Alkaline Phosphatase Reagent

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Alkaline Phosphatase Reagent

Reagent | Alkaline Phosphatase (DEA Method)

Benefits of the Randox Alkaline Phosphatase reagent

Suitable for use on a range of analysers

Alkaline phosphatase can be used on third-party analysers. To enquire about an Instrument Specific Application (ISA), please contact us.

Liquid ready-to-use reagents

 Available in liquid format which is more convenient as the reagent does not need to be reconstituted which aids in reducing the risk of misdiagnosis.

Excellent stability

Stable to expiry when stored at +2 to +8°C

DEA method

  • Available as liquid and lyophilised reagents
  • Stable to expiry when stored at +2 to +8⁰C
  • Measuring range 16.3 – 2183 U/l

Ordering Information

Cat NoSize    
AP9764R1 7 x 38ml (L)
R2 7 x 11.7ml
EnquireKit Insert RequestMSDSBuy Online
AP3803R1 6 x 51ml (L)
R2 6 x 14ml
EnquireKit Insert RequestMSDSBuy Online
AP30710 x 10mlEnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

AMP method

  • Available as liquid and lyophilised reagents
  • Stable to expiry when stored at +2 to +8⁰C
  • Measuring range 18 – 1273 U/

Ordering Information

Cat NoSize    
AP3802R1 6 x 51ml (L)
R2 6 x 14ml
EnquireKit Insert RequestMSDSBuy Online
AP7927R1 5 x 100ml (L)
R2 5 x 20ml
EnquireKit Insert RequestMSDSBuy Online
AP8002R1 7 x 20ml (L)
R2 7 x 8ml
EnquireKit Insert RequestMSDSBuy Online
AP8302R1 4 x 20ml (L)
R2 4 x 7ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is this assay used for?

Alkaline Phosphatase is an enzyme found in the liver, bone, kidney, digestive system and bowel tissues. The highest concentrations of Alkaline Phosphatase are contained within the tissues that make up the bone and liver.

The Alkaline Phosphatase test can be used to diagnose and monitor liver disease and damage including liver cancer, cirrhosis and hepatitis. This assay can also be used to diagnose and monitor bone damage and disease including cancers that have spread to the bone, Paget’s disease which affects how the bones grow, and issues associated with Vitamin D deficiencies.

For more information on the incidence and natural history of Paget’s disease of the bone in England and Wales, please click here.

The Randox tests can also be carried out to determine the root cause of elevated alkaline phosphatase in the blood as well as to monitor liver damage as the result of therapeutic treatment or prescribed drugs that can have implications on the liver.


Events

EVENTS CALENDAR 2021

Randox Events Calendar

After what has been an unprecedented year of travel restrictions due to the global pandemic, we look forward to slowly transitioning back to business as usual – or in some cases the new ‘virtual’ normal!

Whether it’s face-to-face or digital attendance from the comfort of the office, Randox have a wealth of new products and innovative technologies to share with the industry. Check out below what events Randox will be attending this year. We hope to see you there!

EVENT: Medlab Middle East, 2021

DATES: Live 21-24 June 2021 / Online 23 May – 22 July 2021

Randox are attending the live show at the Dubai World Trade Centre on 21-24 June 2021. If you are unable to attend we are showcasing all of our latest product portfolio and services virtually online, starting on 23 May – 22 July 2021.

Visit the Medlab Middle East website here

EVENT: Goodwood Festival of Speed, 2021

DATES: 8-11 July 2021

Randox are attending Goodwood Festival of Speed. Visit our stand at the live Future Lab exhibition and immerse yourself in the latest technologies from Randox.

Visit the Goodwood Festival of Speed website

EVENT: Goodwood Revival, 2021

DATES: 17-19 Sept 2021

Randox are attending Goodwood Revival to celebrate bygone days, vintage fashion and motor racing around the classic circuit, but that’s not all! Randox will be casting a light on all the latest technologies in Clinical Diagnostics to showcase just how far we have come in helping to improve global health worldwide. More details coming soon so stayed tuned.

Visit the Goodwood Revival website

EVENT: 34th Medical & Scientific Virtual Conference 2021

DATES: Online 7, 13, 15, 20, 22 July 2021

Visit our virtual stand for stimulating educational content, webinars, abstracts and networking opportunities.  Heart UK are offering reduced registration fees and with no travel costs all that is required is your time.

Visit the Heart UK website here


Aldolase Assay

Reagent | Aldolase

A Myositis Biomarker

Benefits of the Randox Aldolase Assay

Exceptional correlation

A correlation coefficient of r=0.9917 was displayed when the Randox methodology was compared against commercially available methods.

Excellent measuring range

The Randox aldolase assay has a measuring range of 1.73 – 106U/l for the comfortable detection of clinically important results.

Lyophilised reagents

Lyophilised reagents offer enhanced stability, reducing wastage.

Excellent precision

The Randox assay displayed a within run precision < 4.47% CV.

Dedicated calibrator and controls available

Randox offer a dedicated aldolase calibrator and controls for a complete testing package.

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox aldolase assay on a variety of clinical chemistry analysers.

Ordering information

Cat NoSize    
AD1895 x 20mlEnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Clinical Significance

Elevated levels of aldolase are detected in myotonic muscular disease, including: polymyositis and progressive muscular dystrophy. Elevated levels of this enzyme have been observed in acute coronary syndromes 1. This enzyme has been identified as a myositis biomarker, a muscle-wasting disease resulting in reduced muscle strength and fatigue 2. Testing this enzyme can be utilised as a marker in the differential diagnosis of muscle weakness as aldolase levels remain consistent where weakness is caused by neurological problems such as multiple sclerosis (MS) 3.

Physiological Significance

Aldolase is a glycolytic enzyme responsible for catalysing the conversion of fructose 1-6-diphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate via the glycolysis metabolic pathway. This enzyme is present in all bodily cells, more commonly in the nucleus and cytoplasm. It has been identified as having three isoforms: A, B and C. Isoform A is found bound to the actin-containing filament of the cytoskeleton. By binding (reversible) to these filaments, aldolase aids in regulating cell contractions. The highest concentrations of this enzyme are present in the brain, liver and muscles 1.

Related Products

Aldolase Calibrator

Aldolase Control

A-Z Randox Reagents


Anti-Streptolysin O (ASO) Reagent

Reagent | Anti-Streptolysin O (ASO)

Key benefits of the Anti-Streptolysin O reagent

Excellent correlation to standard methods

The Randox Anti-Streptolysin O assay showed an excellent correlation coefficient of 0.97 compared against other commercially available methods.

Excellent stability

Stable until expiry date when stored at +2 to +8°C

Specificity

The antiserum of Randox Anti-Streptolysin O is monospecific for human ASO and has not been shown to cross react with other serum proteins.

Liquid ready-to-use

Available in a liquid ready-to-use format for convenience and ease-of-use.

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox albumin assay on a variety of clinical chemistry analysers.

Excellent precision

The Randox assay displays a measuring range 28 – 1314 IU/ml

Ordering information

Cat NoSize    
LO3998R1 2 x 9ml
R2 2 x 14ml
EnquireKit Insert RequestMSDSBuy Online
LO8305R1 1 x 7.7ml
R2 1 x 11.2ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the Anti-Streptolysin O (ASO) assay used for?

What is Anti-Streptolysin O (ASO)?

Streptolysin O (SLO) is a toxic and lethal, exocellular immunogenic protein produced and released in response to Group A Streptococcal pyogenes.  For more information on streptococcal infections, please click here [external link].  The release of SLO stimulates the production of Anti-Streptolysin O (ASO) antibodies to neutralise the SLO’s haemolytic effects. The O in the name stands for oxygen-labile.

What is the Anti-Streptolysin O (ASO) assay used for?

The Anti-Streptolysin (ASO) test is used to determine recent streptococcal infection and post streptococcal complications which includes rheumatic fever and glomerulonephritis. The presence and level of ASO antibodies in human serum directly reflects the extent and degree of infection. Elevated levels of ASO may also be present in other conditions including scarlet fever, acute rheumatoid arthritis, tonsillitis and various other streptococcal infections as well as in health carriers.

The Randox Anti-Streptolysin (ASO) assay is used to measure the presence of anti-streptolysin antibodies in the blood to determine if a strep infection is present.

Specific Protein Panel

For more information or to visit more reagents within the specific proteins panel, please click here.

Rapid Tests / Serology Panel

For more information or to visit more reagents within the rapid tests / serology panel, please click here.


Antioxidant Reagents

Why Choose Randox Antioxidants Reagents?

The Randox range of antioxidant reagents are designed for use within a variety of sectors including clinical, research, veterinary, pharma, food and beverages, cosmetics and sports. Furthermore, our range of antioxidant reagents include routine antioxidant reagents, as well as more specialised tests that are unique to Randox.

Download our Antioxidants Brochure

Randox Antioxidant Reagents Benefits

  • Suitable for automation which removes the inconvenience and time consumption associated with traditional ELISA based testing options
  • Instrument Specific Applications (ISA’s) are available for an extensive range of clinical chemistry analysers which includes detailed instrument specific settings for increased convenience.
  • Suitable for a wide variety of sample types, including whole blood (human and animal), serum, plasma, erythrocytes, among others
  • Randox antioxidants are available in liquid and lyophilised formats
  • Suitable for automation which removes the inconvenience and time consumption associated with traditional ELISA based testing options
  • A variety of kits, methods and ranges are available

The role of antioxidant reagents

Antioxidants are important for the body’s immune system to protect the body against free radical attacks. Randox provides a range of antioxidant reagents to assess all three levels of the body’s defence system (preventative antioxidants, scavenging antioxidants and repair enzymes).

Preventative antioxidants – inhibit the formation of free radicals including metal binding proteins like; Ceruloplasmin, Metallothionine, Albumin, Transferrin, Ferritin and Myoglobin.

Repair enzymes – repair damaged biomolecules such as DNA repair enzymes.

Scavenging antioxidants – remove any reactive species once formed such as Superoxide Dismutase, Glutathione Peroxidase, Catalase and small molecules including Ascorbate, Tocopherol, Bilirubin, Uric Acid, Carotenoids and Flavonoids.

Antioxidant benefits against disease

Free radicals have been found to play a role in the development of many diseases including cancer (free radicals are thought to promote cell transformation into a cancer cell), arthritis and inflammatory diseases (increased oxidative stress in rheumatoid arthritis patients suggests antioxidants could have an important role), cardiovascular disease (antioxidants have been found to improve cardiac health), and Alzheimer’s disease (antioxidants have a role in removing deleterious free radicals from the brain).

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Get in touch with Randox via email at reagents@randox.com

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Amylase Reagent

Reagent | Amylase

Key Benefits of the Randox Amylase reagent

Wide measuring range – The healthy range for amylase is 30 – 100 U/l. The Randox reagent can comfortably detect levels outside of this range measuring between 7.3 – 1245 µmol/l.

Excellent stability – Stable to expiry when stored at +2 to +8°C

Methodology – Ethylidene PNPG7 method

Liquid ready-to-use reagents – The Randox reagent comes in a liquid ready-to-use format which is more convenient as the reagent does not need to be reconstituted which aids in reducing the risk of errors occurring

Ordering information

Cat NoSize    
AY3805R1 4 x 16ml (L)
R2 4 x 5ml (L)
EnquireKit Insert RequestMSDSBuy Online
AY7931R1 6 x 50ml (L)
R2 4 x 18ml
EnquireKit Insert RequestMSDSBuy Online
AY158020 x 5mlEnquireKit Insert RequestMSDSBuy Online
AY8004R1 7 x 18ml (L)
R2 7 x 7.3ml
EnquireKit Insert RequestMSDSBuy Online
AY8335R1 4 x 20ml (L)
R2 4 x 7ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Amylase used for?

It is a digestive enzyme / special protein produced by the pancreas and salivary glands.  Salivary amylase is responsible for breaking down starch in the mouth and converting it into maltose.  Pancreatic amylase passes through a duct from the pancreas to the small intestine where the digestive process is completed through converting starch into glucose.  The glucose is then absorbed into the blood and carried throughout the body.

Damage or inflammation to the pancreas can result in under / over production of amylase which can be a sign of pancreatic disorder which includes pancreatic pseudocyst, pancreatic abscess, pancreatic cancer, gallbladder disease, mumps or ectopic pregnancy.  For more information on pancreatic cancer, please click here. The Randox assay is used for the quantitative in vitro determination of amylase activity in serum, urine and plasma.


Randox Toxicology Highly Sensitive ELISA kits

Enzyme-linked immunosorbent assay, or ELISA, has been utilised as a screening tool for some time. The immunoassay technique is a popular choice for the evaluation of various research and diagnostic targets including drugs of abuse testing.

As primary manufacturer of the Biochip Array Technology, Randox Toxicology also provide highly sensitive ELISA kits that are compatible with all microplate processing instruments. Our test menu covers a broad range of drugs of abuse and metabolites including new psychoactive substances, stimulants, analgesics and sedatives. With low specificity, our ELISA kits are available across whole blood, urine and oral fluid matrices. Randox Toxicology develop the highest quality 96-well microtitre plates available on the market, with results providing excellent correlation with confirmatory methods.

Our range of ELISAs are precoated with our own antibodies which are cultivated in the UK. The ready to use reagent format facilitates optimum laboratory efficiency and allows up to 80 samples to be analysed in 2 to 3 hours with ELISA procedures.

 

* EXCLUSIVE to Randox Toxicology

 

For more information on our ELISA solutions email info@randoxtoxicology.com to be put in touch with a sales member in your area or visit www.randoxtoxicology.com.

 

 


Ammonia Reagent

Ammonia

Key Benefits of the Randox Ammonia reagent

Wide measuring range

The Randox Ammonia reagent can comfortably detect excessive concentration levels in the blood with a measuring range of 16.9 – 1180 µmol/l

Excellent stability

Stable to expiry when stored at +2 to +8°C

Suitable for use on a range of analysers

The Randox Ammonia reagent is suitable to use on a number of third party analysers Including Abbott, Olympus, Cobas and Hitachi.

Other features

  • Enzymatic UV method
  • Lyophilised reagents
  • Stable to expiry when stored at +2 to +8°C
  • Measuring range 16.9 – 1180 µmol/l

Ordering information

Cat NoSize    
AM101510 x 5ml (C)EnquireKit Insert RequestMSDSBuy Online
(C) Indicates calibrator included in kit

(S) Indicates standard included in kit

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Ammonia assay used for?

The Randox assay is used for the quantitative in vitro determination of ammonia in plasma.

Ammonia is a nitrogen waste compound and forms when the protein is broken down by bacteria in the intestines.  The liver then converts it into urea which is normally excreted from the body in urine.  Excessive concentration levels is poisonous to cells and occurs as a result of liver or kidney malfunctions.  Several diseases, both inherited and acquired can result in significantly elevated concentration levels resulting in hyperammonemia.

Reye’s syndrome is an acquired hyperammonemia disease and is characterised by high concentration levels of ammonia and decreased concentration levels of glucose. As such, an ammonia test is not usually carried out independently and is usually tested alongside glucose, electrolytes, kidney and liver function tests in adolescents and children showing symptoms.  For more information on Reye’s syndrome, please click here . Excessive concentration levels is also associated with both liver disease and renal failure which is toxic to the central nervous system.


Alanine Aminotransferase (ALT) Reagent

Alanine Aminotransferase (ALT) Reagent

Key Benefits of the Alanine Aminotransferase (ALT) reagent

Wide measuring range

The healthy range for ALT is 7 – 56 U/l but the Randox Alanine Aminotransferase (ALT) assay can comfortably detect levels outside of the healthy range, measuring from 4.25 – 666 U/l

Excellent Stability

ALT is stable to expiry when stored at +2 to +8°C

Suitable for use on a range of analysers

Alanine Aminotransferase (ALT) Reagent is suitable to use on a number of third party analysers Including Abbott, Olympus, Cobas and Hitachi.

More features of the Alanine Aminotrabsferase (ALT) reagent

  • IFCC method
  • Available as liquid and lyophilised reagents
  • Stable to expiry when stored at +2 to +8°C
  • Wide Measuring range 4.25 – 666 U/l

Ordering information

Cat NoSize    
AL120510 x 10mlEnquireKit Insert RequestMSDSBuy Online
AL7930R1 7 x 100ml (L)
R2 3 x 60ml
EnquireKit Insert RequestMSDSBuy Online
AL3801R1 6 x 51ml (L)
R2 6 x 14ml
EnquireKit Insert RequestMSDSBuy Online
AL8006R1 6 x 56ml (L)
R2 6 x 20ml (Mod. IFCC)
EnquireKit Insert RequestMSDSBuy Online
AL8304R1 4 x 20ml (L)
R2 4 x 7ml (Mod ?IFCC)
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Randox ALT-Colorimetric ordering information

Cat NoSize    
AL1462 x 100ml (S)EnquireKit Insert RequestMSDSBuy Online
(S) Indicates standard included in kit

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is ALT assay used for?

Alanine Aminotransferase is one of the enzymes within the aminotransferases group and are among the most sensitive liver enzymes. The highest concentrations of the ALT enzyme can be in the liver, with decreasing concentrations found in the kidneys, heart, skeletal muscle, pancreas, spleen and lung tissue respectively.

ALT measurements are used in the diagnosis of hepatic damage and diseases including viral hepatitis and cirrhosis.

The normal concentration levels of ALT in the blood are low, however, when damaged, the liver releases more ALT into the blood causing the concentration levels to rise.  When diagnosing for hepatic damage, the root cause of the damage can be established, such as disease, drug, or injury

The ALT test not only allows for the diagnosis of liver disease but also allows for the diagnosis of the root cause of the disease

It is often tested in combination with the aspartate aminotransferase (AST) test as part of the hepatic panel with alanine aminotransferase levels being higher in most types of liver disease.  For more information on the validity and clinical utility of AST and ALT when assessing disease severity, please click here


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