Siemens Dimension RxL/ Xpand

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Siemens Dimension RxL/ Xpand

Randox Acetaminophen Reagent

Applications for Siemens Dimension RxL/Xpand

We develop a range of applications for the Siemens Dimension RxL/ Xpand analysers so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer, Randox Laboratories.

We have 44 reagents available for the Siemens Dimension RxL/ Xpand, and are always developing more. If you don’t see the application you are looking for, please contact us to request an application. All kits are produced to international standard and have ISO 13485 accreditation.

Randox applications available

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Get in touch with Randox via email at reagents@randox.com

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Download kit Inserts free on our online portal.

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Hitachi 917/Modular P

Randox Acetaminophen Reagent

Applications for Hitachi 917 / Modular P

Randox have developed a range of applications for the Hitachi 917 and Modular P analysers so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer.

Email Us

Get in touch with Randox via email at reagents@randox.com

Need Instructions?

Download kit inserts for free on our online portal

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Order reagents kits online by visiting our online store 


Hitachi 717/911/912

Applications for Hitachi 717 / 911 / 912 Analysers

Randox have developed a range of applications suitable for the Hitachi 717 /911 /912 analysers, so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer.

Hitachi 717 / 911 / 912 Applications

We have 85 reagents available for the Hitachi 717 / 911 / 912, and are always developing more. If you don’t see the application you are looking for, please email us to request an application. All kits are produced to international standard and have ISO 13485 accreditation.

Please note: The Hitachi 717 analyser does not have a barcode reading facility therefore Easy Read kits for this analyser will require the necessary ISA

Email Us

Get in touch with Randox via email at reagents@randox.com

Need Instructions?

Download kit inserts for free on our online portal

Buy Online

Order reagents kits online by visiting our online store 


Microalbumin Assay

Reagent | Microalbumin

Microalbumin: An Independent Predictor of Progressive Renal Disease

Benefits of the Randox Microalbumin Assay

Exceptional correlation

A correlation coefficient of r=0.99 was displayed when the Randox microalbumin assay was compared to commercially available methods.

Dedicated calibrator & controls available

Dedicated calibrator and controls available offering a complete testing package.

Excellent precision

The Randox microalbumin assay displayed a precision of <4.8% CV.

Liquid ready-to-use

The Randox microalbumin assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox microalbumin assay on a variety of clinical chemistry analsyers.

Ordering Information

Cat NoSize
MA2426R1 1 x 60ml (C) (L)
R2 1 x 7ml
EnquireKit Insert RequestMSDSBuy Online
MA3828R1 6 x 20ml (L)
R2 3 x 8ml
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MA8056R1 2 x 20ml (L)
R2 2 x 6.6ml
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MA8325R1 1 x 20ml (L)
R2 1 x 4.6ml
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MA4072R1 3 x 20ml (L)
R2 3 x 7.5ml
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MA8388R1 1 x 20ml (L)
R2 1 x 7.8ml
EnquireKit Insert RequestMSDSBuy Online
MA8160R1 2 x 20ml (L)
R2 2 x 9ml
EnquireKit Insert RequestMSDSBuy Online
(C) Indicates calibrator included in kit
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

  • PHYSIOLOGICAL SIGNIFICANCE
  • Clinical Significance

Albumin is one of the major plasma proteins and is usually present in very low concentrations in urine. Damage to the glomerular basement membrane can alter its permeability meaning albumin and other proteins usually reabsorbed and recirculated in the blood enter the urine. Sustained elevations of urinary albumin concentrations are called microalbuminuria 1.

Microalbuminuria is strongly associated with poor glycaemic control, hypertension and other diabetic complications including ischaemic heart disease, diabetic retinopathy and neuropathy. Microalbumin is an early biomarker of diabetic nephropathy, the most common complication of type 2 diabetes mellitus (T2DM) 2. Microalbuminuria is an independent predictor of progressive renal disease and cardiovascular mortality. Due to the increasing prevalence of obesity, type 2 diabetes and metabolic syndrome in children, screening for microalbuminuria seems highly relevant in the paediatric population to detect and prevent cardiovascular disease 3.

Microalbumin Calibrator

Human Urine EQA

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Transferrin

Reagent | Transferrin

Key Benefits

Excellent precision

The Transferrin assay has a precision of less than 5% CV

Applications available

For a wide variety of clinical chemistry analysers including the RX series

Strong correlation

The Transferrin assay showed a correlation coefficient of 0.98 against another commercially available method utilising a BCR/CAP/IFCC CRM 470 international standard

Randox Transferrin (Immunoturbidmetric)

  • Immunoturbidimetric method
  • Liquid ready-to-use reagents
  • Stable to expiry at 2-8⁰C
  • Measuring range 7.60-536 mg/dl
  • Applications available
Cat NoSize
TF3831R1 6 x 20ml (L)
R2 3 x 14ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Transferrin assay used for?

Transferrin (siderophilin) is the principal iron binding and transport protein in human plasma and can bind two molecules of iron. The normal range for healthy adults is 200-400 mg/dl. Iron availability in the plasma regulates transferrin levels which increase when plasma iron is low.

Transferrin levels increase during pregnancy and oestrogen administration and correlate closely with Total Iron Binding Capacity of serum. Plasma transferrin levels are associated with a range of conditions including anaemia, iron deficiency, inflammation or malignancy, liver disease, malnutrition and protein loss.

Transferrin can also be described as a preventative antioxidant and acts by binding iron in a redox inactive form. This process is extremely important as free iron is capable of stimulating the production of harmful free radicals

Antioxidant Panel

For more information or to view more reagents within the antioxidant panel, please click here

Specific Proteins Panel

For more information or to view more reagents within the specific proteins panel, please click here

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Total Iron Binding Capacity (TIBC)

Reagent | Total Iron Binding Capacity (TIBC)

Key Benefits

Exceptional correlation

The TIBC assay showed a correlation coefficient of 0.9 against another commercially available method

Eliminates negative bias

Traditional calculation methods using the unsaturated iron-binding capacity (UIBC) and serum iron (TIBC = UIBC + serum iron) have a significant negative bias compared with direct TIBC methods. Randox’s TIBC assay eliminates this bias

Excellent precision

The TIBC assay has a precision of less than 4% CV

Randox Total Iron Binding Capacity (TIBC) (Colorimetric)

  • Colorimetric method
  • Liquid ready-to-use reagents
  • Eliminates negative bias
  • Stable to expiry when stored at 2-8⁰C
  • Minimal interferences
Cat NoSize
TI4064R1 4 x 9ml (L)
R2 4 x 4ml
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TI8065R1 4 x 8.7ml (L)
R2 4 x 4.9ml
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TI8375R1 4 x 10ml (L)
R2 4 x 5.1ml
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(L) Indicates liquid option

What is Total Iron Binding Capacity (TIBC) assay used for?

Iron is transported in the blood by the serum protein transferrin. Transferrin is normally 30% saturated, that is 30% of the iron-binding sites contain an iron atom. The total iron-binding capacity (TIBC) is the amount of iron needed to 100% saturate transferrin. TIBC reflects iron status: levels are elevated when iron levels are low; therefore it is useful in the diagnosis and monitoring of iron deficiency anaemia and iron deficiency in late pregnancy. Abnormal levels of TIBC can point towards a variety of disease states such as hereditary haemochromatosis, a common genetic disorder where iron levels are excessive, other anaemias, liver disease and malnutrition.

Antioxidant Panel

For more information or to view more reagents within the antioxidant panel, please click here

Stay up-to-date with the latest Randox Reagents news & events


Glutathione Reductase

Reagent | Glutathione Reductase

Key Benefits

Applications available

For a wide variety of clinical chemistry analysers

Exceptional correlation

The Glutathione Reductase assay showed a correlation of r=0.988 against another commercially available method

Excellent linearity

387 U/l, removing the need for sample dilution

Randox Glutathione Reductase (UV)

  • UV method
  • Lyophilised reagents
  • Working reagent stable for 2 days when stored at 2-8°C
  • Measuring range 9.69 – 387 U/l

Ordering Information

Cat NoSize
GR2368R1 5 x 5ml
R2 5 x 3ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Glutathione Reductase assay used for?

Glutathione Reductase is required for the regeneration of reduced glutathione which is important for normal cellular metabolism. This enzyme is often discussed in association with Glutathione Peroxidase, which requires reduced glutathione for activation. Glutathione Reductase is responsible for maintaining levels of reduced glutathione which has many important functions in the cell. Glutathione plays a role in protein folding and the maintenance of reduced pools of vitamin C and E. Reduced levels of this enzyme have been described in several diseases.

  • Seghrouchni, I., et al. (2002) Oxidative stress parameters in type I, type II and insulin-treated type 2 diabetes mellitus; insulin treatment efficiency. Clin. Chim. Acta. 321(1-2): 89-96
  • Zachwieja, J. et al. (2003) Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome. Med. Sci. Monit., 9:CR287-291
  • Malinowski, E., et al. (2004) The effect of some drugs injection to pregnant heifers on blood antioxidant status. Pol. J. Vet. Sci.,7: 91-95
  • Banfi, G., et al. (2006) Plasma oxidative stress biomarkers, nitric oxide and heat shock protein 70 in trained elite soccer players.Eur. J. Appl. Physiol., 96: 483-486
  • Celik, I., et al. (2006) Antioxidant and immune potential marker enzymes assessment in the various tissues of rats exposed to indolacetic acid and kinetin: A drink water study. Pesticide Biochemistry and Physiology. 86: 180-185
  • Tátrai, E., et al. (2006) Redox status and expression of chemokines in the rat lungs on exposure to asbestos and asbestos substituents. Neuro. Endocrinol. Lett. 27 Suppl 2: 40-43
  • Drelich, G., et al. (2007) (Article in Polish) Imbalance of oxidoreductive status in suicidal antidepressant drugs poisoning. Przegl. Lek. 64: 258-259
  • Čolak, E. et al. (2008) Biomarkers of enzymatic and non-enzymatic antioxidative defense in type 2 diabetes mellitus-comparative analysis. Biochemia Medica. 18 (2): 42-51
  • Perše, M., et al. (2009) Effect of high-fat mixed-lipid diet and exercise on the antioxidant system in skeletal and cardiac muscles of rats with colon carcinoma. Pharmacol. Rep. 61(5): 909-916
  • Biljak, V.K.. et al. (2010) Glutathione cycle in stable chronic obstructive pulmonary disease. Cell Biochem. Funct. 28(6): 448-453
  • Singh, N. et al. (2010) Adverse health effects due to arsenic exposure: Modification by dietary supplementation of jaggery in mice. Toxicol. Appl. Pharmacol. 242(3): 247-255
  • Djordjevic, J., et al. (2011) Fluoxetine affects antioxidant system and promotes apoptotic signalling in Wistar rat liver. Eur. J.Pharmacol. 659(1): 61-66
  • Huo, H.Z., et al. (2011) Hepatoprotective and antioxidant effects of licorice extract against CCl4-induced oxidative damage in rats. Int. J. Mol. Sci. 12: 6529-6543
  • Voljč., M., et al. (2011) Evaluation of different vitamin E recommendations and bioactivity of α-tocopherol isomers in broiler nutrition by measuring oxidative stress in vivo and the oxidative stability of meat. Poult. Sci. 90(7): 1478-1488
  • Dogliotti, G., et al. (2012) Natural zeolites chabazite/phillipsite/analcime increase blood levels of antioxidant enzymes. J. Clin. Biochem. Nutr. 50(3): 195-198
  • Gravina, L., et al. (2012) Influence of nutrient intake on antioxidant capacity, muscle damage and white blood cell count in female soccer players. J. Int. Soc. Sports Nutr. 9(1): 32
  • Hübner-Wózniak E., et al. (2012) Effect of rugby training on blood antioxidant defenses in able-bodied and spinal cord injured players. Spinal Cord 50(3): 253-256
  • Herbet, M., et al. (2013) Influence of combined therapy with rosuvastatin and amitriptyline on the oxidation-reduction status in rats. Acta Poloniae Pharmaceutica. 70(5): 913-917

Diabetes Panel

For more information or to view more reagents within the diabetes panel, please click here


IgA

Reagent | IgA

Key Benefits

Excellent precision

The IgA assay showed a precision of less than 3% CV

Exceptional correlation

The assay showed a correlation of r=0.98 against another commercially available method

Interference

There is no cross reaction with IgG and IgM under the conditions of the assay. Extremely lipaemic or haemolytic samples and high levels of ionic detergents may interfere in the assay

Other features

  • Immunoturbidimetric method
  • Liquid ready-to-use reagents
  • Stable to expiry when stored at +2⁰C to +8⁰C
Cat NoSize
IA3832R1 3 x 20ml (L)
R2 3 x 14ml
EnquireKit Insert RequestMSDSBuy Online
IA8046R1 5 x 8.7ml (L)
R2 5 x 3.9ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is IgA assay used for?

Measurement of IgA is used to diagnose diseases of the respiratory tract e.g. tuberculosis, Crohn’s disease and early cirrhosis of the liver. It is also useful in monitoring therapy of IgA myeloma and evaluating IgA immunity. IgA in colostrum and milk is important in neonatal defence against infection.

The Randox IgA assay is an immunoturbidimetric end-point method for manual use and on automated analysers. The increase in turbidity in a sample containing human IgA is measured at 340 nm. By constructing a standard curve from the absorbances of standards, the IgA concentration of a sample can be determined.

Specific Proteins Panel

For more information or to view more reagents within the specific proteins panel, please click here


Haptoglobin

Reagent | Haptoglobin

Key Benefits

Excellent traceability

Standardised to Certified Reference Material (CRM Da470k/IFCC)

Exceptional correlation

A correlation coefficient of r=0.97 was obtained against another commercially available kit

Excellent stability

Onboard reagent stability of 28 days. Calibration is only required every seven days

Other features and benefits

  • Immunoturbidimetric method
  • Liquid reagents
  • Stable to expiry when stored at +2 to +8°C
  • Fully automated applications available for a wide range of clinical chemistry analysers

Ordering information

Cat NoSize
HP3886R1 1 x 12ml (L)
R2a 1 x 3.2ml
R2b 1 x 0.625ml
EnquireKit Insert RequestMSDSBuy Online
HP8151R1 1 x 12ml (L)
R2 2 x 4.2ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Haptoglobin assay used for?

Haptoglobin measurements are used in the diagnosis of haemolytic anaemia and to distinguish it from other types of anaemia. In haemolytic anaemia, haptoglobin levels in the blood decrease significantly. Low levels however may also indicate red blood cell destruction due to sickle cell anaemia or thalassemia. In certain cases of liver disease haptoglobin levels may also be low, as the liver cannot manufacture normal levels of the protein.

As an acute phase reactant haptoglobin levels in the blood are significantly increased in response to infection, inflammation, burns, surgery and trauma. However, haptoglobin is not generally used to diagnose or monitor these conditions.

Publications


    Specific Proteins Panel

    For more information or to view more reagents within the specific proteins panel, please click here


    Complement C4 Reagent

    Reagent | Complement C4

    Key Benefits of the Randox Complement C4 reagent

    Exceptional correlation with standard methods

    The Randox methodology was compared against other commercially available methods and the Randox Complement C4 assay showed a correlation coefficient of r=0.98

    Wide measuring range

    The healthy range for Complement C4 is 7 -49 mg/dl. The Randox Complement C4 assay can comfortably detect levels outside of the healthy range measuring between 2.90 – 152 mg/dl

    Excellent stability

    Stable until expiry date when stored at +2 to +8°C

    Other features of the Randox Complement C4 reagent

    • Immunoturbidimetric method
    • Liquid ready-to-use reagents
    • Stable until expiry date when stored at +2 to +8°C
    • Measuring range 2.90 – 152 mg/dl

    Ordering information

    Cat NoSize
    CM3846R1 3 x 20ml (L)
    R2 3 x 6ml
    EnquireKit Insert RequestMSDSBuy Online
    CM8024R1 2 x 11.2ml (L)
    R2 2 x 4.2ml
    EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid option

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is the Complement C4 assay used for?

    What is Complement C4?

    The complement system is one of the major mechanisms of innate immunology consisting of more than 30 plasma and membrane-associated serum proteins which evokes cytolytic immune responses to pathogens, including viruses, bacteria, chemical tissue damage and anything that is classified as foreign to the body. The complement system can be activated through three major pathways: classical, lectin or alternative. Once activated, reactions occur for antibody opsonisation (the process by which a phagocyte marks a pathogen for ingestion and elimination) to fight against the foreign bodies.  Activation can also occur when the body produces antibodies for its own tissues that it views as being foreign, which is known as an autoimmune disorder.

    During the activation process, Complement C4 splits down into C4b and C4a (peptide). C4b acts as an opsonin and remains bound to the complex at the surface of the pathogen which activates the next step of the process. The small peptide, C4a diffuses away and acts as a chemotactic factor and an inflammatory paracrine.

    The Randox Complement C4 assay is used for the quantitative in vitro determination of complement C4 concentration in serum.  The Randox Complement C4 assay allows for the diagnosis and monitoring of autoimmune disorders associated with abnormal levels of complement C4 including lupus and rheumatoid arthritis (RA).  Higher than normal results may be indicative of cancer or ulcerative whereas lower than normal results may be indicative of lupus, hepatitis, or cirrhosis.

    Cell-bound levels of processed complement activation products, especially E-C4d (erythrocyte-bound C4) is a biomarker in the diagnosis and monitoring of systematic lupus erythematous (SLE). For more information on SLE, please click here.

    Specific Proteins Panel

    For more information or to view more reagents within the specific proteins panel, please click here


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