CK-NAC Reagent

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CK-NAC Reagent

Reagent | CK-NAC

Key Benefits of the Randox CK-NAC reagent

Exceptional correlation with standard methods

The Randox methodology was compared against other commercially available methods and the Randox CK-NAC assay showed a correlation coefficient of r=0.99

Excellent stability

Stable until expiry date when stored at +2 to +8°C

Other features of the Randox CK-NAC reagent

  • UV DGKC method
  • Available as liquid and lyophilised reagents
  • Stable until expiry date when stored at +2 to +8°C

Ordering information

Cat NoSize
CK110R1a 1 x 70ml
R1b 20 x 2.5ml
EnquireKit Insert RequestMSDSBuy Online
CK3812R1a 2 x 70ml
R1b 4 x 20ml
R2 4 x 6ml
EnquireKit Insert RequestMSDSBuy Online
CK3892R1 4 x 16.5ml (L)
R2 4 x 6.2ml (IFCC)
EnquireKit Insert RequestMSDSBuy Online
CK8313R1a 2 x 70ml (L)
R1b 4 x 20ml
R2 4 x 7ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the CK-NAC assay used for?

What is CK-NAC?

The small amount of Creatine Kinase (CK) present in the blood primarily comes from skeletal muscle. CK is also found in striated muscle, brain and heart tissues. The CK concentration levels in the blood increase as a result of damage to bodily muscle or interferences with the muscle energy production such as myositis, which is inflammation of the muscles.

What is the CK-NAC assay used for?

The Randox CK-NAC reagent is used for the measurement of CK in serum or plasma to assess the extent of muscle damage and to monitor treatment.

The determination of CK-NAC activity in plasma or serum provides a sensitive marker for the detection of skeletal muscle disease; and is also useful to assess the extent of severe muscle trauma, crush injuries, burns or electrocution, and the likelihood of developing rhabdomyolysis.   For more information on the spectrum of rhabdomyolysis, please click here [external link].

The determination of CK using creatine phosphate and adenosine‑5’‑diphosphate (ADP) as substrates rather than creatine and adenosine‑5’‑triphosphate (ATP) has several advantages in test performance as it allows for a faster reaction rate resulting in greater sensitivity. Small sample volumes are used and sample blanks are not required.

The UV method used is an optimised standard method according to the recommendations of the Deutsche Gesellschaft für Klinische Chemie.

Clinical Chemistry Panel

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CK-MB Reagent

Reagent | CK-MB

Key Benefits of the Randox CK-MB reagent

Liquid and lyophilised reagents available

The Randox CK-MB reagent is available in a liquid ready-to-use or in a lyophilized format offering you convenience and choice when selecting the best choice for your laboratory

Excellent stability

Stable until expiry date when stored at +2 to +8°C

Other features of the Randox CK-MB reagent

  • Immunoinhibition UV method
  • Available as liquid and lyophilised reagents Stable until expiry date when stored at +2 to +8°C
  • Stable until expiry date when stored at +2 to +8°C
Cat NoSize
CK129619 x 2.5mlEnquireKit Insert RequestMSDSBuy Online
CK3813R1 2 x 70ml
R1b 4 x 20ml
R2 4 x 6ml
EnquireKit Insert RequestMSDSBuy Online
CK4043R1 4 x 20ml (L)
R2 4 x 6ml
EnquireKit Insert RequestMSDSBuy Online
CK8148R1 4 x 20ml (L)
R2 4 x 8ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the CK-MB assay used for?

What is CK-MB?

Creatine Kinase (CK) is internationally accepted as a sensitive and specific indicator of acute myocardial infarction (AMI). There are 3 major forms of the iso-enzymes of CK, CK-MM, CK-MB and CK-BB. CK-BB is produced by the brain in very small insignificant amounts. CK-MM is produced by the skeletal and heart tissue. CK-MB is produced by the heart muscle and increases when the heart muscle is damaged. For more information on the structure and function of CK isoenzymes in tissue, please click here.

What is the CK-MB assay used for?

CK-MB is a more sensitive marker to myocardial infarction than total CK activity as CK-MB has a lower basal level and a narrower normal range.  In the vast majority of cases the CK-MB activity rises within 4 to 6 hours of an acute infarction.  Between 10 to 24 hours, maximum values are observed. The CK-MB activity generally returns to normal between the third and fourth day post- infarction.

The Randox CK-MB reagent can measure small, but significant changes in CK-MB activity during the early hours following the onset of chest pain.

Clinical Chemistry Panel

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Cardiology Panel

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Featured Reagent – D-3-Hydroxybutyrate (Ranbut)

Featured Reagent | D-3-Hydroxybutyrate

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Benefits of D-3-Hydroxybutyrate

Superior Methodology – The commercially available nitroprusside method is a semi-quantitative dipstick test which only detects acetone and acetoacetate. As the most abundant ketone produced during ketosis, D-3-hydroxybutyrate is more sensitive and specific.

Excellent precision – The Randox Ranbut assay displayed an excellent precision of <3.5%.

Exceptional correlation – A correlation coefficient of r=0.9954 was displayed when the Randox method was compared against other commercially available methods.

Wide Measuring Range – The Randox Ranbut assay has a measuring range of 0.100 – 5.75mmol/l for the comfortable detection of clinically important results.

Calibrator and controls available – Randox offer a complete testing package.

Applications available – Detail of instrument-specific settings for the convenient use of the Randox Ranbut assay on a variety of clinical chemistry analysers.

Traditional Methods

Ketogenesis is a biochemical process whereby the body produces ketone bodies (acetone, acetoacetate, beta-hydroxybutyrate). As ketone bodies are water soluble, they do not require lipoproteins for transport 1.

In healthy humans, small amounts of ketones are continuously made for the body to use an energy source. Ketone bodies increase in times of fasting and sleeping 1.

Physiological Significance

Urinalysis is an essential part of the diagnostic review for kidney disease and other renal impairments. Whilst the dipstick test allows for rapid and simultaneous chemical analyses of urine, including ketones, the chemical reactions on dipsticks are complicated and can be affected by oxidising, reducing, and discolouring substances in urine. Therefore, false positives and false negative results are common in dipstick testing 4.

Clinical Significance

When the carbohydrate stores are significantly decreased, or the fatty acid concentration is increased, there is an upregulation of the ketogenic pathway and consequently, an increased production of ketone bodies. This is commonly observed in alcoholism, type I diabetes and starvation. Most organs, including the brain, can utilise ketones whereas the heart utilises fatty acids as its source of energy, but can also use ketones. The liver however, cannot utilise ketones, despite producing them as the liver lacks the necessary enzyme ketoacyl-CoA transferase 1.

Ketosis is the presence of ketones. Whilst ketosis is not dangerous, if left untreated, especially in diabetes, ketoacidosis (high levels of ketones) develops 2.

In type 1 diabetes mellitus (T1DM), the body is unable to produce insulin resulting in bodily cells not receiving energy from glucose, causing the body to release hormones to breakdown fat for energy, producing ketones. If left untreated, diabetic ketoacidosis develops, a serious health condition. Diabetic ketoacidosis is commonly triggered by an illness, infection or missing insulin treatments 3.

Did you know?

Ketone bodies increase in times of fasting and sleeping 1 and is considered harmless, however, if left untreated, especially in diabetes, ketoacidosis occurs 2.

References

[1] Dhillon KK, Gupta S. Biochemistry, Ketogenesis. Treasure Island: StatPearls Publishing; 2020. https://www.ncbi.nlm.nih.gov/books/NBK493179/ (accessed 28 September 2020).

[2] Hecht M. Ketosis vs. Ketoacidosis: What You Should Know. https://www.healthline.com/health/ketosis-vs-ketoacidosis (accessed 28 September 2020).

[3] Mayo Clinic. Diabetic ketoacidosis. https://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/symptoms-causes/syc-20371551 (accessed 28 September 2020).

[4] Han TH. Urinalysis: The Usefulness and Limitations of Urine Dipstick Testing. Journal of the Korean Society if Pediatric Nephrology 2013; 17(2): 42-48.

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Cholinesterase (Butyryl) (BCHE / BuCHE) Reagent

Reagent | Cholinesterase (Butyryl) (BCHE / BuCHE)

Key Benefits of the Cholinesterase (Butyryl) (BCHE / BuCHE) reagent

Exceptional correlation with standard methods

The Randox methodology was compared against other commercially available methods and the Randox cholinesterase (butyryl) reagent showed a correlation coefficient of r=0.9959

Excellent stability

Stable for 6 weeks when stored at +2 to +8°C

Other features of the Cholinesterase (Butyryl) (BCHE / BuCHE) reagent

  • Colorimetric method
  • Lyophilised reagents
  • Correlation coefficient of r=0.99 when compared with another commercially available method
  • Stable for 6 weeks when stored at +2 to +8°C
  • Measuring range 455-28722U/l

Ordering information

Cat NoSize
CE190R1 5 x 30ml
R2 5 x 1ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the Cholinesterase (Butyryl) (BCHE / BuCHE) assay used for?

What is cholinesterase (butyryl)?

Cholinesterase (butyryl) (BCHE / BuCHE), also known as pseudocholinesterase, is a protein coding gene and is a serine hydrolase synthesised in the liver and is responsible for catalysing the hydrolysis of numerous choline esters.  It can be found in the liver, intestinal mucosa, plasma, pancreas and the white matter of the central nervous system of mammals.

The Randox Cholinesterase (butyryl) reagent is used for the quantitative in vitro determination of BCHE in serum and plasma. BCHE can be used to diagnose cholinesterase (butyryl) deficiency and curariform drugs toxicity.

The Randox Cholinesterase (butyryl) reagent can also be used as a diagnostic and therapeutic marker for Alzheimer’s disease as BCHE activity progressively increases in patients with Alzheimer’s disease whereas acetylcholinesterase activity remains the same or declines. In Alzheimer’s disease, BCHE is found in association with beta-amyloid plaques and the cerebral cortex, whereas it is not commonly found in any other case. A study carried out by NCBI found that when the BCHE gene is not found in the brain, there are up to 70% less beta-amyloid plaques. For more information on the diagnosis of Alzheimer’s disease, please click here [external link].

Clinical Chemistry Panel

For more information or to view more reagents within the clinical chemistry panel, please click here

Veterinary Panel

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sdLDL Cholesterol Assay

Reagent | Small Dense LDL Cholesterol (sdLDL-C)

Size Matters: The True Weight of Risk in Lipid Profiling

Benefits of the Randox sdLDL-C Assay

Superior Performance

Superior method

The clearance method produces results in as little as ten minutes, facilitating faster patient diagnosis and treatment plan implementation. The previous methods, ultracentrifugation and electrophoresis, were laborious and time consuming.

Exceptional correlation

correlation coefficient of r=0.99 was displayed when the Randox methodology was compared against the gold standard method, ultracentrifugation.

Liquid ready-to-use assay

The Randox sdLDL-C assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Calibrator & Controls

Dedicated calibrator and control available

Dedicated sdLDL-C calibrator and control available offering a complete testing package.

Applications available

Applications are available detailing instrument-specific settings for the convenient use of the Randox sdLDL-C assay on a wide range of clinical chemistry analysers.

  • Ordering Information
  • Physiological Significance
  • Risk Assessment
  • Management
  • Methods of Detection
Cat NoSize
562616R1 1 x 19.8ml (L)
R2 1 x 8.6ml
EnquireKit Insert RequestMSDSBuy Online
CH8153R1 1 x 16.2ml (L)
R2 1 x 8.2ml
EnquireKit Insert RequestMSDSBuy Online
562760 (U)R1 1 x 18ml
R2 1 x 7ml
EnquireKit Insert RequestMSDSBuy Online
562791 *(U)R1 5 x 200ml EnquireKit Insert RequestMSDSBuy Online
562807 *(U)R2 2 x 200mlEnquireKit Insert RequestMSDSBuy Online
(L) Indicates a liquid reagent
(U) Indicates for use in the USA only
(*) Indicates that boths kits must be purchased together

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

When measuring LDL cholesterol (LDL-C), it is the cholesterol mass within the LDL particles that is being measured. The LDL particle population within LDL is heterogeneous – meaning that the size, density & composition of each particle will be different. sdLDL-C is a subfraction of low density lipoprotein (LDL) with smaller particle size and higher density than larger more buoyant LDL. They all transport triglycerides and cholesterol to the tissues, but their atherogenesis varies according to their size. sdLDL-C will more readily permeate the inner arterial wall. sdLDL-C is more susceptible to oxidation and has a lower affinity to the hepatic LDL receptor, and as such circulates in the blood longer1.

As sdLDL-C is particularly atherogenic, a person with elevated sdLDL-C levels has a 3-fold increased risk of myocardial infarction (MI)2.
sdLDL-C measurement therefore provides a more comprehensive understanding of cardiovascular disease (CVD) risk compared to traditional LDL-C tests.

sdLDL-C Scale

Reducing sdLDL-C levels will aid in reducing the risk of CVD and MI. High dose statin therapy has been proven to aid in reducing the levels of sdLDL-C as a risk factor for cardiovascular events and high risk patients. Elevated levels of sdLDL-C arise from multiple sources. A major factor is a sedentary lifestyle with a diet high in saturated fat. Insulin resistance and pre-diabetes have also been implicated, in addition to genetic predisposition3.

The measurement of LDL-C or the review of levels within arteriosclerotic coronary heart disease (ASCHD) treatment are known within different guidelines (including ATP III, AHA/ ACC, ESC/ EAS and NICE). However doubt remains on the impact of targeting LDL-C only. The inclusion of sdLDL-C within the clinical testing panel will assist in removing this doubt.

The only direct automated sdLDL-C kit on the market, the Randox sdLDL-C test is a direct method for the quantitative determination of sdLDL-C using automated chemistry analysers capable of accommodating two-reagent assays. The assay consists of two steps and is based on the use of well-characterised surfactants and enzymes that selectively react with certain groups of lipoproteins.

sdLDL-C Calibrator

sdLDL-C Control

Lipid EQA Scheme


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In order to make your laboratory testing easier, Randox offers a range of clinical chemistry reagents with dedicated barcodes that are optimised for use on a range of specific clinical analysers.

  • All reagents are presented in bottles that fit directly onto the analyser
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  • Simple process saves time and improves laboratory efficiency
  • Offers you freedom of choice from an independent manufacturer

Randox Easy Fit reagents

We are dedicated to providing reagents that fit perfectly with your laboratory needs. In addition to providing an extensive test menu of the highest quality reagents, we also ensure flexibility, convenience and ease-of-use with our Easy Fit reagents bottles.

  • We offer a range of clinical chemistry reagents that are optimised for use on an extensive range of clinical chemistry analysers
  • All reagents are presented in bottles which fit easily onto your analyser avoiding the need to pour reagents into dedicated bottles
  • Randox reagents offer increased accuracy and reliability
  • A wide range of validated analyser applications ensure ease of programming and confidence in results
  • A simple 2 step process allows you to actively run Randox reagents on your clinical chemistry analyser

We also offer general applications that cover a range of requirements from manual use to use on multiple semi-automated and automated analyers.

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The complete A-Z range of reagents offered by Randox.


Valproic Acid

Reagent | Valproic Acid

Valporic Acid Key Benefits

Applications available

For a wide variety of clinical chemistry analysers including the RX series

Strong correlation

The Valproic Acid assay showed a correlation coefficient of 0.99 against another commercially available method

Limited interference

From Bilirubin, Haemoglobin, Intralipid® and Triglycerides

Valproic Acid (Latex Enhanced Immunoturbidimetric) features

  • Latex Enhanced Immunoturbidimetric method
  • Liquid ready-to-use reagents
  • Stable to expiry date when stored at +2 to +8°C
  • Measuring range 8.64-150 µg/ml
  • Applications available

Ordering information

Cat NoSize
TD3414R1 2 x 12ml (L)
R2 2 x 5ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Valproic Acid assay used for?

Valproic acid is a widely used anti-epileptic drug. It is used in the treatment of primary and secondary generalised seizures. Valproic acid has also become increasingly effective in the control of partial seizures. Measurements obtained by this device are used in the diagnosis and treatment of valproic acid overdose and in monitoring levels of valproic acid to ensure appropriate therapy. Within the therapeutic range most individuals will respond well to valproic acid treatment however, the side effects associated with toxicity of this drug can include tremors, gastrointestinal problems, dizziness and vision problems.

Therapeutic Drug Monitoring Panel

For more information or to view more reagents within the therapeutic drug monitoring panel, please click here


Phenytoin

Reagent | Phenytoin

Key Benefits

Exceptional correlation

The Phenytoin assay showed a correlation of r=0.99 against another commercially available method

Wide measuring range

The Randox Phenytoin assay has a wide measuring range of 2.9-44.5 µg/ml, capable of detecting levels beyond the therapeutic range of 10-20 µg/ml

Excellent precision

The Phenytoin assay has a precision of less than 5% CV

Randox Phenytoin (Latex Enhanced Immunoturbidimetric)

  • LEI method
  • Liquid ready-to-use reagents
  • Stable to expiry when stored at 2-8⁰C
  • Measuring range 2.9-44.5 µg/ml
Cat NoSize
TD3409R1 2 x 17ml (L)
R2 2 x 6ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Phenytoin assay used for?

Phenytoin is an anti-epileptic drug used for the control of generalised seizures; however incorrect doses can prove toxic. The effects of incorrect phenytoin treatment can include insomnia, nausea, confusion and fatigue.

Therapeutic Drug Monitoring Panel

For more information or to view more reagents within the therapeutic drug monitoring panel, please click here


Phenobarbital

Reagent | Phenobarbital

Key Benefits

Exceptional correlation

The Phenobarbital assay showed a correlation of r=0.98 against another commercially available method

Applications available

For a wide variety of clinical chemistry analysers including the RX series

Wide measuring range

The Randox Phenobarbital assay has a wide measuring range of 2.55-87.7 µg/ml, capable of detecting levels beyond the therapeutic range of 15-30 µg/ml in infants and children under 5 and 15 – 40 µg/ml in adults

Randox Phenobarbital (Latex Enhanced Immunoturbidimetric)

  • LEI method
  • Liquid ready-to-use reagents
  • Stable to expiry when stored at 2-8⁰C
  • Measuring range of 2.55 – 87.7 μg/ml
  • Limited interference from Bilirubin, Haemoglobin, Intralipid® and Triglycerides
Cat NoSize
TD3408R1 2 x 17ml (L)
R2 2 x 6ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Phenobarbital assay used for?

Phenobarbital is an anti-epileptic and sedative-hypnotic drug. The side effects associated with an incorrect phenobarbital prescription can include drowsiness, depression, headaches and dizziness.

Therapeutic Drug Monitoring Panel

For more information or to view more reagents within the therapeutic drug monitoring panel, please click here


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