Conjugates

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Conjugates

Conjugates

Randox’s antigen-HRP conjugates are optimized for use with Randox polyclonal antibodies for the development of immunoassays. All HRP-conjugates are provided in a conjugate stabilising solution, specifically formulated in-house to prolong the shelf-life of newly conjugated material, enhancing the conjugate’s overall performance and reliability within your immunoassay.

Product NameCat NumberSizeGet In Touch
3-Acetyl-DON HRP97110.5mlEnquire Now
4-AHD (Aminohydantoin)HRP92550.5mlEnquire Now
4-AMOZHRP93550.5mlEnquire Now
4-AOZHRP93540.5mlEnquire Now
5-Hydroxyindole Acetic AcidHRP94760.5ml Enquire Now
17α-Nortestosterone HRP93090.5mlEnquire Now
17α-Boldenone HRP92460.5mlEnquire Now
17α-Estradiol HRP92590.5mlEnquire Now
17α HydroxyprogesteroneHRP94140.5mlEnquire Now
17α-Testosterone HRP92600.5mlEnquire Now
17α-Trenbolone HRP92440.5mlEnquire Now
17β-Boldenone HRP92480.5mlEnquire Now
17β-Estradiol HRP93520.5mlEnquire Now
17β-Estradiol-short linkerHRP93510.5mlEnquire Now
17β-Testosterone HRP92280.5mlEnquire Now
17β-Trenbolone HRP92450.5mlEnquire Now
17β-Nortestosterone HRP93690.5mlEnquire Now
Acepromazine HRP94690.5mlEnquire Now
Albendazole HRP92190.5mlEnquire Now
Albendazole HRP96050.5mlEnquire Now
AmitriptylineHRP93860.5mlEnquire Now
AmikacinHRP94300.5mlEnquire Now
AmpicillinHRP93390.5mlEnquire Now
Androstenedione HRP93070.5mlEnquire Now
Avilamycin HRP96150.5mlEnquire Now
Azaperone HRP95030.5mlEnquire Now
Benzimidazole HRP94090.5mlEnquire Now
Carazolol HRP96240.5mlEnquire Now
Carbadox HRP92710.5mlEnquire Now
Carbamazepine HRP94980.5mlEnquire Now
Carbamazepine HRP95110.5mlEnquire Now
Carboxymethyl LSD HRP94810.5mlEnquire Now
Cephalexin HRP96420.5mlEnquire Now
ChloramphenicolHRP92630.5mlEnquire Now
Chlormadinone Acetate HRP92300.5mlEnquire Now
Chlorpromazine HRP94570.5mlEnquire Now
Cimaterol HRP94100.5mlEnquire Now
ClostebolHRP92430.5mlEnquire Now
Closantel HRP96170.5mlEnquire Now
Cocaine HRP95240.5mlEnquire Now
CocaineHRP93350.5mlEnquire Now
CodeineHRP93170.5mlEnquire Now
Cocaine/Benzoylecgonine HRP93360.5mlEnquire Now
Cotinine HRP94780.5mlEnquire Now
Cortisol HRP92860.5mlEnquire Now
CortisoneHRP94160.5mlEnquire Now
Creatinine Acid HRP94770.5mlEnquire Now
CreatinineHRP96580.5mlEnquire Now
Cyclic AMPHRP93710.5mlEnquire Now
CyclopentobarbitalHRP92990.5mlEnquire Now
D8-THC-COOHHRP93200.5mlEnquire Now
D9-THCHRP93210.5mlEnquire Now
Dehydronorketamine HRP95130.5mlEnquire Now
Dehydroepiandrosterone Sulphate (DHEA)HRP96480.5mlEnquire Now
Demethyl Salvinorin HRP94800.5mlEnquire Now
Deoxynivalenol HRP97100.5mlEnquire Now
DesipramineHRP94220.5mlEnquire Now
Desmethylnaproxen HRP95170.5mlEnquire Now
Desmycosin HRP96770.5mlEnquire Now
DexamethasoneHRP93740.5mlEnquire Now
Dextromethorphan HRP95000.5mlEnquire Now
Dehydroepiandrosterone (DHEA) HRP96180.5mlEnquire Now
Dehydroepiandrosterone (DHEA-17) HRP92410.5mlEnquire Now
Diclazuril HRP92800.5mlEnquire Now
Dicloxicillin HRP96030.5mlEnquire Now
Dienestrol (p-OH) HRP92580.5mlEnquire Now
Diethylstilbestrol HRP95140.5mlEnquire Now
Digoxin HRP94700.5mlEnquire Now
Digoxigenin HRP94310.5mlEnquire Now
Dihydrotestosterone HRP93060.5mlEnquire Now
Dinitrosalicylic Acid Hydrazide (DNSH) HRP93960.5mlEnquire Now
Dipyrone HRP92850.5mlEnquire Now
Epiandrosterone HRP93080.5mlEnquire Now
EPI-Demethyl Salvinorin HRP95020.5mlEnquire Now
Epitestosterone HRP96020.5mlEnquire Now
Ergot Alkaloids HRP97080.5mlEnquire Now
Ergot Alkaloids HRP97090.5mlEnquire Now
Erythromycin HRP96010.5mlEnquire Now
Escitalopram HRP94600.5mlEnquire Now
EstriolHRP94150.5mlEnquire Now
Estriol HRP94650.5mlEnquire Now
Estriol (6) HRP94000.5mlEnquire Now
Estriol (6a) HRP93990.5mlEnquire Now
Ethinylestradiol HRP92350.5mlEnquire Now
Ethyl Glucuronide HRP95310.5mlEnquire Now
Etodolac HRP93420.5mlEnquire Now
Fentanyl HRP96260.5mlEnquire Now
FentanylHRP93150.5mlEnquire Now
Florfenicol HRP94070.5mlEnquire Now
Flunixin HRP93410.5mlEnquire Now
Flumequine HRP92540.5mlEnquire Now
Fumonisin HRP97130.5mlEnquire Now
Gentamycin HRP96090.5mlEnquire Now
Gestrinone HRP94270.5mlEnquire Now
Halofuginone HRP96730.5mlEnquire Now
Haloperidol HRP94960.5mlEnquire Now
Heroin HRP94990.5mlEnquire Now
Hydrocodone HRP93010.5mlEnquire Now
Hydromorphone HRP92890.5mlEnquire Now
17α HydroxyprogesteroneHRP96470.5mlEnquire Now
Hygromycin B HRP96760.5mlEnquire Now
Ibuprofen HRP96750.5mlEnquire Now
ImipramineHRP93880.5mlEnquire Now
Isoxsuprine HRP92640.5mlEnquire Now
JWH-018 HRP95220.5mlEnquire Now
JWH-018 HRP95230.5mlEnquire Now
Kanamycin HRP92220.5mlEnquire Now
Kebuzone HRP93450.5mlEnquire Now
Ketamine HRP96740.5mlEnquire Now
Ketamine HRP95180.5mlEnquire Now
Ketoprofen HRP93430.5mlEnquire Now
Lasalocid HRP92780.5mlEnquire Now
Leucomalachite Green HRP92670.5mlEnquire Now
Lidocaine HRP95260.5mlEnquire Now
Lidocaine HRP96200.5mlEnquire Now
Lorazepam HRP96070.5mlEnquire Now
LSDHRP92980.5mlEnquire Now
Lysergic Acid Diethylamide (LSD)HRP94610.5mlEnquire Now
Maduramicin HRP96000.5mlEnquire Now
MDMA HRP96210.5mlEnquire Now
MDPVHRP96840.5mlEnquire Now
Medroxyprogesterone Acetate HRP92330.5mlEnquire Now
Megestrol Acetate HRP92320.5mlEnquire Now
Megestrol HRP93530.5mlEnquire Now
Melengestrol AcetateHRP92310.5mlEnquire Now
Meloxicam HRP93900.5mlEnquire Now
Meperidine-Normeperidine HRP93020.5mlEnquire Now
Meprobamate HRP94560.5mlEnquire Now
Mescaline HRP94470.5mlEnquire Now
Mestanolone HRP94020.5mlEnquire Now
MethadoneHRP93230.5mlEnquire Now
Methamphetamine HRP94670.5ml Enquire Now
Methamphetamine HRP97200.5mlEnquire Now
Methandriol HRP92390.5mlEnquire Now
Methcathinone HRP95350.5mlEnquire Now
MethotrexateHRP94630.5mlEnquire Now
Methylphenidate HRP96270.5mlEnquire Now
Methylprednisolone HRP93910.5mlEnquire Now
Methyltestosterone HRP92370.5mlEnquire Now
Monensin HRP92920.5mlEnquire Now
MorphineHRP96560.5mlEnquire Now
Morphine-6-Hemisuccinate HRP94950.5mlEnquire Now
Mycophenolic AcidHRP94320.5mlEnquire Now
Nalidixic Acid HRP93460.5mlEnquire Now
Naltrexone HRP94540.5mlEnquire Now
Neomycin HRP92250.5mlEnquire Now
Nicarbazin HRP92790.5mlEnquire Now
Nitrazepam HRP94580.5ml Enquire Now
NicarbazinHRP93730.5mlEnquire Now
NorbuprenorphineHRP94030.5mlEnquire Now
Norescitalopram HRP94590.5mlEnquire Now
Norfentanyl HRP95390.5mlEnquire Now
Norfentanyl HRP94750.5mlEnquire Now
Norfluoxetine HRP94620.5mlEnquire Now
Norsertraline HRP94970.5mlEnquire Now
NortriptylineHRP93890.5mlEnquire Now
Ochratoxin A HRP97070.5mlEnquire Now
Olaquindox HRP95200.5mlEnquire Now
Olaquindox HRP95270.5mlEnquire Now
Oxazepam HRP94790.5mlEnquire Now
Oxazepam HRP96610.5mlEnquire Now
Oxolinic Acid HRP92960.5mlEnquire Now
OxycodoneHRP96640.5mlEnquire Now
Oxyphenbutazone HRP93440.5mlEnquire Now
Phenobarbital HRP96700.5mlEnquire Now
Phenytoin HRP94180.5mlEnquire Now
Pirlimycin HRP94060.5mlEnquire Now
Prednisolone HRP96360.5mlEnquire Now
Procainamide HRP96380.5mlEnquire Now
Progesterone HRP92610.5mlEnquire Now
Quinidine HRP96860.5mlEnquire Now
Ractopamine HRP92510.5mlEnquire Now
Ractopamine HRP92520.5mlEnquire Now
Ritodrine HRP92660.5mlEnquire Now
Robenidine HRP96040.5mlEnquire Now
Ronidazole HRP92530.5mlEnquire Now
Ronidazole HRP96800.5mlEnquire Now
SalbutamolHRP93490.5mlEnquire Now
Salicyclic AcidHRP95050.5mlEnquire Now
Salinomycin HRP95190.5mlEnquire Now
Salmeterol HRP93980.5mlEnquire Now
Salvinorin HRP94710.5mlEnquire Now
Secobarbital HRP96720.5mlEnquire Now
SEMHRP93570.5mlEnquire Now
Sirolimus HRP96790.5mlEnquire Now
Spectinomycin HRP95250.5mlEnquire Now
Spiramycin/JasamycinHRP92270.5mlEnquire Now
Stanozolol HRP94660.5ml Enquire Now
StreptomycinHRP94550.5ml Enquire Now
StreptomycinHRP93380.5mlEnquire Now
Sulphabenzamide HRP94080.5mlEnquire Now
Sulphaguanidine HRP92680.5mlEnquire Now
SulphamerazineHRP93470.5mlEnquire Now
SulphanitranHRP94280.5mlEnquire Now
Sulphaphenazole HRP92930.5mlEnquire Now
TestosteroneHRP93050.5mlEnquire Now
TetracyclineHRP92180.5mlEnquire Now
TilidineHRP97060.5mlEnquire Now
Tetracycline(amide)-HRPHRP93670.5mlEnquire Now
Theophylline HRP95370.5mlEnquire Now
Thiabendazole HRP92830.5mlEnquire Now
Thiamphenicol/FlorenicolHRP92760.5mlEnquire Now
Tolfenamic Acid HRP94050.5mlEnquire Now
Toltrazuril HRP93970.5mlEnquire Now
Tacrolimus HRP94240.5mlEnquire Now
Tacrolimus HRP94250.5mlEnquire Now
Tramadol/DesmethyltramadolHRP93040.5mlEnquire Now
Tramadol/NortramadolHRP93030.5mlEnquire Now
Trazodone HRP94510.5mlEnquire Now
Trazodone HRP94520.5mlEnquire Now
Triamcinolone HRP96250.5mlEnquire Now
Triamcinolone Acetonide HRP95010.5mlEnquire Now
Triclabendazole HRP93950.5mlEnquire Now
Trimethoprim HRP92940.5mlEnquire Now
Tylosin/TilmicosinHRP92260.5mlEnquire Now
Urochloralic Acid HRP94740.5mlEnquire Now
Venlafaxine HRP96850.5mlEnquire Now
VirginiamycinHRP92230.5mlEnquire Now
Warfarin HRP96080.5mlEnquire Now
Zaleplon HRP94480.5mlEnquire Now
Zearalenone HRP97120.5mlEnquire Now
ZearalanoneHRP94010.5mlEnquire Now
Zilpaterol HRP92650.5mlEnquire Now
Zolpidem HRP95080.5mlEnquire Now
ZolpidemHRP95090.5mlEnquire Now
Zopiclone HRP95060.5mlEnquire Now

Our Range of BioReagents


COVID-19 Cytokine Testing Solutions

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COVID-19 Risk Stratification & Treatment Monitoring

Randox Cytokine Testing Solutions

COVID-19 Risk Stratification and Treatment Monitoring

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    Simultaneous detection of up to 12 cytokines and growth factors from a single patient sample
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    Suitable for use with serum and plasma samples
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    Fully automated and semi-automated solutions available to suit all laboratory throughputs
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    Excellent analytical performance
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    Comprehensive test menu comprising 26 cytokines, cytokine receptors and growth factors
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    Availability of complementary quality controls for a complete testing package

Randox offer testing solutions for a comprehensive range of cytokines, cytokine receptors and growth factors designed to assist with COVID-19 risk stratification, monitoring of treatment efficacy and recovery. Utilising patented Biochip technology up to 12 cytokines and growth factors may be detected simultaneously from a single patient sample.

Cytokines play a vital role in the immune system and are known to be involved in the body’s response to a variety of inflammatory and infectious diseases. The over stimulation of these cytokines in response to infection is referred to as a ‘cytokine storm’ and strongly correlates with poor disease outcomes.

Cytokine storms are a common complication of SARS-CoV-2 (COVID-19) infection triggering viral sepsis, where viral replication and excessive, uncontrolled systemic inflammation may lead to pneumonitis, Acute Respiratory Distress Syndrome (ARDS), respiratory failure, shock, multiple organ failure, secondary bacterial pneumonia, and potentially death.

 

 

 

Biochip

Cytokine Array I (12-plex)

  • IL-1α
  • IL-1β
  • IL-2
  • IL-4
  • IL-6
  • IL-8
  • IL-10
  • IFNγ
  • EGF
  • MCP-1
  • TNFα
  • VEGF

Interleukin-1 (IL-1) is a regulatory and inflammatory cytokine, which exists in two forms, (IL-1α) and (IL-1β), which share 25% homology at amino acid level. IL-1α is produced as a biologically active 31 kDa precursor, which undergoes proteolytic cleavage yielding a 17 kDa protein of 159 amino acids.

There are two forms of IL-1, IL-1α and IL-1β ,which share 25% homology at amino acid level. IL-1β is synthesised as a biologically inactive precursor of 269 amino acids with a molecular mass of 31 kDa , which undergoes proteolytic cleavage by IL1 converting enzyme (ICE), which yields a 17kDa protein of 153 amino acids.

Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15 – 18 kDa protein which has varying degrees of glycosylation accounting for the observed molecular weight range. IL-2 regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity.

IL-4 is a glycoprotein synthesised as a precursor protein of 153 amino acids. The first 24 amino acid residue signal peptide is cleaved to produce a 129 amino acid 15-19 kDa protein.

IL-6 is synthesised as a precursor protein of 212 amino acids. The N-terminal 28 amino acid residue signal peptide is cleaved to produce a 21kDa protein. It has two potential N-glycosylation sites which have no effect on bioactivity. Different post-translational alterations such as glycosylation and phosphorylation give various forms of IL-6 with molecular masses of 21.5-28 kDa. The IL-6 receptor is a strongly glycosylated 80 kDa protein of 449 amino acids. Two different forms of the receptor have been described that bind IL-6 with differing affinities, a soluble form of the IL-6 receptor has also been described. The IL-6 receptor is expressed on T cells, mitogen activated B cells, peripheral monocytes and some macrophage and B cell derived tumour cell types. IL-6 also influences antigen-specific immune responses and inflammatory reactions.

IL-8 is a member of a structurally similar family of cytokines called chemokines, which demonstrate chemotactic activity for neutrophils. IL-8 is a non-glycosylated protein of 8 kDa and consists of 99 amino acids with a 22 residue signal peptide that is cleaved to generate a 77 amino acid sequence. IL-8 is produced in response to proinflammatory stimuli. It is produced by monocytes, macrophages, fibroblasts, endothelial cells, keratinocytes, melanocytes, hepatocytes, chondrocytes, T-cells, neutrophils, and astrocytes.

Interleukin-10 (IL-10), alternatively known as B-cell-derived T-cell growth factor (B-TCGF), cytokine synthesis inhibitory factor (CSIF) or T-cell growth inhibitory factor is a homodimeric protein with a molecular weight of 18 kDa. It is produced as a 178 amino acid residue precursor, which is cleaved to give a mature protein of 160 amino acids. IL-10’s primary function is as an anti-inflammatory agent, which inhibits cytokine production by T cells and natural killer cells caused by activation of monocytes/macrophages.

IFN-γ is a cytokine critical to both innate and adaptive immunity, and functions as the primary activator of macrophages, in addition to stimulating natural killer cells and neutrophils. Biologically active interferon gamma is a 20 or 25 kDa glycoprotein depending on its glycosylation state. This lymphokine is synthesised as a 166 amino acid sequence but is cleaved to give a 143 amino acid residue.

Human EGF is produced as a long precursor protein of 1207 amino acids which is released by proteolytic cleavage to give a globular protein of 6.4 kDa consisting of 53 amino acids. EGF is a common mitogenic factor that stimulates the proliferation of different types of cells, especially fibroblasts and epithelial cells. EGF activates the EGF receptor (EGFR/ErbB), which initiates, in turn, intracellular signaling.

Monocyte chemoattractant protein (MCP-1) is part of the chemotactic family of cytokines called chemokines. ). It is a 76 amino acid peptide and has a molecular weight of 8.6 kDa. MCP-1 in particular chondrocytes confirming its role in inflammatory responses. MCP-1 has been implicated in a wide variety of inflammatory diseases such as artherosclerosis, delayed hypersensitivity reactions, rheumatoid arthritis, alveotitis and idiopathic pulmonary fibrosis.

Tumour necrosis factor alpha (TNFα) is a 157 amino acid 26 kDa transmembrane protein which is secreted as a soluble mature 233 amino acid homotrimer of 17 kDa by proteolytic cleavage. TNF-α is secreted by macrophages in response to stimuli for the induction of systemic inflammation. The binding of the ligand TNF-α to the TNF receptor (TNFR1) initiates the pro-inflammatory and pro-apoptotic signaling cascades.

Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is secreted as a glycosylated homodimeric protein of 46 kDa that is made up of two 24 kDa subunits linked by disulphide bonds. VEGF is expressed by vascularised tissue such as pituitary, brain, lungs, kidneys, heart and adrenal glands, although it is assumed that all tissues have the potential to produce the growth factor. VEGF is stimulated when cells become deficient in oxygen or glucose or under inflammatory conditions.

Ordering Information

 

Cat. NumberDescriptionKit Size
EV3508Cytokine Array I Evidence360 Biochips
EV3544Cytokine Array I Evidence180 Biochips
EV3513Cytokine Array I Evidence Investigator54 Biochips
EV3623Cytokine Array I High Sensitivity Evidence Investigator54 Biochips

Cytokine Array III (4-plex)

  • IL-5
  • IL-15
  • GM-CSF
  • MIP-1 α

Interleukin-5 (IL-5) is a disulphide linked homodimer and belongs to a family of structurally related proteins that includes: interleukin-2, interleukin-4, macrophage colony-stimulating factor, granulocyte macrophage colony-stimulating factor and growth hormone. It is a glycoprotein with the apparent molecular weight of recombinant IL-5 produced by mammalian cells in the range 45 to 60 kDa. The large variation in the molecular weight caused predominantly by the addition of heterogeneous carbohydrate chains.

Interleukin-15 (IL-15) is a 14 to 15 kDa protein of 114 amino acids. It contains 2 disulphide bonds and 2 N-linked glycosylation sites at the C-terminus1. IL-15 is expressed at the mRNA level in numerous normal human tissues in a broad range of cell types, including activated monocytes, dendritic cells, osteoclasts and fibroblasts. IL-15 has an essential role in natural killer (NK) cell development. It activates NK cell proliferation, cytotoxicity, and cytokine production and regulates NK cell/macrophage interaction. Studies have suggested that IL-15 may have a role in establishing innate immune responses and maintaining neutrophil-mediated inflammatory processes.

Granulocyte-macrophage colony stimulating factor (GMCSF) isolated from human sources is glycosylated with an apparent molecular mass of 23 kDa. The mature protein has 127 amino acids and is preceded by a hydrophobic leader sequence of 25 amino acids.

Macrophage inflammatory protein-1α (MIP-1α, CCL3) is a member of the CC chemokine subfamily whose members are known for chemotactic and proinflammatory effects and also for the promotion of homeostasis. MIP-1α is synthesised as a 92 amino acid precursor that is proteolytically processed to a mature protein of about 70 amino acids. MIP-1α has roles in inflammatory responses at sites of injury or infection by recruiting proinflammatory cells.

Ordering Information

 

Cat. NumberDescriptionKit Size
EV3680Cytokine Array III Evidence180 Biochips
EV3678Cytokine Array III Evidence Investigator54 Biochips

Cytokine Array IV (5-plex)

  • MMP-9
  • sIL-2Rα
  • sIL-6R
  • sTNFR I
  • sTNFR II

Matrix metalloproteinase-9 (MMP-9) (gelatinase B) (92 kDa) is a member of the matrix metalloproteinase (MMP) family. MMP-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis.

Soluble IL-2 receptor α (sIL-2Rα) results from the proteolytic cleavage of IL-2Rα at the cell surface by a membrane metalloproteinase; which is encoded by IL2RA on human chromosome. It’s widely noted in research that sIL-2Rα has been found in diseases caused by infections, autoimmune disease and organ transplantation.

Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. The IL-6 receptor complex belongs to the haematopoietic receptor superfamily and mediates the biological activities of IL-6. It consists of two distinct membrane bound glycoproteins, an 80 kDa cognate receptor subunit (IL-6R) and a 130 kDa signal-transducing element (gp130). The gp130 subunit is expressed in almost all organs including heart, kidney, spleen, liver, lung, placenta and brain.

Tumour necrosis factor receptor I is one of two specific, high affinity cell surface receptors that function as transducing elements, providing the intracellular signal for cell responses to tumour necrosis factor (TNF). TNF is a proinflammatory cytokine mainly produced by stimulated monocytes, macrophages and T-lymphocyte subsets. It has a key role in host defence and immunosurveillance, mediating complex cellular responses of a different, even contrasting nature. TNFRI has a molecular mass of 55 kDa1 and is expressed by almost all cell types2 especially those cells that are susceptible to the cytotoxic action of TNFI. TNFRs are detectable in normal serum, but their concentration increases significantly in inflammatory and non-inflammatory diseases.

Tumour necrosis factor receptor II (TNFRII) is one of two specific, high affinity cell surface receptors that function as transducing elements, providing the intracellular signal for cell responses to tumour necrosis factor (TNF). TNF is a proinflammatory cytokine mainly produced by stimulated monocytes, macrophages and T-lymphocyte subsets. It has a key role in host defence and immunosurveillance, mediating complex cellular responses of a different, even contrasting nature. TNFRII has a molecular mass of 75 kDa1. Although TNFRII is expressed by almost all cell types, it is expressed primarily by cells of the immune system, cells of myeloid origin and endothelial cells.

Ordering Information

 

Cat. NumberDescriptionKit Size
EV3659Cytokine Array IV Evidence180 Biochips
EV3661Cytokine Array IV Evidence Investigator54 Biochips

Cytokine Array V (5-plex)

  • IL-3
  • IL-7
  • IL-12p70
  • IL-13
  • IL-23

Interleukin-3 (IL-3) possesses diverse biological activities and was discovered independently in studies on its biological activities. IL-3 is a heavily glycosylated protein with a polypeptide chain of 133 amino acids. It occurs naturally in a diversity of glycoforms generated by the addition of carbohydrate groups which results in size heterogeneity from 28 to 45 kDa. The function of the extensive carbohydrate modifications of the IL-3 polypeptide is not known however IL-3 has been linked with various diseases including colorectal and pancreatic cancers.

Interleukin-7 (IL-7) is classified as a type 1 short-chain cytokine of the haematopoietin family, a group that also includes IL-2, IL-3, IL-4, IL-5, GM-CSF, IL-9, IL-13, IL-15, M-CSF, and stem cell factor. The human gene for IL-7 is located on chromosome 8q12-13. The amino acid sequence of IL-7 predicts a molecular weight of 17.4 kDa, but glycosylation results in an active protein of 25 kDa. IL-7 appears to be involved in the development of an effective immune system and also in the generation and maintenance of strong and effective cellular immune responses directed against cancer cells, or infectious diseases.

Interleukin-12 (IL-12) is a 75 kDa heterodimeric glycoprotein cytokine composed of disulphide linked p40 (40 kDa) and p35 (35 kDa) subunits that are derived from separate genes1. p35 is expressed in a limiting and tightly regulated fashion by many different cell types, however the expression of p40, though in greater quantities than required for p70 formation, appears to be restricted to antigen presenting cells. IL-12 stimulates IFN production, which is essential in resistance to intracellular protozoan, fungal and bacterial infections and, in addition, tumours. Traditionally, IL-12 is accepted as an important mediator of autoimmunity and is involved in a number of autoimmune diseases including rheumatoid arthritis, psoriasis, inflammatory bowel disease and insulin-dependent diabetes mellitus.

Interleukin-13 (IL-13) is a 12 kDa protein that folds into four I-helical bundles. It contains four potential N-glycosylation sites and four cysteine residues that form two intramolecular disulphide bonds. IL-13 shares a number of structural features and functional characteristics with IL-4. The IL-13 protein is approximately 25% homologous1 with IL-4 and belongs to the same I-helix protein family. IL-13 plays a dominant role in resistance to most gastrointestinal nematodes and also modulates resistance to intracellular organisms by regulating cell mediated immunity. IL-13 is the central mediator of allergic asthma, where it regulates eosinophilic inflammation, mucus secretion, and airway hyperresponsiveness. Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties.

Interleukin 23 (IL-23) is member of the IL-12 family. The IL-12 family consists of cytokines IL-12(p40p35), IL-23(p40p19) and IL-27(EBI13p28), and monomeric and homodimeric p401. IL-23 is a heterodimeric cytokine composed of disulphide linked p19 and p40 subunits. IL-23 plays a role in a signaling pathway that triggers inflammation.

Ordering Information

 

Cat. NumberDescriptionKit Size
EV3666Cytokine Array V Evidence Investigator54 Biochips

Immunoassay Platforms

Want to know more?

Contact us or visit our COVID-19 Monitoring & Management page

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Randox Discovery

Randox Discovery | The Benchtop Lab

Discover The Future Of Molecular & Immunoassay Diagnostics

Why Choose the Discovery?

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    The Discovery is an exciting and disruptive analyser capable of molecular and immunoassay testing
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    Simultaneous detection of hundreds of targets from a single patient sample via patented biochip technology
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    Flexible test menu comprising immunoassay and genetic tests for infectious diseases & oncology
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    Rapid turnaround time. Three hours to first batch of results with results for subsequent batches every hour after
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    Fully automated platform increasing operator walkaway time.  A single operator is all that’s required to run up to 3 Discovery analysers
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    Simple and easy to use. Intuitive user interface guides the operator through the entire testing process

Discover The Power Of Automation

Randox Discovery is comprised of three interconnected modules which each  operate independently performing different aspects of the diagnostic testing process. Each module is separated by a physical barrier to prevent contamination and is accessible via a door. The workflow process runs from right to left and is compatible with lean working principles.

  • Module I
  • Module II
  • Module III

Nucleic Acid Extraction

Module I is responsible for DNA/RNA extraction. After extraction the sample is automatically transferred to Module II. Before transfer, Module I detects the presence of Module II cartridges using a unique vision system.

Multiplex PCR

Module II is responsible for amplification of the extracted nucleic acid by End-Point PCR. UV light is used to sterilise the module and reduce the risk of crossover contamination.

Biochip Hybridisation & Detection

Module III is used in both immunoassay & molecular workflows and is responsible for hybridisation and subsequent detection using patented biochip technology. The detection camera uniquely moves between sample cartridges to detect biochip chemiluminescence.

Discover the Power of Randox Biochip Technology

 

The Randox Discovery is an exciting and disruptive molecular & immunoassay diagnostic analyser capable of consolidating the normal workload of multiple laboratories, into one compact benchtop platform. Randox patented Biochip Technology allows simultaneous detection of hundreds of targets from a single patient sample.  The benefits of multiplexing in this way are endless; allows complete patient profiling, reduces the amount of time spent on individual tests, identifies co-infections, differentiates between pathogens that exhibit similar symptoms and eliminates the need to run multiple time consuming and sample intensive assays. The biochip detection system is based on a chemiluminescent signal, this is the emission of light, without heat, as a result of a chemical reaction.

Discover Our Comprehensive Test Menu

 

  • SARS-CoV-2 Array (COVID-19)
  • Extended Coronavirus Array
  • Molecular Test Menu
  • Immunoassay Test Menu
  • Toxicology Test Menu
VIRUSES
SARS-CoV-2 (COVID-19)Sarbecovirus
(SARS, SARS like, SARS-CoV-2)
Detectable Viruses
SARS-CoV-2 (COVID-19)Sarbecovirus
(SARS, SARS like, SARS-CoV-2)
Influenza A
Coronavirus 229E/NL63Adenovirus A/B/C/D/EInfluenza B
Coronavirus OC43/HKUIEnterovirus A/B/C/D / Rhinovirus A/B/CRespiratory Syncytial Virus A/B (RSV)
Middle East Respiratory
Syndrome Coronavirus (MERS-CoV)
Adenovirus A/B/C/D/E

*In Development – Respiratory Tract Infections Array, Chronic Lung Infections Array, Sexually Transmitted Infections Array & Urinary Tract Infections Array, KRAS, BRAF & PIK3CA Array, Familial Hypercholesterolemia Array & Cardiac Risk Array.

*In Development – A number of clinical immunoassay arrays covering a range of disease markers including adhesion molecules, alzheimers, anaemia, bone disease, cancer, cardiac, cytokines, diabetes, endocrines, fibrinolysis, fertility, gastrointestinal, metabolic, renal, stroke, thyroid & tissue damage.

*In Development – A number of clinical toxicology arrays are in development covering a wide range of Drugs of Abuse (DoA) & New Psychoactive Substances (NPS) detecting over 500 drug and drug metabolites using innovative Biochip Technology.

Product availability may vary from country to country. Some product may be for Research use Only. For more information on product application and availability, please contact your local Randox Representative.

Discover Randox’s Molecular Platforms

All In One Point Of Care Molecular Platform

Compact, Semi-Automated Benchtop Analyser

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Vivalytic

Evidence Investigator


The world’s most extensive Drugs of Abuse Test Menu

Randox Toxicology offers the most comprehensive Drugs of Abuse (DoA) test menu across multiple forensic matrices. Our level of expertise in toxicology research and development allows us to adapt quickly to the ever-changing market influences and develop assays for current and novel drugs trends. Excellent assay precision and performance eliminates false reporting, therefore reducing unnecessary confirmatory tests and time lost in the laboratory as a result. Our Biochip Arrays offer CVs typically less than 10%, producing an accurate drug profile to ensure confidence in results.

DoA II
Buprenorphine Ketamine Oxycodone I
Creatinine LSD Oxycodone II
Fentanyl MDMA Propoxyphene
Generic Opioids Methaqualone

The Evidence Series of immunoassay analysers are powered by Biochip Array Technology and combine the latest technological advances for drug residue detection using immunoassay principles. The Drugs of Abuse II panel is available for both the Evidence and the Evidence Investigator analysers. The Evidence has a throughput of 90 samples per hour, testing up to 44 tests per sample.  The Evidence is a fully automated batch immunoanalyser, allowing for 3960 tests per hour, while the Evidence Investigator is a semi-automated, bench top analyser with testing capabilities of 2376 tests in 70 minutes.

 

 

To find out more about our Biochip Array Technology and our Evidence Series analysers, visit www.randoxtoxicology.com, or email us at info@randoxtoxicology.com


Product Spotlight: HbA1c Quality Controls

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Product Spotlight

HbA1c Quality Controls

Diabetes

Diabetes is a life-long condition which occurs when the glucose level in the blood is too high because it can’t enter the body’s cells to be used as fuel. There are two types of diabetes: type 1 and type 2. They are distinct conditions and must be treated and managed differently.

Type 1 Diabetes

Type one diabetes is an autoimmune condition in which the body attacks insulin-producing cells, this causes a lack of insulin, leading to an increased blood glucose level. Around 10% of people with diabetes has type 1.

Type 2 Diabetes

A mixture of genetic and environmental factors causes type 2 diabetes. The body doesn’t make enough insulin or the insulin it does create does not work correctly, leading to a glucose build up in the blood. It’s thought that up to 58% of type 2 diabetes can be prevented or delayed through healthy lifestyle choices.

HbA1c

HbA1c is the average blood glucose level for the past two to tthree months. A high HbA1c means there is too much sugar in the bloodstream. This means the patient is more likely to develop complications associated with diabetes, like problems with feet and eyes [1].

HbA1c in Diagnostics

In 2011, the WHO accepted the use of glycated haemoglobin (HbA1c) testing in the diagnosis of diabetes, Diabetes UK also supports this decsion [2].

HbA1c can be used as a diagnostic test for diabetes providing that stringent quality assurance tests are in place and assays are standardised to criteria aligned to the international reference values, and there are no conditions present which preclude its accurate measurement.”
World Health Organisation (2011)

Clinically Significant Levels

A HbA1c level of 6.5% is recomended as the cut off for diabetes diagnosis [3], this can be seen in Fig. 1.

HbA1c Levels

Fig. 1. Clinically relevant levels for Diabetes diagnosis.

Acusera HbA1c Controls

Acusera HbA1c Quality Control

The Randox Acusera HbA1c control is designed for use in the quality control of both HbA1c and Total Haemoglobin assays. Assayed instrument and method specific target values and ranges are provided for all major systems and methods including HPLC. A reconstituted stability of 4 weeks keeps waste to a minimum and helps to reduce costs.

View HbA1c Control

Acusera Liquid HbA1c Quality Control

Conveniently supplied liquid ready-to-use the Liquid HbA1c control is ideally suited to both clinical laboratories and POCT helping to significantly reduce preparation time. With a stability of 30 days waste and costs are also kept to a minimum.

View Liquid HbA1c Control
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  • References

    [1] “What is HbA1c?”, Diabetes UK, 2018. [Online] Availabel: https://www.diabetes.org.uk/guide-to-diabetes/managing-you-diabetes/hba1c.

    [2] Diabetes UK, “Diagnostics criteria for deabetes”, Diabetes UK, 2018. [Online]. Available: https://www.diabetes.org.uk/professionals/position-statements-reports/diagnosis-ongoing-management-monitoring/new_diagnostic_criteria_for_diabetes.

    [3] WHO, “Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus”, World Health Organisation, 2011.


sTfR Quality Control

Therapeutic Drug Quality Control

Providing a true third party solution for the measurement of Soluble Transferrin Receptor (sTfR), the Acusera sTfR Control  will deliver an unbiased, independent assessment of analytical performance.

Designed for use with sTfR assays, this handy single analyte control saves money on wasted material.

Features & Benefits

  • Lyophilised control
  • Human based material
  • Assayed target values available
  • Stable to expiry date at 2°C to 8°C
  • Reconstituted stability of 30 days at 2°C to 8°C
DescriptionSizeAnalytesCat No
sTfR Control (Bi-level)3 x 2 x 1 ml1TF10162
sTfR Calibrator6 x 1 ml1TF10161

Analytes

  • Soluble Transferrin Receptor (sTfR)

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Product Spotlight: Respiratory Controls – Molecular Infectious Disease Testing

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Product Spotlight

Molecular Controls for Respiratory Infection Testing

Respiratory Infections

Flu is a contagious respiratory illness cause by influenza viruses that infect the throat, nose, and sometimes lungs. It can cause illness and sometimes death. Getting vaccinated is the best way to prevent catching flu [1].

There are four types of seasonal flu, A, B, C, and D. Types A and B cause seasonal epidemics of disease. Illnesses range from severe to mild and can even result in death in high risk groups. High risk groups include, pregnant women, children under 5 years of age, the elderly, and people with chronic or immunosuppressive medical conditions [2].

Flu season begins as early as October, reaches its peak in February, and ends in March. In the southern hemisphere, flu season falls between June and September. Wherever it’s cold, it’s flu season.

Diagnosing Flu

A test to detect Influenza viruses can be used to determine whether a patient has the flu. A swab is taken from either the nose or back of the throat and sent for testing. Molecular assays can be used to detect genetic material of the virus [3]. Molecular methods play an important role in the diagnosis and surveillance of influenza viruses. Molecular diagnostics allow timely and accurate detection of influenza and are already implemented in many laboratories. The combination of automated purification of nucleic acids with real-time PCR should enable even more rapid identification of viral pathogens such as influenza viruses in clinical material [4].

Learn more about Flu Season
Qnostics - Molecular Controls for Infectious Disease Testing

The Qnostics range of complete molecular controls for infectious disease testing can be used in the daily monitoring of assay performance, linearity assessment, assay evaluation, validation/verification of new assays and staff training. As whole pathogen controls, the range is designed to mimic the performance of patient samples and can be used to effectively monitor the entire testing process including extraction, amplification and detection.

Qnostics offers a range of solutions for molecular respiratory testing:

Q Controls

Independently manufactured, these positive and externally run controls are designed to be treated as a patient sample within an assay run. Helping to support a laboratory’s accreditation requirements in line with ISO 15189:2012, Q Controls are supplied in an unassayed, liquid frozen format delivering accurate and reliable test results.

Analytical Q Panels

Each Analytical Q Panel consists of five or more individual samples including a negative and is designed to cover the dynamic range of individual infectious disease assays, in a linear progression. Analytical Q Panels are intended for use in the validation and verification of new assays with the main purpose of helping to ensure assays are linear throughout the dynamic range. In addition, Analytical Q Panels will support a laboratory’s accreditation requirements, in line with ISO 15189:2012.

Evaluation Panels

Evaluation Panels may be used to evaluate assay characteristics, confirm performance claims and ultimately ensure the assay is fit for purpose. Evaluation Panels may also be used in the validation of clinical assays and the development of diagnostic tests.

Learn more about Qnostics Respiratory Testing
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  • References

    [1] “Key Facts About Influenza (Flu) | Seasonal Influenza (Flu) | CDC”, Cdc.gov, 2018. [Online]. Available: https://www.cdc.gov/flu/keyfacts.htm. [Accessed: 25- Sep- 2018].

    [2] “Influenza (Seasonal)”, World Health Organization, 2018. [Online]. Available: http://www.who.int/en/news-room/fact-sheets/detail/influenza-(seasonal). [Accessed: 27- Sep- 2018].

    [3] “Diagnosing Flu | Seasonal Influenza (Flu) | CDC”, Cdc.gov, 2018. [Online]. Available: https://www.cdc.gov/flu/about/qa/testing.htm. [Accessed: 25- Sep- 2018].

    [4] J. Ellis and M. Zambon, “Molecular diagnosis of influenza”, Reviews in Medical Virology, vol. 12, no. 6, pp. 375-389, 2002.


Product Spotlight: Acusera Cardiac Quality Control

Product spotlight - Cardiac Quality Control Solutions
Cardiac Quality Control Solutions

For this month’s product spotlight, we have chosen our whole range of cardiac quality control solutions. Randox offers options for both Internal Quality Control (IQC) and External Quality Assessment (EQA).

29th September is World Heart Day. World Heart Day is a global campaign during which individuals, families, communities and governments around the world participate in activities to take charge of their heart health and that of others.

Cardiovascular disease (CVD) is a term to describe conditions that affect the heart and blood vessels. It is normally associated with a build up of fatty deposits in the arteries and an increased risk of blood clots. CVD is the leading casues of death globally, representing around 30% of all deaths. A healthy lifestyle can help prevent CVD; however, increasingly busy lifestyles mean that it is difficult to avoid CVD. This means it is vitally important that individuals are tested for CVD and to ensure that diagnoses are acurate.

Acusera Internal Quality Controls

The accurate diagnosis of a potentially life threatening cardiac event is essential in order to avoid misdiagnosis and/or incorrect treatment. The Acusera Cardiac Quality Controls have been designed to cover a wide range of cardiac markers at clinical decision levels eliminating the need for additional low level controls at extra expense. Available in a choice of both liquid ready-to-use and lyophilised formats, they are ideal for use at the point-of-care and in the laboratory. Manufactured from 100% human serum a matrix similar to that of the patient is guaranteed.

  • Liquid Controls

    Control Vial

    Liquid Cardiac Control

    Liquid, Assayed, 100% Human serum
    8 Analytes

    Control Vial

    BNP Control

    Liquid, Assayed, 100% Human serum
    1 Analyte

  • Lyophilised Controls

    Control Vial

    Cardiac Control

    Lyophilised, Assayed, 100% Human serum
    7 Analytes

    CK-MB Control

    Lyophilised, Assayed, 100% Human serum
    2 Analytes

    Control Vial

    H-FABP Control

    Lyophilised, Assayed, 100% Human serum
    1 Analyte

    hsTnT Control

    Lyophilised, Assayed, 100% Human serum
    1 Analyte

RIQAS External Quality Assessment

The RIQAS Cardiac EQA programme is designed to monitor the performance of up to 7 clinically significant cardiac markers. Two flexible reporting options are available to suit the needs of all laboratory sizes.

Accredited to ISO/IEC 17043

•  Lyophilised for enhanced stability
•  100% human serum
•  Bi-weekly reporting
•  Submit results and view reports online via RIQAS.Net
•  Register up to five instruments at no extra cost

Parameters

CK, Total | CK-MB activity units | CK-MB mass units | Homocysteine | Myoglobin | Troponin I | Troponin T

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Cardiac EQA

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The Evidence Series

Having developed the patented Biochip Array Technology following £250 million investment in research and development, we needed a platform that allowed Biochip Array Technology capabilities to be showcased. Step forward the Evidence Series.

The series includes the Evidence, the Evidence Evolution, the Evidence Investigator and the Evidence MultiSTAT. Each analyser has been designed and built with boundary pushing engineering, to ensure financial, labour and time savings for the end user.

Have a read below of the overview of each analyser in the Evidence Series

Evidence Evolution

The world’s first fully automated random-access biochip testing platform, the Evidence Evolution is the world’s most advanced immunoanalyser. With the capability to process up to 2,640 tests per hour, the Evidence Evolution offers complete system integration, as well as the most comprehensive test menu on the market.

Evidence

As the world’s first Biochip Array Technology system, the Evidence immunoanalyser has revolutionised laboratory screening worldwide. With the capability to process 3,960 tests per hour and a sample capacity of 360, the Evidence is ideal for use in a high throughput laboratory.

Evidence Investigator

The Evidence Investigator is a compact, semi-automated benchtop immunoanalyser that offers efficient and comprehensive testing across a range of applications including clinical diagnostics, molecular, toxicology and food diagnostics. The Evidence Investigator boasts a throughput of up to 2,376 tests per hour, offering efficiency without compromising on accuracy.

Evidence MultiSTAT

The Evidence MultiSTAT is a fully automated immunoanalyser that enables on-site simultaneous detection of up to 44 analytes from a single sample of oral fluid, urine or blood. With a three-step process and results generated in less than 20 minutes, the Evidence MultiSTAT is an ideal solution for those with no knowledge of laboratory procedures and offers a throughput of up to 132 tests per hour.

 

 

 

About the Randox Evidence Series

The Evidence Series is set to revolutionise diagnostic testing forever. Offering unrivalled capabilities across all analysers, we truly believe that the Evidence Series range of immunoassay analysers can meet your diagnostic testing capabilities.

For more information on any of the Evidence Series analysers, please visit https://www.randox.com/evidence-series/ or contact us evidenceseries@randox.com.