Dealing with not being a dad yet – is IVF always the answer to infertility?

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Dealing with not being a dad yet – is IVF always the answer to infertility?

“Little things would set me off. I’d walk into work and a colleague’s car had a baby seat in the back. I’d question myself as a man. I question my masculinity.”

A new survey has been carried out by Infertility Network UK and Middlesex University London looking at the impact upon men of fertility problems. One in six couples in Northern Ireland experience difficulties conceiving a baby.

Two men spoke to the BBC about their own experiences.

Aaron, 42, said he and his wife have been trying to have a baby for eight years. “When people ask why we don’t have kids, it’s like are people that idiotic, that insensitive?” 40 year old James said he and his wife have been struggling to conceive for five years. “The silence is stifling. It’s like someone needs to say something.”

Fertility problems are as common in men as women. Male or female – your body’s fertility is a complex department that relies on total health and wellbeing. With Randox Health, you can find out exactly how your body is performing before trying for a baby.

Common causes of infertility for men

  • low sperm count
  • problems with the tubes carrying sperm
  • problems getting an erection or ejaculating
  • diabetes
  • being overweight

Is IVF the only option?

Not according to one of the founding fathers of in-vitro fertilisation – Dr Robert Winston. In his book, The Essential Fertility Guide, he outlines fertility treatment options and suggests more than half of people referred to IVF clinics may be treated by alternatives. “There are numerous causes of infertility and the best treatment may be different in each circumstance. Unfortunately, the massive publicity given to IVF has led to most people believing that it is almost the only treatment and the most successful. This is utterly wrong. Couples rush into IVF far too frequently.”

He believes this happens when not enough time is spent investigating the underlying cause of infertility. “IVF is not the only treatment for infertility, and it’s often not the best treatment or the most successful. There are many treatments depending on the cause, and the cause should be established first.”

What you can do

If you’re thinking about trying for a baby, you might want to find out more about your current fertility levels and also whether or not there are any risk factors to consider in the future.

Randox has created one of the world’s most advanced reproductive health checks. Our personalised service involves physical and biological assessments, with 110 tests carried out in total, including DNA-based protein testing.

Dr Peter FitzGerald, founder and CEO of Randox said, “One in every six couples in Northern Ireland will experience difficulty conceiving. Through our research, we know it won’t always be down to a problem with the sperm, eggs and reproductive organs, but could also be a consequence of issues in other parts of the body such as hormone imbalance, obesity or stress.

“We use the very latest in diagnostic innovation to assess your whole body health, which gives clarity on how well you are now and crucially assesses your future health, which can help to boost your fertility levels.

“For many couples, we know that very sophisticated treatment, such as IVF is not always needed. Sometimes a deceptively simple change in lifestyle or diet will deliver positive results.”


Prepare for a stroke or take action to prevent one?

“If you experience any neurological symptom that comes on suddenly and is unfamiliar (eg not like your normal migraine) then you should seek urgent medical advice. And take an Aspirin (unless you’re allergic to it).” That’s the advice today from Dr Mark Porter, writing in The Times about what to do in the event you think you’re suffering a stroke.

It’s good advice to keep a packet in your medicine cabinet, but did you know that it’s thought 91% of strokes are avoidable?

What is a stroke?

For the brain to function properly, it needs the oxygen and nutrients provided by the blood. Stroke occurs when a blood vessel in the brain bursts or, more commonly, when a blockage develops which leaves the supply of the blood to the brain limited or completely obstructed and without treatment, cells in the brain quickly begin to die.

There are 3 different types of stroke:

  1. Ischaemic Stroke
  2. Haemorrhagic Stroke
  3. Transient Ischaemic Attack (TIA)

Avoidable risk factors

Research was carried out by McMaster University Canada – it compared the lifestyles of people who had a stroke with those who had not, involving nearly 27,000 participants from 32 countries. It found that 9 out of 10 strokes worldwide could be caused by risk factors – many of which can be avoided:

  • Lowering blood pressure
  • Exercising
  • Eating healthily
  • Maintaining a healthy weight
  • Preventing diabetes
  • Lowering cholesterol
  • Cutting down on alcohol
  • Stopping smoking
  • Lowering stress
  • Taking preventive medication for any heart arrhythmia

The most important modifiable risk is high blood pressure, increasing the risk by 47.9%, which is why it’s the key target across the world for reducing strokes.

Randox Health can help

Randox Health clinics offer you personalised preventive health programmes that provide a full profile of your entire body’s health, including diabetes health, lung health, liver health, heart health and many more areas. Upon receiving your results, you are given a programme to follow to help improve any areas of your health which are not ‘in the green’ on our scale. This helps you to prevent future illnesses and any unwanted surprises such as a stroke. We’ve helped over 3000 people in our clinics to date – book your test today.


The scary facts about cholesterol!

Cholesterol is a fatty substance also known as a lipid. It is made by the liver but can also be found in some foods. It is essential to let the body function normally. You will be sad to hear that high levels can increase your risk of serious health conditions. There are two main types; high-density lipoproteins (HDL) and low-density lipoproteins (LDL). HDL is known as good cholesterol. It carries cholesterol back to the liver, where it is broken down. LDL on the other hand carries cholesterol to the cells however if there is a surplus it can build up in the artery walls increasing the chances of a heart attack or stroke occurring.

Here are some scary facts about cholesterol…

  1. You can’t live without it – Cholesterol has been in your body since the day you were born. It is a building block for all cells.  Not only that but all of our cells and hormones need it to function properly…unfortunately you are very unlikely to find good cholesterol in your typical trick-or-treat offerings.
  1. Not all patients on cholesterol-lowering medication respond optimally to it – In the recent past, aspirin (a drug used to reduce levels) was prescribed for people who had a perceived risk of a heart attack. However aspirin does not always work; up to 30% of patients could have a below optimum response to the drug and therefore be at a considerably increased risk of a recurrent cardiovascular event. This is may also be referred to as “aspirin resistance”.
  1. One third of adults have high cholesterol – Testing is advised every 5 years to monitor your levels to see any changes. To get the most accurate results tests should be carried out one week apart, however most testing facilities won’t follow this.
  1. High levels could be down to genetics – Diet you can change, genes you can’t! If your family has a history of high cholesterol then you are likely to have it as well. It has been suggested that 75% of cholesterol is due to genetics and the remaining 25% is down to diet and lifestyle choices.
  1. Women’s levels will fluctuate over their lifespan – Did you know that ladies? During the average woman’s lifespan, cholesterol levels will rise and fall due to pregnancy and menopause. During pregnancy levels will rise in order to help the baby develop. After birth the mother’s levels should return to normal however after menopause a woman’s LDL levels will rise to that higher of a man’s.

However it is not all doom and gloom this Halloween!  Randox are here to treat you to a vast range of specialised blood tests to allow the most accurate diagnosis of cholesterol levels, allowing you to gauge how many sweets you can sneak in this Halloween! We offer a large array of routine and niche tests. The most popular and widely tested are HDL, LDL, total cholesterol and triglycerides. Some further risk assessment cholesterol tests which are not routinely run include sLDL, HDL3, Lp(a). These cholesterol biomarkers are also affected by the usual risk factors such as age, weight, smoking, etc.; however they can also be a result of one’s genes. As mentioned before aspirin resistance is a big problem affecting up to 30% of all patients on aspirin therapy. However Randox offer the TxBCardio™ test which is a unique test to diagnose and assess the effectiveness of aspirin therapy.

From all of us here at Randox we wish you a safe and happy Halloween!

 


For health professionals

Randox Laboratories manufacture a wide range of routine and niche biochemistry reagents suitable for both research and clinical use.  These include a wide variety of automated routine and niche cardiac tests and our new HDL3-C assay.  Please contact reagents@randox.com for further information.



Don’t Get Tricked This Halloween

Don’t Get Tricked This Halloween – Treat Your Lab to Randox True Third Party Controls Today!

Halloween – a celebration observed by many countries around the world on a yearly basis. Falling on October 31st this holiday is a chance for people to dress up, carve pumpkins, bob for apples, attend costume parties, trick-or-treat and tell scary stories.

It just so happens that we have a scary story for you – and what makes this story even scarier is that it’s a true story!

Our story starts off in a medical laboratory. This laboratory was running QC on their machine as they would do every day. Getting accurate results with no faults or problems arising from their machine, this laboratory was happy with how things were going – until one day when it all went wrong!

Having run their EQA/PT samples, the laboratory found themselves reviewing their report with shock –they noticed a large negative bias. To their horror the perceived ‘accuracy’   they had once achieved was now no longer the case. Right away the laboratory professional’s thoughts turned to the fact that approx. 70% of all clinical decisions are based on laboratory test results, meaning it is essential that the results provided are accurate and reliable in order to prevent potential misdiagnosis or inappropriate treatment. Had they sent incorrect patient results to the clinicians? Had a patient been misdiagnosed? Many thoughts fluttered around in their heads.

The laboratory repeated their QC and found that the results obtained were almost identical to the previous run. The laboratory knew there must be a problem with their QC or their instrument, so they began the troubleshooting process. Nothing. Nada. Zilch. “What was going on?” was the question on the lips of the laboratory professionals.

One of the laboratory professionals then stumbled across a case study that took place in the University of Verona and Academic Hospital of Parma, Italy. The study was related to a field recall of Intact PTH, the reagent was recalled after falsely elevated patient results were discovered.  The alarming thing was that the same elevated performance was not identified by the instrument manufacturer’s control. The study reported that due to this issue there was potential for 40,000 inaccurate patient results from just 18 labs in the Lombardy region of Italy. The study also concluded that the issue could have been prevented if a third-party control, independent from calibrator materials had been used.

This PTH case study got the laboratory thinking that maybe they should source a true third party manufacturer… Having sampled a third party QC, the lab found their results now mirrored that of their EQA and patient samples and as such proceeded to make the switch from first party to third party.

The moral of this story is that first party controls can sometimes “trick” the lab into thinking their performance is acceptable. Quite often target values provided with first party quality controls are in the middle of the analytical range thus masking the issues at the low and high ends of the assay range. Laboratory professionals should “treat” their labs to the best QC material. ISO 15189 highlights that the “use of independent third party control materials should be considered, either instead of, or in addition to, any control materials supplied by the reagent or instrument manufacturer”. So this Halloween don’t randomly choose your QC supplier, treat your laboratory to the best, Randox QC.

All Randox controls are manufactured independently of any instrument or reagent, and designed for use with multiple instruments and methods ensuring, unbiased performance assessment.


Heart disease study suggests benefits of testing toddlers

Heart disease experts have suggested today that toddlers get tested for an inherited form of the condition, from as early as twelve months old.

Familial hypercholesterolemia (FH) is a genetic disorder characterised by very high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL – so-called ‘bad’ cholesterol). FH is the main cause of heart disease and increases by 10-fold the chance of someone having a heart attack under the age of 40. However people who have been diagnosed can control their cholesterol levels by taking a daily dose of statins.

Currently testing is carried out when an adult who had has heart problems is found to be FH positive. Doctors then recommend testing for others in the family. It’s estimated that currently between 80-90% of FH cases remain undiagnosed.

However a new study led by a team from Queen Mary University of London took a different approach. They tested a group of one-year-old children for known genetic mutations which are linked to FH. Out of 10,000, 40 were found to be FH positive. Not only has this group of children been identified early, but because the condition is genetic, one or both of their parents must have it too. For every one positive FH test, at least two people were diagnosed.

According to the lead researcher Dr David Wald, preventive diagnostic testing for FH could prevent up to 600 heart attacks a year among the under-40s in England and Wales. He told the BBC,

“This is the only screening method that stands a reasonable chance of covering the whole population and identifying those at highest risk of an early heart attack.”

The broadcaster also spoke to the British Heart Foundation’s Medical Director Professor Sir Nilesh Samani who said,

“Early diagnosis in children is likely to substantially improve treatment of their condition and will help find other family members with FH. But before nationwide screening is adopted by the NHS, more work needs to be done to show it’s a cost-effective way for picking up individuals with FH which will be acceptable to families.”

Randox Biosciences have developed a FH test in partnership with the Belfast Health and Social Care Trust to proactively diagnose FH. Utilised on our patented Biochip Array Technology, our FH arrays simultaneously detect 40 of the most common FH-causing mutations within the LDLR, ApoB and PCSK9 genes, with results available in just three hours.

The test, which is available through Randox Health Clinics, has also been adopted by medical professionals within the NHS including Dr. Colin Graham, recently retired Consultant Clinical Scientist and former Head of the Regional Genetics Lab in the Belfast Health and Social Care Trust, who introduced the test within his Belfast Laboratory screen for suspected cases of FH.

He said the availability of this test marked a key milestone in the detection of the condition,

“Current FH diagnostic tests require a large volume of samples to be batched, leading to lengthy turnaround times of two to three months. With the new test, the turnaround time is dramatically reduced, enabling more rapid patient diagnosis. This new test has the potential to enable FH screening to become routine in the clinical setting for improved detection and earlier identification of familial cases.”

Dr. Peter FitzGerald, Managing Director of Randox Laboratories said,

“In the battle against cardiovascular disease, people with FH are on the front line. It is important to raise awareness of FH as many people do not even know that they and their family members have this life-threatening condition. There is so much that can be done to support families with FH and with this readily available and much-needed test, detecting and treating entire families with FH is now possible.”


Does Your QC Cover Clinically Relevant Ranges?

Following recommendations from recognized institutions such as ISO and CLIA, more laboratories are using third party controls than ever before. However, great care should be taken when choosing which third party control to use. A number of factors should be considered, and primarily among these is whether the control challenges the complete Clinical Range and the Medical Decision Levels. ISO 15189:2012 states that ‘The laboratory should choose concentrations of control materials wherever possible, especially at or near clinical decision values, which ensure the validity of decisions made’.

Measuring the Complete Clinical Range

It is important to assess the full clinical range of an assay i.e. the range between the lowest and highest results which can be reliably reported. In order to make sure a laboratory instrument is working across the full clinical range, a QC which covers low, normal and elevated concentrations must be used.

Question: “If the full clinical range isn’t covered by QC, how will we know whether patient results which fall outside the range of quality controls are accurately reported?”

What are Medical Decision Levels?

Medical Decision Levels (MDL) are the analyte values at which medical professionals can determine whether a patient may be suffering from a certain condition. The MDL is determined by a consensus of medical professionals and clinical research. Patients’ test results are compared to the MDL and appropriate diagnoses or medical interventions can be made.

For example, the MDL of Glucose can indicate a certain diabetic status:

Analyte Medical Decision Level Diagnostic Status
Glucose (fasting) <100 mg/dL Non-Diabetic
100–125 mg/dL Pre-Diabetic
>125 mg/dL Diabetic

Competitor QC

Many QC manufacturers ‘cut corners’ in an attempt to keep costs down, which often results in the sale of controls which do not cover the complete clinical range or vital medical decision levels. Below is an example of the Glucose concentrations present in a competitor control:

Competitor Chemistry Control Level 1 – 68 mg/dL

Competitor Chemistry Control Level 2 – 134 mg/dL

Competitor Chemistry Control Level 3 – 386 mg/dL

In the examples above, the competitor’s level 1 control covers the non-diabetic MDL, but the level 2 control is not within the ‘Pre-Diabetic’ decision range. The level 3 control is also much higher than can be expected for an elevated diabetic patient result (200 mg/dL or more).

Randox QC

Due to the superior manufacturing process used by Randox, QC target values are consistently within the MDL of tests. For example, the Glucose concentrations present in our Liquid Assayed Chemistry Premium Plus control are:

Level 1 – 57 mg/dL

Level 2 – 114 mg/dL

Level 3 – 236 mg/dL

The MDL for Glucose is covered by the Randox control, meaning laboratory professionals can be confident that patient results will be accurately interpreted.

Immunoassay Medical Decision Levels

Controls which cover the MDL can reduce the number of Quality Controls required by laboratories. For example, Randox Acusera Lyophilised Immunoassay Controls contain particularly low levels of TSH, Ferritin and Vitamin B12 in the Level 1 control, eliminating the need for an additional control at extra expense:

Analyte Medical Decision Level Randox Level 1 IA Control Competitor Level 1 IA Control
TSH 0.1 or 0.27 uU/mL 0.15uU/mL 0.37 uU/mL
Vitamin B12 190 pmol/L 174 pmol/L 327 pmol/L
Ferritin 12 ng/mL 11.1 ng/mL 49.6 ng/mL

In this example the competitor offers an anaemia control with lower levels of TSH, Vitamin B12 and Ferritin at an additional cost. With Randox Acusera QC, only one control is required for anemia monitoring and detection.


Randox Equine Health Programmes: Keeping racehorses healthy from the paddock to the podium

As sponsors of the Randox Health Grand National, the welfare of horses is of paramount importance to us and is a cause very close to our own hearts.

Did you know that one of the reasons we entered into partnership with the Jockey Club is because we are experts in the field of Equine Health?

Well now you do!

Not only do we have a history of being involved in equestrian events, (we host the Randox Point-to-Point event for our local community every year, and International Polo Tournaments in both Scotland and Bushmills, on the Causeway Coast of Northern Ireland), but we also have over 34 years’ experience in the diagnostics industry, during which we have developed innovative and accurate diagnostic products for Equine Health.

That may sound complicated but vets, trainers and owners have been working with us for years so that we can help them better understand their horses’ health and wellbeing.

To recognise the importance of what we do, you must know that more than 70% of all medical decisions are based on an analysis of your blood.

Using our innovative blood-science technology we can obtain a comprehensive profile of not only your body’s current health, but also your future health.  This is the same for horses!

In the development of our own dedicated Equine Health Programme, we’ve learnt a thing or two. We know that endurance racehorses require extra attention as a result of intense physical exercise, and therefore monitoring what’s going on in their blood is vitally important.

To give an example, monitoring the Total Antioxidant Status of your horse is a sure-fire way to detect whether he or she has suffered muscle cell injury or trauma.

A reduction in the overall antioxidant status of your horse inhibits its body’s defence and monitoring the TAS is therefore an efficient way to identify risk of injury, determine the levels of training required and establish appropriate recovery times to maintain their wellbeing.

If your horse is often transported between locations it’s also important to monitor his or her TAS.  The Total Antioxidant Status of a horse may increase after long-haul road transportation, indicating that your horse is stressed.

So, as you can see, you can tell a lot about the health of your horse by looking at what’s going on in their blood.  We’re the experts in this area so we can share our knowledge with you, explain the importance of particular biomarkers in observing the health of your horse, and advise you what areas of your horse’s health you should be monitoring if you have particular concerns.

Let’s say for example your horse is undergoing intense training.

We would recommend that you monitor their levels of Superoxide Dismutase. This enzyme can let you know whether they are suffering from any muscle pain, stiffness, joint weakness, loss of muscle strength, stamina and flexibility, amongst other issues.  It is important to know whether their current training is regime is benefitting them, or encumbering them.

If injury is suspected, we then advise that you monitor your horse’s levels of Creatine Kinase.

Any damage to your horse’s heart, skeletal muscle or brain tissue will result in a spike of Creatine Kinase in the blood.  By monitoring CK, you can determine any muscle trauma, bruising, wasting, abscesses, inflammation, infection and recurring muscle damage.

Laminitis, a painful inflammatory condition of the tissue, is often one of the most concerning conditions for any horse, as historically there has been minimal opportunity to detect the risk or early stages of the disease. Randox Adiponectin, a protein hormone, is now being used in conjunction with other current biomarkers to successfully detect the risk of this disease and allow earlier management of the condition in the aim to remove the risk completely or reduce its life-altering impact.

The importance in monitoring these biomarkers is of course that it enables early treatment, which greatly improves your horse’s prognosis and chances of recovery.

Swift treatment upon diagnosis of trauma ensures that your horse is kept healthy and happy, and our customers agree!  We work with a number of key Veterinary Hospitals around the world, including Rood and Riddle Equine Hospital, the Official Equine Hospital of the Breeders’ Cup in Lexington, Kentucky, (known as ‘The Horse Capital of the World!), and The Irish Equine Centre in Kildare, Ireland.

Jean Hearn, Biochemistry Lab Manager at The Irish Equine Centre, commented;

“As a long time customer of Randox Laboratories, over thirty years, I feel I am in a good position to offer an opinion on the company. Initially we dealt with Randox for Chemistry Reagents and ELISA kits, as they offered a very good range for us working in the veterinary field. However when they launched their Randox Daytona, we found it to be an essential additional analyser in our laboratory, due to the fact that it was capable of running tests that prior to that we were running with very labour intensive methods. eg various minerals and it also broadened the range of tests we could offer to our customers ,eg. acute phase proteins. 

“Support has always been good from Randox and the staff always very pleasant and helpful.”

Of course what your horse eats plays a huge role in their health too.

High quality horse feed is paramount for race horses in particular whose speed, agility and most importantly, health, is dependent on them receiving all the nutrients they require.

Our Randox Food Diagnostics ensures the safety of horse feed by screening the food for harmful mycotoxins which can grow on a variety of different crops including cereals, grains and fruits, and can cause a number of health issues for horses, including problems with fertility, sports performance and malnutrition.

And our work in the racing industry doesn’t stop there.

Our Randox Toxicology division creates custom testing panels for the screening of drugs of abuse, on our patented Randox Biochip Array Technology, which has revolutionised the diagnostics industry by allowing multiple tests to be run simultaneously on a single, undivided patient sample.

Screening for drug abuse amongst jockeys in this way (we currently work with Jockey Clubs around the world including Sha Tin racecourse in Hong Kong) protects the safety of the horses and ensures races are won on the jockeys’ and the animals’ natural abilities.

Hopefully you now have a flavour for the work that we do in the racing and veterinary industries to ensure the health and wellbeing of horses.  We hope that through our sponsorship of the Randox Health Grand National we can share our knowledge and expertise in the field of Equine Health, Horse Feed Screening and Jockey Toxicology with the racing fraternity.

Just as we promote a message of preventive health to racing fans, the same applies to the horses we love.

 

For further information on how we work to keep horses healthy, please contact our Randox PR Team.

E: nicola.mchugh@randox.com or amy.mcilwaine@randox.com

T: 028 9445 1016


We Are Randox | Charlie Graham tells us about her time spent volunteering in Ethiopia

Here at Randox we are celebrating our creative and talented work force whose fresh perspectives and world experience help Randox operate on such a global scale.

Recently, Charlie Graham, a member of the Randox Food Diagnostics Marketing team told us about her time spent in Ethiopia, volunteering with Volunteer Service overseas (VSO) as part of the International Citizenship Service (ICS) Programme.

Charlie sat down with us to tell us her story.

“I first heard about the ICS program when I was studying at Glasgow Caledonian University. My friend who was also studying Business Management with Marketing alongside me, had pre-warned me about the intense application process, and although it seemed quite daunting at the time, I have always been interested in volunteer work and  international travel so I felt up for the challenge.

To be considered for a place on the program I had to firstly complete an online application. Then if you passed this initial stage you were invited to attend a group interview that took place in London. Here I undertook both group and individual assessments throughout the day that tested my knowledge of international development, conflict resolution and team work skills. Surprisingly, I found the interview process extremely rewarding as there was a strong focus on personal development and feedback. It was also interesting to learn about the possible charities that we could be placed with based on our skill sets.

I was excited when I finally received the news eight weeks later that I been matched with VSO and would be placed in a livelihoods development programme in Addis Ababa. To finalise my place I had to raise £800 that would go towards the work that I would be doing when I arrived in Ethiopia. I decided to host a bake sale in the foyer of Caledonian University and also compete a 5KM run to help raise the money.

As a group, we underwent pre-departure training before our flight from London. Once I landed there was a week of in-country training where I met up with the Ethiopian volunteers that I would be working alongside for the next three months. We also met our new families that we would be staying with throughout the duration of the program.

One of the first projects that I worked on was with the Women’s Income Generating Activity Groups. This Government funded program provided both training and guidance for local women who had received a small loan which enabled them to start up their own business ideas. One memory that has stuck with me from working with this group was the power of knowledge. Almaz, the project leader, highlighted that for many of the women learning how to read and being able to sign their own names was truly empowering and allowed them to become financially independent for the first time in their lives. This really brought home to me how valuable the work of ISC is, and how much I as a volunteer was able to impact the lives of these women by teaching them this simple act.

I also organised community action days during my time in Ethiopia. I visited a rehabilitation centre called Mecadonia that housed 170 people aged between 10 – 94 who are bed ridden or elderly. As this centre runs solely on donations we provided meals and clothing for all the residents. I even got a local newspaper to come and write about the centre to help raise awareness and potentially generate new sponsorship for the future.

One of the residents of Mecadonia was called Addis, he was 26 and was in desperate need of a kidney transplant. He had been suffering from kidney problems for five years and his family could only afford to treat him with traditional remedies – nothing had worked. As his health deteriorated he was unable to live with his family as he needed to attend the hospital for weekly dialysis. The evening that I met him, he was trying to fundraise 1 million birr which is the equivalent of £25,000 to secure a kidney transplant. His story really opened my eyes and put into perspective how blessed we are in the UK to have the NHS. After meeting Addis I felt very fortunate for the health of my family and myself.

During the time I spent in Addis Ababa one of the other projects I worked on was capacity building for a charity called Redeem the Generation which focused on the potential of young people and women. I worked on developing and improving their facilities to ensure they were providing a good service for the local community. One of my biggest achievements during the project was organising ICT training programme for women which was attended by 15 women and several community elders.

The three months I spent in Addis Ababa were truly unforgettable: I learnt a new language, experienced a new culture and made life-long friends. What’s more I got the opportunity to make a tangible difference in the lives of others.

Since my trip I have become a real advocate for international development and female entrepreneurship. My experience has not only helped cement the importance of being a team player but also developed my leadership skills – which has really helped me here at Randox.”

We hope Charlie’s story has inspired you to grab new international opportunities that will help improve the wellbeing of others. Randox is committed to revolutionising healthcare through its diverse and multi-talented team.

Make sure to follow Randox Careers on Facebook, Twitter and Instagram to stay up-to-date with the hashtag #WeAreRandox


What is Six Sigma?

Six Sigma is a method of process improvement which focuses on minimizing variability in process outputs. The Six Sigma model was developed by Motorola in 1986, and Motorola have reportedly saved over $17 Billion due to its successful implementation.

The model looks at the number of standard deviations (SD) or ‘sigmas’ that fit within the quality specifications of the process. In the laboratory, the quality specifications relate to the Total Allowable Error (TEa).  The higher the number of standard deviations that fit between these limits, the higher the sigma score and the more robust the process or method is. As sources of error or variation are removed from a process, the SD becomes smaller and therefore the number of deviations that can fit between the allowable limits is greater; ultimately resulting in a higher sigma score.

A process with a sigma score of six is considered to be a high quality process, making six the target for many industries including the clinical laboratory.

In order to achieve Six Sigma, a process must not produce more than 3.4 defects per million opportunities. In a Laboratory context, this would equate to 3.4 failed QC results per million QC runs.

Sigma is calculated using the following equation:

Sigma = (TEa – %Bias) / %CV

TEa – Total Allowable Error

%Bias – Deviation from the target or peer group mean

%CV – Imprecision of the data

Acusera 24.7 now featuring

Why is Six Sigma useful in the laboratory?

Six Sigma can be used to help answer one of the most commonly asked questions in laboratory quality control. How often should I run QC?

The Six Sigma model allows laboratories to evaluate the effectiveness of their current QC processes. Its most common use is to help implement a risk-based approach to QC, where an optimum QC frequency and multi-rule procedure can be based on the sigma score of the test in question. The performance of tests or methods with a high sigma score of six or more may be evaluated with one QC run (of each level) and a single 1:3s warning rule. On the other hand, tests or methods with a lower sigma score should be evaluated more frequently with multiple levels of QC and a multi-rule strategy designed to increase identification of errors and reduce false rejections.

The below table shows how multi-rules and QC frequency can be applied according to Sigma Metrics:

Sigma Score QC Frequency Number of QC Samples QC Rules
6 or more Once per day Each level of QC 1:3s
5 Once per day Each level of QC Multi-rule strategy
4 At least twice per day Each level of QC Multi-rule strategy
< 4 At least four times per day Each level of QC Multi-rule strategy

 

It is important to note that this is just an example and it may be necessary to run QC samples more often than three times per day.  Some high throughput laboratories prefer to run QC samples before and after a set number of patient samples, while others opt to run QC samples after a set period of time.  Whatever frequency you choose it is vital that the frequency is appropriate for the test in use.  Download our guide ‘How often is right for QC’ to find out more.

What can Randox offer?

Randox’s Acusera 24.7 Live Online is a peer group reporting software application designed to complement the Acusera QC range. The intuitive and user-friendly software boasts some of the most advanced features on the market, and Version 1.6 provides automatic calculation of sigma scores for individual assays, giving the user an at-a-glance overview of assay performance.

Peer group reporting software is an integral part of any modern laboratory seeking to streamline their QC processes and reduce costs. With Acusera 24.7 Live Online, there has never been a better time to implement, save and succeed.

Contact us today to find out how Randox can help your laboratory achieve its goals.


Maintaining optimal brain health

Do you want to have optimal brain function later in life? We do. The majority of people focus on keeping their bodies in optimal condition but often forget about the most important organ, the brain. With more of us living until we’re much older, reduced brain function and Alzheimer’s are becoming increasingly more common; it is one of the most feared consequences of aging. We expect our bodies to age due to wear and tear; however there are easy ways to slow it, you will be glad to hear. Here are some top tips to keep your brain health at its peak.

  1. Get physical exercise

It is becoming an increasingly well-known fact by scientists that regular exercise may be the single most important thing you can do to ensure optimum brain health. The reason for this is that exercise increases the blood supply to your brain so therefore increases your brain capacity. Experts advise 30 minutes of exercise every other day to ensure good mental health. Exercise also helps with cholesterol levels, mental stress and diabetes.

  1. Eat, eat, eat

Good nutrition is also essential for good brain health. Your brain is no different to any other organ: the better the fuel it receives; the better it works, simple. As with everything it is important to keep your calories in check as it has been proven to reduce mental illness. We aim to reduce the consumption of saturated fats and cholesterol as these can decrease brain function. No matter who you are, vitamins are also very important to ensure not only a healthy brain, but a healthy body.  Vitamins of particular importance are folic acid, B6 and B12 which it is well-known can help lower your homocysteine levels. There is an ever-growing body of research which suggests that homocysteine levels have a strong correlation with Alzheimer’s and dementia. If you would like to read more about the link between homocysteine and Alzheimer’s, check out our previous blog post ‘How important is homocysteine research for Alzheimer’s disease?’

  1. Get enough sleep

Recent studies have suggested that a poor sleeping pattern is linked with cognitive decline in old age. A good night’s rest can actually double the chances of finding creative solutions to problems faced in everyday life! It has been proven that when we don’t sleep, proteins build up on the brain. These proteins build on the synapses, making it hard to think and learn new information; which is not conducive to good brain health.

  1. De-stress

Relaxation is key in a healthy lifestyle. Stress has a negative impact on the brain. It creates harmful chemicals to flow over areas of the brain that are in control of memory. Too much of these chemicals can lead to dementia and other memory loss related diseases, so maybe it’s not such a bad idea that you take that trip to the Bahamas you were thinking about!

  1. Improve you cholesterol

Cholesterol is commonly split up into good cholesterol (HDL) and bad cholesterol (LDL). There are loads of ways to improve your cholesterol levels such as exercise, weight control, dieting and avoiding tobacco. It is very important to keep you levels of LDL down as high levels can increase the risk of Alzheimer’s, dementia and cardiac problems in old age. At Randox we are constantly coming up with new and exciting ways of monitoring your cholesterol and the launch of our new HDL3 test is coming soon. For more information on HDL3, check it out here!

  1. Brain exercises

Challenging your mind from time to time is important for good brain health; it keeps your brain active and uses cognitive thought to try and learn or solve a problem. It is thought that a lack of education is a strong influence in cognitive decline. Challenging your brain improves memory, develops critical thinking and stimulates the whole brain ensuring brain health is kept to a maximum. It can often be done in fun ways like brain teasers, puzzles and jigsaws. Check out our recent brain teaser here!

 

These are only some of the ways in which to keep your brain in peak condition. Aging will take a toll on everyone and it is impossible to avoid; however these 6 techniques can help maintain optimal brain function!  We have been keeping up to date with Alzheimer’s in celebration of World Alzheimer’s Month. Remember a healthy brain is the key to success!

 


For health professionals

Randox Laboratories manufacture a wide range of routine and niche biochemistry reagents suitable for both research and clinical use.  These include an automated homocysteine test and our new HDL3 cholesterol assay.  Please contact reagents@randox.com for further information.


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