinical chemistry analysers

    Exceptional correlation

    The Glycerol assay showed a correlation of r=0.999 against another commercially available method

    Limited interference

    Ascorbic Acid up to a concentration of 400 µmol/l will not affect this test

    Other Features

    • GPO-PAP method
    • Lyophilised reagents
    • Working reagent stable for 14 days when stored at 2-8⁰C or 3 days at 15-25°C
    • Measuring range 14.5 – 2545 µmol/l
    • For manual or semi-automated use only
    Cat NoSize
    GY1056x 15ml (S)EnquireKit Insert RequestMSDSBuy Online
    (S) Indicates standard included in kit

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is Glycerol assay used for?

    Glycerol measurements are used in the diagnosis and treatment of patients with diabetes mellitus, nephrosis, liver obstruction, other diseases involving lipid metabolism, or various endocrine disorders.

    • Beatty, O.L. Insulin resistance in offspring of hypertensive parents. BMJ 1993, 307(6896): 92-96
    • Ranganath, L., et al. The effect of circulating non-esterified fatty acids on the entero-insular axis. European Journal of Clinical Investigation. 1999, 29(1): 27-32
    • McTernan, P.G., et al. Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro. Diabetes2002, 51(5): 1493-1498
    • Lutoslawska, G., et al. Relationship between fasting insulin resistance index (FIRI) and plasma glycerol and free fatty acid levels in physically active males and females. Biol. Sport 2006, 23: 341-351
    • Kos, K., et al. Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass. Am. J. Physiol. Endocrinol. Metab. 2007, 293: E1335-E1340
    • Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393

    Related Products

    • Glycerol Controls

    Standard included in the kit

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    GLDH

    Glutamate Dehydrogenase (GLDH)

    Key benefits of the Randox Glutamate Dehydrogenase (GLDH) reagent

    Lyophilised Reagents

    The Randox GLDH (DGKC) assay is lyophilised for enhanced stability

    Exceptional correlation

    The GLDH (DGKC) assay showed a correlation of r=0.99 against another commercially available method

    Stability

    Open vial stability of 1 week at+2oC to +8oC.

    Ordering information

    Cat NoSize
    GL441R1a 1 x 70ml
    R1b 8 x 6ml
    R2 2 x 20ml
    EnquireKit Insert RequestMSDSBuy Online
    GL442R1a 5 x 100ml
    R1b 5 x 100ml
    R2 2 x 20ml
    EnquireKit Insert RequestMSDSBuy Online

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is GLDH assay used for?

    GLDH measurements can be taken to evaluate the liver function. Elevated blood serum levels indicate liver damage. GLDH also plays an important role in the differential diagnosis of liver disease, especially in combination with aminotransferases.

    Liver diseases such as toxic liver damage or hypoxic liver disease are characterised by high serum levels. In clinical trials, GLDH can also be used as a measurement for the safety of a drug.

    The Randox GLDH is an optimised standard method according to the recommendations of the Deutsche Gesellschaft für Klinische Chemie. This procedure measures the non specific creep reaction.

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    Gamma GT

    Reagent | Gamma GT

    Benefits of the Gamma GT Assay

    Exceptional correlation

    The assay showed a correlation of r=0.99 against another commercially available method

    Excellent stability

    Stable to expiry when stored at 2-8⁰C

    Liquid ready-to-use

    The Randox Gamma GT reagent is available in a liquid ready to use format for convenience and ease of use.

    Randox Gamma GT (Colorimetric)

    • Colorimetric method
    • Liquid ready-to-use reagents
    • Stable to expiry when stored at 2-8⁰C

    Ordering Information

    Cat NoSize
    GT3817R1 6 x 51ml (L)
    R2 6 x 14ml
    EnquireKit Insert RequestMSDSBuy Online
    GT38746 x 21ml (L)EnquireKit Insert RequestMSDSBuy Online
    GT8320R1 4 x 20ml (L)
    R2 4 x 7ml
    (Mod. IFCC)
    EnquireKit Insert RequestMSDSBuy Online
    GT8146R1 7 x 20ml (L)
    R2 7 x 8ml
    EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid option

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is Gamma GT assay used for?

    Gamma-glutamyltransferase (GT) in serum originates primarily from the hepatobiliary system. Therefore GT is elevated in all forms of liver disease and has been shown to be more sensitive than alkaline phosphatase in detecting obstructive jaundice, cholangitis and cholecystitis. High levels of GT are also seen in patients with primary or secondary liver cancer. Increased levels are also observed in cases of alcohol abuse and in alcoholic liver cirrhosis. In patients receiving anticonvulsant drugs such as phenytoin and phenobarbital, increased levels of the enzyme in serum may reflect induction of new enzyme activity and the toxic effects of alcohol and other drugs on the microsomal structures in liver cells. GT is the most sensitive enzymatic indicator of hepatobiliary disease, and can be used in combination with other biochemical markers to discriminate between different types of hepatobiliary disease.

    • Haçariz, O. et al. The effect of Quil A adjuvant on the course of experimental Fasciola hepatica infection in sheep. Vaccine 2009, 27(1): 45-50
    • Haçariz, O. et al. IL-10 and TGF-β1 are associated with variations in fluke burdens following experimental fasciolosis in sheep. Parasite Immunol. 2009, 31(10): 613-622
    • Gbadegesin, M.A., et al. In vitro antioxidant/radical scavenging activities and hepatoprotective roles of ethanolic extract of Cassia occidentalis leaves in sodium arsenite-treated male Wistar rats. Br. J. Med. Med. Res. 2013, 3(4): 2141-2156

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    CO2 Total Reagent

    Reagent | CO2 Total

     

    Key Benefits of the Randox CO2 Total Reagent

    Exceptional correlation with standard methods

    The Randox methodology was compared against other commercially available methods and the Randox CO2 Total assay showed a correlation coefficient of r=0.94

    Wide measuring range

    The healthy range for CO2 Total is 18 – 28 mmol/l. The Randox CO2 Total assay can comfortably detect levels outside of this healthy range measuring between 0.004 – 50 mmol/l

    Suitable for use on a range of automated analysers

    The Randox CO2 Total reagent is suitable for use on a number of third party automated analysers. To enquire about an Instrument Specific Application (ISA), please click the Contact Us button below.

    Other features

    • Enzymatic method
    • Liquid ready-to-use reagent
    • Stable until expiry date when stored at +2 to +8°C
    • Open vial stability of 14 days at +10°C
    • Measuring range 0.004 – 50 mmol/l

    Ordering information

    Cat NoSize
    CD40064 x 21.7ml (C)(L)EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid reagent
    (C) Indicates calibrator included in kit

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is CO2 Total used for?

    Carbon dioxide (CO2) is a metabolic waste product of cellular respiration. It is transported in the bloodstream to the lungs and expelled from the body. CO2 exists in the body in two forms: 90% exists as bicarbonate (HCO3) and the remaining exists as carbonic acid (H2CO3) or dissolved CO2. The kidneys and lungs are responsible for the regulation on CO2, H2CO3 and HCO3 in the blood.

    What is the CO2 Total assay used for?

    The Randox CO2 Total assay is used for the quantitative in vitro determination of CO2 in serum and plasma.  It aids in diagnosing diseases associated with high and low levels of CO2 in the bloodstream.

    Slightly elevated levels of CO2 do not have any serious consequences on the body, but overexposure to CO2 due to decreased alveolar ventilation or the inhalation of CO2 enriched air can cause serious implications in the body including: deterioration of respiratory functions due to respiratory acidosis and asphyxiation, cardiovascular effects due to low blood pressure and cardiac arrhythmia and nerve damage due to hypercapnia and acidemia.

    For more information on the contrasting effects of hypoxia and hypercapnia, please click here.

    High CO2 levels usually indicates that the lungs are not functioning properly and are unable to expel the required amount of CO2. During an acute illness, the levels of CO2 can increase suddenly, however, over time, some people are able to establish a new ‘baseline’ for CO2. An example of this is a person with stable chronic obstructive pulmonary disease (COPD) This means that the body is able to function with higher than normal levels of CO2.

    There are some medical conditions and drugs that can cause low CO2 levels including: kidney disease as the kidneys are unable to carry out their functions, diabetic ketoacidosis due to the production of ketones resulting in reduced CO2 levels, hyperchloremic acidosis due to diarrhea, Addison’s disease, and metabolic acidosis due to chemical toxicity.

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    Zinc Assay

    Reagent | Zinc


    Benefits of the Randox Zinc Assay

    Excellent correlation

    A correlation coefficient of r=0.9946 was displayed when the Randox method was compared against other commercially available methods.

    Excellent precision

    The Randox zinc assay displayed a within run precision of <3.87%.

    Liquid ready-to-use

    The Randox zinc assay is available in a liquid ready-to-use format for convenience and ease-of-use.

    Standard supplied with the kit

    The standard is supplied with the zinc kit, simplifying the ordering process.

    Controls available

    Controls available offering a complete testing package.

    Applications available

    Applications available detailing instrument-specific settings for the convenient use of the Randox zinc assay on a variety of clinical chemistry analysers.

    Ordering Information

    Cat NoSize
    ZN2341R1 1 x 50ml (S) (L)
    R2 1 x 250ml
    with Deproteinisation
    EnquireKit Insert RequestMSDSBuy Online
    ZN26076 x 50ml (L)
    Deproteinising Solution
    EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid option
    (S) Indicates standard included in kit

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    Physiological Significance

    Zinc (ZN) is an essential trace element (micronutrient) and plays a vital role in several biological processes 1. ZN is released from food as free ions during digestion. Specific transport proteins facilitate the passage of ZN across cell membranes into circulation. 70% of circulatory ZN is bound to albumin 2. As ZN does not attain redox properties, it is capable of transportation around the biological systems without inducing oxidative damage, which can occur with other essential trace elements like copper 3.

    ZN has a key role in growth, reproduction, sexual maturity and the immune system. ZN is vitally important in the functionality of >300 enzymes utilised in the stabilisation of DNA and gene expression 1. ZN can constitute strong, yet readily available flexible and exchangeable, complexes with organic molecules, enabling it to modify the three-dimensional structure of specific proteins, nucleic acids, and cellular membranes, thereby influencing the catalytic properties of many enzyme systems and intracellular signalling. ZN is associated with >50 metalloenzymes with a diverse range of functions and so ZN plays a central role in metabolism, differentiation and cellular growth 3.

    Deficiency

    Zinc deficiency has been identified as a malnutrition issue worldwide. ZN deficiency is more prevalent in areas of low animal consumption and high cereal consumption. It’s not that the diet is low in ZN but more so the bio-availability of ZN which plays a major role in its absorption. Phytic acid has been identified as the main inhibitor of ZN. Adolescents, children, infants, lactating women and pregnant women have increased requirements for ZN and so are at higher risk of zinc depletion. During growth periods, ZN deficiency causes growth failure. The organs most affected by ZN deficiency include: central nervous system, epidermal, gastrointestinal, immune, reproductive and skeletal systems 2.

    Toxicity

    As there are multiple sources of ZN in the environment, exposure to and toxicity from ZN are not uncommon. Case reports have documented zinc toxicity caused by: overuse of dietary supplements, inhalation from occupational sources, denture cream and ingestion of pennies, to which some of these cases had fatal outcomes 4.

    It is believed that ZN toxicity from acute exposure differs significantly from chronic toxicity. In acute exposures, ingestions of ZN sulfate and concentrated ZN chloride will primarily result in gastrointestinal symptoms, such as haematemesis. Renal injury, liver necrosis, coagulopathy and even death have been reported following acute exposures 4.

    Chronic exposure caused by excessive consumption of ZN, resulting in copper deficiency can lead to myelodysplastic syndrome, granulocytopenia and sideroblastic anaemia 4.

    Publications


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      D-3-Hydroxybutyrate (Ranbut)

      Reagent | D-3-Hydroxybutyrate (Ketone)

      D-3-Hydroxybutyrate: A Superior Marker of Ketoacidosis

      Benefits of the Randox D-3-Hydroxybutyrate (Ketone) Assay

      Superior Performance

      Superior methodology

      The commercially available nitroprusside method is a semi-quantitative dipstick test which only detects acetone and acetoacetate. As the most abundant ketone produced during ketosis, D-3-hydroxybutyrate is more sensitive and specific.

      Correlation

      Exceptional correlation

      A correlation coefficient of r=0.9954 was displayed when the Randox method was compared against other commercially available methods.

      Precision

      Excellent precision

      The Randox Ranbut assay displayed an excellent precision of <3.5%.

      Calibrator & Control

      Calibrator and controls available

      Calibrator and controls are available offering a complete testing package.

      Logos-07

      Applications available

      Applications available detailing instrument-specific settings for the convenient use of the Randox Ranbut assay on a variety of clinical chemistry analysers.

      Ordering Information

      Cat NoSize
      RB100710 x 10ml (S)EnquireKit Insert RequestMSDSBuy Online
      RB100810 x 50ml (S)EnquireKit Insert RequestMSDSBuy Online
      RB4067R1 2 x 20ml (L)
      R2 2 x 5.8ml
      EnquireKit Insert RequestMSDSBuy Online
      RB8378R1 2 x 20ml (L)
      R2 2 x 6.1ml
      EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option (S) Indicates standard included in kit

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      Diagnostic Uses

      • Diabetic Ketoacidosis (DKA)
      • Traditional Methods
      • Clinical Significance
      • Physiological Significance

      Ketosis is a metabolic process that occurs when the body switches from glucose to predominantly fat metabolism for energy production, this happens when carbohydrate availability reaches low levels. The metabolism of fatty acids in the liver results in the production of chemical by-products known as ketone bodies or ketones. Ketosis occurs when the body produces more ketones than the liver can process.

      DKA is a serious complication of both Type I Diabetes Mellitus (T1DM), however can also affect individuals with T2DM. The condition is linked to insulin deficiency and occurs when glucose levels are consistently high and insulin levels are severely low. Due to this imbalance glucose builds up in the blood and the body responds by metabolising fat rather than glucose. DKA is usually one of the first indicators of T1DM.

      Ketosis is not normally dangerous and is typical of ketogenic diets which are low in carbohydrates. Ketones however are poisonous when present in high levels leading to ketoacidosis, DKA for example if left untreated can cause damage to vital organs and in some instances may lead to a coma or death. DKA is commonly triggered by an illness, infection or missing insulin treatments.

      The American Diabetes Association recommends testing for ketosis in diabetics when symptoms of ketoacidosis are present, when
      glucose levels are consistently elevated, during pregnancy and if experiencing any illness. NICE also recommend monitoring ketones in patients with T1DM especially during periods of illness.

      Semi-quantitative, nitroprusside-based methods remain common for the detection of ketones in the blood and urine of diabetic patients. The nitroprusside method is available in both tablet and reagent test strip form where urine or blood is applied, and a colour change observed. There are several limitations associated with Nitroprusside methods;

      1. Capable of detecting only acetone and acetoacetate, as such they lack sensitivity especially in early stages of DKA.
      2. The intensity of the colour change observed is subjective compared to quantitative methods like D-3-Hydroxybutyrate which can be used to monitor  recovery and improvements to treatment.
      3. Several medications including Valproic Acid and Vitamin C can interfere with nitroprusside methods leading to false positive
        results.
      4. False negative results are common as the method does not detect the main ketone body – D-3-Hydroxybutyrate. As ketoacidosis improves and D-3-Hydroxybutyrate is converted to acetoacetate the result with urine dipsticks can appear positive despite the patient’s status improving by this stage.
      5. D-3-Hydroxybutyrate is a more reliable indicator of ketosis and DKA due to its superior stability when compared to acetone and
        acetoacetate.

        When the carbohydrate stores are significantly decreased, or the fatty acid concentration is increased, there is an upregulation of the ketogenic pathway and consequently, an increased production of ketone bodies. This is commonly observed in alcoholism, type I diabetes and starvation. Most organs, including the brain, can utilise ketones as its source of energy. The liver however, cannot utilise ketones, despite producing them, as the liver lacks the necessary enzyme ketoacyl-CoA transferase 1.

        Ketosis is the presence of ketones. Whilst ketosis is not dangerous, if left untreated, especially in diabetes, ketoacidosis (high levels of ketones) develops 2.

        In type 1 diabetes mellitus (T1DM), the body is unable to produce insulin resulting in bodily cells not receiving energy from glucose, causing the body to release hormones to breakdown fat for energy, producing ketones. If left untreated, diabetic ketoacidosis develops, a serious health condition. Diabetic ketoacidosis is commonly triggered by an illness, infection or missing insulin treatments 3.

        There are three main ketones produced as a result of ketosis; D – 3 – Hydroxybutyrate, acetoacetate and acetone.

        D-3-Hydroxybutyrate is the most abundant of the three accounting for 75% of total ketones in the body, it is later catabolised into acetoacetate and then into acetone. Due to the higher levels of D-3-Hydroxybutyrate, it is the more sensitive marker for the diagnosis of ketosis, in particular DKA.

         

        Ketogenesis is a biochemical process whereby the body produces ketone bodies (acetone, acetoacetate, beta-hydroxybutyrate. As ketone bodies are water soluble, they do not require lipoproteins for transport 1.

        In healthy humans, small amounts of ketones are continuously made for the body to use an energy. Ketone bodies increase in times of fasting and sleeping 1.

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        Calcium Reagent

        Reagent | Calcium

        Key Benefits of the Randox Calcium reagent

        Exceptional correlation with standard methods

        The Randox methodology was compared to other commercially available methods and the Randox Calcium assay showed a correlation coefficient of 0.99.

        Excellent stability

        Stable for 7 days at +2 to +8°C or 3 days at +15 to +25°C

        Liquid ready-to-use

        The Randox calcium reagent is available in a liquid ready to use format for convenience and ease of use.

        Other features of the Randox Calcium reagent (CPC/AMP)

        • CPC/AMP method
        • Liquid ready-to-use reagents
        • Open vial stability of 21 days
        Cat NoSize
        CA590R1 1 x 100ml (S)(L)
        R2 1 x 100ml
        R3 1 x 10ml
        EnquireKit Insert RequestMSDSBuy Online
        (S) Indicates standard included in kit
        (L) Indicates liquid reagent

        Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

        Other features of the Randox Calcium reagent (Arsenazo)

        • Arsenazo method
        • Liquid ready-to-use reagents
        • Stable until expiry date when stored at +15 to +25°C
        Cat NoSize
        CA38719 x 51ml (L)EnquireKit Insert RequestMSDSBuy Online
        CA80218 x 68ml (L)EnquireKit Insert RequestMSDSBuy Online
        CA83094 x 20ml (L)EnquireKit Insert RequestMSDSBuy Online
        (L) Indicates liquid option

        Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

        What is the Calcium assay used for?

        What is calcium?

        Calcium is the fifth most abundant element in the body. Most of it in the human adult is extracellular and 99% of it exists as crystalline hydroxyapatite in bones and teeth where it confers rigidity. It plays a major role in the mechanisms of nerve impulse transmission, muscular contraction and blood coagulation. Secretion from the parathyroid glands, thyroid C cells and pancreatic B cells is controlled by the extracellular ionised calcium concentration at the cell surface.

        What is the calcium assay used for?

        It is tested to diagnosis and monitor numerous conditions related to the heart, nerves, bones and kidneys.

        Hypercalcemia can be the result of hyperparathyroidism (overactive parathyroid gland), cancer, carcinomas, vitamin D overdoses and are of diagnostic value in detecting chronic renal disease and acute pancreatic disease.

        Hypocalcemia is associated with hypoparathyroidism (underactive parathyroid gland), vitamin D deficiency, calcium deficiency, kidney dysfunction and renal failure. For more information on risk factors for post-thyroidectomy hypocalcemia, please click here [external link].

        The Randox Calcium assay is used for the quantitative in vitro determination of calcium concentration in serum, plasma and urine.

        • Kauther, M.D., et al. Biochemical markers of particle induced osteolysis in C57BL/6 mice. Clin. Chem. Lab. Med., 2010, 48 (11): 1641-1646.

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        Homocysteine Assay

        Reagent | Homocysteine

        A Marker of Hyperhomocysteinemia

        Benefits of the Randox Homocysteine Assay

        Two-part liquid ready-to-use

        The Randox homocysteine assay is available in a two-part liquid ready-to-use format, limiting interference from bilirubin, haemoglobin, triglycerides and intralipid®, producing more accurate and precise results.

        Exceptional correlation

        The Randox homocysteine assay is standardised to the NIST SRM 1955 (Homocysteine Standard Reference Material) displaying a correlation coefficient of r=0.98 when compared to industry comparative methods.

        Excellent measuring range

        The Randox homocysteine assay has a measuring range of 1.7 – 47.9 μmol/l for the comfortable detection of clinically important results.

        Calibrator included in the kit

        The Randox homocysteine kit includes the calibrator simplifying the ordering process.

        Controls available

        Controls available offering a complete testing package.

        Applications available

        Applications available detailing instrument-specific settings for the convenient use of the Randox homocysteine assay on a variety of clinical chemistry analysers.

        Ordering information

        Cat NoSize
        HY4036R1 2 x 21.7ml (C)(L)
        R2 2 x 4.6ml
        EnquireKit Insert RequestMSDSBuy Online
        (L) Indicates liquid option
        (C) Indicates calibrator included in kit

        Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

        • PHYSIOLOGICAL SIGNIFICANCE
        • Clinical Significance

        Homocysteine is a sulfur-containing amino acid produced by the intracellular demethylation of the essential amino acid, methionine. Homocysteine has three metabolic functions within the human body: firstly, to be remethylated into methionine; secondly, to enter the biosynthetic pathway of cysteine; and thirdly, to be released into the extracellular medium (blood and urine). The third metabolic function is the direct cause of elevated homocysteine concentrations in urine and plasma 1, 2.

        Hyperhomocysteinemia (elevated levels of homocysteine) has been identified in numerous conditions and disease states including, cardiovascular disease (atherosclerosis and thrombosis), pregnancy complications, psoriasis, cognitive impairment in the elderly, mental disorders, neural tube defects and birth defects 1, 2.

        Women with elevated levels of homocysteine have a 3-fold increased risk of CVD, whereas men have a 2-fold increased risk 3. Hyperhomocysteinemia correlates with an increased risk of colorectal cancer with elevated homocysteine levels being highly prevalent in patients with inflammatory bowel diseases which is believed to be associated with either an increased or decreased absorption of folate and other B vitamins 4. Hyperhomocysteinemia was associated with a 2 to 3-fold increased risk of abrupyio placentae, pregnancy-induced hypertension, and intrauterine growth restriction 5.

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